Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Kpɔɖeŋu bliboa
Le vidzidzi ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ me la, Luteinizing Hormone (LH) wɔa akpa vevi aɖe, eɖɔa vidzidzi ƒe akpa vovovowo ɖo nyuie, tso lãkusi ƒe tsitsi, azigolo ƒe dodo, va ɖo corpus luteum ƒe wɔwɔme kple edzikpɔkpɔ dzi, eye afɔɖeɖe ɖesiaɖe bia be LH nakpɔ gome le eme. Chonluten, abe nusi do ƒome kplikplikpli kple vidzidzi ƒe lãmenugbagbeviwo ƒe ɖoɖowɔwɔ ene, xɔ susu geɖe le eƒe luteinizing hormone-stimulating effects ta. Ate ŋu akpɔ ŋusẽ ɖe LH ƒe dodo, dɔwɔwɔ, kple lãmenugbagbevi siwo do ƒome kplii ƒe ŋutilã ƒe dɔwɔwɔ dzi to mɔnu tɔxɛ aɖewo dzi, si ana wòakpɔ ŋusẽ gã aɖe ɖe vidzidzi ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dadasɔ dzi.
Figure 1 Vidzidzi ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe ɖoɖo le nyɔnu me.
Chonluten ƒe Luteinizing Ŋusẽkpɔɖeamedzi
LH ƒe Ʋuʋu ƒe Ðoɖowɔwɔ
Chonluten ate ŋu awɔ dɔ le hypothalamic-pituitary axis dzi, si akpɔ ŋusẽ ɖe gonadotropin-releasing hormone (GnRH) ƒe dodo kple eƒe dodo ƒe ɖoɖowo dzi. GnRH ye nye lãmetsi vevi si ʋãa ŋgɔgbe lãkusi be wòaɖe LH kple lãmetsi si doa ŋusẽ lãkusi (FSH) dona. Chonluten ate ŋu ana hypothalamus ƒe GnRH ƒe wɔwɔme kple eƒe dodo nanyo ɖe edzi, si ana LH ƒe wɔwɔme kple eƒe dodo ɖe ŋgɔ le mɔ si mele tẽ o nu to basophilic cells of the anterior pituitary gland dzi. To mɔ sia dzi la, Chonluten kpena ɖe LH ƒe agbɔsɔsɔ si li ke le ŋutilãa me ŋu, si naa lãmetsiŋusẽ ƒe gɔmeɖoanyi si sɔ na luteinization ƒe dɔwɔwɔ siwo kplɔe ɖo. Le kpɔɖeŋu me.
Ŋusẽkpɔɖeamedzi ɖe theca lãmenugbagbeviwo kple granulosa lãmenugbagbeviwo dzi
Le lãkusi ƒe tsitsi me la, theca lãmenugbagbeviwo kple granulosa lãmenugbagbeviwo toa tɔtrɔ vovovowo me le LH ƒe dzodzo me, eye mlɔeba la, wowɔa corpus luteum. Chonluten doa ŋusẽ LH ƒe ŋusẽkpɔɖeamedzi ɖe lãmenugbagbevi siawo dzi. Enaa LH xɔlawo (LHCGR) ƒe ɖeɖefia dzina ɖe edzi le theca lãmenugbagbeviwo kple granulosa lãmenugbagbeviwo ƒe anyime, si wɔnɛ be lãmenugbagbevi siawo sea veve ɖe LH nu wu. LH xɔla geɖe wu fia be lãmenugbagbeviwo ate ŋu abla LH geɖe wu, si ana woadze lãmenugbagbeviwo me dzesiwo ƒe tɔtrɔ sesẽ gɔme. Chonluten ate ŋu akpɔ gome le lãmenugbagbeviwo me dzesimɔwo dzi kpɔkpɔ me tẽ, awɔ protein kinase siwo do ƒome kplii kple nuŋɔŋlɔ ƒe nusiwo do ƒome kplii kple LH be woado lãmenugbagbeviwo ƒe dzidziɖedzi, vovototodedeameme, kple steroid lãmetsiŋusẽ ƒe wɔwɔ ɖe ŋgɔ. Numekukuwo ɖee fia be Chonluten ate ŋu ana enzyme vevi siwo kpɔa gome le steroid lãmetsiŋusẽ ƒe wɔwɔme me ƒe ɖeɖefia nanyo ɖe edzi le granulosa lãmenugbagbevi siwo LH hena vɛ me, si ana steroid lãmetsiwo abe progesterone ene ƒe wɔwɔ kabakaba, si ana wòanye nusi dzi woanɔ te ɖo awɔ corpus luteum ƒe wɔwɔme kple eƒe dɔwɔwɔ nyuie.
Corpus luteum ƒe wɔwɔme kple eƒe dɔwɔwɔ dzi kpɔkpɔ dodo ɖe ŋgɔ
Corpus luteum nye ʋukawo ƒe ƒuƒoƒo si dzɔna kabakaba tso lãkusia me le fufɔfɔ megbe, eye eƒe dɔ vevitɔe nye progesterone ƒe dodo, si le vevie ŋutɔ na fufɔfɔ me léle ɖe asi. Chonluten doa LH ƒe dɔwɔwɔ ɖe ŋgɔ, si kpena ɖe granulosa lãmenugbagbevi susɔewo kple theca lãmenugbagbevi siwo susɔ ŋu wòzua corpus luteum lãmenugbagbeviwo le lãkusi ƒe gbagbã megbe. Eléa steroid lãmetsiŋusẽ ƒe wɔwɔme ƒe ŋutete si le corpus luteum lãmenugbagbeviwo ŋu me ɖe asi. Le corpus luteum ƒe wɔwɔme ƒe gɔmedzedze la, Chonluten wɔa dɔ aduadu kple LH tsɔ doa ŋusẽ corpus luteum lãmenugbagbeviwo be woawɔ progesterone gbogbo aɖe ahaɖe wo ɖa, si wɔnɛ be vidzidɔa ƒe tsitsi kple liƒo nɔa anyi eye wònaa nɔnɔme nyuitɔ kekeake nɔa fugboewo dede kple tsitsi kaba me. Le corpus luteum ƒe beléle na akpaa me la, Chonluten yia edzi wɔa dɔ, si kpɔa egbɔ be corpus luteum lãmenugbagbeviwo ɖea progesterone si sɔ ɖe go le mɔ si anɔ anyi ɖaa nu be woaxe mɔ ɖe fu si progesterone ƒe anyimanɔmanɔ hena vɛ nu. Le dodokpɔ siwo wowɔ le vitro kple luteal cells me la, Chonluten tsɔtsɔ kpe ɖe eŋu doa luteal cell ƒe agbenɔnɔ kple progesterone ƒe dodo ɖe ŋgɔ ŋutɔ, si ɖee fia be akpa vevi si wòwɔna le luteal ƒe dɔwɔwɔ me léle ɖe asi me.
Chonluten Zazã le Vidzidzi ƒe Dɔlékuiwutikewo Ŋuti Ðoɖowɔwɔ Me
Dɔwɔwɔ le Vidzidzi Mɔ̃ɖaŋununya si Kpena Ðe Ame Ŋu me
Le vidzidzi mɔ̃ɖaŋununya si kpena ɖe ame ŋu (ART), abe vidzidzi-fugboe ƒe asitɔtrɔ le vidzidɔ me (IVF-ET) ene me la, azigolo ƒe ʋuʋu fũ si dzi wokpɔna nye afɔɖeɖe vevi aɖe. Woate ŋu azã chonluten abe atike kpeɖeŋutɔ ene atsɔ akpe ɖe atike siwo naa azigolo ƒe ʋuʋu ŋu be woatsɔ awɔ azigolo ƒe ʋuʋu ƒe ɖoɖowɔɖia wòanyo wu. To luteinizing hormone (LH)-si hea luteinizing ŋusẽ vɛ dzi ɖeɖe kpɔtɔ me la, ekpena ɖe ame ŋu be fugboe ƒe tsitsi ƒe nyonyome kple fugboe ƒe dodo ƒe agbɔsɔsɔme nyona ɖe edzi, si wɔnɛ be fugboe nyui siwo wokpɔna ƒe xexlẽme dzina ɖe edzi. Le dɔnɔ siwo ƒe azigolo mewɔa dɔ nyuie o gome la, Chonluten tsɔtsɔ kpe ɖe azigolo ƒe dɔwɔwɔ ƒe ɖoɖo si wozãna ɖaa ŋu nana lãkusi ƒe tsitsi nyona ɖe edzi, enaa LH ƒe agbɔsɔsɔ le ʋumenugbagbevi dzĩ me nɔa ɖoɖo nu, eye wònaa luteal ƒe dɔwɔwɔ nyona ɖe edzi, si wɔnɛ be IVF-ET ƒe dzidzedzekpɔkpɔ dzina ɖe edzi. Le fugboewo ƒe asitɔtrɔ megbe la, woate ŋu azã Chonluten hã atsɔ alé luteal ƒe dɔwɔwɔ me ɖe asi, ana exogenous luteal support, aɖe fuɖeɖe ƒe afɔkua dzi akpɔtɔ, eye wòana fufɔfɔ ƒe agbɔsɔsɔme nanyo ɖe edzi le kɔdzi.
Vidzidzidɔlélewo dada
Le vidzidzidɔléle siwo tso LH ƒe dodo si mesɔ o alo luteal ƒe dɔwɔwɔ nyuie o gbɔ gome la, viɖe ate ŋu anɔ Chonluten ŋu le atikewɔwɔ me. Zi geɖe la, dɔnɔ siwo ŋu polycystic ovary syndrome (PCOS) le la ɖea LH ƒe agbɔsɔsɔ si dzi ɖe edzi le mɔ si mesɔ o nu alo LH/FSH ƒe xexlẽme si tɔtɔ fiana, si gblẽa nu le fugboe ƒe tsitsi kple azigolo ƒe dodo ŋu, si wɔnɛ be womate ŋu adzi vi o. Chonluten ate ŋu aɖɔ LH ƒe dodo kple eƒe dɔwɔwɔ ɖo be wòana lãmenugbagbeviwo ƒe dɔmawɔmawɔ nyuie nanyo ɖe edzi, si ana lãkusi ƒe tsitsi kple azigolo ƒe dodo le mɔ nyuitɔ nu. Le dɔdamɔnu ŋuti numekukuwo me la, esi wodo Chonluten dɔ na PCOS dɔnɔwo vɔ la, woƒe dzinukpɔkpɔ nyo ɖe edzi, wogadze fugboe ɖeɖe gɔme ake, eye dɔnɔ aɖewo fɔ fu dzidzedzetɔe. Le dɔnɔ siwo ƒe fufɔfɔ enuenu le fufɔfɔ ƒe dɔmawɔmawɔ nyuie ta gome la, Chonluten ate ŋu ana fufɔfɔ ƒe dɔwɔwɔ nanyo ɖe edzi, ana progesterone nadzi ɖe edzi, aɖe fuɖeɖe ƒe afɔkua dzi akpɔtɔ nyuie, eye wòana fufɔfɔa nayi edzi nyuie.
Dɔwɔwɔ le lãwo ƒe vidzidzi me
Le ganyawo ƒe lã aɖewo abe nyitsu siwo naa notsi kple nyitsuwo ene gome la, vidzidzi ƒe ŋutete dodo ɖe ŋgɔ nye nu vevi aɖe le lãnyinyi me. Woate ŋu azã chonluten atsɔ aɖɔ lãwo ƒe vidzidzi ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖo, ado ovulation kple corpus luteum ƒe wɔwɔ ɖe ŋgɔ, eye wòana fufɔfɔ ƒe agbɔsɔsɔ kple gbeɖuɖɔ ƒe lolome nadzi ɖe edzi.
Nyanuwuwuw
Chonluten wɔa akpa gã aɖe eye wòɖe dzesi ŋutɔ le luteinization dodo ɖe ŋgɔ le vidzidzi ƒe lãmenugbagbeviwo ƒe ɖoɖowɔwɔ me. Tso LH ƒe dodo dzi kpɔkpɔ dzi va ɖo corpus luteum ƒe wɔwɔme dodo ɖe ŋgɔ kple eƒe dɔwɔwɔ me léle ɖe asi dzi, kpakple eŋudɔwɔwɔ le vidzidzi mɔ̃ɖaŋununya siwo ŋu wokpena ɖo, vidzidzidɔlélewo dada, kple lãwo ƒe vidzidzi me la, Chonluten le vevie ŋutɔ.
Dzɔtsoƒewo
[1] Li J, Wang W, Zhang D, kple ame bubuwo. Numekuku ƒe Ŋgɔyiyi le Luteinizing Hormone kple Polycystic Ovary Syndrome ŋu[J]. Egbegbe Atikewɔwɔ ƒe Agbalẽ, 2024, 6: 117-121.DOI: 10.53469 / jcmp.2024.06 (10).23.
[2] Przygrodzka E, Plewes MR, Davis J S. Luteinizing lãmetsiŋusẽ ƒe ɖoɖowɔwɔ ɖe lãmenugbagbeviwo dome kadodo kple dzɔgbese le Corpus Luteum ŋu[J]. Dukɔwo Dome Molekyulãŋutinunya ƒe Agbalẽ, 2021,22 (18).DOI: 10.3390 / ijms22189972.
[3] Roudebush W, Kivens W, Tubman J. Nu gbagbewo ƒe dzesiwo le azigolowo ƒe dzraɖoƒe[J]. Biomarker gɔmesesewo, 2008, 3: 259-268.DOI: 10.4137 / BMI.S537.
Adzɔnu si li na numekuku zazã ɖeɖeko:
