Na Cocer Peptides 
ukwezi gushize
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Intangiriro
Kunanirwa k'umutima, nk'indwara ikomeye y'umutima n'imitsi, bigira ingaruka zikomeye ku mibereho y'abarwayi no guhanura. Kumenya uburyo bwiza bwo kuvura kurinda imikorere yumutima byahindutse ahantu h’ubushakashatsi mu gice cyumutima. Corgaten, nk'umuti ufite agaciro gashobora kuvurwa kunanirwa k'umutima, witabiriwe cyane mumyaka yashize.
Igicapo 1 Impamvu gakondo zishobora gutera umutima-mitsi zishobora gutera indwara z'umutima kubarwayi barwaye IIM.
Incamake ya Corgaten
Corgaten ni imiti yumutima nimiyoboro yumutima igira ingaruka nziza mumikorere yumutima yibasira ahantu runaka mumutima. Ugereranije n’imiti gakondo ivura umutima, Corgaten ifite uburyo bwihariye bwibikorwa nibyiza, itanga uburyo bushya bwo kuvura abarwayi bafite ikibazo cyumutima.
Mu gihe ubushakashatsi ku bitera indwara yo kunanirwa k'umutima bukomeje kwiyongera, bimaze kugaragara ko imiti gakondo ifite aho igarukira mu kuvura indwara z'umutima. Kugirango ubone uburyo bunoze bwo kuvura, abashakashatsi bitangiye guteza imbere imiti mishya. Nyuma yimyaka myinshi yubushakashatsi bwibanze nigeragezwa ryamavuriro, Corgaten yerekanye buhoro buhoro ubushobozi bwayo mukuvura umutima.
Ingaruka zo Kurinda Corgaten kumikorere yumutima mubarwayi bananirwa kumutima
(1) Kunoza imikorere ya Myocardial Amasezerano
Kongera calcium ion yinjira mu ngirabuzimafatizo ya myocardial: Corgaten ikora ku miyoboro ya calcium ion ku mitsi ya myocardial selile, igatera calcium ion yinjira, bityo bikazamura uburyo bwo guhuza imbaraga no guhuza ingirabuzimafatizo za myocardial no kunoza ubwonko bwa myocardial. Mu kunanirwa k'umutima, ubushobozi bwa calcium ion yo gufata ingirabuzimafatizo ya myocardial buragabanuka, bigatuma imikorere ya myocardial igabanuka. Corgaten igarura imikorere isanzwe ya myocardial igabanya imikorere ya calcium ion yinjira, bityo ikongerera ubushobozi bwo kuvoma umutima.
Kuzamura isano iri hagati ya troponine na calcium ion: Troponine ni poroteyine nyamukuru igenga myocardial. Corgaten yongerera umubano hagati ya troponine na calcium ion, bigatuma troponine ikora cyane muburyo bwa calcium ion ion, bityo bigatuma myocardial igabanuka. Izi ngaruka zifasha kunoza imikorere ya myocardial no kugabanya imikorere yumutima kubarwayi bananirwa kumutima.
(2) Kugenga imbaraga z'umutima metabolism
Gukoresha ingufu za myocardial substrate ikoreshwa: Mugihe cyo kunanirwa k'umutima, imbaraga za myocardial metabolism zirahungabana, hamwe na okiside ya aside irike kandi bikagabanya okiside ya glucose. Corgaten irashobora kugenga inzira ya metabolisme yingufu muri selile ya myocardial, igatera ihinduka kuva metabolism cyane cyane ishingiye kuri okiside ya aside irike ikajya kuri imwe ishingiye cyane cyane kuri okiside ya glucose. Glucose okiside ikora neza mugutanga ingufu kandi ikenera ogisijeni nkeya ugereranije, ifasha kuzamura ingufu za myocardial, kugabanya umutwaro w'ingufu kuri myocardium, no kurinda imikorere yumutima.
Guteza imbere imikorere ya mitochondrial: Mitochondria niho hantu hambere h’umusaruro w’ingirabuzimafatizo muri myocardial, kandi imikorere yazo irabangamiwe no kunanirwa k'umutima. Corgaten irashobora kugenga inzira zerekana ibimenyetso bya mito-iyambere kugirango iteze imbere ibinyabuzima bya mito-iyambere, byongera umubare wa mito-iyambere. Itezimbere kandi imikorere yubuhumekero ya mitochondial, ikongerera ingufu ingufu, itanga ingufu zihagije za selile myocardial, kandi ikomeza ibikorwa bisanzwe byo kwikuramo umutima no kuruhuka.
(3) Kugabanya kuvugurura myocardial
Kurinda myocardial selile apoptose: Mugihe cyo gutera imbere kunanirwa k'umutima, kwiyongera kwa myocardial selile apoptose itera kugabanuka kwimibare ya myocardial selile, bityo bikangiza imikorere yumutima. Corgaten irashobora gukora inzira yo kurwanya inzira ya anti-apoptotique yerekana inzira, ikabuza kwerekana poroteyine ziterwa na apoptose muri selile myocardial, kandi bikagabanya apoptose ya myocardial selile. Ibi bifasha kugumana umubare nuburinganire bwimiterere ya selile myocardial, bityo bikadindiza iterambere ryumutima.
Kugenzura matrix metabolisme idasanzwe: Mugihe cyo kuvugurura myocardial, ubusumbane muri synthesis no kwangirika kwa matrise idasanzwe itera fibrosis ya myocardial. Corgaten irashobora kugenga imvugo ya matrix metalloproteinase hamwe na inhibitor za tissue, ikomeza kuringaniza metabolisme ya matrixique idasanzwe no kugabanya indwara ya fiboside ya myocardial. Mugabanya fibrosis ya myocardial, Corgaten irashobora kunoza iyubahirizwa rya myocardial no kurinda imikorere ya diastolique yumutima.
Gukoresha Corgaten mukuvura kunanirwa k'umutima
Imiterere yubuvuzi bwa none
Kugeza ubu, Corgaten yakoreshejwe mubigeragezo bimwe na bimwe byamavuriro kandi imaze kugera ku ngaruka zimwe na zimwe zo kuvura. Mu bushakashatsi bumwe na bumwe bw’ubuvuzi, ibipimo byerekana imikorere yumutima nkibice byo gusohora umuyaga w’ibumoso hamwe n’umutima uva mu barwayi bafite ikibazo cy’umutima bavuwe na Corgaten bagaragaje iterambere ryinshi. Ibimenyetso by'abarwayi nka dyspnea n'umunaniro nabyo byagabanutse, kandi imibereho yabo yarazamutse.
Umwanzuro
Nkumuti wumutima wamaraso, Corgaten igira uruhare runini mukurinda imikorere yumutima kubarwayi bananirwa kumutima. Binyuze mu buryo bwinshi, harimo kunoza imikorere ya myocardial contractile, kugenzura imbaraga z'umutima umutima, no kugabanya myocardial kuvugurura, Corgaten itanga uburyo bushya bwo kuvura kunanirwa k'umutima.
Inkomoko
[1] Diederichsen L. Uruhare rw'umutima n'imitsi muri myosite [J]. Igitekerezo cya none muri rubagimpande, 2017,29: 1.DOI: 10.1097 / BOR.0000000000000442.
Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
