Na Cocer Peptides 
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INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Incamake
Cardiogen, ikintu gishishikaje cyane mu bijyanye no kwita ku buzima bw’umutima n’imitsi, gifite isoko na kamere bifite akamaro kanini mu gusobanukirwa uruhare rwayo mu kubungabunga ubuzima bw’umutima. Ihuza nintego zihariye muri sisitemu yumutima nimiyoboro yimitsi, bityo ikagira ingaruka zokubungabunga ubuzima kuri sisitemu yumutima.
Igishushanyo 1. Uburyo bwa Epigenetike mu ndwara zifata umutima. Umutima (hagati) uhuza uburyo butatu bwingenzi bwo kugenzura epigenetike bugira ingaruka kumutima.
Ingaruka
Ingaruka ku mutima
Kugena umuvuduko wumutima: Cardiogen irashobora kugenzura neza injyana yumutima, bigatuma umuvuduko wumutima uri mubisanzwe. Mubihe bigoye, nkigihe umubiri ushutswe na hormone zo guhangayika nka adrenaline, umutima urashobora kugira tachycardia. Cardiogen isubiza neza ingaruka ziterwa na adrenaline kumutima, ifasha kugabanya umuvuduko wumutima kugiciro gisanzwe cyo kugenzura mugihe hagabanijwe kubaho kwa arththmias, bityo bikagumana imikorere isanzwe yo kuvoma umutima no gutuma amaraso ahagije mumubiri wose.
Guteza imbere myocardial regeneration: Nyuma yindwara z'umutima nka infarction myocardial, tissue myocardial yangiritse. Cardiogen ifite uruhare runini mugutezimbere myocardial kuvugurura ingirabuzimafatizo ya endogenous mesenchymal stem selile (MSCs) kugirango itandukane na cardiomyocytes, bityo isane ingirangingo za myocardial zangiritse. Mugukangurira inzira zerekana ibimenyetso-inzira zingenzi zigira uruhare mu kwinjiza umutima no kwinjiza angiogenezi - biteza imbere kuvugurura no gukwirakwira kwa cardiomyocytes, bityo bigateza imbere imikorere yumutima no kongera ubushobozi bwumutima hamwe na diastolique.
Ingaruka ku mitsi y'amaraso
Kunoza imikorere ya endoteliyale yimitsi: Utugingo ngengabuzima twa endoteliyale ningirakamaro mugukomeza imirimo isanzwe yimitsi yimitsi. Cardiogen iteza imbere ubuzima bwingirabuzimafatizo ya endoteliyale kandi ikongerera ubushobozi bwo gusohora ibintu bya vasodilatory nka okiside ya nitric. Okiside ya Nitric iruhura imitsi yoroshye yimitsi, bityo ikaguka imiyoboro yamaraso, kugabanya kurwanya imitsi, kunoza umuvuduko wamaraso, no kugabanya ibyago byindwara zifata umutima.
Kurinda imitsi y'amaraso: Ibisubizo bitera bigira uruhare runini mugutezimbere indwara zifata imitsi nka aterosklerose. Cardiogen irashobora guhagarika ibisubizo byumuriro murukuta rwamaraso, bikagabanya kwinjira kwingirabuzimafatizo no kurekura ibintu bitera umuriro. Muguhagarika kasake yaka umuriro, igabanya kwangirika kwurukuta rwimitsi, ifasha kugumana imiterere yimitsi nimikorere isanzwe no kwirinda kugabanuka kwamaraso no kuziba.
Porogaramu
Kuvura infirasiyo ya Myocardial: Ku barwayi barwaye infiyine ya myocardial, gutabara hakiri kare na Cardiogen nyuma yo gutangira indwara birashobora guteza imbere myocardial kuvugurura no gusana, kugabanya agace ka infarct, no kunoza imikorere yumutima. Ubuyobozi bushobora kunyura munzira cyangwa inshinge, hamwe ninzira zubuyobozi hamwe na dosiye byahinduwe kugiti cye ukurikije uko umurwayi ameze ndetse numubiri. Ubushakashatsi ku mavuriro bwerekanye ko abarwayi bafite infarction myocardial bahabwa imiti ya Cardiogene bagaragaza iterambere ryinshi mu bipimo by’imikorere y’umutima nkigice cyo gusohora, bityo bakazamura imibereho yabo n’ubuzima bwabo.
Kuvura indwara ya Arththmia: Cardiogen irashobora kugenga umuvuduko wumutima no guhagarika arththmia kubwoko butandukanye bwa arththmia. Ku barwayi bafite ikibazo cyoroheje, kuvura hamwe na Cardiogen birashobora kugabanya inshuro nuburemere bwibihe bidasanzwe, kwirinda cyangwa kugabanya ingaruka ziterwa n’imiti gakondo igabanya ubukana. Mubikorwa byubuvuzi, abaganga bazakoresha Cardiogene uko bikwiye bashingiye kubisubizo bya electrocardiogram yumurwayi nibimenyetso byerekana.
Ubushakashatsi bujyanye
Ubushakashatsi Bw’inyamaswa: Ubushakashatsi bwinshi bw’inyamaswa bwakoze ubushakashatsi bwimbitse ku ngaruka zo gukingira umutima n’umutima. Mu bushakashatsi bwimbeba, nyuma yo gushyiraho urugero rwindwara ya myocardial no gutanga infashanyo ya Cardiogene, kuvugurura cyane kwa myocardial byagaragaye mugace ka infocarike ya myocardial, hamwe nibimenyetso byerekana imikorere yumutima nkibice byo gusohora ibumoso byateye imbere cyane. Byongeye kandi, mu bushakashatsi bujyanye n’imitsi, byagaragaye ko Cardiogen ishobora kubuza ikwirakwizwa ry’imitsi ya endoteliyale no kugabanya imiterere ya plaque ya aterosklerotike, byerekana ingaruka nziza zo kurinda imiyoboro y'amaraso. Ubu bushakashatsi bwinyamanswa butanga urufatiro rukomeye hamwe nibimenyetso byubushakashatsi byerekana ikoreshwa rya Cardiogene mu kubungabunga ubuzima bwumutima nimiyoboro yubwonko.
Ubuvuzi bwa Clinical: Bimwe mubushakashatsi buto bwo kwa muganga nabwo bwakoze isuzuma ryibanze ryumutekano ningaruka za Cardiogen. Mu bushakashatsi bwibanze ku barwayi barwaye rubagimpande, byagaragaye ko nyuma yo kuvurwa na Cardiogen, ibimenyetso by’indwara z’abarwayi byateye imbere ku buryo bugaragara, kandi ko nta ngaruka zikomeye zabayeho, byerekana agaciro gakoreshwa mu kuvura indwara ya rubagimpande. Mu bushakashatsi bw’amavuriro y’abarwayi ba infarction myocardial, byagaragaye ko abarwayi bavuwe na Cardiogen bafite imikorere myiza yumutima kurusha itsinda rishinzwe kugenzura, bikomeza kwemeza ingaruka zayo zo kuvura indwara ya myocardial.
Umwanzuro
Muri make, Cardiogen igira uruhare runini mukubungabunga ubuzima bwumutima. Binyuze mu ngaruka zinyuranye ku mutima no mu mitsi y'amaraso, ifite imbaraga zo gukoresha mu kuvura no kubungabunga ubuzima bwa buri munsi.
Inkomoko
[1] Martínez-Iglesias O, Naidoo V, Carrera I, n'abandi. Ibinyabuzima bisanzwe bifite Epigenetike yo kuvura indwara zifata umutima [J]. Intangiriro, 2025.16 (5},
INGINGO-UMUBARE = {566). DOI: 10.3390 / genes16050566.
[2] Lin X, Peng P, Cheng L, n'abandi. Ikomatanyirizo karemano ryateye itandukanyirizo ryumutima wa MSC ya endogenous yo gusana umutima wanduye [J]. Itandukaniro, 2012,83 (1): 1-9.DOI: 10.1016 / j.diff.2011.09.001.
[3] Cheng L, Chen H, Yao X, n'abandi. Umuti ukomoka ku bimera byo gusana umutima wanduye [J]. Ikibanza cya mbere, 2009,4 (2): e4461.DOI: 10.1371 / ikinyamakuru.pone.0004461.
Ibicuruzwa biboneka mubushakashatsi bukoreshwa gusa:
