CJC1295, Ipamorelin 5/5 (ngwakọta)

▎ Ipamorelin

Ipamorelin bụ ngwakọta pentapeptide sịntetik. Dị ka onye dị mkpa n'ime ezinụlọ secretagogue hormone na-eto eto, nhazi ihe owuwu molekụla ya na-enye ya ikike ịhazi kpọmkwem axis secretion hormone uto. Ngwakọta a na-ejikọta ya na njikọ dị elu na onye na-anabata ihe nzuzo nke hormone nke uto (GHS-R), na-eme ka ụzọ mgbama dị n'okpuru ala, si otú a na-ebute ntọhapụ nke hormone uto (GH) nke ọma na n'otu oge na-akwalite okwu mkpụrụ ndụ na protein njikọ nke insulin-dị ka ihe na-eto eto-1 (IGF-1). Usoro ihe omume abụọ a ọ bụghị naanị na-achịkwa usoro metabolism ume (gụnyere ịkwalite nnabata amino acid, ịgbatị njikọ protein ngwa ngwa, na ịkwalite catabolism abụba), kamakwa ọ na-arụkwa ọrụ nchịkwa dị mma na nrụzi anụ ahụ na uto site n'ịkwalite mgbama mgbasa cell.

Na nyocha ngwa ụlọ ọgwụ, Ipamorelin egosila mmetụta nchịkwa ọtụtụ usoro: mmetụta ya na imeziwanye motility nke eriri afọ na-egosipụta dị ka ngwa ngwa nkwụsị nke gastric. Karịsịa na pathological ọnọdụ nke postoperative ileus, ọ nwere ike n'ụzọ dị irè na-ebelata intestinal motility ọrịa site n'ịkwalite peristaltic ugboro na mkpịsị ike nke eriri afọ ezigbo uru; N'ihe gbasara nchịkwa mgbu, ihe a na-achịkwa nnyefe mgbaàmà nociceptive site na ụzọ etiti na nke dị n'akụkụ, na-egosi mmetụta dị ịrịba ama na-ebelata ihe mgbu na-adịghị emetụta visceral na mgbu somatic. Usoro ya nwere ike ịgụnye ịgbalite sistemu peptide opioid endogenous na nhazi nke ọrụ ọwa ion.

N'iji ya tụnyere omenala uto hormone secretagogues, ịrịba uru nke Ipamorelin dabeere ya elu selectivity maka ibu hormone ntọhapụ - mgbe n'ụzọ dị irè na-akpali akpali GH secretion, ọ dịghị mmetụta dị ịrịba ama na secretion nke ndị ọzọ pituitary-adrenal axis hormones dị ka adrenocorticotropic hormone (ACTH) na cortisol, si otú ibelata ihe ize ndụ nke ọjọọ mmeghachi omume kpatara hormonal ọrịa. Ngwongwo ọgwụ a na-enye ya ohere maka ntinye aka kpọmkwem na ngbanwe ọgwụgwọ nke ụkọ hormone nke uto, ma n'otu oge ahụ na-enye ihe mgbaru ọsọ ọgwụ ọhụrụ maka nchọpụta banyere pathogenesis nke ọrịa motility nke eriri afọ na njikarịcha nke nchọpụta mgbu na mmemme ọgwụgwọ. Ugbu a, dabere na usoro ya pụrụ iche nke omume na njirimara nchekwa, nyocha ngwa ntụgharị nke Ipamorelin n'ọhịa nke ọrịa endocrine, ọrịa usoro nri digestive, na ọgwụ mgbu na-aga n'ihu na-emiwanye emi, na-egosi atụmanya ngwa ahụike sara mbara.

▎ Nchịkọta

Na-akwalite uto na mmezi akwara:

Ejikọtara ọnụ nke CJC1295 Ọ dịghị DAC na Ipamorelin nwere ike ịbawanye njikọ nke protein muscle ma mee ka nrụzi na ịmaliteghachi anụ ahụ. Usoro ya nwere ike ịgụnye mkpali mkpụrụ ndụ akwara kpọmkwem site na hormone na-eto eto, yana ịkwalite uto akwara na-apụtaghị ìhè site na ịhazi ihe ndị ọzọ na-eto eto na ụzọ metabolic. N'ihe gbasara nkà mmụta ọgwụ egwuregwu, ngwakọta ngwa ngwa nke ihe abụọ a peptide nwere uru dị mkpa. Maka ndị na-anụ ọkụ n'obi na-ahụ maka ahụike, ọ nwere ike ịkwalite mgbake anụ ahụ mgbe mgbatị ahụ gasịrị, kwalite ike na olu, ma melite mmetụta ọzụzụ. Nnyocha e mere egosiwo na hormone na-eto eto nwere ike ime ka mkpụrụ ndụ sel anụ ahụ rụọ ọrụ, na-akwalite mmụba ha na ọdịiche ha n'ime mkpụrụ ndụ anụ ahụ tozuru okè, si otú a na-eme ka usoro mmezi ahụ dịkwuo ngwa.

Na-ebuli metabolism abụba:

Ejikọtara ọnụ nke Ipamorelin na CJC1295 Ọ dịghị DAC nwere ike ịbawanye ọkwa nke hormone na-eto eto, si otú ahụ na-akwalite ire ere na oxidation nke abụba. Hormone na-eto eto nwere ike ịbawanye ọrụ nke enzymes lipolytic na sel abụba, na-akwalite mwepu nke abụba n'ime acid fatty free na glycerol iji nye ahụ ike. N'otu oge ahụ, ọ nwekwara ike melite itinye n'ọrụ arụmọrụ nke abụba, ibelata nchekwa nke ahu abụba, na melite ahu mejupụtara. Nke a dị oke mkpa maka mfu abụba na ịkpụzi ahụ, ọkachasị ndị chọrọ ibelata pasentị abụba anụ ahụ ma melite ahịrị ahụ ha.

Ịkwalite Ọkwa Ike na Ịrụ Egwuregwu:

Mmụba nke hormone na-eto eto nwere ike ime ka ọnụ ọgụgụ basal metabolic dịkwuo elu ma welie arụmọrụ nke mmepụta ume na itinye n'ọrụ. Mmụba na basal metabolic ọnụego pụtara na ahụ nwere ike na-eri ọzọ ume ọbụna na ezumike, nke na-enyere aka ịnọgide na-enwe ike ahu itule. Nke a na-enyere ndị ọrụ aka inweta ike dị elu n'oge mmemme na mmega ahụ kwa ụbọchị, ịgbatị ntachi obi mgbatị ahụ, ma melite arụmọrụ egwuregwu.

Na-emeziwanye ogo ụra:

Hormone uto na-arụ ọrụ dị mkpa n'ịhazi usoro ụra na ịdị mma. Ejikọtara ọnụ nke Ipamorelin na CJC1295 Ọ dịghị DAC nwere ike imeziwanye usoro ihi ụra ma mee ka oge ihi ụra dịkwuo elu. Ụra miri emi dị oke mkpa maka mgbake na nrụzi ahụ. Ọ nwere ike ịkwalite nzuzo nke hormone na-eto eto, kwalite ọrụ nke usoro ahụ ji alụso ọrịa ọgụ, ma melite ikike ọgụgụ isi nke ụbụrụ.

Ịkwalite ọrụ mgbochi ọrịa:

Hormone uto na-akwado ọrụ nkịtị nke usoro ahụ ji alụso ọrịa ọgụ. Ọ nwere ike ịkwalite ọrụ na ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ, meziwanye ihe nchebe nke ahụ, ma nyere aka iguzogide ọrịa. Site n'ịbawanye ọkwa nke hormone na-eto eto, ijikọta ọnụ nke Ipamorelin na CJC1295 Ọ dịghị DAC nwere ike ime ka mmụba na ike dị iche iche nke mkpụrụ ndụ na-alụso ọrịa ọgụ dịkwuo elu, na-akwalite mmepụta nke ọgwụ nje, na imeziwanye ihe mgbochi ahụ na-eguzogide ọrịa.

2. Ngwa Ngwa

Ọgwụ mgbochi ịka nká:

Site na mmụba nke afọ, ọkwa nke hormone na-eto eto na ahụ mmadụ ji nwayọọ nwayọọ na-ebelata, na-eduga n'ihe ndị na-eme agadi dị ka mfu anụ ahụ, uru abụba, na ntụrụndụ anụ ahụ. Ejikọtara ọnụ nke Ipamorelin na CJC1295 Ọ dịghị DAC nwere ike ịbawanye ọkwa nke hormone na-eto eto ma nwee mmetụta mgbochi ịka nká. Ndị na-eme nchọpụta na-enyocha ntinye nke ihe abụọ a peptide n'ime oge ịka nká na imeziwanye ndụ ndị agadi. Dịka ọmụmaatụ, enwere ike iji ha gbochie na ịgwọ ọrịa ndị metụtara ịka nká dị ka atrophy muscle agadi, ọkpụkpụ ọkpụkpụ, na ọrịa obi.

Ọgwụ egwuregwu:

N'egwuregwu egwuregwu, ijikọta ọnụ nke CJC1295 Ọ dịghị DAC na Ipamorelin nwere ike ịkwalite uto na nrụzi ahụ, kwalite arụmọrụ egwuregwu, ma belata ihe omume nke mmerụ egwuregwu. Ndị na-anụ ọkụ n'obi na-ahụ maka ahụike nwere ike iji peptide abụọ a dị ka ụzọ enyemaka iji meziwanye mmetụta ọzụzụ ma mee ka usoro mgbake ahụ dịkwuo ngwa.

Ọgwụgwọ ọrịa Endocrine:

Maka ọrịa endocrine dị ka ụkọ hormone na-eto eto na mkpụmkpụ idiopathic, ijikọ Ipamorelin na CJC1295 Ọ dịghị DAC na-enye echiche na ụzọ ọhụrụ maka ọgwụgwọ. Site n'ịchịkwa nzuzo nke hormone na-eto eto, ọ na-enyere aka imeziwanye ihe mgbaàmà nke ndị ọrịa ma kwalite mmepe nkịtị na uto nke ahụ.

Banyere Onye dere ya

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