By Cocer Peptides 
1 ọnwa gara aga
Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.
Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.
Okwu mmalite
Ọkpụkpụ obi, dị ka ọrịa obi siri ike, na-emetụta ndụ ndị ọrịa nke ukwuu na amụma amụma. Ịmata ndị na-ahụ maka ọgwụgwọ dị irè iji kpuchido ọrụ obi abụrụla ebe nyocha na mpaghara obi obi. Corgaten, dị ka ọgwụ nwere uru bara uru na ọgwụgwọ nkụda obi, enwetala nlebara anya n'afọ ndị na-adịbeghị anya.
Ihe onyonyo 1 ọdịnala nwere ike ibute ọrịa obi na ndị ọrịa nwere IIM.
Nkọwa nke Corgaten
Corgaten bụ ọgwụ ọhụrụ nke obi na-arụ ọrụ dị mma na-arụ ọrụ obi site na ilekwasị anya na saịtị ndị dị na obi. Tụnyere ọgwụ ọgwụgwọ nkụda mmụọ nke ọdịnala, Corgaten nwere usoro omume na uru pụrụ iche, na-enye nhọrọ ọgwụgwọ ọhụrụ maka ndị ọrịa nkụda mmụọ.
Ka nyocha banyere pathogenesis nke nkụda obi na-aga n'ihu na-abawanye ụba, ọ bịara doo anya na ọgwụ ọdịnala nwere oke ụfọdụ n'ịgwọ nkụda obi. Iji chọta ụzọ ọgwụgwọ dị irè karị, ndị nchọpụta etinyela aka n'ịmepụta ọgwụ ọhụrụ. Mgbe ọtụtụ afọ nke nchọpụta bụ isi na ule ụlọ ọgwụ gasịrị, Corgaten ejirila nwayọọ nwayọọ gosipụta ike ya n'ịgwọ ọrịa obi.
Mmetụta nchebe nke Corgaten na arụ ọrụ obi na ndị ọrịa obi na-ada mbà
(1) Imelite ọrụ nkwekọrịta myocardial
Ịba ụba ion calcium na-abanye n'ime sel myocardial: Corgaten na-arụ ọrụ na ọwa calcium ion na akpụkpọ anụ myocardial myocardial, na-akwalite ntinye nke calcium ion, si otú ahụ na-eme ka usoro mmechi nke sel myocardial na-akpali akpali ma na-eme ka nkwekọrịta myocardial dịkwuo mma. Na nkụda mmụọ obi, ikike njikwa calcium ion nke mkpụrụ ndụ myocardial na-ebelata, na-eduga n'ịrụ ọrụ nkwekọrịta myocardial adịghị ike. Corgaten na-eweghachite ọrụ nkwekọrịta myocardial nkịtị site n'ịchịkwa mmụba nke calcium ion, si otú a na-eme ka ikike ịmịpụta obi dịkwuo mma.
Na-eme ka mmekọrịta dị n'etiti troponin na calcium ion: Troponin bụ isi ihe na-achịkwa protein na myocardial contraction. Corgaten na-eme ka mmekọrịta dị n'etiti troponin na calcium ion, na-eme ka troponin na-arụ ọrụ ngwa ngwa n'otu ntinye calcium ion, si otú ahụ na-akwalite myocardial myocardial. Mmetụta a na-enyere aka melite arụmọrụ myocardial myocardial na ọrụ obi na ndị ọrịa nkụda obi.
(2) Na-achịkwa metabolism ike obi
Na-eme ka ojiji mkpụrụ ndụ ike myocardial dị mma: N'oge nkụda mmụọ obi, metabolism ike myocardial na-akụghasị, na-abawanye oxidation fatty acid na mbelata oxidation glucose. Corgaten nwere ike ịhazi ụzọ metabolism ike n'ime sel myocardial, na-akwalite ngbanwe site na metabolism nke sitere na fatty acid oxidation na nke dabere na glucose oxidation. Glucose oxidation na-arụ ọrụ nke ọma n'ịmepụta ume ma na-achọ ikuku oxygen dị ntakịrị, nke na-enyere aka melite ike myocardial, belata ibu ike na myocardium, ma chekwaa ọrụ obi.
Na-akwalite mgbake ọrụ mitochondrial: Mitochondria bụ ebe bụ isi maka mmepụta ume na mkpụrụ ndụ myocardial, ọrụ ha na-emebikwa na nkụda obi. Corgaten nwere ike ịhazi ụzọ mgbaàmà metụtara mitochondrial iji kwalite mitochondrial biogenesis, na-amụba nọmba mitochondrial na ọrụ. Ọ na-emekwa ka ọrụ iku ume mitochondrial dịkwuo mma, na-eme ka nrụpụta ike na-arụ ọrụ nke ọma, na-enye ume zuru oke maka mkpụrụ ndụ myocardial, ma na-ejigide mkpụkọ obi na ọrụ ntụrụndụ nkịtị.
(3) Na-ebelata ngbanwe nke myocardial
Na-egbochi myocardial cell apoptosis: N'oge ọganihu nke nkụda obi obi, ụbara apoptosis cell myocardial myocardial na-eduga na mbelata nọmba cell myocardial, si otú ahụ na-emebi ọrụ obi. Corgaten nwere ike ịgbalite ụzọ mgbaàmà mgbochi apoptotic intracellular, gbochie okwu nke protein ndị metụtara apoptosis na sel myocardial, ma belata apoptosis cell myocardial. Nke a na-enyere aka ịnọgide na-enwe ọnụ ọgụgụ na nhazi nke sel myocardial, si otú a na-ebelata ọganihu nke nkụda obi.
Na-achịkwa metabolism matrix extracellular: N'oge a na-emegharị myocardial, enweghị ahaghị nhata na njikọ na mmebi nke matrix extracellular na-eduga na fibrosis myocardial. Corgaten nwere ike ịhazi okwu nke matrix metalloproteinases na ndị na-egbochi anụ ahụ ha, na-edobe nguzozi nke matrix extracellular metabolism na ibelata ihe omume fibrosis myocardial. Site na ibelata fibrosis myocardial, Corgaten nwere ike melite nnabata myocardial ma chebe ọrụ diastolic obi.
Ngwa nke Corgaten na ọgwụgwọ nke nkụda obi
Ọnọdụ ngwa ụlọ ọgwụ ugbu a
Ugbu a, etinyere Corgaten na ụfọdụ ule ụlọ ọgwụ wee nweta ụfọdụ mmetụta ọgwụgwọ. N'ime ụfọdụ obere ọmụmụ ụlọ ọgwụ, ndị na-egosi ọrụ obi dị ka akụkụ nke mpụ ventricular aka ekpe na mmepụta obi n'ime ndị ọrịa obi mgbawa nke a na-emeso Corgaten gosipụtara ọganihu dị ukwuu. E wepụrụkwa mgbaàmà ndị ọrịa dị ka dyspnea na ike ọgwụgwụ, na ndụ ha ka mma.
Mmechi
Dị ka ọgwụ ọhụrụ obi, Corgaten na-ekere òkè dị ukwuu n'ichekwa ọrụ obi na ndị ọrịa obi mgbawa. Site n'ọtụtụ usoro, gụnyere imeziwanye ọrụ myocardial contractile, na-achịkwa metabolism ike nke obi, na ibelata ngbanwe myocardial, Corgaten na-enye ụzọ ọhụrụ maka ọgwụgwọ nkụda obi.
Isi mmalite
[1] Diederichsen L. Ntinye aka obi na myositis[J]. Echiche dị ugbu a na Rheumatology, 2017,29:1.DOI:10.1097/BOR.000000000000442.
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