Ènya be ɖiƒoƒonuwo kple nuteɖeamedziwo gblẽa nu le wò lãkusiwo ŋu ɣesiaɣia? Le ɣeyiɣi aɖe megbe la, esia ate ŋu ahe gbɔgbɔtsixe ƒe kuxi siwo nɔa anyi didi vɛ.Bronchogen, a bioregulator peptide , kpena ɖe ame ŋu wòdzraa lãkusiwo ɖo hegbugbɔa wo yeyee le dzɔdzɔme nu.
Le nyati sia me la, míadzro alesi Bronchogen doa alɔ lãkusi ƒe lãmesẽ kple hayahaya me. Àsrɔ̃ alesi wòkpena ɖe wò lãkusiwo ta.Srɔ̃ nu geɖe tso míaƒe atikewo ŋu le Cocer Peptides kple alesi woate ŋu ado alɔ wò lãkusiwo ƒe lãmesẽ.
Bronchogen nye bioregulator peptide si wowɔ koŋ be wòaɖo taɖodzinu na lãkusiwo. Enye tetrapeptide si me amino acid ene le: alanine (Ala), glutamic acid (Glu), aspartic acid (Asp), kple leucine (Leu), si woyɔna zi geɖe to eƒe atike ƒe nɔnɔme si nye AEDL me. Enye Khavinson peptide ƒomea ƒe akpa aɖe, si me peptide bubu siwo ku ɖe lãmenugbagbeviwo koŋ ŋu abe Epitalon (pineal gland) kple Cortexin (ahɔhɔ̃) le. Bronchogen ƒe nɔnɔme tɔxɛae nye ŋutete si le esi be wòatiae be wòawɔ nu kple lãkusiwo, si doa gbugbɔgadzɔ ɖe ŋgɔ eye wòléa lãkusi ƒe dɔwɔwɔ ɖe te.
Le Bronchogen ƒe lolome sue (a molecule ƒe kpekpeme nye 446.45 g/mol) ta la, ate ŋu age ɖe lãmenugbagbeviwo ƒe lãkusiwo me bɔbɔe eye wòaɖo ta DNA si le lãkusi me lãmenugbagbeviwo me. Ŋutete sia na wòte ŋu trɔa asi le domenyiŋusẽfianu ƒe ɖeɖefia ŋu eye wòdoa ŋusẽ lãmenugbagbeviwo ƒe ɖɔɖɔɖo, si le vevie ŋutɔ na lãkusi ƒe lãmesẽ kple hayahaya tso gbɔgbɔtsixe ƒe nɔnɔme vovovowo me.
Bronchogen ƒe mɔnu vevitɔe nye DNA ƒe liƒolili. Ebla ɖe ɖoɖo tɔxɛ aɖewo ŋu le DNA la me, vevietɔ esiwo ŋu CTG ƒe nɔnɔmetata le (cytosine, thymine, kple guanine). Blanuiléle sia dzia DNA ƒe dzoxɔxɔ si le ʋeʋẽm ɖe edzi, si wɔnɛ be wòte ŋu nɔa te ɖe oxidative ƒe nugbegblẽ nu wu. To DNA ƒe liƒolili me la, Bronchogen kpɔa egbɔ be lãkusi me lãmenugbagbeviwo te ŋu yia edzi le dɔ wɔm ahadzra wo ɖo evɔ nutoa me ƒe nuteɖeamedziwo magblẽ nu le wo ŋu o. Etrɔa asi le domenyiŋusẽfianu ƒe ɖeɖefia ŋu to domenyiŋusẽfianu ƒe asixɔxɔ dzi kpɔkpɔ me, si doa alɔ lãkusi me lãmenugbagbeviwo ƒe gbugbɔgadzɔ kple wo dzadzraɖo mlɔeba.
Dɔdzẽ si nɔa anyi didi nye nu vevi aɖe si nana aɖuɖɔtoedɔlélewo abe asrã, COPD, kple fibrosis ene dona. Bronchogen kpena ɖe ame ŋu wòwɔa avu kple dɔdzẽ to cytokines siwo doa alɔ dɔdzẽ abe TNF-α kple IL-6 ene ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ me, si dzina ɖe edzi le gbɔgbɔtsixe ƒe nɔnɔme geɖe siwo nɔa anyi didi me. Esi Bronchogen ɖoa taɖodzinu na dɔdzẽ ƒe mɔnuwo la, eɖea lãmenugbagbeviwo ƒe gbegblẽ dzi kpɔtɔna, enaa wohayana kabakaba, eye wòxea mɔ na lãkusiwo ƒe gbegblẽ ɣeyiɣi didi.
Ŋutete ɖedzesi aɖe le bronchogen ŋu be wòagbugbɔ aɖuɖɔtoemekawo awɔ yeyee to aɖuɖɔtoe ƒe lãkusi si ŋu dɔdzẽ si nɔa anyi didi, dɔlékuiwo, alo ɖiƒoƒonuwo gblẽna zi geɖe la dzadzraɖo me. Ewɔa dɔ to lãmenugbagbevi siwo le lãkusi me ƒe gbugbɔgadzɔ dodo ɖe ŋgɔ me eye wòɖea goblet cell hyperplasia, si nana ʋuʋudedi si gbɔ eme la dzi kpɔtɔna. Esia kpena ɖe ame ŋu be lãkusiwo gawɔa dɔ nyuie to mucociliary clearance kple yaƒoƒomɔ̃wo ƒe ʋuʋu dzi ɖeɖe kpɔtɔ me. Tsɔ kpe ɖe eŋu la, Bronchogen doa alɔ lãmenugbagbevi siwo le lãkusi me ƒe hayahaya, si wɔnɛ be lãkusiwo ƒe wɔwɔme bliboa kple dɔwɔwɔ nyona ɖe edzi.
Bronchogen kpɔa ŋusẽ ɖe lãkusi ƒe gbugbɔgadzɔ dzi tẽ to lãmenugbagbevi siwo gblẽ ƒe dzadzraɖo dodo ɖe ŋgɔ me. Edoa alɔ lãkusi me lãmenugbagbevi siwo le yaƒoƒomɔ̃wo me eye wowɔa akpa vevi aɖe le gbɔgbɔtsixe ƒe lãmesẽ me léle ɖe asi me la ƒe gbugbɔgadzɔ. Numekukuwo ɖee fia be Bronchogen ate ŋu ana lãkusi nate ŋu aʋã eye wòawɔ dɔ, vevietɔ le nɔnɔme siwo me lãkusi ƒe lãkusiwo gblẽna ɣesiaɣi me.
Tsɔ kpe ɖe eŋu la, Bronchogen wɔa akpa aɖe le lãmenugbagbeviwo ƒe tɔtrɔ me, si kpena ɖe ame ŋu be woatrɔ dɔléle ƒe tɔtrɔ siwo dona tso gbɔgbɔmedɔléle siwo nɔa anyi didi me. Esia lɔ abi ƒe lãkusiwo ƒe ƒuƒoƒo dzi ɖeɖe kpɔtɔ kple lãmenugbagbevi siwo me ʋuʋudedi le siwo ɖea ʋuʋudedi ɖa le lãkusiwo me ƒe dɔwɔwɔ nyuie wu ɖe eme.
Aklã ƒe Dɔwɔwɔ ƒe Akpa |
Bronchogen ƒe Ŋusẽkpɔɖeamedzi |
Metsonu |
Mucociliary ƒe Ʋuʋudedi |
Eɖea goblet cell hyperplasia kple mucus ƒe dzidziɖedzi fũ dzi kpɔtɔna |
Enaa ʋuʋudedi gazɔna nyuie eye wòɖea yaƒoƒomɔ̃ ƒe xexe dzi kpɔtɔna |
Lãmenugbagbeviwo ƒe Gbugbɔgadzɔ |
Eʋãa aɖuɖɔtoe ƒe lãkusi si gblẽ la dzadzraɖo |
Edoa dɔyɔyɔ kabakaba ɖe ŋgɔ eye wònaa yaƒoƒomɔ̃wo gawɔa blibo |
Alveolar ƒe Dɔwɔwɔ |
Enaa lãmenugbagbevi siwo le ʋukawo me la gbugbɔna dzɔna eye wònaa woƒe ʋuʋu nyona ɖe edzi |
Enaa gas ƒe asitɔtrɔ kple lãkusi ƒe ŋutete bliboa nyona ɖe edzi |
Aklãdɔléle si xea mɔ na dɔlékuiwo (COPD) kple asrã nye gbɔgbɔtsixe ƒe dɔléle siwo bɔ wu la dometɔ eve. Bronchogen wɔa akpa vevi aɖe le dɔléle siawo dzi kpɔkpɔ me to dɔdzẽ dzi ɖeɖe kpɔtɔ kple kpekpeɖeŋu nana be woaɖɔ lãkusiwo ɖo me. Ekpena ɖe ame ŋu wònaa lãkusia wɔa dɔ nyuie wu, eɖea dzobibi dzi kpɔtɔna, eye wòhayana kabakaba le dɔlélea ƒe sesẽɣi. To dɔdzẽ si nɔa anyi didi kple yaƒoƒomɔ̃wo ƒe tɔtrɔ gbɔ kpɔkpɔ me la, Bronchogen na mɔnu yeye si wɔa dɔ nyuie si dzi woato akpɔ gbɔgbɔtsixe ƒe lãmesẽ gbɔ eye woana agbenɔnɔ ƒe nyonyome nanyo ɖe edzi na ame ɖekaɖeka siwo ŋu COPD kple asrã le.
Zi geɖe la, hayahaya tso lãkusi me dɔlékuiwo abe aklãdɔ alo COVID-19 ene me ate ŋu anɔ blewu, eye nusiwo gblẽ le lãkusiwo ŋu bia be woada gbe le wo ŋu geɖe. Bronchogen naa hayahaya sia kabakaba to lãmekawo ɖɔɖɔɖo dodo ɖe ŋgɔ kple lãkusi ƒe wɔwɔme gbugbɔgaɖoanyi me. Ekpena ɖe lãkusi me lãmenugbagbeviwo ŋu be woagbugbɔ awɔ dɔ eye wòdoa dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖe ŋgɔ le lãkusi ƒe ɖoɖo nu, si wɔnɛ be wodaa dɔ kabakaba eye wòwɔa dɔ nyuie wu. Esia na Bronchogen nye dɔwɔnu vevi aɖe le gbɔgbɔtsixe ƒe dɔwɔwɔ nyuie wu me le gbɔgbɔtsixe ƒe dɔlékuiwo megbe.
Viɖe vevi siwo le Bronchogen ŋu dometɔ ɖekae nye ŋutete si le esi be wòana lãkusiwo nali ke, si kpena ɖe ame ŋu be woaxe mɔ ɖe gbɔgbɔtsixe ƒe nɔnɔme siwo nɔa anyi didi ƒe sesẽ nu. To aɖuɖɔtoe me lãkusiwo dzadzraɖo kple dɔdzẽ ƒe ŋuɖoɖowo ɖɔɖɔɖo me la, Bronchogen ɖea aɖuɖɔtoe ƒe ʋuʋu zi gbɔ zi geɖe kple eƒe sesẽ dzi kpɔtɔna. Esia hea aɖuɖɔtoewo ƒe lãmesẽ bliboa nyona ɖe edzi eye wokpɔa gbɔgbɔtsixetsixe ƒe nɔnɔme siwo nɔa anyi didi dzi nyuie wu, si wɔnɛ be ame ɖekaɖeka siwo kpɔa aɖuɖɔtoedɔléle siwo nɔa anyi didi gbɔ la ƒe agbenɔnɔ nyona ɖe edzi mlɔeba.
Ne míele tsitsim la, lãkusi ƒe ʋuʋu dzi ɖena kpɔtɔna le dzɔdzɔme nu, si ate ŋu ana gbɔgbɔ goglo si wɔa dɔ nyuie nasesẽ ɖe edzi. Bronchogen kpena ɖe ame ŋu wòléa lãkusi ƒe tete ɖe anyi to alesi wòʋãa aɖuɖɔtoe ƒe lãkusi siwo le lãmesẽ me ƒe gbugbɔgadzɔ me. Edoa atike siwo wɔa dɔ ɖe anyigba dzi, siwo le vevie ŋutɔ be woalé lãkusia ƒe nɔnɔme si te ŋu trɔna ɖe nɔnɔmewo nu eye wòte ŋu nɔa te ɖe nɔnɔme sesẽwo nu la wɔwɔ ɖe ŋgɔ. Esi Bronchogen nana lãkusi ƒe dɔwɔwɔ nyona ɖe edzi ta la, eɖea vi na ame tsitsiwo koŋ, si kpena ɖe ame ŋu be gbɔgbɔtsixe ƒe lãmesẽ nanɔ anyi ne wole tsitsim.
Bronchogen ƒe ŋutete be wòado alɔ lãmenugbagbeviwo ƒe yeyewɔwɔ eye wòaɖe oxidative stress dzi akpɔtɔ na wònye dɔwɔnu sẽŋu aɖe si woatsɔ aɖe lãkusi ƒe ɖiɖi si do ƒome kple tsitsi dzi akpɔtɔ. To aɖuɖɔtoemekawo ƒe blibonyenye me léle ɖe asi kple nusiwo gblẽna le ame ŋu dzi ɖeɖe kpɔtɔ me la, Bronchogen naa mɔxexeɖedɔléle nu ƒe mɔnu aɖe le gbɔgbɔtsixe ƒe nya siwo kpena ɖe tsitsi ŋu zi geɖe la gbɔ. Esia wɔnɛ be lãkusiwo gakpɔtɔ wɔa nu ɖe dɔ ŋu eye wote ŋu nɔa te ɖe nɔnɔme sesẽwo nu, si wɔnɛ be lãkusiwo ƒe dɔwɔwɔ bliboa nyona ɖe edzi ne ŋutilãa le tsitsim gɔ̃ hã.
Bronchogen ƒe amegãxiwo takpɔnu ɖe dzesi ŋutɔ, elabena ekpena ɖe ame ŋu be lãkusiwo ƒe tsitsi le dzɔdzɔme nu blewu. Enaa lãkusi me lãmenugbagbeviwo ƒe gbugbɔgawɔ ŋutetewo gaɖoa wo ŋu, si wɔnɛ be lãkusi ƒe dɔwɔwɔ si do ƒome kple tsitsi dzi ɖena kpɔtɔna. Le ame ɖekaɖeka siwo le didim be yewoalé lãkusi ƒe lãmesẽ nyuitɔ me ɖe asi eye yewoaɖe tsitsi ƒe ŋusẽkpɔɖeamedzi ɖe yewoƒe gbɔgbɔtsixetsixe dzi dzi akpɔtɔ gome la, Bronchogen nye egbɔkpɔnu xɔasi aɖe si ado agbenɔƒe didi kple ŋusẽ ɖe ŋgɔ le lãkusiwo me.
Wokpɔe be aɖuɖɔtoe me dɔlékuiwutikewo dzia dɔlélenutsiŋutete si nye secretory immunoglobulin A (sIgA) ƒe agbɔsɔsɔ ɖe edzi le lãkusiwo me. sIgA nye dɔlélenutsiŋutete ƒe akpa vevi aɖe, si kpɔa lãkusi ta tso dɔlékuiwo me. To nutoa me ƒe dɔlélenutsiŋutete dodo ɖe ŋgɔ me la, Bronchogen kpena ɖe ame ŋu be wòakpɔ lãkusiwo ta tso dɔlékuiwo si me eye wòɖea gbɔgbɔmedɔlélewo ƒe afɔkua dzi kpɔtɔna, vevietɔ le nuto siwo me ɖiƒoƒo le me. Dɔlélenutsiŋutete ƒe ametakpɔnu sia si wodo ɖe ŋgɔ la doa alɔ lãkusi ƒe lãmesẽ bliboa eye wòkpena ɖe ame ŋu le mɔxexe ɖe dɔlékuiwo nu me.
Oxidative stress nye nu vevi aɖe si nana lãkusiwo gblẽna, vevietɔ le nuto siwo me ɖiƒoƒo le me alo le dɔdzẽ si nɔa anyi didi me. Bronchogen kpena ɖe ame ŋu be woaɖe oxidative stress dzi akpɔtɔ to antioxidants ƒe wɔwɔ ɖe edzi le lãkusi me lãmenugbagbeviwo me. To free radicals ɖeɖeɖa kple mɔxexe ɖe lãmenugbagbeviwo ƒe gbegblẽ nu me la, Bronchogen wɔa akpa vevi aɖe le lãkusiwo takpɔkpɔ kple gbɔgbɔtsixe ƒe lãmesẽ si nɔa anyi didi dodo ɖe ŋgɔ me. Esia le vevie ŋutɔ na lãkusi ƒe dɔwɔwɔ takpɔkpɔ kple mɔxexe ɖe lãkusidɔléle siwo nɔa anyi didi nu.
Tsɔ kpe ɖe dɔlélenutsiŋutete si le nutoa me ƒe ŋusẽdodo ŋu la, Bronchogen doa alɔ dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe gbugbɔgadzɔ le lãkusiwo me. Esia kpena ɖe ame ŋu be gbɔgbɔtsixe ƒe ŋutete be wòawɔ avu kple dɔlékuiwo eye wòada asɔ. To dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe yeyewɔwɔ dodo ɖe ŋgɔ me la, Bronchogen kpɔa egbɔ be wokpɔ ta na dɔlékuiwo nyuie wu eye wòkpena ɖe ame ŋu wòhayana kabakaba tso dɔlélewo me. Dɔlélenutsiŋutete ƒe kpekpeɖeŋu sia nye nu vevi aɖe si ana lãkusi nawɔ dɔ nyuie eye wòana woate ŋu anɔ te ɖe gbɔgbɔmedɔlélewo nu nyuie wu.
Peptide si woyɔna be peptide |
Dzᴐtsoƒe |
Dɔwɔwɔ ƒe Mɔnu |
Viɖe Veviwo |
Bronchogen si woyɔna be bronchogen |
Nusiwo woɖe tso aklã me |
Egbugbɔa lãkusi ƒe lãkusiwo wɔa yeyee, eɖea dɔdzẽ kple oxidative stress dzi kpɔtɔna |
Doa alɔ hayahaya tso dɔlékuiwo me, ewɔa avu kple lãkusi ƒe tsitsi |
Cortexin si woyɔna be cortexin |
Ahɔhɔ̃ me tsonu |
Etrɔa asi le ahɔhɔ̃a ƒe dɔwɔwɔ ŋu, ekpɔa ahɔhɔ̃mekawo ta |
Ahɔhɔ̃mekawo takpɔkpɔ, kpena ɖe ame ŋu wokpɔa ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie ƒe nɔnɔmewo gbɔ |
Thymalin ƒe atike |
Thymus-si woɖe tso eme |
Doa dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖe ŋgɔ, edoa lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ |
Doa dɔlélenutsiŋutete ƒe dɔwɔwɔ ɖe ŋgɔ, doa alɔ gbɔgbɔtsixe ƒe lãmesẽ |
Bronchogen li le atike siwo wodona ɖe lãme na ame kple esiwo wozãna le nu me siaa me. Agbɔsɔsɔ si woazã la toa vovo le alesi nɔnɔmea nu sẽe kple atikewɔwɔ me tsonu siwo wodi nu.
Le ame ɖekaɖeka siwo le aɖuɖɔtoemedɔléle siwo nɔa anyi didi gbɔ kpɔm alo amesiwo ɖoe be yewoagbugbɔ aɖuɖɔtoewo awɔ dɔ sesĩe wu gome la, agbɔsɔsɔme si wokafu be woadze egɔmee nye 500 mcg gbesiagbe. Ele be woado esia ɖe ŋutigbalẽ te, zi geɖe le ƒodo me. Le dɔléle siwo de ŋgɔ alo esiwo hiã gbɔgbɔtsixe ƒe kpekpeɖeŋu si ɖe dzesi wu gome la, woate ŋu adzi agbɔsɔsɔa ɖe edzi va ɖo 1000 mcg gbesiagbe.
Le amesiwo lɔ̃a atike siwo woano gome la, woate ŋu akpɔ Bronchogen le atikekui me. Agbɔsɔsɔ si wozãna zi geɖe le nu me enye atikekui 1-2 zi ɖeka alo zi eve gbesiagbe. Agbɔsɔsɔ si tututu woazãe nɔ te ɖe ame ɖekaɖekawo ƒe lãmesẽnyawo kple taɖodzinuwo dzi, eye woate ŋu atrɔ asi le eŋu le aɖaŋuɖoɖo tɔxɛ siwo lãmesẽdɔwɔla aɖe ɖo nu.
Zi geɖe la, wobua bronchogen be ele dedie ne wozãe ɣeyiɣi didi evɔ womegblɔa eƒe nugbegblẽ le ame ŋu boo o. Ezãla akpa gãtɔ ɖea mɔ ɖe eŋu nyuie evɔ womekpɔa ŋusẽ gbegblẽ aɖeke ɖe edzi o. Gake ame aɖewo ate ŋu akpɔ nuɖuɖumeŋusẽ ƒe dɔmawɔmawɔ nyuie, vevietɔ ne wodze atikewɔwɔa gɔme. Ele vevie be nàbia lãmesẽdɔwɔla hafi adze peptide zazã ɖesiaɖe gɔme, vevietɔ ne atikewɔwɔ me dɔléle aɖewo le ŋuwò do ŋgɔ alo èfɔ fu. Esia nana be atikewɔwɔa sɔ ɖe wò lãmesẽ ƒe nɔnɔme kple nuhiahiãwo nu.
Bronchogen si woyɔna be bronchogen peptide ɖea vi geɖe na lãkusi ƒe lãmesẽ, siwo dometɔ aɖewoe nye lãmenugbagbeviwo ƒe gbugbɔgadzɔ, dɔdzẽ dzi ɖeɖe kpɔtɔ, kple dɔlélenutsiŋutete ƒe kpekpeɖeŋu. Ekpena ɖe ame ŋu wògawɔa dɔ nyuie, eɖea oxidative stress dzi kpɔtɔna, eye wòkpɔa ame ta tso tsitsi ƒe ɖiɖi me. Esi numekukuwo le edzi yim la, ŋutete le Bronchogen si be wòatrɔ asi le atike siwo wozãna na aɖuɖɔtoedɔléle siwo nɔa anyi didi ŋu.
Le Cocer Peptides , míenaa atike siwo ŋu wotrɔ asi le be woado alɔ lãkusi ƒe lãmesẽ ahadzii ɖe edzi, si naa dzɔdzɔme mɔnu si dzi woato alé gbɔgbɔtsixe ƒe dɔwɔwɔ me ɖe asi.
Kpekpeɖeŋu: Kpɔ lãmesẽdɔwɔla gbɔ ɣesiaɣi hafi nàtsɔ Bronchogen alo peptide-dɔdamɔnu bubu ɖesiaɖe ade wò ɖoɖowɔɖi me hena mɔfiame si sɔ na wò.
A: Bronchogen nye bioregulator peptide si kpena ɖe lãkusi ƒe gbugbɔgadzɔ ŋu, eɖea dɔdzẽ dzi kpɔtɔna, eye wònaa dɔlélenutsiŋutete ƒe dɔwɔwɔ nyona ɖe edzi, si doa alɔ lãkusi ƒe lãmesẽ bliboa.
A: Bronchogen kpena ɖe ame ŋu wòɖea abi dzi kpɔtɔna eye wòdzraa lãkusi siwo gblẽ ɖo, si wɔnɛ be wòɖea vi na nɔnɔmewo abe asrã kple COPD ene.
A: Ẽ, Bronchogen doa alɔ lãkusi ƒe dɔwɔwɔ to oxidative stress dzi ɖeɖe kpɔtɔ kple lãmenugbagbeviwo ɖɔɖɔɖo dodo ɖe ŋgɔ me, si xea mɔ na lãkusi ƒe ɖiɖi si do ƒome kple tsitsi.
A: Dedienɔnɔ ƒe nɔnɔme sẽŋu aɖe le bronchogen ŋu eye eƒe nugbegblẽ le ame ŋu mesɔ gbɔ o, si wɔe be wòsɔ na aɖuɖɔtoe ƒe lãmesẽkpekpeɖeŋu ɣeyiɣi didi.
