Los ntawm Cocer Peptides 
31 hnub dhau los
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Txheej txheem cej luam
Cardiogen, ib yam khoom muaj txiaj ntsig zoo hauv kev kho mob plawv, muaj qhov chaw thiab qhov tseem ceeb rau kev nkag siab txog nws lub luag haujlwm hauv kev kho mob plawv. Nws cuam tshuam nrog cov hom phiaj tshwj xeeb hauv cov hlab plawv, yog li siv nws cov txiaj ntsig kev noj qab haus huv ntawm cov hlab plawv.
Daim duab 1. Epigenetic mechanisms hauv plawv plawv. Lub plawv (chaw) txuas mus rau peb qhov tseem ceeb ntawm kev tswj hwm kev tswj hwm kev tswj hwm ntawm cov hlab plawv pathophysiology.
Cov teebmeem
Cov teebmeem ntawm lub siab
Kev tswj lub plawv dhia: Cardiogen tuaj yeem tswj lub plawv dhia ceev ceev, ua kom lub plawv dhia hauv qhov qub. Nyob rau hauv cov xwm txheej kev ntxhov siab, xws li thaum lub cev raug txhawb los ntawm cov tshuaj hormones kev ntxhov siab xws li adrenaline, lub plawv yuav muaj tachycardia. Cardiogen tau txais txiaj ntsig zoo rau kev ntxhov siab ntawm adrenaline ntawm lub plawv, pab txo qis lub plawv dhia mus rau qhov kev tswj hwm ib txwm muaj thaum txo qhov tshwm sim ntawm arrhythmias, yog li tswj hwm lub plawv dhia ua haujlwm thiab ua kom cov ntshav txaus rau tag nrho lub cev.
Txhawb nqa myocardial regeneration: Tom qab cov kab mob plawv xws li myocardial infarction, cov ntaub so ntswg myocardial puas lawm. Cardiogen muaj lub luag haujlwm tseem ceeb hauv kev txhawb nqa myocardial regeneration los ntawm inducing endogenous mesenchymal qia hlwb (MSCs) kom sib txawv rau hauv cardiomyocytes, yog li kho cov ntaub so ntswg myocardial puas. Los ntawm kev txhawb nqa cov kev taw qhia tseem ceeb - txoj hauv kev tseem ceeb koom nrog hauv lub plawv embryonic induction thiab angiogenesis - nws txhawb kev tsim kho thiab kev loj hlob ntawm cardiomyocytes, yog li txhim kho lub plawv ua haujlwm thiab txhim kho lub plawv contractile thiab diastolic muaj peev xwm.
Kev cuam tshuam rau cov hlab ntsha
Txhim kho vascular endothelial muaj nuj nqi: Vascular endothelial hlwb yog qhov tseem ceeb rau kev tswj hwm lub cev kev ua haujlwm ntawm cov hlab ntsha. Cardiogen txhawb kev noj qab haus huv ntawm vascular endothelial hlwb thiab txhim kho lawv lub peev xwm los zais cov tshuaj vasodilatory xws li nitric oxide. Nitric oxide relaxes vascular du nqaij, li no dilating cov hlab ntsha, txo vascular kuj, txhim kho cov ntshav ncig, thiab txo cov kev pheej hmoo ntawm cov kab mob plawv.
Inhibiting vascular o: Inflammatory teb ua lub luag haujlwm tseem ceeb hauv kev txhim kho cov kab mob vascular xws li atherosclerosis. Cardiogen tuaj yeem cuam tshuam cov lus teb inflammatory nyob rau hauv cov phab ntsa vascular, txo cov infiltration ntawm inflammatory cells thiab tso tawm ntawm inflammatory yam. Los ntawm inhibiting inflammatory cascades, nws alleviates kev puas tsuaj rau lub vascular phab ntsa, pab tswj lub cev vascular qauv thiab muaj nuj nqi thiab tiv thaiv vascular nqaim thiab blockages.
Daim ntawv thov
Kev kho mob myocardial infarction: Rau cov neeg mob uas muaj myocardial infarction, kev cuam tshuam ntxov nrog Cardiogen tom qab pib ntawm tus kab mob tuaj yeem txhawb nqa myocardial regeneration thiab kho, txo qhov mob hauv cheeb tsam, thiab txhim kho kev ua haujlwm plawv. Kev tswj hwm tuaj yeem yog los ntawm qhov ncauj lossis kev txhaj tshuaj, nrog rau cov kev tswj hwm tshwj xeeb thiab cov koob tshuaj hloov kho tus kheej raws li tus neeg mob tus mob thiab lub cev. Cov kev tshawb fawb soj ntsuam tau pom tias cov neeg mob uas muaj myocardial infarction uas tau txais kev kho mob Cardiogen muaj kev txhim kho tseem ceeb hauv kev ua haujlwm ntawm lub plawv xws li ejection feem, yog li txhim kho lawv lub neej zoo thiab kev ciaj sia.
Kev kho mob arrhythmia: Cardiogen tuaj yeem tswj lub plawv dhia thiab ua kom muaj zog arrhythmia rau ntau hom arrhythmia. Rau cov neeg mob uas muaj mob arrhythmia me, kev kho mob nrog Cardiogen tuaj yeem txo qhov zaus thiab qhov hnyav ntawm arrhythmia ntu, zam lossis txo cov kev mob tshwm sim cuam tshuam nrog cov tshuaj antiarrhythmic. Hauv kev xyaum kho mob, cov kws kho mob yuav siv Cardiogen kom tsim nyog raws li tus neeg mob qhov kev soj ntsuam xyuas electrocardiogram thiab cov tsos mob tshwm sim.
Kev tshawb fawb ntsig txog
Kev Tshawb Fawb Tsiaj: Ntau qhov kev sim tsiaj tau tshawb xyuas qhov tob rau hauv Cardiogen's cardiovascular tiv thaiv cov teebmeem. Hauv kev sim nas, tom qab tsim tus qauv myocardial infarction thiab tswj hwm Cardiogen cuam tshuam, qhov tseem ceeb ntawm myocardial regeneration tau pom nyob rau hauv cheeb tsam myocardial infarction, nrog rau cov ntsuas kev ua haujlwm xws li sab laug ventricular ejection feem ntau txhim kho. Tsis tas li ntawd, hauv kev sim vascular-txog kev sim, nws tau pom tias Cardiogen tuaj yeem cuam tshuam vascular endothelial proliferation thiab txo qhov tsim ntawm atherosclerotic plaques, qhia txog nws cov kev tiv thaiv zoo ntawm cov hlab ntsha. Cov tsiaj sim no muab lub hauv paus tseem ceeb theoretical thiab kev sim pov thawj rau kev siv Cardiogen hauv kev kho mob plawv thiab cerebrovascular.
Kev tshawb fawb soj ntsuam: Qee qhov kev tshawb fawb me me kuj tau ua qhov kev ntsuam xyuas ua ntej ntawm kev nyab xeeb thiab kev ua tau zoo ntawm Cardiogen. Hauv cov kev tshawb fawb tsom rau cov neeg mob arrhythmia, nws tau pom tias tom qab kev kho mob nrog Cardiogen, cov neeg mob cov tsos mob arrhythmia tau zoo tuaj, thiab tsis muaj qhov tshwm sim tsis zoo tshwm sim, qhia tau tias nws muaj peev xwm siv tau hauv kev kho mob arrhythmia. Hauv kev tshawb fawb soj ntsuam ntawm cov neeg mob myocardial infarction, nws tau pom tias cov neeg mob kho nrog Cardiogen muaj kev ua haujlwm zoo ntawm lub plawv zoo dua li pawg tswj hwm, ntxiv kev lees paub nws cov txiaj ntsig kho mob ntawm myocardial infarction.
Xaus
Hauv cov ntsiab lus, Cardiogen plays lub luag haujlwm tseem ceeb hauv kev kho mob plawv. Los ntawm nws cov teebmeem ntau yam ntawm lub plawv thiab cov hlab ntsha, nws tuav cov ntaub ntawv tseem ceeb hauv kev kho mob thiab kev noj qab haus huv txhua hnub.
Qhov chaw
[1] Martínez-Iglesias O, Naidoo V, Carrera I, et al. Ntuj Bioproducts nrog Epigenetic Properties rau Kev Kho Mob plawv [J]. Genes, 2025,16(5},
ARTICLE-NUMBER = {566). DOI: 10.3390/genes16050566.
[2] Lin X, Peng P, Cheng L, et al. Lub ntuj sib xyaw ua rau kev sib txawv cardiogenic ntawm endogenous MSCs rau kev kho mob plawv [J]. Differentiation, 2012,83(1):1-9.DOI:10.1016/j.diff.2011.09.001.
[3] Cheng L, Chen H, Yao X, et al. Ib tsob nroj-derived tshuaj kho mob plawv [J]. Plos Ib, 2009,4(2):e4461.DOI:10.1371/journal.pone.0004461.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
