Tesamoreli, Ipa 5/5 (ngwakọta)

▎ Ipa

Dị ka ihe sịntetik pentapeptide compound, Ipa, dị ka onye dị mkpa so na uto hormone secretagogue ezinụlọ, na-enweta kpọmkwem ụkpụrụ nke uto hormone secretion axis site n'omume nke pụrụ iche molekụla Ọdịdị nhazi. Ngwakọta a na-ejikọta ya na njikọ dị elu na onye na-anabata ihe nzuzo nke hormone uto (GHS-R), na-eme ka ụzọ mgbama dị n'okpuru ala, na-eme ka ntọhapụ nke hormone na-eto eto (GH) nke ọma, ma na-akwalite okwu mkpụrụ ndụ na protein njikọ nke insulin-dị ka ihe na-akpata-1 (IGF-1). Usoro ihe omume abụọ a abụghị naanị na-ahazi usoro metabolism ume (gụnyere ịkwalite nnabata amino acid, ịgbakọ njikọ protein ngwa ngwa, na ịkwalite catabolism abụba) kamakwa ọ na-arụkwa ọrụ nchịkwa dị mma n'ịrụzi anụ ahụ na uto site n'ịkwalite mgbama mmụba cell.

Na ọmụmụ ụlọ ọgwụ, Ipa egosipụtala mmetụta nchịkwa ọtụtụ usoro. A na-egosipụta mmetụta ya n'ịkwalite motility eriri afọ ka ọ na-eme ka ọnụ ọgụgụ mkpofu afọ dị ngwa ngwa. Karịsịa na steeti postoperative ileus, site n'ịkwalite peristaltic ugboro na mkpirisi ike nke eriri afọ na-eji ire ụtọ uru, ọ na-arụ ọrụ nke ọma na-ebelata moto eriri afọ dysfunction. N'ihe gbasara nchịkwa mgbu, onyinye a na-achịkwa ntụgharị mgbaàmà nociceptive site na ụzọ etiti na nke dị n'akụkụ ma gosipụta mmetụta dị ịrịba ama na-ebelata ihe mgbu visceral na-adịghị mma na mgbu somatic. Usoro ya nwere ike ịgụnye ịgbalite sistemu peptide opioid endogenous na nhazi nke ọrụ ọwa ion.

E jiri ya tụnyere ndị nzuzo nzuzo homonụ uto ọdịnala, uru dị ịrịba ama nke Ipa dị na nhọrọ ya dị elu maka mwepụta homonụ uto. Ọ bụ ezie na-akpali akpali nke ọma GH secretion, a compound enweghị mmetụta dị ịrịba ama na secretion nke ndị ọzọ pituitary-adrenal axis hormones dị ka adrenocorticotropic hormone (ACTH) na cortisol, si otú ibelata ihe ize ndụ nke ọjọọ mmeghachi omume kpatara hormonal ọrịa. Ngwongwo ọgwụ a na-enye ya ohere maka ntinye aka kpọmkwem na ngbanwe ọgwụgwọ nke ụkọ hormone nke uto, ma n'otu oge ahụ na-enye ihe mgbaru ọsọ ọgwụ ọhụrụ maka nchọpụta banyere pathogenesis nke ọrịa motility nke eriri afọ na njikarịcha nke nchọpụta mgbu na mmemme ọgwụgwọ.

▎ Nchịkọta

1. Uto Hormone Regulation

Usoro mmekọrịta:

Tesamoreli na-akpali mmepụta nke hormone nke na-eto eto (GH) site na pituitary gland site na-eme ka hormone na-ewepụta hormone (GHRH) na-eto eto na-eto eto, ebe Ipa na-akwalite mmepụta nke GH site na-ahọrọ na-eme ka hormone na-eto eto secretagogue receptor (GHSR).

Mgbe ejiri ya mee ihe, ha abụọ nwere ike ịkwalite nzuzo nke GH site na ụzọ dị iche iche, na-emepụta mmetụta synergistic ma si otú ahụ na-abawanye ọkwa GH n'ime ahụ.

Nhazi na njikwa nke nzuzo GH:

Ipa na-ezere ihe ize ndụ nke mkpali GH dị ukwuu site n'iṅomi usoro nzuzo nzuzo pulsatile nke GH, ebe Tesamoreli na-enye ihe ndabere siri ike maka nzuzo nzuzo GH site na ụzọ GHRH. Ojiji a jikọtara ọnụ nwere ike ịnọgide na-enwe ọkwa GH ka ọ na-ahụ na ụda na nguzozi nke nzuzo ya.

2. Metabolic Optimization

Lipid metabolism:

Tesamoreli na-ebelata abụba visceral site n'ịkwalite ndakpọ abụba na imeziwanye metabolism lipid, ebe Ipa na-eme ka metabolism abụba dịkwuo elu site n'ịkwalite fatty acid oxidation. Mgbe ejiri ya na ngwakọta, ha abụọ nwere ike ijikọ ọnụ kwalite metabolism lipid, belata mkpokọta abụba metụtara afọ, yana melite mmetụta insulin.

Metabolism nke glucose:

Tesamoreli na-ebelata ihe ize ndụ nke ọrịa metabolic site na imeziwanye arụmọrụ nke iji glucose eme ihe, ebe Ipa na-echebe anụ ahụ ma na-ezere ike ọnwụ site na mmetụta anti-catabolic ya.

Nke a synergistic mmetụta na-enyere aka ịnọgide na-enwe metabolic itule na-akwado ike ịka nká.

3. Nkwado anụ ahụ na mmezi

Njikọ protein na mmeghari cell:

Tesamoreli na-akwalite nrụzi anụ ahụ na mmụgharị site na-akpali akpali njikọ protein na cell ọhụrụ, ebe Ipa na-egbochi ike mgbaka site na ichekwa usoro anụ ahụ dị. Mgbe ejikọtara ọnụ, ha abụọ nwere ike inye nkwado anụ ahụ zuru oke, ma na-akwalite nrụzi nke anụ ahụ mebiri emebi ma na-echebe anụ ahụ dị ugbu a ka ọ ghara imebi.

Mmetụta mgbochi ịka nká:

Mmụba nke ọkwa GH nwere njikọ chiri anya na mmetụta mgbochi ịka nká. Ngwakọta ejikọtara ọnụ nke Tesamoreli na Ipa nwere ike igbu oge ịka nká cell, melite ngbanwe akpụkpọ ahụ, belata wrinkles, ma kwado ahụike ọkpụkpụ.

4. Mgbochi ịka nká na uru bara uru

Neuroprotection na ọrụ ọgụgụ isi:

GH na-arụ ọrụ dị mkpa na ọrụ ụbụrụ na neuroprotection. Ejikọta ọnụ nke peptides abụọ a nwere ike imeziwanye ọrụ ọgụgụ isi ma belata ịda mbà n'obi metụtara afọ site na ịhazi ọkwa GH.

Nkwụghachi sistemu:

Site n'ịhazi ihe nzuzo GH na imeziwanye metabolism, ijikọta ọnụ nwere ike ime ka usoro ahụ dịkwuo elu ma kwado ahụike na ọrụ ọrụ ogologo oge.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadobeghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.