Èse Vilon ŋkɔ kpɔa peptide kple ŋutete si le esi be wòana dɔlélenutsiŋutete kple lãmenugbagbeviwo ƒe lãmesẽ nanyo ɖe edzia? Woɖea peptide sesẽ sia tso thymic lãkusi me eye wòwɔa akpa vevi aɖe le dɔlélenutsiŋutete ƒe kpekpeɖeŋunana kple lãmenugbagbeviwo ɖɔɖɔɖo me.
Le nyati sia me la, míadzro alesi Vilon wɔa dɔe, viɖe siwo le eŋu na gbugbɔgadzɔ, kple akpa si wòwɔna le dɔlélenutsiŋutete ƒe lãmesẽ me.
Srɔ̃ nu geɖe tso míaƒe atikewo ŋu le Cocer Peptides kple alesi woate ŋu ana wò lãmesẽ nanyo ɖe edzi.
Woke ɖe vilon peptide, si me amino acid eve—lysine kple glutamic acid—le ŋu zi gbãtɔ le ƒe 1980-awo me abe numekuku aɖe si wowɔ le peptide siwo wokpɔna tso thymus me ŋu ƒe akpa aɖe ene. Wokpɔe be peptide siawo doa alɔ lãmenugbagbeviwo ƒe dɔwɔwɔ siwo hiã vevie be woalé dɔlélenutsiŋutete ƒe dɔwɔwɔ kple lãmenugbagbeviwo ɖɔɖɔɖo me ɖe asi. Vilon, si wogayɔna be Lys-Glu, nye peptide bɔbɔetɔwo dometɔ ɖeka le hatsotso sia me, ke hã ekpɔa ŋusẽ gã aɖe ɖe domenyiŋusẽfianu ƒe ɖeɖefia, dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ, kple lãmenugbagbeviwo ƒe gbugbɔgadzɔ dzi.
Vilon ƒe xɔtuɖoɖo bɔbɔe nye eƒe ŋusẽ veviwo dometɔ ɖeka. Esi wònye dipeptide ta la, eƒe molecule ƒe lolome le sue (anɔ abe dalton 275 ene), si wɔnɛ be wòte ŋu wɔa nu kple lãmenugbagbeviwo ƒe lãkusiwo nyuie eye wòɖoa taɖodzinu na molecule tɔxɛ siwo le lãmenugbagbeviwo me. Agbɔsɔsɔ sue sia na Vilon te ŋu gena ɖe lãmenugbagbeviwo me eye wòblana ɖe chromatin, si nye DNA-protein ƒe ƒuƒoƒo si kpɔa domenyiŋusẽfianu ƒe ɖeɖefia dzi. Ne Vilon nya ge ɖe eme ko la, ekpena ɖe DNA ƒe akpa siwo zi ɖoɖoe le tsitsi alo nutome ƒe nuteɖeamedzi ta la ʋuʋu ŋu, si wɔnɛ be domenyiŋusẽfianu ƒe gbugbɔgawɔ nɔa bɔbɔe eye wòdoa gbugbɔgadzɔ ɖe ŋgɔ.
Thymus wɔa akpa vevi aɖe le dɔlélenutsiŋutete ƒe dɔwɔwɔ me to T lãmenugbagbeviwo wɔwɔ me, siwo hiã vevie be woatsɔ aʋli ŋutilã ta tso dɔlékuiwo si me. Ne míele tsitsim la, thymus la dzi ɖena kpɔtɔna, si wɔnɛ be T-lãmenugbagbeviwo ƒe wɔwɔme kple dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi ɖena kpɔtɔna. Vilon, si woɖena tso thymic tissue me ta la, ekpɔa ŋusẽ ɖe thymus kple dɔlélenutsiŋutete ƒe lãmenugbagbeviwo dzi tẽ. To kpekpeɖeŋu nana T-lãmenugbagbeviwo ƒe vovototodedeameme kple dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ me la, Vilon kpena ɖe ame ŋu wògbugbɔa dɔlélenutsiŋutete ƒe sɔhɛmenɔɣi ƒe ŋusẽ aɖewo ɖoa anyi.
Peptide si woyɔna be peptide |
Dzᴐtsoƒe |
Dɔwɔwɔ ƒe Mɔnu |
Viɖe Veviwo |
Vilon ƒe ŋkɔ |
Thymus-si woɖe tso eme |
Chromatin ƒe domenyiŋusẽfianu ƒe ɖoɖowɔwɔ, dɔlélenutsiŋutete ƒe tɔtrɔ |
Dɔlélenutsiŋutete ƒe kpekpeɖeŋu, lãmenugbagbeviwo ƒe gbugbɔgadzɔ, tsitretsitsi ɖe tsitsi ŋu |
Thymalin ƒe atike |
Thymus-si woɖe tso eme |
Dɔlélenutsiŋutete ƒe tɔtrɔ, T-lãmenugbagbeviwo ƒe dɔwɔwɔ |
Thymic gbugbɔgadzɔ, dɔlélenutsiŋutete ƒe dɔwɔwɔ ƒe nyonyome |
Sema |
Ahɔhɔ̃ me tsonu |
Etrɔa asi le ahɔhɔ̃a ƒe asitɔtrɔ kple ahɔhɔ̃mekawo ƒe wɔwɔme ŋu |
Sidzedze ƒe ŋgɔyiyi, ahɔhɔ̃mekawo takpɔkpɔ |
Vilon wɔa dɔ koŋ to nuwɔwɔ kple chromatin, si nye nusi le lãmenugbagbeviwo ƒe nucleus me si me DNA le me. Chromatin blana sesĩe le tsitsime, si wɔnɛ be domenyiŋusẽfianu aɖewo, siwo dometɔ aɖewoe nye esiwo kpɔa gome le DNA ɖɔɖɔɖo kple lãmenugbagbeviwo gbugbɔgawɔ me la, zi ɖoɖoe. Vilon kpena ɖe 'unpack' chromatin nuto siawo ŋu, si wɔnɛ be domenyiŋusẽfianuawo gawɔa dɔ le nuŋɔŋlɔ me ake.
To ribosomal domenyiŋusẽfianuwo ƒe ɖeɖefia dodo ɖe ŋgɔ me la, Vilon doa protein ƒe wɔwɔ ɖe ŋgɔ, si nye nu vevi aɖe si wozãna tsɔ dzraa lãmenugbagbeviwo ɖo eye wogbugbɔa lãmenugbagbeviwo gbugbɔna. Le numekukuwo me la, wokpɔe be enaa ribosomal RNA domenyiŋusẽfianu siwo wɔa protein siwo hiã na lãmenugbagbeviwo ƒe dɔwɔwɔ la ƒe dɔwɔwɔ dzina ɖe edzi.
Vilon ƒe ŋutete be wòakpɔ ŋusẽ ɖe domenyiŋusẽfianu ƒe ɖeɖefia dzi evɔ matrɔ DNA ƒe ɖoɖoa o nye epigenetic regulation ƒe kpɔɖeŋu. Epigenetic changes fia tɔtrɔ siwo kpɔa ŋusẽ ɖe domenyiŋusẽfianu ƒe dɔwɔwɔ dzi evɔ wometrɔa domenyiŋusẽfianu ƒe ɖoɖo si le ete o. Vilon wɔa dɔ abe epigenetic modulator ene to kadodo kple DNA kple chromatin ƒe akpa aɖewo koŋ me, si doa chromatin ƒe nɔnɔme si le ʋuʋu ɖi wu eye wòwɔa dɔ ɖe ŋgɔ. Chromatin ƒe tsinyenye sia nana domenyiŋusẽfianu siwo wozi ɖoɖoe tsã la gagate ŋu wɔa dɔ ake, si wɔnɛ be lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ nɔa bɔbɔe.
Vilon peptide ƒe viɖe vevitɔwo dometɔ ɖekae nye ŋutete si le esi be wòado alɔ thymic ƒe gbugbɔgadzɔ kple T-cell ƒe dɔwɔwɔ. Ne míele tsitsim la, thymus la dzi ɖena kpɔtɔna le dzɔdzɔme nu, si wɔnɛ be dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi ɖena kpɔtɔna. Numekukuwo ɖee fia be Vilon ate ŋu aʋã thymic dɔwɔwɔ, si ana T lãmenugbagbeviwo ƒe wɔwɔ kple woƒe vovototodedeameme nadzi ɖe edzi. To T lãmenugbagbeviwo ƒe tsitsi dodo ɖe ŋgɔ me la, Vilon kpena ɖe ame ŋu be dɔlélenutsiŋutete ƒe dɔwɔwɔ nyona ɖe edzi eye wòdoa ŋusẽ ŋutilã ƒe ŋutete be wòawɔ avu kple dɔlékuiwo.
Le numekuku siwo wowɔ le lãwo ŋu me la, wokpɔe be Vilon nana thymocytes, siwo nye T lãmenugbagbevi siwo metsi o siwo le thymus me la dzina ɖe edzi. Ena lãmenugbagbevi siwo le dzidzim ɖe edzi ƒe anyinɔnɔ hã dzi ɖe edzi le thymic lobules, siwo le vevie na T lãmenugbagbevi siwo wɔa dɔ la wɔwɔ me.
Vilon wɔa akpa vevi aɖe le dɔlélenutsiŋutete ƒe dɔwɔwɔ ƒe tɔtrɔ me, vevietɔ le tsitsi kple dɔlélenutsiŋutete ƒe nutete me. To domenyiŋusẽfianu siwo do ƒome kple dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔwɔwɔ ake dodo ɖe ŋgɔ me la, Vilon kpena ɖe ame ŋu wògada asɔ le dɔlélenutsiŋutete me. Wokpɔe be enaa cytokine ƒe wɔwɔme nɔa ɖoɖo nu, eɖea abi si gbɔ eme dzi kpɔtɔna eye wònaa ŋutilã ƒe ŋutete be wòawɔ nu ɖe dɔlékuiwo ŋu nyuie wu. Le numekuku siwo wowɔ le lã tsitsiwo ŋu me la, Vilon dodo kpe ɖe dɔlélenutsiŋutete ƒe dɔwɔwɔ ŋu wòsɔ eye wòɖe dɔlélenutsiŋutete ƒe dɔwɔwɔ ƒe dzesiwo dzi kpɔtɔ, si nye dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ vivivi ne ame tsi.
Dɔlélenutsiŋutete ƒe Lãmenugbagbevi Ƒomevi |
Vilon ƒe Ŋusẽkpɔɖeamedzi |
Emetsonu Vevitɔ |
Thymocytes (lãmenugbagbevi siwo woyɔna be thymocytes). |
Eʋãa ame ƒe dzidziɖedzi kple vovototodedeameme |
T-lãmenugbagbevi siwo wɔa dɔ ƒe dzidziɖedzi |
Lãmetsiŋusẽ ƒe lãmenugbagbeviwo |
Enaa domenyiŋusẽfianu ƒe ɖeɖefia kple dzidziɖedzi nyona ɖe edzi |
Dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie wu |
Monocytes ƒe lãmenugbagbevi siwo woyɔna be monocytes |
Etrɔa asi le dɔdzẽ ƒe cytokine ƒe wɔwɔme ŋu |
Dɔdzẽ dzi ɖe kpɔtɔ eye dɔlélenutsiŋutete ƒe dadasɔ nyo ɖe edzi |
Vilon ƒe gbugbɔgadzɔ ƒe ŋutetewo keke ta yi ŋgɔ wu dɔlélenutsiŋutete. Eɖe ŋutete gã aɖe fia le lãmenugbagbeviwo ɖɔɖɔɖo kple lãmenugbagbeviwo ƒe gbugbɔgadzɔ dodo ɖe ŋgɔ me. Peptide la kpena ɖe domenyiŋusẽfianu siwo kpɔa gome le lãmenugbagbeviwo ƒe dzidziɖedzi kple lãmenugbagbeviwo ƒe gbugbɔgadzɔ me ŋu wòwɔa dɔ, si kpena ɖe ame ŋu le lãkusi siwo gblẽ la dzadzraɖo me. Esia xɔ asi ŋutɔ le nɔnɔme siwo me dɔdzẽ si nɔa anyi didi, tsitsi, alo lãmenugbagbeviwo ƒe abixɔxɔ le, afisi lãmenugbagbeviwo ƒe gbugbɔgadzɔ megblẽna le zi geɖe.
Le numekukuwo me la, wokpɔe be Vilon nana fibroblasts, lãmenugbagbevi siwo ƒe dɔe nye be woawɔ collagen eye woalé lãkusiwo ƒe wɔwɔme ƒe blibonyenye me ɖe asi la ƒe dɔwɔwɔ nyona ɖe edzi. To fibroblast ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ me la, Vilon doa lãmenugbagbeviwo ɖɔɖɔɖo ɖe ŋgɔ eye wòkpena ɖe ame ŋu be woaxe mɔ ɖe kadodoŋusẽwo ƒe gbegblẽ nu.
Lãmenugbagbeviwo ƒe tsitsi, si nye nɔnɔme si me lãmenugbagbeviwo dzudzɔa mama tegbee, nye tsitsi ƒe dzesi. Zi geɖe la, lãmenugbagbevi siwo tsina la ƒoa ƒu ɖe lãkusiwo me eye woɖea molecule siwo doa alɔ dɔdzẽ si nana ame tsitsi kple lãmenugbagbeviwo ƒe dɔmawɔmawɔ nyuie dona. Vilon kpena ɖe ame ŋu wòhea lãmenugbagbeviwo ƒe tsitsi ɖe megbe alo trɔa asi le eŋu gɔ̃ hã to domenyiŋusẽfianu siwo zi geɖe la, zi geɖe la, wozi ɖoɖoe ne ame tsi la gbugbɔgawɔ dɔ me. Le numekuku siwo wowɔ le fibroblasts kple dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ŋu me la, wokpɔe be Vilon ɖea lãmenugbagbeviwo ƒe tsitsi ƒe dzesiwo dzi kpɔtɔna, si doa lãmenugbagbeviwo ƒe nuwɔna si le lãmesẽ me, si nye sɔhɛmenɔnɔ ɖe ŋgɔ.
Vilon ƒe ŋutete be wòagbugbɔ domenyiŋusẽfianu siwo wozi ɖoɖoe awɔ dɔ eye wòdo lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ na wònye atike nyui aɖe si tsia tsitsi nu. Le numekuku siwo wowɔ le lãwo ŋu me la, wokpɔe be Vilon didia agbenɔƒe ɖe edzi eye wònaa ame tsitsiwo ƒe lãmesẽ bliboa nyona ɖe edzi. Peptide la kpena ɖe lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie ŋu eye wòɖea oxidative stress kple inflammation, siwo katã do ƒome kple tsitsi, ƒe nugbegblẽ le ame ŋu dzi kpɔtɔna. To kpekpeɖeŋu nana ŋutilãa ƒe dzɔdzɔmenuwo gbugbɔgawɔ me la, Vilon kpena ɖe ame ŋu be dɔlélenutsiŋutete ƒe dɔwɔwɔ, lãmenugbagbeviwo ƒe ɖɔɖɔɖo, kple lãmenugbagbeviwo ƒe gbugbɔgadzɔ ƒe ɖiɖi le tsitsi ta ƒe ŋgɔyiyi dzi ɖena kpɔtɔna. Esia wɔnɛ be míenɔa agbe didi wu eye míaƒe agbenɔnɔ nyona ɖe edzi ne míele tsitsim.
Vilon ƒe gbugbɔgadzɔ ƒe ŋutetewo kpena ɖe ŋutilã ƒe tenɔnɔ ɖe nɔnɔme sesẽwo nu kple eƒe hayahaya ŋu nyuie wu. To lãmenugbagbeviwo ɖɔɖɔɖo dzi ɖeɖe kpɔtɔ kple lãmenugbagbeviwo ƒe gbugbɔgadzɔ dodo ɖe ŋgɔ me la, Vilon kpena ɖe ŋutilãa ŋu wòhayana kabakaba tso nuteɖeamedzi, abixɔxɔ, alo dɔléle me. Esia ɖea vi na ame ɖekaɖeka siwo le hayahayam tso amekoko, nuveviwɔame, alo dɔdzẽ ƒe nɔnɔme siwo nɔa anyi didi me koŋ. Ŋutete si le esi be wòado alɔ dɔyɔɣi siwo le kabakaba wu eye wòado lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ ate ŋu akpe ɖe ame ɖekaɖekawo ŋu be ŋusẽ nagaɖo wo ŋu eye woawɔ dɔ nyuie wu, si ana ŋutilã ƒe dɔwɔwɔ bliboa kple tenɔnɔ ɖe nɔnɔme sesẽwo nu nanyo ɖe edzi. Peptide la kpena ɖe ŋutilãa ƒe dzɔdzɔme dɔyɔyɔmɔnu ŋu, si wɔnɛ be wòhayana kabakaba eye afɔku si le eme be wòagblẽ nu le eŋu ɣeyiɣi didi la mebɔ o.
Vilon doa ŋusẽ dɔlélenutsiŋutete ƒe tenɔnɔ ɖe nɔnɔme sesẽwo nu to T-lãmenugbagbeviwo ƒe vovototodedeameme dodo ɖe ŋgɔ kple dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie wu me. Esia le vevie ŋutɔ na ame tsitsiwo, amesiwo ƒe dɔlélenutsiŋutete megawɔa dɔ nyuie zi geɖe le ɣeyiɣi aɖe megbe o. Vilon kpena ɖe dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ŋu to domenyiŋusẽfianu veviwo gbugbɔgawɔ kple cytokine ƒe wɔwɔme dzi kpɔkpɔ me. To dɔdzẽ dzi ɖeɖe kpɔtɔ me la, ekpena ɖe ame ŋu be woaxe mɔ ɖe dɔdzẽ ƒe ŋuɖoɖo siwo nɔa anyi didi siwo ate ŋu ana dɔlélenutsiŋutete nagbɔdzɔ la nu. Esia wɔnɛ be Vilon wɔa akpa vevi aɖe le dɔlélenutsiŋutete sesẽ me, si wɔnɛ be ŋutilãa te ŋu nɔa te ɖe dɔlékuiwo kple dɔlélewo nu. Esia xɔ asi ŋutɔ le dɔlélenutsiŋutete ƒe lãmesẽ dodo ɖe ŋgɔ me ne míele tsitsim, be míakpɔ egbɔ be ŋutilãa gakpɔtɔ le ta kpɔm tso dɔlékuiwo kple ŋɔdzinu bubuwo si me.
Viɖekpɔkpɔ ƒe Nuto |
Vilon ƒe Ŋusẽkpɔɖeamedzi ɖe Tsitsi Dzi |
Kpeɖodzi/Emetsonu |
Lãmenugbagbeviwo ƒe Gbugbɔgadzɔ |
Edoa lãmenugbagbeviwo ɖɔɖɔɖo ɖe ŋgɔ, edoa lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ |
Fibroblast ƒe dɔwɔwɔ dzi ɖe edzi, collagen ƒe wɔwɔme |
Atike si Tsi Tre Ðe Dzoxɔxɔ Ŋu |
Eɖea abi si nɔa anyi didi si do ƒome kple tsitsi dzi kpɔtɔna |
TNF-α, IL-6 cytokines ƒe agbɔsɔsɔ si bɔbɔ ɖe anyi le tsitsi ƒe kpɔɖeŋuwo me |
Agbenɔƒe ƒe Kekeɖenudɔ |
Ŋutete si le ame si be wòadidi agbenɔƒe ɖe edzi to lãmenugbagbeviwo ƒe dɔwɔwɔ kple dɔlélenutsiŋutete ƒe dɔwɔwɔ nyuie wu me |
Lãwo ŋuti numekukuwo ɖee fia be agbenɔƒe dzi ɖe edzi eye lãmesẽ nyo ɖe edzi |
Numekuku siwo wowɔ do ŋgɔ na dɔdamɔnua te gbe ɖe ŋusẽ nyui siwo Vilon kpɔna ɖe lãwo ƒe kpɔɖeŋuwo dzi dzi. Numekukuwo ɖee fia be Vilon doa ŋusẽ dɔlélenutsiŋutete ƒe dɔwɔwɔ, edoa lãmenugbagbeviwo ƒe gbugbɔgadzɔ ɖe ŋgɔ, eye wòdoa alɔ lãmenugbagbeviwo ƒe lãmesẽ bliboa. Le kpɔɖeŋu me, le lã tsitsiwo ƒe kpɔɖeŋuwo me la, Vilon dodo na thymic ƒe dɔwɔwɔ nyo ɖe edzi ŋutɔ, si na T-lãmenugbagbeviwo ƒe wɔwɔme dzi ɖe edzi. Dɔlélenutsiŋutete ƒe gbugbɔgawɔ sia ɖee fia be Vilon ate ŋu awɔ akpa vevi aɖe le dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie si tso tsitsi gbɔ gbɔ kpɔkpɔ me, eye mlɔeba la, ado tsitsi si le lãmesẽ me ɖe ŋgɔ eye wòana dɔlélenutsiŋutete nate ŋu anɔ te ɖe nɔnɔme sesẽwo nu nyuie wu.
Numekuku siwo wowɔ le vitro hã na kekeli klẽ ɖe alesi Vilon kpɔa ŋusẽ ɖe dɔlélenutsiŋutete ƒe lãmenugbagbeviwo dzi le lãmenugbagbeviwo ƒe ɖoɖo nu dzi. Numekukuwo ɖee fia be Vilon ate ŋu ana ʋumenugbagbevi dzĩwo ƒe dzidziɖedzi ƒe ŋutete nadzi ɖe edzi, si ana woƒe dɔwɔwɔ ɖe nuteɖeamedzi kple abi siaa ŋu nanyo ɖe edzi. To ŋutete si le esi be wòatrɔ asi le domenyiŋusẽfianu ƒe ɖeɖefia ŋu eye wòado chromatin ƒe ʋuʋu ɖe ŋgɔ dzi la, ekpena ɖe ame ŋu be dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe sɔhɛmenɔɣi ƒe nuwɔna nagaɖo anyi. Mɔnu sia le vevie ŋutɔ be woado ŋusẽ dɔlélenutsiŋutete ƒe ŋutete be wòawɔ avu kple dɔlékuiwo, ada asɔ le dɔlélenutsiŋutete ƒe ŋuɖoɖowo me, eye wòado alɔ lãmenugbagbeviwo ƒe blibonyenye bliboa.
Vilon peptide nyea egbɔkpɔnu sẽŋu aɖe na lãmenugbagbeviwo ƒe gbugbɔgadzɔ kple dɔlélenutsiŋutete ƒe kpekpeɖeŋu. To dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe vovototodedeameme dzi ɖeɖe kpɔtɔ kple lãmenugbagbeviwo ɖɔɖɔɖo dodo ɖe ŋgɔ me la, enaa viɖe gãwo, vevietɔ na ame tsitsiwo kple amesiwo ƒe dɔlélenutsiŋutete gbɔdzɔ. Esi numekukuwo le edzi yim la, ŋutete si le Vilon si be wòatrɔ asi le atikewɔwɔ si naa ame ƒe lãme gbugbɔgawɔ ŋu la me kɔna ɖe edzi, si kpena ɖe ame ŋu wòdidia lãmesẽnyawo ɖe edzi eye wònana ame ƒe hayahaya nanyo ɖe edzi.
Le Cocer Peptides , míenaa atike deŋgɔ siwo ŋu wotrɔ asi le be woado alɔ dɔlélenutsiŋutete ƒe dɔwɔwɔ nyuitɔ eye woado agbenɔƒe didi ɖe ŋgɔ, eye míenaa dɔwɔnu xɔasiwo na ame ƒe nyonyo bliboa.
A: Vilon peptide nye bioregulator si wokpɔ tso thymic tissue me. Edoa dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe vovototodedeameme ɖe ŋgɔ eye wòdoa lãmenugbagbeviwo ɖɔɖɔɖo ɖe ŋgɔ, si doa alɔ lãmenugbagbeviwo ƒe gbugbɔgadzɔ kple dɔlélenutsiŋutete ƒe dɔwɔwɔ.
A: Vilon peptide doa ŋusẽ dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ to T-lãmenugbagbeviwo ƒe vovototodedeameme dodo ɖe ŋgɔ kple cytokine wɔwɔ dzi kpɔkpɔ me, si wɔnɛ be ŋutilã ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ nyona ɖe edzi.
A: Vilon peptide kpena ɖe ame ŋu wòwɔa avu kple tsitsi to lãmenugbagbeviwo ƒe gbugbɔgadzɔ dodo ɖe ŋgɔ, dɔlélenutsiŋutete ƒe dɔwɔwɔ dodo ɖe ŋgɔ, kple lãmenugbagbeviwo ƒe lãmesẽ dodo ɖe ŋgɔ me, si wɔnɛ be wohayana nyuie wu eye wonɔa agbe didi.
A: Ẽ, Vilon peptide doa alɔ lãmenugbagbeviwo ƒe gbugbɔgadzɔ to protein ƒe wɔwɔme dzi ɖeɖe kpɔtɔ kple domenyiŋusẽfianu vevi siwo kpɔa gome le lãmenugbagbeviwo dzadzraɖo me ƒe dɔwɔwɔ me, si wɔnɛ be wòɖea vi na lãmenugbagbevi siwo tsi kple esiwo gblẽ.
