|
1kits （10Ibikoresho）
| Umubare: | |
|---|---|
▎ Imiterere ya GHK CU
Inkomoko: PubChem |
Urukurikirane: Gly-His-Lys Inzira ya molekulari: C 28H 46CuN 12O.8 Uburemere bwa molekuline: 742.3g / mol Numero ya CAS: 130120-56-8 PubChem CID: 9831891 Synonyme: Bisprezatide umuringa ； DL1TR6W6VM |
GHK CU Ubushakashatsi
Ni ubuhe bushakashatsi bwakozwe na GHK CU?
Iterambere ryubushakashatsi bwa Peptide ikora:
Kuva mu kinyejana cya 20, ubushakashatsi kuri peptide ya bioaktike mu bumenyi bwubuzima bwakomeje kwiyongera. Abahanga bagiye bamenya buhoro buhoro peptide igira uruhare runini mubinyabuzima. Ntabwo ari ibice bya poroteyine gusa ahubwo bifite n'imikorere y’ibinyabuzima byigenga kandi bigira uruhare mu kugenzura imikorere itandukanye y’ibinyabuzima, nko gukura kw ingirabuzimafatizo, gutandukanya, no gukingira indwara. Uku gusobanukirwa byimbitse kuri peptide gutanga ishingiro ryubuyobozi hamwe nicyerekezo cyubushakashatsi bwo kuvumbura no kwiga GHK CU.
Ubushakashatsi bwibigize Plasma:
Mu bushakashatsi burambuye bwibice bya plasma byabantu, abahanga biyemeje gusesengura imiterere nimirimo ya biomolecules zitandukanye muri plasma. Nkamazi yingenzi yumubiri mumubiri wumuntu, plasma irimo proteyine zitandukanye, peptide, imisemburo, electrolytite, nibindi bintu, kandi nuburyo bwingenzi bwo gukomeza imirimo isanzwe yumubiri wumuntu. Mu myaka ya za 70, abashakashatsi bavumbuye ku bw'impanuka tripeptide idasanzwe mu gihe cyo gusesengura poroteyine za plasma. Urutonde rwa aside amine ni glycyl-histidyl-lysine, aribyo GHK. Ubu buvumbuzi bwashishikaje cyane abahanga kandi butuma barushaho gucukumbura uruhare n'ibiranga iyi tripeptide muri plasma.
Akamaro k'ibinyabuzima k'umuringa:
Muri icyo gihe, uruhare rukomeye rwa ion z'umuringa muri biyolojiya rwagiye rukurura abantu buhoro buhoro. Umuringa ni kimwe mu bintu by'ingenzi bigize umubiri wa kimuntu kandi bigira uruhare mu myitwarire myinshi ya biohimiki. Nibigize cyangwa ukora enzymes nyinshi zingenzi kandi bigira uruhare runini mugukomeza metabolisme isanzwe yingirabuzimafatizo, guhumeka, hamwe na synthesis ya kolagen. Mu bushakashatsi bwakozwe ku mikorere y’ibinyabuzima ya ion z'umuringa, abahanga basanze ion z'umuringa zishobora guhuza ibintu bimwe na bimwe bya peptide kugira ngo bibe inganda zifite ibikorwa by’ibinyabuzima bidasanzwe. Ubu buvumbuzi butanga ibimenyetso byingenzi byo kwiga guhuza GHK na ion z'umuringa n'imikorere yazo.
Gutezimbere Ubushakashatsi bujyanye no gusaza:
Hamwe niterambere ryabaturage hamwe nikibazo kigaragara cyane cyo gusaza kwabaturage, ubushakashatsi bujyanye no gusaza bwabaye ingingo yingenzi mubumenyi bwubuzima. Abahanga baragerageza gushakisha biomarkers nibintu bigenga bifitanye isano cyane no gusaza kugirango bagaragaze uburyo bwo gusaza no gushakisha uburyo bwo gutinda gusaza. Ni muri urwo rwego, byagaragaye ko kwibumbira hamwe kwa GHK CU mu mubiri w'umuntu bigenda bigabanuka buhoro buhoro uko imyaka igenda ishira, bivuze ko GHK CU ishobora kuba ifitanye isano no gusaza. Ubu buvumbuzi bukangurira abashakashatsi gukora ubushakashatsi bwimbitse ku nkomoko, imikorere, no gushyira mu bikorwa GHK CU mu rwego rwo kurwanya gusaza, kandi biteza imbere iterambere ry’ubushakashatsi bujyanye.
Ni ubuhe buryo bwo gukora bwa GHK CU?
Guteza imbere gusana imyenda no kuvugurura:
Kubyutsa imiyoboro y'amaraso no gukura kw'imitsi:
Ubushakashatsi buriho bwerekanye ko GHK CU ishobora gutera imikurire y'imitsi n'amaraso. Irashobora kugera kuriyi ngaruka muguhindura ibintu byihariye byo gukura no kwerekana inzira. Kurugero, irashobora guteza imbere imvugo yikura ryimyanya ndangagitsina (VEGF), bityo igatera angiogenez [1] . Ku bijyanye no gukura kw'imitsi, irashobora guteza imbere kubaho, gukwirakwira, no gukura kwa axon ya selile nervice bigira ingaruka kuri molekile zerekana zijyanye no gukura kw'imitsi.
Kongera Synthesis ya Collagen, Elastin, na Glycosaminoglycans:
GHK CU irashobora kongera synthesis ya kolagen, elastine, na glycosaminoglycans. Kolagen ni ikintu cy'ingenzi kigize ingirangingo nk'uruhu n'amagufa, elastine itanga ingirabuzimafatizo, kandi glycosaminoglycans igira uruhare runini mu kubungabunga ubushuhe n'ubukonje bw'imitsi. Uburyo bwihariye bushobora kuba bukubiyemo kugenzura imiterere ya genes zifitanye isano ninzira zerekana inzira, nko gukora ibintu byihariye byo kwandukura muri fibroblast kugirango biteze imbere genes zijyanye na synthesis ya kolagen [1].
Gushyigikira Imikorere ya Dermal Fibroblast:
Fibroblast ya Dermal igira uruhare runini mukubungabunga imiterere nimikorere yuruhu. GHK CU irashobora gushyigikira imikorere ya fibroblast ya dermal, harimo guteza imbere ikwirakwizwa ryimikorere, kwimuka, hamwe no guhuza ibice bigize matrice idasanzwe. Ibi birashobora kugerwaho muguhuza inzira yerekana ibimenyetso na gene imvugo muri fibroblast.
Ingaruka zo Kurinda Akagari:
Igikorwa cya Anticancer:
GHK CU ifite ibikorwa byinshi birwanya antikanseri. Irashobora kugira ingaruka za anticancer mukurinda ikwirakwizwa rya selile kanseri, gutera apoptose ya selile kanseri, no guhagarika igitero na metastasis ya selile. Uburyo bwihariye bushobora kuba bukubiyemo kugenzura ingirabuzimafatizo, gukora inzira yerekana ibimenyetso bya apoptose, no guhagarika inzira zerekana ibimenyetso bifitanye isano n'ibibyimba [1].
Ingaruka zo kurwanya inflammatory:
GHK CU ifite ingaruka zikomeye zo kurwanya inflammatory. Irashobora kubuza kubyara ibintu bitera umuriro nka feri yibibyimba-α (TNF-α) na interleukin-6 (IL-6), kandi icyarimwe bikongera ibikorwa byimisemburo ya antioxydeant nka superoxide dismutase (SOD). Uburyo bwayo bwo kurwanya inflammatory bushobora kuba bufitanye isano no kubuza inzira ya NF-κB p65 na p38 MAPK yerekana inzira, bityo bikagabanya igisubizo cyo gutwika [2].
Kurinda ibihaha no gusana indwara zidakira zifata ibihaha (COPD):
GHK CU igira ingaruka zo gukingira no kwisubiza ku bihaha. Irashobora guhagarika ibisubizo byumuriro mubice by ibihaha, kugabanya ibyangiritse na fibrosis yumubiri wibihaha. Kuri fibroblast yibihaha yabarwayi bafite indwara zidakira zifata ibihaha (COPD), GHK CU irashobora kugarura imikorere yabo, bishoboka muguhuza inzira zerekana ibimenyetso hamwe na gene [1].
Ingaruka za Anxiolytike, Analgesic, na Anti-Agression:
GHK CU ifite kandi ingaruka za anxiolytique, analgesic, na anti-agression, ariko uburyo bwihariye ntiburasobanuka neza. Irashobora kuba ifitanye isano no kugenzura inzira zerekana ibimenyetso na neurotransmitter muri sisitemu ya nervice.
Gusana ADN no Gusukura Akagari:
Gusana ADN:
GHK CU ifite umurimo wo gusana ADN. Irashobora gusana ADN yangiritse mugukoresha imisemburo yihariye ya ADN yo gusana cyangwa inzira yerekana inzira. Ibi bifite akamaro kanini mugukomeza imikorere isanzwe ya selile no kwirinda ko habaho indwara nko gusaza na kanseri [1].
Gukora isuku y'utugari (binyuze muri Proteasome Sisitemu):
GHK CU irashobora gukora proteasome ya selile, igatera kwangirika no gukuraho poroteyine zo mu nda. Ibi bifasha kubungabunga umutekano w’ibidukikije no kurinda poroteyine no kudakora neza kwa selile [1].
Hypothesis on Mechanism of Acupuncture: Ubushakashatsi bumwe bwerekanye hypothesis ko uburyo bwibikorwa bya acupuncture bushobora kugerwaho binyuze muri GHK CU. Nubwo uburyo bwihariye bugikomeza kwigwa, ibi bitanga icyerekezo gishya cyo gusobanukirwa nuburyo bwibikorwa bya GHK CU [3].
Urwego rwa plasma hamwe nubuvuzi bwa GHK kubarwayi barwaye silicose: A. Plasma GHK murwego rwiza hamwe nabarwayi barwaye silicose. B. Urwego rwa plasma GHK kubarwayi barwaye silicose mubyiciro bitandukanye byindwara. C. Kwerekana amashusho yibihaha hamwe na plasma ya GHK mubaturage bagenzura neza no mubarwayi mubyiciro bitandukanye byubuvuzi bwa silicose. D. Isano riri hagati yurwego rwa plasma GHK na FEV1% pre kubarwayi barwaye silicose. E. Isano riri hagati yurwego rwa plasma GHK na DLCO% pre kubarwayi barwaye silicose.
Inkomoko: Byatangajwe [6]
Ni ubuhe buryo bukoreshwa muri GHK CU?
Gusana uruhu n'ubwiza:
Gukangura Collagen Synthesis:
GHK CU irashobora gukangura synthesis ya kolagen, elastine, na glycosaminoglycans. Kolagen ni ikintu cyingenzi cyuruhu, rutanga uruhu rworoshye kandi rukomeye [1] . Hamwe no kwiyongera kwimyaka, synthesis ya kolagen igenda igabanuka buhoro buhoro, biganisha kuruhuka kuruhu no kugaragara kwiminkanyari. Mugutezimbere umusaruro wa kolagen, GHK CU irashobora kunoza ubuhanga no gukomera kwuruhu no kugabanya iminkanyari.
Guteza imbere imitsi y'amaraso no gukura kw'imitsi:
Ifite ingaruka zo gukura kw'imitsi y'amaraso n'imitsi [1] . Gutembera neza kwamaraso ningirakamaro kubuzima bwuruhu. Irashobora gutanga intungamubiri zihagije na ogisijeni ku ngirabuzimafatizo z'uruhu kandi bigatera metabolism y'uruhu. Byongeye kandi, imikurire yimitsi nayo igira uruhare mubushobozi bwo kumva no kwitabira uruhu.
Gushyigikira Imikorere ya Dermal Fibroblast:
GHK CU ishyigikira imikorere ya fibroblast ya dermal. Fibroblast ni bumwe mu bwoko bw'ingirabuzimafatizo nyamukuru mu ruhu, kandi zifite inshingano zo guhuza kolagen, elastine, n'ibindi bigize matrice idasanzwe [1] . GHK CU irashobora kongera ibikorwa bya fibroblast no kunoza ubushobozi bwabo bwo guhuza matrise idasanzwe, bityo igafasha kugumana imiterere nimikorere yuruhu.
Gukiza ibikomere:
GHK CU yerekana ingaruka zikomeye mugukiza ibikomere. Ubushakashatsi bwerekanye ko bushobora kwihutisha inzira yo gukira ibikomere, bigatera imikurire yimitsi ya granulation, no kubyara no kwegeranya kwa kolagen. Byongeye kandi, GHK CU irashobora kugenga ihinduka rya macrophage kuva mu cyiciro cya M2, ikabuza neza kwerekana ibintu bitera TNF-α na IL-6 mu ngingo, kurekura ibintu birwanya inflammatory nka TGF-β na iNOS, kwihutisha imvugo y’inzira ya HIF-1α, guteza imbere imvugo ya VEGF kugira ngo igere ku ngaruka zo guteza imbere angiogenez, no kwihutisha gusana ingirabuzimafatizo.
Kurwanya gusaza:
GHK CU ifite ingaruka nyinshi zo kurwanya gusaza. Irashobora guhagarika ibikorwa bya molekile nka NFκB, zifatwa nko kwihutisha gusaza (Pickart L, 2018). Byongeye kandi, ifite kandi ibikorwa bya anxiolytike, analgesic, hamwe no kurwanya ibitero, gusana ADN, hamwe ninshingano yo gukora isuku ya selile binyuze muri sisitemu ya proteasome.
Nkibikoresho byo kwisiga:
Bitewe n'ingaruka zabyo mugusana uruhu no kurwanya gusaza, GHK CU ikoreshwa cyane mumavuta yo kwisiga. Kurugero, liposomes ishingiye kuri anionic (AL) na cationic (CL) hydrogenated lecithine irashobora gukoreshwa nka sisitemu yo gutanga uruhu kuri GHK CU [4] . Izi liposomes zirahamye, zifite ingano ntoya (hafi 100nm), hamwe na fluide ya bilayeri nyinshi, ishobora kugeza GHK CU neza muruhu. Nkibintu byo kwisiga, GHK CU ntishobora gusa kunoza isura yuruhu gusa ahubwo inazamura ubuzima bwuruhu.
Urwego rw'ubuvuzi:
Umuti wo gukomeretsa ibihaha bikaze:
GHK CU igira ingaruka zo gukingira ibikomere bikabije (ALI). Mu bushakashatsi bwa vitro kuri macrophage ya RAW 264.7 iterwa na lipopolysaccharide (LPS) no muburyo bwimbeba yimvune yibihaha ikaze muri vivo, kuvura GHK CU byagabanije umusaruro wubwoko bwa ogisijeni ikora (ROS), byongera ibikorwa byo guhagarika superoxide (SOD), kandi icyarimwe bigabanya umusaruro wa TNF-α na IL-6 p. [2] . Byongeye kandi, GHK CU irashobora kandi kugabanya impinduka ziterwa nindwara zifata ibihaha zatewe na LPS kandi bikabuza kwinjira mu ngirabuzimafatizo zandurira mu bihaha parenchyma.
Umuti wa Fibrosis yo mu bihaha:
GHK CU yerekanye ingaruka zo kuvura muburyo bwimbeba ya fibrosis yimpyisi iterwa na bleomycine (BLM) [5] . Idiopathic pulmonary fibrosis nindwara ikomeye yibihaha, kandi guhangayikishwa na okiside hamwe no gutwika nuburyo bwingenzi butera indwara. GHK CU irashobora kugira uruhare mukurinda binyuze mumaganya ya antioxydeant n'inzira zo kurwanya inflammatory.
Umuti wa Silicose:
Silicose ni ubwoko bukunze kwibasira pneumoconiose, kandi kuri ubu nta muti wihariye wo kuvura. Ubushakashatsi bwerekanye ko GHK CU igira ingaruka zo kuvura silicose. Irashobora kugabanya ibihaha hamwe na fibrosis mu mbeba za silicose yibasira peroxiredoxin 6 (PRDX6), igice kimwe bitewe no guhagarika imbaraga za okiside muri macrophage ya alveolar iterwa na silika kristaline [6].
GHK CU ifite imikorere myinshi nibisobanuro bikomeye. Irashobora gukangura synthesis yibintu nka kolagen, gusana uruhu, no gutinda gusaza, bifasha abantu gukurikirana uruhu rwiza kandi rwiza mubijyanye nubwiza no kwita kuruhu. Ku rwego rw’ubuvuzi, itanga icyerekezo gishya cyo kuvura indwara z’ibihaha nko gukomeretsa ibihaha bikabije na fibrosis yo mu bihaha, bikaba biteganijwe ko bizamura ubuzima bw’abarwayi. Muri rusange, GHK CU igira uruhare mu iterambere ry'ubumenyi bw'ubuzima, ubuvuzi, n'inganda z'ubwiza, kandi igira ingaruka nziza mu kuzamura imibereho y'abantu.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Bian Y numushakashatsi ufatanije nimiryango myinshi izwi. Harimo Leta ya Laboratwari ya Leta Resp Hlth & Multimorbid, -Ibitaro by’Ubucuti by’Ubuyapani, Ishuri Rikuru ry’Ubuvuzi ry’Ubushinwa - Ishuri Rikuru ry’Ubuvuzi rya Peking Union, Natl Clin Res Ctr Resp Dis, Natl Ctr Resp Med, na kaminuza ya Tongji. Inzego afitanye ninzego zigaragaza amateka menshi mubushakashatsi mubuvuzi na siyansi.
Ubushakashatsi bwe bukubiyemo ibyiciro byinshi byingenzi. Afite ubuhanga muri sisitemu y'ubuhumekero, Oncology, Ubuvuzi rusange & Imbere mu Gihugu, Ubushakashatsi & Ubuvuzi bw'Ubushakashatsi, na Biochemie & Molecular Biology. Ibikorwa bye muri izi nzego ni ingenzi mu guteza imbere ubumenyi bw’ubuvuzi no guteza imbere ubuvuzi. Bian Y yanditse murutonde rwibisobanuro [6].
