▎ Nnyocha Prostamax
Kedu ihe bụ ndabere nyocha nke Prostamax?
Site na mmụba nke ụkpụrụ ndụ ndị mmadụ na mmụba nke ịka nká nke ndị mmadụ, ọnụ ọgụgụ nke ọrịa prostate na-abawanye kwa afọ, na-enwe mmetụta dị ukwuu na ahụike ụmụ nwoke. Ya mere, ịchọta ụzọ dị irè maka nlekọta ahụike na ọgwụgwọ prostate aghọwo isiokwu dị mkpa na nyocha ahụike.
N'oge nyocha miri emi banyere ọrụ physiological nke prostate na usoro nke ọrịa prostate, ndị ọkà mmụta sayensị achọpụtala na prostate n'onwe ya nwere ike izobe ihe dị iche iche nke bioactive, nke na-arụ ọrụ dị mkpa n'ịkwado ọrụ nkịtị nke prostate na n'omume na mmepe nke ọrịa. Site na nyocha nke akụkụ nke anụ ahụ prostate na nyocha nke ọrụ ya, ndị nchọpụta etinyela aka na ịchọta ihe nwere ike imeziwanye ahụike prostate kpọmkwem. Achọpụtara Prostamax wee mụọ ya n'ọnọdụ a. A na-ewere ya dị ka peptide na-achịkwa ihe ndị dị ndụ nke nwere ọrụ nchịkwa dị mkpa na prostate, na nchọpụta banyere mmalite ya na-enye ntụziaka ọhụrụ na ụzọ maka ịga n'ihu na-enyocha mgbochi na ọgwụgwọ nke ọrịa prostate na nlekọta ahụike ụmụ nwoke.
Kedu ihe bụ usoro nke Prostamax?
Usoro nke ime ihe n'ịgwọ ọrịa prostatitis na-adịghị ala ala
Iweghachite ihe mgbaàmà na-egbuke egbuke: Nnyocha egosiwo na Prostamax nwere ike ibelata mgbaàmà nke mbufụt na-adịghị ala ala, dị ka ibelata ọzịza, nkwụsị nke vaskụla, na ibelata ntinye nke lymphatic, na ọgwụgwọ nke prostatitis na-adịghị ala ala nke nnwale na nsogbu ya [1] . Enwere ike nweta nke a site n'ịhazi nzaghachi mgbochi ọrịa na anụ ahụ prostate, na ụzọ usoro nchịkwa mgbochi ahụ ka chọrọ ọmụmụ ihe ọzọ.
Na-egbochi usoro sclerosis na atrophy: Prostamax nwere ike igbochi mmepe nke usoro sclerosis na atrophy na prostate anụ ahụ. Usoro ya nwere ike ịgụnye nhazi nke metabolism nke mkpụrụ ndụ prostate na mgbochi nke usoro pathophysiological na-eduga na sclerosis anụ ahụ na atrophy.
Tụnyere ọgwụ ọgwụgwọ prostate ndị ọzọ: Mmetụta ọgwụgwọ nke Prostamax karịrị nke ụfọdụ ọgwụ prostate a na-ejikarị eme ihe nke sitere na saw palmetto wepụ na prostates anụmanụ. Nke a bụ n'ihi nhazi kemịkal pụrụ iche na usoro omume ya, na-eme ka ọ rụọ ọrụ nke ọma na usoro pathophysiological nke prostatitis na-adịghị ala ala ..
Usoro nke ime ihe na heterochromatin nke lymphocytes mmadụ
Mgbanwe nke okpomọkụ na mgbanwe okpomọkụ: Prostamax nwere ike ime ka redistribution nke chromatin dị na lymphocytes mmadụ ma gbanwee okpomọkụ denaturation abụọ (TdVII na TdVIII) iji belata okpomọkụ site na 2.9 na 1.0 ° C n'otu n'otu [2] . Mgbanwe nke okpomọkụ a nwere ike jikọta na ntụrụndụ nke akụkụ 30-nanometer-thick fiber n'ime eriri 10-nanometer, na-atụ aro na Prostamax nwere ike ịrụ ọrụ ya site na imetụta nhazi nke chromatin.
Mgbanwe na nucleosome nzukọ: TdVII na TdVIII nke lymphocytes a na-emeso na Prostamax dị ntakịrị ala karịa nke mkpụrụ ndụ a na-adịghị edozi, nke metụtara obere mgbanwe nhazi na nhazi nucleosome nke 10- na 30-nanometer-thick fibers [2]..
Kedu ihe bụ ngwa nke Prostamax?
1. Imelite ahụike prostate
Iwepụ ihe mgbaàmà nke hyperplasia prostatic na-adịghị mma: Ọrịa prostate na-adịghị mma bụ otu n'ime ọrịa na-enwekarị nsogbu ndị agadi nwoke. Ka afọ na-abawanye, anụ ahụ prostate na-eji nwayọọ nwayọọ na-amụba, na-akpakọba urethra ma na-ebute mgbaàmà dị ka mmamịrị ugboro ugboro, urination ngwa ngwa, na ihe isi ike na mmamịrị. Prostamax nwere ike ịkwalite ọrụ ahụike nke mkpụrụ ndụ prostate. Site n'ịhazi metabolism cellular na ụzọ ntụgharị mgbaàmà, ọ na-ebelata mgbaàmà nke hyperplasia prostate kpatara. Ọ nwere ike ime ihe na-eto eto, ndị na-anabata ya, na enzymes nke mkpụrụ ndụ prostate, na-egbochi ịba ụba nke cell, ma kwalite nguzozi nke ọdịiche cell na apoptosis, si otú ahụ belata nrụgide na anụ ahụ prostate na imeziwanye ọnọdụ urination [3]..
Na-akwalite mmeghari nke anụ ahụ prostate: Mweghachi nke anụ ahụ prostate dị oke mkpa maka idowe usoro dị mma nke prostate. Ihe ndị dị ka ịka nká, ọrịa, na mmerụ ahụ nwere ike ime ka mgbanwe dị njọ na anụ ahụ prostate, na-emetụta ọrụ ya. Prostamax na-enyere aka ịkwado mmeghari nke anụ ahụ prostate, ikekwe site n'ịkwalite nrụzi cell na usoro mmeghari. Dịka ọmụmaatụ, ọ nwere ike ịkpalite mmụba na ọdịiche nke mkpụrụ ndụ sel, mee ka ọnụ ọgụgụ nke mkpụrụ ndụ sel dị na prostate anụ ahụ, ma si otú ahụ kwalite nrụzi nke anụ ahụ mebiri emebi. Na mgbakwunye, Prostamax nwekwara ike ịhazi njikọ na mmebi nke matrix extracellular iji nọgide na-enwe nguzozi n'usoro nke anụ ahụ prostate [2, 4]..
2. Mmetụta mgbochi mkpali
Na-ebelata mbufụt nke prostate: Ọrịa prostate na-egbuke egbuke dị ka prostatitis na-adịghị ala ala na-ewetara ndị ọrịa nnukwu mgbu. Nzaghachi nke mkpasu iwe ga-eduga na mgbaàmà dị ka ọzịza, nkwụsị nke vaskụla, na lymphocytic infiltration nke prostate, na-akpata mgbu na ahụ erughị ala. Prostamax nwere ike inwe mmetụta mgbochi mkpali site n'ịhazi usoro ahụ ji alụso ọrịa ọgụ na mmepụta nke ndị mgbasa ozi mkpali iji belata mbufụt prostate. Ọ nwere ike igbochi ọrụ na ịkwaga nke mkpụrụ ndụ na-egbuke egbuke ma belata ntọhapụ nke ihe ndị na-egbuke egbuke, dị ka tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), na interleukin-6 (IL-6). Tụkwasị na nke ahụ, Prostamax nwekwara ike ịkwalite mmepụta nke cytokines na-egbochi mkpali, dị ka interleukin-10 (IL-10), si otú ahụ na-achịkwa nguzozi nke nzaghachi mkpali na iwepụ ihe mgbaàmà [3]..
3. Mgbochi ịka nká mmetụta
Ịka nká cell: ịka nká cell nwere njikọ chiri anya na omume na mmepe nke ọrịa dị iche iche. Prostamax nwere ike imetụta usoro chromatin, belata condensation nke DNA, ma debe mkpụrụ ndụ n'ọnọdụ dị obere. Mgbanwe na nhazi chromatin nwere ike imetụta okwu mkpụrụ ndụ ihe nketa na nhazi, si otú ahụ na-emetụta ọrụ na ndụ nke mkpụrụ ndụ. Prostamax nwere ike na-ahazi ọrụ chromatin na-emezigharị enzymes, gbanwee kọmpat nke chromatin, ma kwalite ndegharị na nkwupụta mkpụrụ ndụ ihe nketa. Nke a na-enyere aka ịnọgide na-arụ ọrụ nkịtị na ume nke mkpụrụ ndụ ma na-egbu oge usoro ịka nká cell. Na mgbakwunye, Prostamax nwekwara ike ibelata mmepụta na mmebi nke free radicals site na mmetụta antioxidant ya, na-echebekwa mkpụrụ ndụ site na mmetụta nke ịka nká [2].
4. Na-akwado ọrụ mgbochi
Usoro ahụ ji alụso ọrịa ọgụ na-ekere òkè dị mkpa n'ịkwado ahụike mmadụ. Prostamax nwere ike inwe mmetụta dị mma na usoro ahụ ji alụso ọrịa ọgụ, kwalite ọrụ nke lymphocytes, ma melite ikike nzaghachi nke ahụ. Lymphocytes bụ akụkụ dị mkpa nke usoro ahụ ji alụso ọrịa ọgụ, nke nwere ike ịmata na ịwakpo nje na-echebe ahụ pụọ na ọrịa. Prostamax nwere ike ịkwalite ọrụ mgbochi nke lymphocytes site n'ịhazi mmụba, ọdịiche, na ọrụ ha. Dịka ọmụmaatụ, ọ nwere ike ịkwalite lymphocytes iji mepụta cytokines na ọgwụ mgbochi, na-eme ka ikike ha gbuo ọrịa nje. Na mgbakwunye, Prostamax nwekwara ike ịhazi ọrụ nke mkpụrụ ndụ ndị ọzọ na-alụso ọrịa ọgụ, dị ka macrophages na sel ndị na-egbu egbu, na-ejikọ ọnụ na-emeziwanye ikike nchekwa nke ahụ [5].
5. Na-achịkwa nguzozi nke homonụ
Nhazi nke ọkwa hormone dị ka testosterone na dihydrotestosterone dị ezigbo mkpa maka ịnọgide na-enwe ahụike prostate na ahụike nwoke dum. Mmebi nke homonụ nwere ike ibute ọrịa ndị dị ka hyperplasia prostatitis na prostatitis. Prostamax na-enyere aka ịhazi ọkwa homonụ ndị a, ikekwe site na imetụta njikọ, metabolism, na ngosipụta nke homonụ. Dịka ọmụmaatụ, ọ nwere ike ịhazi ọrụ nke njikọ testosterone na enzymes metabolism, na-emetụta mmepụta na ntụgharị nke testosterone. Na mgbakwunye, Prostamax nwekwara ike ịhazi okwu nke ndị na-anabata dihydrotestosterone, na-agbanwe mmetụta nke dihydrotestosterone na sel prostate. Site n'ịhazi nguzozi homonụ, Prostamax nwere ike idowe ọrụ nkịtị nke prostate ma gbochie ma gwọọ ọrịa prostate [3].
N'ikpeazụ, dị ka peptide na-achịkwa ihe ndị dị ndụ sitere na prostate, Prostamax nwere mmetụta dị ịrịba ama n'ịkwalite ahụike prostate. Ọ bụghị naanị na ọ ga-ebelata ihe mgbaàmà nke hyperplasia prostate na-adịghị mma ma kwalite mmeghari nke anụ ahụ prostate kamakwa ọ na-ebelata mbufụt prostate na igbu oge ịka nká cell. Ọ na-arụkwa ọrụ dị mma n'ịhazi ọrụ mgbochi na nguzozi nke homonụ, na-enye nkwado siri ike maka idobe ahụike prostate ụmụ nwoke na ọkwa ahụike zuru oke, ma nwee uru ngwa dị mkpa na uru na mpaghara ahụike metụtara ya.
Banyere Onye dere ya
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Onye ode akwụkwọ akụkọ sayensị
Karthaus WR bụ onye nyocha ama ama na ngalaba oncology na bayoloji cell. Ọ nọrọla n'ọkwa n'ọtụtụ ụlọ ọrụ a na-akwanyere ùgwù, gụnyere Switzerland Institute of Experimental Cancer Research (ISREC) na École Polytechnique Fédérale de Lausanne (EPFL) . E jikọtara Karthaus na Memorial Sloan Kettering Cancer Center, ebe o nyere aka na nyocha ọrịa kansa. Njem agụmakwụkwọ ya gụnyere njikọ na Utrecht University Medical Center na Hubrecht Institute (KNAW) na Netherlands. Ọzọkwa, o nwere njikọ na Mahadum Johns Hopkins.
Ihe nyocha Karthaus nwere mmasị gbasara oncology, biology cell, biochemistry, biology biology, na ọgwụ nnwale. Ọrụ ya na-agụnyekarị ọmụmụ nke akụkụ ahụ na-achịkwa homonụ steroid, dị ka prostate, mammary gland, na endometrium. Ọ na-eji usoro multidisciplinary, na-ejikọta omenala organoid, ụdị òké, genomics, na usoro otu cell iji lebara ajụjụ ndị dị mgbagwoju anya anya. Ụlọ nyocha ya na-elekwasị anya n'ịghọta ndị ọkwọ ụgbọala nke mmalite tumor, ọganihu, na nguzogide ọgwụ na ọrịa cancer na-adabere na hormone steroid. Edepụtara Karthaus WR na ntụnye aka [4].
