Cocer Peptides fɛ 
a bɛ kalo 1 bɔ
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Kuma bɛɛ lajɛlen
Bangekɔlɔsi fɛɛrɛw la, Luteinizing Hormone (LH) jɔyɔrɔ ka bon kosɛbɛ, a bɛ bangekɔlɔsi taabolo taabolo caman ɲɛnabɔ ka ɲɛ, k’a ta foli la, k’a ta kɔnɔbara falenni na, ka taa a bila corpus luteum dilanni n’a ladonni na, sen kelen-kelen bɛɛ bɛ LH sen don a la. Konlutɛni, n’o ye fɛn ye min ni bangekɔlɔsi fɛɛrɛw ɲɛnabɔli bɛ tali kɛ ɲɔgɔn na kosɛbɛ, o ye jateminɛba sɔrɔ a ka luteinizing hormone-stimulating nɔw kosɔn. A bɛ se ka nɔ bila LH bɔli la, a ka baara la, ani a ni ɲɔgɔn cɛ farikolo baara la, fɛɛrɛ kɛrɛnkɛrɛnnenw fɛ, o la, a bɛ nɔba bila bangekɔlɔsi fɛɛrɛw balansi la.
Jaa 1 Muso ka bangekɔlɔsi fɛɛrɛw jateminɛcogo.
Chonluten ka luteinizing nɔ min bɛ sɔrɔ a la
LH bɔli ɲɛnabɔli
Kɔnlutɛni bɛ se ka baara kɛ hipotalamu-pituitaire axis kan, ka nɔ bila gonadotropin-releasing hormone (GnRH) bɔli ni a bɔli cogoya la. GnRH ye ɔrimɔni jɔnjɔn ye min bɛ ɲɛgɛnɛsira ɲɛfɛla bila ka LH ni ɔrimɔni min bɛ folikɛlan (FSH) bɔ. Kɔnlutɛni bɛ se ka GnRH sɔrɔli ni a bɔli fanga bonya hipotalamus fɛ, o la, a bɛ LH sɔrɔli ni a bɔli sabati cogo la min tɛ ɲɛ, ɲɛgɛnɛsira ɲɛfɛla basophilikiw fɛ. O cogo la, Chonluten bɛ dɛmɛ ka LH hakɛ sabatilen mara farikolo la, ka ɔrimɔni jusigilan ɲuman di luteinization (luteinization) taabolo nataw ma. Misali la, baganw ka kɔlɔsiliw la, a jirala ko Chonluten furakɛli kɔfɛ, GnRH jirali hakɛ min bɛ ARNm la hipotalamus kɔnɔ, o cayara, ka sɔrɔ LH hakɛ min bɛ joli lamini na, o fana wulila ka kɛɲɛ ni o ye, o b’a jira ko Chonluten ka se ka ɲɛnabɔli ɲuman kɛ LH bɔli la.
A bɛ nɔ bila theca cellules ni granulosa cellules la
Folikiliw yiriwali waati, teka seliluw ni granulosa seliluw bɛ fɛn caman Changer LH lawulili kɔrɔ, a laban na, u bɛ kɛ corpus luteum ye. Kɔnlutɛni bɛ LH nɔw bonya o farikolokisɛw la. A bɛ LH minɛbagaw (LHCGR) jirali wuli ka taa a fɛ theka selilɛriw ni granulosa selilɛriw sanfɛ, o bɛ kɛ sababu ye ka o farikolokisɛw kɛ LH la. LH minɛbaga caman kɔrɔ ye ko seliluw bɛ se ka LH caman siri, o la, selilu kɔnɔ taamasiɲɛw cili barikama bɛ daminɛ. Kɔnlutɛni bɛ se ka a sen don farikolo kɔnɔ taamasiɲɛw siraw labɛnni na k’a ɲɛsin u yɛrɛ ma, ka poroteyini kinazi ni sɛbɛnnikɛlan minnu bɛ tali kɛ ɲɔgɔn na, olu ni LH bɛ baara kɛ ɲɔgɔn fɛ walasa ka selilu caya, ka danfara don u ni ɲɔgɔn cɛ, ani ka stɛroyi ɔrimɔni dilan. Kɔlɔsiliw y’a jira ko Kɔnlutɛni bɛ se ka dɔ fara anzimu jɔnjɔnw jirali kan minnu bɛ stɛroyi ɔrimɔni dilancogo la LH-induite granulosa selilɛriw kɔnɔ, ka stɛroyi ɔrimɔni sɔrɔli teliya i n’a fɔ porojɛsitɛri, o la, a bɛ kɛ sababu ye ka fɛnɲɛnɛmafagalanw dilan ani k’a ladon.
Ka farikolojidɛsɛ (corpus luteum) dilancogo ni a baarakɛcogo sabatili sabati
Corpus luteum ye joli siraw ye minnu bɛ sɔrɔ teliya la ka bɔ foli la kɔnɔmaya kɔfɛ, a baara fɔlɔ ye porojɛsitɛri bɔli ye, o min nafa ka bon kɔnɔmaya sabatili la. Kɔnlutɛni bɛ LH ka baara sabati, o bɛ dɛmɛ don ka granulosa selilɛri tɔw ni theka selilɛriw caman tigɛli teliya la ka kɛ farikolokisɛw ye, folikili karilen kɔfɛ. A bɛ farikolojidɛsɛbanakisɛw ka ɔrimɔni sɛnɛcogo seko mara. Kɔnɔnatumuw dilanni daminɛ waatiw la, Kɔnlutɛni bɛ jɛ ka baara kɛ ni LH ye walasa ka farikolojidɛsɛbanakisɛw lawuli walasa u ka porojɛsitɛri hakɛ caman dilan ani ka u bɔ, ka kɔnɔbara basigilen bonya ni a sabatili sabati ani ka sigida ɲuman dilan denw doncogo ni u yiriwali joona kama. Kɔnɔbara basigilen ladonni waati la, Kɔnlutɛni bɛ taa a fɛ ka baara kɛ, ka a lajɛ ko farikolojidɛsɛbanakisɛw bɛ porojɛsitɛri caman bɔ ka ɲɛ walasa ka kɔnɔtiɲɛw bali minnu bɛ sɔrɔ porojɛsitɛri dɛsɛ fɛ. Kɔrɔbɔliw la in vitro ni luteal cellules ye, Chonluten farali bɛ luteal cellules ɲɛnamaya ni porojɛsitɛri bɔli bonya kosɛbɛ, o b’a jira ko a jɔyɔrɔ ka bon luteal baara sabatili la.
Kɔnlutɛni tali bangekɔlɔsi fɛɛrɛw labɛnni na
Baarakɛcogo minnu bɛ kɛ bangeko dɛmɛni fɛɛrɛbɔ la
Bangekɔlɔsi fɛɛrɛ dɛmɛnanw na (ART), i n’a fɔ kɔnɔmaya-denmisɛnni jiginni in vitro (IVF-ET), kɔnɔbara basigilen caya min bɛ kɔlɔsi, o ye fɛɛrɛ kɔrɔba ye. Kɔnlutɛni bɛ se ka kɛ fura dɛmɛnan ye ka fara furaw kan minnu bɛ kɔnɔbara basigilen don walasa ka kɔnɔbara basigilen furakɛli kɛcogo ɲɛ. Ni a bɛ luteinizing hormone (LH)-induite luteinizing effect (luteinizing hormone (LH)) fanga bonya, a bɛ dɛmɛ ka folikɛlanw yiriwali cogoya ɲɛ ani ka kɔnɔbara bɔli hakɛ ɲɛ, o la, a bɛ dɔ fara denw hakɛ kan minnu bɛ sɔrɔ. Banabagatɔ minnu ka kɔnɔbara jaabi man ɲi, ni u ye Chonluten fara ovulation induction protocole standard kan, o bɛ folikiliw yiriwali ɲɛ, ka LH hakɛ kɛ joli la, ani ka luteal baara kɛcogo ɲɛ, o bɛ dɔ fara IVF-ET ɲɛtaa hakɛ kan. Den jiginni kɔfɛ, Chonluten bɛ se ka kɛ fana walasa ka luteal baara sabati, ka luteal dɛmɛni di kɛnɛma, ka kɔnɔtiɲɛ farati dɔgɔya, ani ka kɔnɔta hakɛ ɲɛ kɛnɛyaso la.
Bangekɔlɔsi banaw furakɛli
Bangekɔlɔsi gɛlɛya minnu bɛ sɔrɔ LH bɔli fɛ cogo la min tɛ bɛn walima luteal baarakɛbaliya fɛ, Chonluten bɛ se ka furakɛli nafa sɔrɔ. Banabagatɔ minnu bɛ ni sindrome polycystique ovaire (PCOS) ye, olu ka teli ka LH hakɛ caya cogo la min tɛ deli ka kɛ walima LH/FSH hakɛ bɛ tiɲɛ, o bɛ folikɛlanw yiriwali ni kɔnɔbara bɔli tiɲɛ, o bɛ na ni bangekɔlɔsi ye. Kɔnlutɛni bɛ se ka LH bɔli ni a kɛcogo ɲɛnabɔ walasa ka farikolojidɛsɛ furakɛ, ka ɲɛgɛnɛsiralabanaw yiriwali ni kɔnɔbara bɔli ɲɛ. Dɔgɔtɔrɔso ka sɛgɛsɛgɛliw la, Chonluten furakɛli kɛlen kɔ PCOS banabagatɔw la, u ka kalolabɔ bɛ ɲɛ, kɔnɔbara bɔli daminɛna kokura, wa banabagatɔ dɔw ye kɔnɔ ta ka ɲɛ. Banabagatɔ minnu kɔnɔtiɲɛ bɛ segin-ka-bɔ ka a sababu kɛ kɔnɔtiɲɛ dɛsɛ ye, Kɔnlutɛni bɛ se ka kɔnɔtiɲɛ baara ɲɛ, ka dɔ fara porojɛsitɛri hakɛ kan, ka kɔnɔtiɲɛ farati dɔgɔya kosɛbɛ, ani ka kɔnɔta taabolo ɲɛ.
A kɛcogo baganw ka bangeko la
Sɔrɔko bagan dɔw fɛ, i n’a fɔ nɔnɔma misiw ni misidenw, bangeko ɲuman yiriwali ye ko fɔlɔ ye baganmara la. Kɔnlutɛni bɛ se ka kɛ ka baganw ka bangekɔlɔsi fɛɛrɛw labɛn, ka kɔnɔbara bɔli ni farikolojidɛsɛ sɔrɔli sabati, ani ka kɔnɔta hakɛ ni nɔgɔ hakɛ caya.
Kuncɛli
Kɔnlutɛni jɔyɔrɔ ka bon ani a jɔyɔrɔ ka bon luteinization (luteinization) sabatili la bangekɔlɔsi fɛɛrɛw ɲɛnabɔli kɔnɔ. K’a ta LH bɔli labɛnni na ka se farikolojidɛsɛ sɔrɔli sabatili ma ani a baara sabatili ma, ka fara a kɛcogo kan bangekɔlɔsi fɛɛrɛ dɛmɛnanw na, bangekɔlɔsi banaw furakɛli la, ani baganw ka bangeko la, Chonluten nafa ka bon kosɛbɛ.
Sosow (Sɔrɔyɔrɔw).
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[2] Przygrodzka E, Plewes MR, Davis J S. Luteinizing hormone régulation de la communication inter-organelle et la fate de la corpus luteum[J]. Duniya kɔnɔ, 2021,22(18).DOI:10.3390/ijms22189972.
[3] Roudebush W, Kivens W, Tubman J. Ovari reserve ka biyomarkɛriw[J]. Biomarker Insights, 2008,3:259-268.DOI:10.4137/BMI.S537. Kalanjɛ ni sɛbɛnni: kalanjɛ ni sɛbɛnni gafew.
Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama:
