Tesamoreli, Ipa 5/5 (Kuvanga)

Ipa​

Nka sintetike ya pentapeptide, Ipa, nkumunyamuryango wingenzi wumuryango ukura imisemburo ya secretagogue, igera ku kugenzura neza imisemburo ikura ya hormone ikura bitewe nuburyo bwihariye bwa molekile. Uru ruganda ruhuza cyane na hormone yo gukura ya septagogue reseptor (GHS-R), ikora inzira yerekana ibimenyetso byerekana inzira, itera neza gusohora imisemburo ya hormone ikura (GH), kandi icyarimwe igateza imbere imvugo ya gene hamwe na proteyine ya synthesis ya insuline imeze nkikura-1 (IGF-1). Ubu buryo bubiri bwibikorwa ntabwo bugenga gusa uburyo bwo guhindura ingufu za metabolisme (harimo guteza imbere gufata aside amine, kwihutisha intungamubiri za poroteyine, no kugabanya ibinure bya catabolisme) ariko kandi bigira uruhare runini mugusana ingirabuzimafatizo no gukura byongera ibimenyetso byo gukwirakwiza selile.

Mu bushakashatsi bw’amavuriro, Ipa yerekanye ingaruka nyinshi za sisitemu. Ingaruka zayo mugutezimbere igifu kigaragarira nko kwihutisha igipimo cya gastric. By'umwihariko muri leta ya ileus nyuma yo kubagwa, mugutezimbere inshuro ya peristaltike no kugabanuka kwimitsi ya gastrointestinal imitsi yoroshye, igabanya neza imikorere mibi yo munda. Mu rwego rwo gucunga ububabare, iyi nteruro igenga ibimenyetso bya nociceptive transduction binyuze mumihanda yo hagati ndetse no kuri peripheri kandi ikerekana ingaruka zorohereza ububabare bwimyanya myibarukiro nububabare bwa somatike. Uburyo bwibikorwa bushobora kuba bukubiyemo ibikorwa bya endogenous opioid peptide sisitemu no kugenzura ibikorwa bya ion umuyoboro.

Ugereranije na hormone gakondo ikura ya secretagogues, ibyiza byingenzi bya Ipa biri muburyo bwo guhitamo imisemburo ikura. Nubwo bitera imbaraga cyane gusohora kwa GH, iyi nteruro nta ngaruka nini igira ku isohoka ry’indi misemburo ya pituito-adrenal axis nka hormone adrenocorticotropic hormone (ACTH) na cortisol, bityo bikagabanya ibyago byo kwitwara nabi biterwa n’imiterere y’imisemburo. Uyu mutungo wa farumasi uyiha amahirwe yo kugira uruhare rugaragara mugusimbuza imiti yo kubura imisemburo ikura, kandi icyarimwe itanga intego nshya yibiyobyabwenge kubushakashatsi ku ndwara ziterwa na gastrointestinal motility disorder no kunoza gahunda yo gusuzuma ububabare no kuvura gahunda.

Incamake​

1. Gukura kwa Hormone

Uburyo bukoreshwa:

Tesamoreli itera gusohora imisemburo ikura (GH) ivuye muri glande y'imbere ya pitoito ikoresheje imisemburo ikura ya hormone irekura imisemburo (GHRH), mu gihe Ipa iteza imbere imisemburo ya GH mu guhitamo imisemburo ikura ya reseptor (GHSR).

Iyo ikoreshejwe hamwe, byombi birashobora kongera ururenda rwa GH kuva munzira zitandukanye, bigakora ingaruka zoguhuza bityo bikongera cyane urwego rwa GH mumubiri.

Kuringaniza no kugenzura ibanga rya GH:

Ipa irinda ibyago byo guterwa na GH ikabije yigana uburyo busanzwe bwa GHH, mugihe Tesamoreli itanga urufatiro ruhamye rwo gusohora GH binyuze mumihanda ya GHRH. Iyi mikoreshereze ihuriweho irashobora gukomeza urwego rwa GH mugihe harebwa injyana nuburinganire bwururenda rwayo.

2. Gukwirakwiza Metabolic

Lipid Metabolism:

Tesamoreli igabanya ibinure byijimye mu kongera ibinure no kunoza metabolisme ya lipide, mugihe Ipa ikomeza kwihutisha metabolisme itera okiside ya aside irike. Iyo ikoreshejwe hamwe, byombi birashobora guhuriza hamwe uburyo bwa metabolisme ya lipide, kugabanya ibinure bijyanye nimyaka, no kunoza insuline.

Glucose Metabolism:

Tesamoreli igabanya ibyago byo guhungabana no guhindura imikorere ya glucose, mugihe Ipa irinda ingirangingo z'imitsi kandi ikirinda gutakaza ingufu binyuze mu ngaruka zayo zo kurwanya catabolika.

Izi ngaruka zifatika zifasha kugumya guhinduranya no gushyigikira gusaza neza.

3. Inkunga y'inyama no gusana

Intungamubiri za poroteyine no kuvugurura ingirabuzimafatizo:

Tesamoreli iteza imbere gusana no kuvugurura ibibyimba bitera intungamubiri za poroteyine no kuvugurura ingirabuzimafatizo, mu gihe Ipa irinda imitsi kumeneka ikingira imiterere ihari. Iyo ikoreshejwe hamwe, byombi birashobora gutanga infashanyo yuzuye, byombi biteza imbere gusana ingirangingo zangiritse no kurinda ingirangingo zisanzwe kwangirika.

Ingaruka zo gusaza:

Ubwiyongere bw'urwego rwa GH bufitanye isano rya bugufi n'ingaruka zo kurwanya gusaza. Gukoresha hamwe kwa Tesamoreli na Ipa birashobora gutinza gusaza kwa selile, kunoza uruhu rworoshye, kugabanya iminkanyari, no gushyigikira ubuzima bwamagufwa.

4. Kurwanya gusaza hamwe ninyungu zo kumenya

Neuroprotection n'imikorere yo kumenya:

GH igira uruhare runini mumikorere yubwonko na neuroprotection. Gukoresha hamwe peptide zombi birashobora kunoza imikorere yubwenge no kugabanya kugabanuka kwimyaka bijyanye no kumenya kugabanuka kurwego rwa GH.

Kwihangana kwa Sisitemu:

Muguhuza ururenda rwa GH no guhindura metabolisme, gukoresha hamwe birashobora kongera imbaraga zumubiri kandi bigashyigikira ubuzima bwigihe kirekire nubushobozi bwimikorere.

Ibyerekeye Umwanditsi

Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.

INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.  

Ibicuruzwa bitangwa kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorerwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemewe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.