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1 kits (10 Vials)
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▎ Tsarin GHK CU
Source: PubChem |
Jeri: Gly-His-Lys Tsarin kwayoyin halitta: C 28H 46CuN 12O8 Nauyin Kwayoyin Halitta: 742.3g/mol Lambar CAS: 130120-56-8 Takardar bayanai:9831891 Synonyms: Bisprezatide jan karfe;DL1TR6W6VM |
▎ GHK CU Bincike
Menene asalin bincike na GHK CU?
Ci gaban Bincike na Peptides masu aiki:
Tun daga karni na 20, ana ci gaba da zurfafa bincike kan peptides na bioactive a fannin kimiyyar rayuwa. Masana kimiyya a hankali sun gane cewa peptides suna taka muhimmiyar rawa a cikin halittu masu rai. Ba wai kawai abubuwan sunadaran sunadaran ba amma kuma suna da ayyukan ilimin halitta masu zaman kansu kuma suna shiga cikin daidaita tsarin tsarin halittar halitta daban-daban, kamar haɓakar tantanin halitta, rarrabuwa, da rigakafi. Wannan zurfin fahimtar peptides yana ba da tushen ka'idar da jagoranci bincike don ganowa da nazarin GHK CU.
Binciken Abubuwan Plasma:
A cikin cikakken binciken abubuwan da ke cikin plasma na ɗan adam, masana kimiyya sun himmatu don yin nazarin abun da ke ciki da ayyukan ƙwayoyin halittu daban-daban a cikin plasma. A matsayinsa na ruwa mai mahimmanci a cikin jikin mutum, plasma ya ƙunshi nau'ikan sunadaran, peptides, hormones, electrolytes, da sauran abubuwa, kuma ita ce hanya mai mahimmanci don kula da ayyukan yau da kullun na jikin ɗan adam. A cikin shekarun 1970, masu bincike sun gano wani abu na musamman na tripeptide da gangan yayin nazarin sunadaran plasma. Jerin amino acid ɗinsa shine glycyl-histidyl-lysine, wato GHK. Wannan binciken ya tayar da sha'awa sosai a tsakanin masana kimiyya kuma ya sa su kara nazarin matsayi da halayen wannan tripeptide a cikin plasma.
Muhimmancin Halitta na Copper Ions:
A lokaci guda kuma, muhimmiyar rawa na ions jan ƙarfe a cikin ilimin halitta ya jawo hankali a hankali. Copper yana ɗaya daga cikin mahimman abubuwan ganowa a cikin jikin ɗan adam kuma yana shiga cikin halayen sunadarai masu yawa. Abu ne ko mai kunnawa na manyan enzymes masu yawa kuma yana taka rawar da ba dole ba a kiyaye al'ada metabolism na sel, numfashi, da kuma hadawar collagen. A yayin nazarin ayyukan nazarin halittu na ions jan ƙarfe, masana kimiyya sun gano cewa ions na jan karfe na iya ɗaure wasu abubuwan peptide don samar da hadaddun abubuwa tare da ayyukan ilimin halitta na musamman. Wannan binciken yana ba da muhimmiyar ma'ana don nazarin ɗaurin GHK da ions na jan karfe da ayyukansu masu yuwuwa.
Haɓaka Bincike mai alaƙa da tsufa:
Tare da ci gaban al'umma da kuma ƙara fitowar matsalar tsufa na yawan jama'a, bincike mai alaka da tsufa ya zama wani muhimmin batu a fannin kimiyyar rayuwa. Masana kimiyya suna ƙoƙari su nemo alamomin halittu da abubuwan da suka dace da ke da alaƙa da tsarin tsufa don bayyana tsarin tsufa da kuma gano hanyoyin jinkirta tsufa. A cikin wannan mahallin, an gano cewa ƙaddamar da GHK CU a cikin jikin mutum a hankali yana raguwa da shekaru, wanda ke nuna cewa GHK CU na iya samun dangantaka da tsarin tsufa. Wannan binciken ya kara zaburar da masu bincike don gudanar da zurfafa bincike kan tushen, aiki, da aikace-aikacen GHK CU a fagen rigakafin tsufa, kuma yana haɓaka ci gaba da ci gaban bincike mai alaƙa.
Menene tsarin aikin GHK CU?
Inganta Gyaran Nama da Farfaɗowa:
Rukunin Jini da Ci gaban Jijiya:
Binciken da aka yi ya nuna cewa GHK CU na iya haɓaka haɓakar jijiyoyin jini da jijiyoyi. Yana iya cimma wannan tasiri ta hanyar daidaita takamaiman abubuwan haɓaka da hanyoyin sigina. Alal misali, yana iya inganta bayyanar cututtuka na jijiyoyi na jijiyoyi (VEGF), ta haka yana ƙarfafa angiogenesis [1] . Dangane da ci gaban jijiya, yana iya haɓaka rayuwa, haɓakawa, da haɓakar axonal na ƙwayoyin jijiya ta hanyar tasirin siginar ƙwayoyin cuta masu alaƙa da haɓakar jijiya.
Ƙara haɓakar haɓakar collagen, Elastin, da Glycosaminoglycans:
GHK CU na iya ƙara haɓakar collagen, elastin, da glycosaminoglycans. Collagen wani abu ne mai mahimmanci na kyallen takarda kamar fata da kasusuwa, elastin yana ba da kyallen takarda, kuma glycosaminoglycans suna taka muhimmiyar rawa wajen kiyaye danshi da elasticity na kyallen takarda. Ƙayyadaddun tsari na iya haɗawa da daidaita maganganun kwayoyin halittar da ke da alaƙa da hanyoyin sigina, kamar kunna takamaiman abubuwan rubutu a cikin fibroblasts don haɓaka maganganun kwayoyin halittar da ke da alaƙa da haɗin gwiwar collagen [1].
Taimakawa Aikin Dermal Fibroblasts:
Dermal fibroblasts suna taka muhimmiyar rawa wajen kiyaye tsari da aikin fata. GHK CU na iya tallafawa aikin fibroblasts na dermal, ciki har da haɓaka haɓakar ƙwayoyin cuta, ƙaura, da haɓakar abubuwan matrix na waje. Ana iya samun wannan ta hanyar daidaita hanyoyin sigina da maganganun kwayoyin halitta a cikin fibroblasts.
Tasirin Kariyar Kwayoyin:
Ayyukan Anticancer:
GHK CU yana da ayyukan anticancer da yawa. Yana iya yin tasirin maganin cutar kansa ta hanyar hana yaduwar ƙwayoyin cutar kansa, haifar da apoptosis na ƙwayoyin cutar kansa, da hana mamayewa da metastasis na ƙwayoyin kansa. Ƙayyadadden tsari na iya haɗawa da daidaita tsarin tantanin halitta, kunna hanyar siginar apoptosis, da hana hanyoyin sigina masu alaƙa da ƙari [1].
Tasirin Anti-mai kumburi:
GHK CU yana da tasirin anti-mai kumburi mai ƙarfi. Zai iya hana samar da abubuwa masu kumburi irin su ciwon necrosis factor-α (TNF-α) da interleukin-6 (IL-6), kuma a lokaci guda yana ƙara yawan aikin enzymes antioxidant kamar superoxide dismutase (SOD). Tsarin sa na maganin kumburi na iya kasancewa yana da alaƙa da hanawa na NF-κB p65 da p38 MAPK hanyoyin siginar, don haka rage amsawar kumburi [2].
Kariyar Huhu da Gyara Cutar Cutar Cutar Cutar Cutar Cutar Cutar Cutar (COPD):
GHK CU yana da tasiri mai kariya da gyarawa akan ƙwayar huhu. Zai iya hana amsawar kumburi a cikin ƙwayar huhu, rage lalacewa da fibrosis na ƙwayar huhu. Ga huhu fibroblasts na marasa lafiya tare da na kullum obstructive huhu cuta (COPD), GHK CU iya mayar da aikin su, yiwu ta hanyar daidaita alaka da sigina hanyoyin da gene magana [1].
Anxiolytic, Analgesic, da Tasirin Ta'addanci:
GHK CU kuma yana da anxiolytic, analgesic, da anti-ta'addanci, amma takamaiman hanyoyin ba a fahimta ba tukuna. Yana iya zama dangantaka da ka'idodin hanyoyin sigina da masu amfani da neurotransmitters a cikin tsarin jin tsoro.
Gyaran DNA da Tsabtace Tantanin halitta:
Gyaran DNA:
GHK CU yana da aikin gyaran DNA. Yana iya gyara DNA da ya lalace ta hanyar kunna takamaiman enzymes na gyaran DNA ko hanyoyin sigina. Wannan yana da matukar mahimmanci don kiyaye aikin al'ada na sel da kuma hana faruwar cututtuka kamar tsufa da ciwon daji [1].
Kunna Tsabtace Tantanin halitta (ta hanyar Tsarin Proteasome):
GHK CU na iya kunna tsarin proteasome na sel, inganta lalata da kuma kawar da sunadaran intracellular. Wannan yana taimakawa wajen kiyaye zaman lafiyar muhallin cikin salula da kuma hana tara furotin da tabarbarewar salula [1].
Hasashe akan Tsarin Acupuncture: Wasu nazarin sun ba da shawarar hasashen cewa ana iya samun hanyar aiwatar da acupuncture ta hanyar GHK CU. Kodayake takamaiman tsarin ya rage don ƙarin nazarin, wannan yana ba da sabon hangen nesa don fahimtar tsarin aikin GHK CU [3].
Matsayin plasma da kuma dacewa na asibiti na GHK a cikin marasa lafiya da silicosis: A. Plasma GHK matakan a cikin batutuwa masu lafiya da marasa lafiya tare da silicosis. B. Matsayin Plasma GHK a cikin marasa lafiya da silicosis a cikin matakai daban-daban na asibiti na cutar. C. Bayanan hoto na huhu da matakan GHK na plasma a cikin yawan kulawa da lafiya da kuma marasa lafiya a cikin matakai daban-daban na silicosis. D. Daidaita tsakanin matakan plasma GHK da FEV1% pre a cikin marasa lafiya da silicosis. E. Daidaita tsakanin matakan plasma GHK da DLCO% pre a cikin marasa lafiya da silicosis.
Source:PubMed [6]
Menene aikace-aikacen GHK CU?
Gyaran Fata da Kyau:
Ƙarfafa Ƙwararrun Ƙwararrun Ƙwararru:
GHK CU na iya tayar da kira na collagen, elastin, da glycosaminoglycans. Collagen wani muhimmin sashi ne na fata, wanda ke ba wa fata elasticity da ƙarfi [1] . Tare da karuwar shekaru, haɗin collagen yana raguwa a hankali, yana haifar da shakatawa na fata da bayyanar wrinkles. Ta hanyar inganta samar da collagen, GHK CU na iya inganta elasticity da fata fata da kuma rage samuwar wrinkles.
Inganta Jirgin Jini da Ci gaban Jijiya:
Yana da tasirin ƙarfafa haɓakar jijiyoyin jini da jijiyoyi [1] . Kyakkyawan zagayawa na jini yana da mahimmanci ga lafiyar fata. Yana iya samar da isasshen abinci mai gina jiki da iskar oxygen don ƙwayoyin fata kuma yana haɓaka metabolism na fata. Bugu da ƙari, haɓakar jijiyoyi kuma yana ba da gudummawa ga iyawar hankali da amsawa na fata.
Taimakawa Aikin Dermal Fibroblasts:
GHK CU yana goyan bayan aikin dermal fibroblasts. Fibroblasts suna ɗaya daga cikin manyan nau'ikan tantanin halitta a cikin fata, kuma suna da alhakin haɗakar da collagen, elastin, da sauran abubuwan matrix na extracellular [1] . GHK CU na iya haɓaka aikin fibroblasts kuma inganta ikon su don haɗa matrix na extracellular, don haka yana taimakawa wajen kula da tsari da aikin fata.
Warkar da Rauni:
GHK CU yana nuna tasiri mai mahimmanci a warkar da rauni. Nazarin ya nuna cewa zai iya hanzarta tsarin warkar da rauni, inganta haɓakar ƙwayar granulation, da samarwa da tarawa na collagen. Bugu da ƙari, GHK CU na iya tsara tsarin canji na macrophages daga lokaci na M2, yadda ya kamata ya hana bayyanar cututtuka masu kumburi TNF-α da IL-6 a cikin kyallen takarda, saki abubuwa masu kumburi kamar TGF-β da iNOS, haɓaka bayyanar hanyar HIF-1a, inganta bayyanar VEGF don cimma sakamako na gyare-gyaren nama, inganta haɓakawa da haɓakawa.
Maganin tsufa:
GHK CU yana da tasirin rigakafin tsufa da yawa. Yana iya hana ayyukan ƙwayoyin cuta irin su NFκB, waɗanda aka ɗauka don haɓaka tsarin tsufa (Pickart L, 2018). Bugu da ƙari, yana da anxiolytic, analgesic, da ayyukan anti-gurna, gyaran DNA, da aikin kunna tsaftacewa ta hanyar tsarin proteasome.
A matsayin Sinadarin Gyaran jiki:
Saboda tasirinta akan gyaran fata da rigakafin tsufa, ana amfani da GHK CU sosai a cikin kayan kwalliya. Alal misali, liposomes dangane da anionic (AL) da cationic (CL) hydrogenated lecithin za a iya amfani dashi azaman tsarin isar da fata don GHK CU [4] . Wadannan liposomes ba su da ƙarfi, suna da ƙananan ƙwayar ƙwayar cuta (kimanin 100nm), da kuma yawan ruwa mai yawa, wanda zai iya sadar da GHK CU cikin fata yadda ya kamata. A matsayin kayan shafawa, GHK CU ba zai iya inganta bayyanar fata kawai ba amma yana inganta lafiyar fata.
Filin Kiwon Lafiya:
Maganin Rauni Mai Mutuwar Huhu:
GHK CU yana da tasirin kariya akan mummunan rauni na huhu (ALI). A cikin gwaje-gwajen in vitro akan RAW 264.7 macrophages da aka haifar da lipopolysaccharide (LPS) da kuma a cikin samfurin linzamin kwamfuta na mummunan rauni na huhu a cikin vivo, maganin GHK CU ya rage yawan samar da nau'in oxygen mai amsawa (ROS), ƙara yawan aikin superoxide dismutase (SOD), kuma a lokaci guda ya rage samar da aikin TILNF-6. NF-κB p65 da p38 MAPK hanyoyin sigina [2] . Bugu da ƙari, GHK CU na iya rage sauye-sauyen cututtuka na ƙwayar huhu da LPS ke haifar da shi kuma ya hana shigar da ƙwayoyin kumburi a cikin parenchyma na huhu.
Maganin Fibrosis na Pulmonary:
GHK CU ya nuna sakamako na warkewa a cikin samfurin linzamin kwamfuta na fibrosis na huhu wanda ya haifar da bleomycin (BLM) [5] . Idiopathic pulmonary fibrosis cuta ce mai tsanani na huhu, kuma danniya da kumburi sune mahimman hanyoyin sa. GHK CU na iya taka rawar kariya ta hanyar damuwa na antioxidant da hanyoyin hana kumburi.
Maganin Silicosis:
Silicosis shine nau'in pneumoconiosis da aka fi sani da shi, kuma a halin yanzu babu takamaiman magani don maganin sa. Nazarin sun gano cewa GHK CU yana da tasirin warkewa akan silicosis. Yana iya rage kumburin huhu da fibrosis a cikin mice silicosis ta hanyar niyya peroxiredoxin 6 (PRDX6), wani ɓangare saboda hana damuwa na oxidative a cikin macrophages alveolar da aka jawo ta silica crystalline [6].
GHK CU yana da ayyuka da yawa da mahimmanci. Yana iya tayar da haɗewar abubuwa kamar collagen, gyara fata, da jinkirta tsufa, yana taimaka wa mutane su bi lafiya da kyakkyawar fata a fagen kyau da kula da fata. A matakin likita, yana ba da sabon jagora don magance cututtukan huhu kamar mummunan rauni na huhu da fibrosis na huhu, kuma ana sa ran inganta lafiyar marasa lafiya. Gabaɗaya, GHK CU tana ba da gudummawa ga haɓaka ilimin kimiyyar rayuwa, likitanci, da masana'antar kyakkyawa, kuma yana da tasiri mai kyau akan inganta rayuwar ɗan adam.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Bian Y mai bincike ne mai alaƙa da manyan ƙungiyoyi masu yawa. Waɗannan sun haɗa da Jiha Key Lab Resp Hlth & Multimorbid, -Asibitin Abota na Japan, Kwalejin Kimiyyar Kiwon Lafiya ta Sin - Kwalejin Kiwon Lafiya ta Peking Union, Natl Clin Res Ctr Resp Dis, Natl Ctr Resp Med, da Jami'ar Tongji. Ƙungiyoyin sa na cibiyoyi suna nuna babban tushe a cikin binciken likita da kimiyya.
Bincikensa ya ƙunshi nau'ikan batutuwa masu mahimmanci da yawa. Yana da gwaninta a cikin Tsarin Numfashi, Oncology, Janar & Magungunan Ciki, Bincike & Magungunan Gwaji, da Biochemistry & Halittar Halitta. Ayyukansa a waɗannan fagagen suna da mahimmanci don haɓaka ilimin likitanci da haɓaka kiwon lafiya. An jera Bian Y a cikin ambaton ambaton [6].
