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1kits (10Vials) .
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▎ Epitalon ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: Ala-Glu-Asp-Gly Molekyulãwo ƒe Mɔfiame: C 14H 22N 4O9 Molekyulã ƒe Kpekpeme: 390.35 g/mol CAS ƒe xexlẽdzesi: 307297-39-8 PubChem ƒe CID: 219042 Nya siwo sɔ kple wo nɔewo: Epithalon |
▎ Epitalon ƒe Numekuku
Nukae nye Epitalon ƒe numekuku?
Le ƒe 1980 ƒeawo me la, Russiatɔ numekulawo ƒe ƒuƒoƒo aɖe si Vladimir Khavinson nɔ ŋgɔ na la ke ɖe Epitalon1 ŋu zi gbãtɔ [1] . Epitalon nye peptide kpui si wowɔ si me amino acid ene le: alanine, glutamic acid, aspartic acid, kple glycine. Dzɔdzɔme peptide epithalamion si woɖe tso pineal gland me dzie wotu eƒe wɔwɔme ɖo. Woxɔe se be epitalon ƒe dɔlékuiwutikewo sɔ kple melatonin tɔ eye ate ŋu aɖe vi be wòana agbenɔƒe nadidi ɖe edzi [2] . Numekulawo kpɔe be Epitalon ate ŋu aʋã telomerase ƒe dɔwɔwɔ. Telomerase nye enzyme si ate ŋu akpɔ telomere siwo le domenyiŋusẽfianu ƒe nuwuƒewo ta ahakeke wo ɖe enu. Ne amewo le tsitsim la, telomerewo nɔa kpuie, si do ƒome kple dɔléle siwo do ƒome kple tsitsi eye woƒe agbenɔƒe nɔa kpuie. To telomerase ƒe dɔwɔwɔ dodo ɖe ŋgɔ me la, Epitalon ate ŋu akpe ɖe telomeres ƒe kekeɖenudɔ ŋu, si ana tsitsi ƒe dɔwɔwɔ nagbɔdzɔ eye wòaxe mɔ ɖe dɔléle siwo do ƒome kple tsitsi nu [1] . Numekuku aɖewo ɖee fia be Epitalon ate ŋu akpɔ gome le CCL11 kple HMGB1 domenyiŋusẽfianuwo ƒe ɖeɖefia dzi kpɔkpɔ me eye wòawɔ dɔ abe domenyiŋusẽfianu siawo ƒe ɖeɖefia ƒe dɔwɔwɔ ene. Le ɣeyiɣi ma ke me la, dipeptide vilon (Lys-Glu) kple tetrapeptide Epitalon (Ala-Glu-Asp-Gly) ate ŋu awɔ woƒe ŋusẽ si tsi tre ɖe tsitsi ŋu to domenyiŋusẽfianu siawo dzi ɖuɖu me. Wonya be Epitalon kple vilon ne wotsɔ wo katã ƒo ƒui be woɖɔa domenyiŋusẽfianu ƒe ɖeɖefia kple protein ƒe wɔwɔme ɖo, si doa ku dzi ɖena kpɔtɔna eye dɔlélewo ƒe tsitsi dzi ɖena kpɔtɔna le ame tsitsiwo me [3] . Fifia la, numekuku si wowɔ tso Epitalon ŋu la ku ɖe lãwo dodokpɔ ƒe afɔɖeɖea ŋu koŋ, eye womekpɔ nya alesi wòawɔ dɔ nyuie ɣeyiɣi didi kple eƒe dedienɔnɔ le amegbetɔwo me bliboe o. Togbɔ be lãwo ŋuti numekuku aɖewo kpɔ nu dedziƒonamewo, abe le lãklewo gome ene hã la, Epitalon do ƒome kple agbenɔƒe didi kple lãmesẽ nyuitɔ hã la, nusiwo do tso eme siawo zazã le amegbetɔwo me hiã numekuku bubuwo kokoko [1] ..
Nukae nye Epitalon ƒe dɔwɔwɔ le tsitsi dzi ɖuɖu me?
Oxygen ƒomevi siwo wɔa dɔ ƒe agbɔsɔsɔ dzi ɖeɖe kpɔtɔ:
Oxygen ƒomevi siwo wɔa dɔ (ROS) wɔa akpa vevi aɖe le oocytes ƒe tsitsi me. ROS si gbɔ eme ana oxidative nagblẽ nu le oocytes ŋu, si akpɔ ŋusẽ ɖe woƒe nyonyome kple woƒe tsitsi ƒe ŋutete dzi. Numekukuwo ɖee fia be Epitalon ate ŋu aɖe oocytes ƒe cytoplasmic fragmentation si tsitsi hena vɛ kple intracellular reactive oxygen species ƒe agbɔsɔsɔ dzi akpɔtɔ [2] . Abe antioxidant ene la, Epitalon ate ŋu aɖe lãmenugbagbeviwo me ROS ɖa eye wòaɖe eƒe nugbegblẽ le oocytes ŋu dzi akpɔtɔ. Etɔxɛe la, woate ŋu akpɔe to mɔ eve siwo gbɔna dzi: Gbã la, ROS ɖeɖeɖa tẽ. Ŋutete ate ŋu anɔ Epitalon si be wòawɔ nu kple ROS tẽ eye wòatrɔe wòazu nusiwo megblẽa nu le ame ŋu o. Evelia, enzyme siwo tsia dzoxɔxɔ nu ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ. Epitalon ate ŋu aʋã lãmenugbagbeviwo me antioxidant enzymes ƒe dɔwɔwɔ, abe superoxide dismutase (SOD), catalase (CAT), kple bubuawo ene Enzyme siawo ate ŋu akpe ɖe ROS ɖeɖeɖa ŋu eye woalé lãmenugbagbeviwo me redox ƒe dadasɔ me ɖe asi.
Mitochondria ƒe dɔwɔwɔ nyuie wu:
Mitochondria wɔa akpa vevi aɖe le ŋusẽ ƒe asitɔtrɔ kple lãmenugbagbeviwo ƒe agbenɔnɔ le oocytes me. Ne oocytes le tsitsim la, mitochondria ƒe dɔwɔwɔ dzi aɖe akpɔtɔ vivivi, si adze abe mitochondrial membrane ƒe ŋutete dzi ɖeɖe kpɔtɔ kple mitochondrial DNA ƒe kɔpi xexlẽme dzi ɖeɖe kpɔtɔ ene. Epitalon ate ŋu ana mitochondrial membrane ƒe ŋutete kple mitochondrial DNA ƒe kɔpi xexlẽme nadzi ɖe edzi [2] . Esia kpena ɖe ame ŋu be ŋusẽ si naa fugboewo nanyo ɖe edzi eye wòléa lãmenugbagbeviwo ƒe ŋutilã ƒe dɔwɔwɔ nyuie ɖe te. Mɔnu tɔxɛ si dzi wòtona wɔa dɔ ate ŋu anye: Gbã la, mitochondrial membrane ƒe ŋutete dzi ɖeɖe kpɔtɔ. Mitochondria ƒe lãkusi ƒe ŋutete me léle ɖe asi le vevie ŋutɔ na mitochondria ƒe dɔwɔwɔ nyuie. Epitalon ate ŋu ana mitochondria ƒe lãkusi ƒe ŋutete nadzi ɖe edzi to ion mɔwo dzi kpɔkpɔ alo protein siwo le mitochondrial membrane dzi tsɔtsɔ yi teƒe bubuwo me, si ana mitochondria ƒe ŋusẽ wɔwɔ ƒe ŋutete nadzi ɖe edzi. Evelia, mitochondrial DNA ƒe kɔpi xexlẽme dzi ɖeɖe kpɔtɔ. Mitochondrial DNA ƒe kɔpi xexlẽme dzi ɖeɖe kpɔtɔ ate ŋu ana mitochondria ƒe nuwɔwɔ ƒe ŋutete nanyo ɖe edzi eye wòana ŋusẽ geɖe lãmenugbagbeviwo. Epitalon ate ŋu ana mitochondrial DNA ƒe kɔpi xexlẽme nadzi ɖe edzi to mitochondrial DNA ƒe dzidziɖedzi dodo ɖe ŋgɔ alo eƒe gbegblẽ dzi ɖeɖe kpɔtɔ me.
Spindle ƒe nɔnɔme si mesɔ o kple cortical granules ƒe exocytosis si mesɔ o dzi ɖeɖe kpɔtɔ:
Le oocytes ƒe tsitsi me la, spindle ƒe nɔnɔme si mesɔ o kple cortical granules ƒe exocytosis si mesɔ o ƒe xexlẽme adzi ɖe edzi, si akpɔ ŋusẽ ɖe oocytes ƒe vidzidzi kple fugboe ƒe tsitsi ŋutete dzi. Epitalon ate ŋu aɖe spindle ƒe nɔnɔme si mesɔ o kple exocytosis si mesɔ o ƒe sɔsɔme dzi akpɔtɔ le cortical granules me [2] . Esia ate ŋu atso ŋusẽ si Epitalon kpɔna ɖe lãmenugbagbeviwo ƒe ƒunukpeƒe kple lãmenugbagbeviwo ƒe lãkusi ƒe liƒo dzi le ɖoɖowɔwɔ me gbɔ: Gbã la, ena spindle ƒe wɔwɔme nali ke. Spindle nye wɔwɔme vevi aɖe le lãmenugbagbeviwo ƒe mama me, eye eƒe nɔnɔme si mesɔ o ana domenyiŋusẽfianu ƒe mama si mesɔ o nava eye wòakpɔ ŋusẽ ɖe oocytes ƒe tsitsi dzi. Epitalon ate ŋu ana spindle ƒe wɔwɔme nali ke to tubulin ƒe polymerization kple depolymerization dzi kpɔkpɔ me, si aɖe nɔnɔme si mesɔ o ƒe dzɔdzɔ dzi akpɔtɔ. Evelia, cortical granules ƒe liƒo me léle ɖe asi. Cortical granules wɔa akpa vevi aɖe le oocytes ƒe vidzidzi ƒe ɖoɖoa me. Epitalon ate ŋu alé cortical granules ƒe liƒo me ɖe asi to lãmenugbagbeviwo ƒe lãkusi alo calcium ion signaling ƒe gege ɖe eme dzi kpɔkpɔ me, si aɖe exocytosis si mesɔ o ƒe dzɔdzɔ dzi akpɔtɔ.
Apoptosis ƒe dzesiwo dzi ɖeɖe kpɔtɔ:
Le oocytes ƒe tsitsi me la, apoptosis ƒe dzesiwo adzi ɖe edzi, si ana lãmenugbagbeviwo naku. Epitalon ateŋu aɖe Annexin V ƒe amadede ƒe agbɔsɔsɔ nyuitɔ kple γH2AX ƒe keklẽ ƒe sesẽ dzi akpɔtɔ le oocytes tsitsiwo me le vitro [2] . Esia ɖee fia be Epitalon ate ŋu aɖe oocytes ƒe apoptosis dzi akpɔtɔ. Mɔnu tɔxɛa ate ŋu anye: Gbã la, mɔxexe ɖe apoptosis ƒe dzesimɔa nu. Epitalon ate ŋu axe mɔ ɖe apoptosis ƒe dzesiwo ƒe kaka nu to protein vevi siwo le apoptosis ƒe dzesiwo ƒe mɔ dzi, abe Bcl-2 ƒomea ƒe proteinwo kple caspase ƒomea ƒe proteinwo ene, dzi kpɔkpɔ me, eye wòaɖe lãmenugbagbeviwo ƒe ku dzi akpɔtɔ. Evelia, domenyiŋusẽfianu ƒe liƒo me léle ɖe asi. γH2AX nye nusiwo dea dzesi DNA ƒe gbegblẽ dometɔ ɖeka. Epitalon ate ŋu alé domenyiŋusẽfianu ƒe liƒo me ɖe asi to DNA ƒe gbegblẽ dzi ɖeɖe kpɔtɔ kple apoptosis ƒe dzesiwo dzi ɖeɖe kpɔtɔ me.
Epitalon lé spindle ƒe blibonyenye kple CGs ƒe mama si sɔ me ɖe asi.
Dzɔtsoƒe:PubMed [2] .
Mɔnu kae koŋ Epitalon wɔa dɔ le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie dada me?
Dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi kpɔkpɔ:
Numekukuwo ɖee fia be Epitalon ate ŋu akpɔ ŋusẽ ɖe sisiblisiwo ƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi le nuteɖeamedzi ƒe nɔnɔme vovovowo me. Le dɔlélenutsiŋutete ƒe tɔtrɔ ƒe nuteɖeamedzi kple dɔlélenutsiŋutete ƒe nuteɖeamedzi ƒokpli me la, Epitalon ateŋu adzi thymocytes ƒe dzidziɖedzi ƒe dɔwɔwɔ ɖe edzi [4] . Esia fia be Epitalon ate ŋu ana ŋutilãa nate ŋu anɔ te ɖe ahɔhɔ̃mekawo ƒe dɔlélewo nu to dɔlélenutsiŋutete ƒe dɔwɔwɔ nyuie me. Thymocytes ƒe dzidziɖedzi do ƒome kplikplikpli kple dɔlélenutsiŋutete ƒe dɔwɔwɔ, eye dɔlélenutsiŋutete wɔa akpa vevi aɖe le ahɔhɔ̃mekawo ƒe dɔléle siwo gblẽa nu le ame ŋu ƒe dzɔdzɔ kple woƒe dzɔdzɔ me. Le kpɔɖeŋu me, ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie ate ŋu atso dɔlélenutsiŋutete ƒe dɔwɔwɔ alo dɔmawɔmawɔ nyuie si mesɔ o gbɔ. Epitalon ƒe ŋusẽkpɔɖeamedzi si doa ŋusẽ thymocytes ƒe dzidziɖedzi ate ŋu akpe ɖe dɔlélenutsiŋutete ƒe dadasɔ ŋu, si ana ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie ƒe dzesiwo dzi naɖe akpɔtɔ.
Ŋusẽkpɔɖeamedzi ɖe dzesiwo ƒe tɔtrɔmɔ dzi:
Epitalon kpɔa ŋusẽ ɖe interleukin-1β (IL-1β) ƒe dzesiwo ƒe tɔtrɔmɔ dzi le ɖoɖowɔwɔ me. Etɔxɛe la, Epitalon ateŋu adzi IL-1β ƒe dɔwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedzi ɖe edzi eye wòakpɔ ŋusẽ ɖe enzyme vevi si le ceramide dzesi ƒe tɔtrɔmɔ dzi le ahɔhɔ̃mekawo ƒe lãkusi me, si nye membrane neutral sphingomyelinase (nSMase) ƒe dɔwɔwɔ dzi [4] . IL-1β nye cytokine vevi aɖe si kpɔa gome le ŋutilã kple dɔléle ƒe dɔwɔwɔ vovovowo me. Le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie me la, IL-1β ƒe ɖeɖefia si mesɔ o ate ŋu ahe ahɔhɔ̃mekawo ƒe dɔdzẽ kple ahɔhɔ̃mekawo ƒe gbegblẽ vɛ. To IL-1β ƒe dzesiwo ƒe tɔtrɔmɔa dzi kpɔkpɔ me la, Epitalon ate ŋu aɖe ahɔhɔ̃mekawo ƒe dɔdzẽ dzi akpɔtɔ eye wòakpɔ ahɔhɔ̃mekawo ta tso nusiwo agblẽ le wo ŋu me. Tsɔ kpe ɖe eŋu la, tɔtrɔ siwo va le nSMase ƒe dɔwɔwɔ me hã do ƒome kple ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie. Epitalon ƒe nSMase ƒe dɔwɔwɔ dzi kpɔkpɔ ate ŋu akpe ɖe lãmekawo ƒe dɔwɔwɔ nyuie ŋu.Le nyataƒoƒo me la, alesi Epitalon wɔa dɔ le ahɔhɔ̃mekawo ƒe dɔlélewo dada me ate ŋu alɔ dɔlélenutsiŋutete ƒe ɖoɖowɔwɔ kple dzesiwo ƒe tɔtrɔmɔ ƒe ɖoɖowɔwɔ ɖe eme. Gake numekuku si wowɔ fifia le Epitalon ŋu le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie dada me gakpɔtɔ le ŋgɔdonya me, eye ehiã be woagawɔ numekuku bubuwo atsɔ aɖo kpe eƒe dɔwɔwɔ kple dedienɔnɔ dzi.
Epitalon ƒe numekuku ƒe ŋgɔyiyi
Ŋusẽ si wòkpɔna ɖe oocytes ƒe nyonyome dzi
Oocytes ƒe tsitsi hehe ɖe megbe:
Dodokpɔ siwo wowɔ le vitro ɖee fia be Epitalon ate ŋu aɖe intracellular reactive oxygen species (ROS) ƒe agbɔsɔsɔ dzi akpɔtɔ le sisiblisi ƒe fugboe tsitsiwo me le ovulation megbe. Le ɣeyiɣi aɖe megbe la, oocytes ƒe tsitsi ŋutete dzi aɖe akpɔtɔ vivivi le ovulation megbe le vivo alo in vitro. Abe peptide kpui si wowɔ ene la, Epitalon wɔa dɔ abe melatonin ene eye wònye antioxidant nyui aɖe, si ate ŋu aɖe vi be wòana agbenɔƒe nadidi ɖe edzi. Epitalon zazã ɖe spindle ƒe gbagbãƒewo kple cortical granules ƒe mama si mesɔ o dzi kpɔtɔ ŋutɔ le gaƒoƒo 12 kple gaƒoƒo 24 ƒe tsitsi me, eye le ɣeyiɣi ma ke me la, edzi mitochondrial membrane potential kple mitochondrial DNA ƒe kɔpi xexlẽme ɖe edzi, si wɔe be oocytes ƒe apoptosis dzi ɖe kpɔtɔ le gaƒoƒo 24 ƒe tsitsi le vitro me. Nusiwo do tso eme siawo ɖee fia be Epitalon ate ŋu ahe oocytes ƒe tsitsi ɖe megbe le vitro to mitochondrial ƒe dɔwɔwɔ kple ROS ƒe agbɔsɔsɔ dzi kpɔkpɔ me [2]..
Oocytes ƒe nyonyome dodo ɖe ŋgɔ:
Epitalon 0.1 mM tsɔtsɔ kpe ɖe in vitro culture medium ŋu ate ŋu aɖe cytoplasmic fragmentation ƒe agbɔsɔsɔme le parthenogenetic activation of oocytes si in vitro tsitsi le ovulation megbe hena vɛ dzi akpɔtɔ, aɖe spindle ƒe nɔnɔme si mesɔ o kple cortical granules ƒe exocytosis si mesɔ o ƒe xexlẽme dzi akpɔtɔ, ana mitochondrial membrane potential kple mitochondrial DNA ƒe kɔpi xexlẽme nadzi ɖe edzi, eye wòaɖe nyuitɔa dzi akpɔtɔ Annexin V ƒe amadede ƒe agbɔsɔsɔme kple γH2AX ƒe keklẽ ƒe sesẽme le oocyte siwo tsi le vitro me. Esia ɖee fia be Epitalon ate ŋu ana ŋutinuwo ƒe dɔléle nanyo ɖe edzi le oocytes ƒe tsitsi le vitro me eye wòana oocytes ƒe nyonyome nanyo ɖe edzi (Xue Yue).
Ŋusẽ si wòkpɔna ɖe lãmekawo ƒe vovototodedeameme dzi
Numekukuwo ɖee fia be AEDG peptide (Epitalon) ate ŋu ana ahɔhɔ̃mekawo ƒe vovototodedeameme dzesiwo ƒe wɔwɔme nadzi ɖe edzi le amegbetɔ ƒe aɖuɖɔtoe mesenchymal stem cells, abe Nestin, GAP43, β Tubulin III, kple Doublecortin ene me. Molekyulãwo ƒe kpɔɖeŋuwɔwɔ mɔnuwo ɖee fia be Epitalon lɔ̃a kadodo ɖe H1/6 kple H1/3 histones ŋu, si ate ŋu anye mɔnu siwo dzi woato adzi ahɔhɔ̃mekawo ƒe vovototodedeameme domenyiŋusẽfianu siawo ƒe nuŋɔŋlɔ ɖe edzi la dometɔ ɖeka [5]..
Ŋusẽ si ɖoɖowɔwɔ ɖe lãmekawo ŋui
Ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi kpɔkpɔ:
To numekuku siwo wowɔ le sisiblisiwo ŋu me la, wokpɔe be Epitalon (2 ng) dodo ɖe no me ateŋu ana ahɔhɔ̃mekawo ƒe dɔwɔwɔ nawɔ dɔ ŋutɔ le sisiblisiwo ƒe ahɔhɔ̃mekawo me le miniti ʋee aɖewo me, eye ahɔhɔ̃mekawo ƒe tudada zi gbɔ zi 2 - 2.5 dzina ɖe edzi zi gbɔ zi 2 - 2.5 [6] . Le nuŋlɔɖi aɖewo siwo wolé ɖe mɔ̃ dzi me la, wokpɔ ŋuɖoɖo sesẽ siwo me afɔɖeɖe vovovowo le hã. Epitalon ƒe ahɔhɔ̃mekawo ƒe dɔwɔwɔ le wo ɖokui si ƒe dzidziɖedzi tso unit siwo le dɔ wɔm xoxo ƒe dzidziɖedzi kple lãmenugbagbevi siwo meɖoa to tsã ƒe gomekpɔkpɔ le eme gbɔ. Ne mede ɖeke o la, woate ŋu aɖe Epitalon ƒe dɔwɔwɔ ƒe akpa gbãtɔ me to ŋusẽ si peptide sia kpɔna ɖe motor cortex ƒe lãmenugbagbeviwo dzi tẽe me.
Nuteɖeamedzi takpɔkpɔ ƒe ŋusẽkpɔɖeamedzi:
Epitalon kpɔa ŋusẽ ɖe nuteɖeamedzi takpɔkpɔ dzi le sisiblisi siwo wodo go nuteɖeamedzi ƒe nɔnɔme vovovowo me. Dodokpɔwo ɖee fia be Epitalon dzia thymocytes ƒe dzidziɖedzi ƒe dɔwɔwɔ ɖe edzi. Eɖanye be wodoe ɖe ŋgɔ le dɔlélenutsiŋutete ƒe tɔtrɔ ƒe nuteɖeamedzi te alo woxe mɔ nɛ le dɔlélenutsiŋutete ƒe nuteɖeamedzi ƒokpli te o, Epitalon ateŋu awɔ akpa aɖe le ɖoɖowɔwɔ me (Vladimir Kh Khavinson, 2002). Le ɣeyiɣi ma ke me la, Epitalon ate ŋu adzi interleukin-1β (IL-1β) ƒe dɔwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedzi hã ɖe edzi eye wòakpɔ ŋusẽ ɖe tɔtrɔ siwo vaa sphingomyelinase (nSMase) ƒe dɔwɔwɔ le ahɔhɔ̃mekawo ƒe lãkusi me si nuteɖeamedzi hena vɛ dzi. Esia ɖee fia be Epitalon kpɔa ŋusẽ ɖe nuteɖeamedzi ta le IL-1β ƒe dzesi ƒe tɔtrɔ ƒe seƒe le sphingomyelin mɔa me kple le thymocyte ƒe dzidziɖedzi si woɖo taɖodzinu na le lãmekawo me ƒe seƒe.
Ŋusẽ si wòkpɔna ɖe primate siwo menye amegbetɔwo o ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi:
Le boso tsitsi siwo nye rhesus me la, Epitalon ate ŋu aɖe sukli kple insulin ƒe agbɔsɔsɔ si le gɔmedzedzea me dzi akpɔtɔ eye wòana melatonin ƒe agbɔsɔsɔ si le gɔmedzedzea me le zã me nadzi ɖe edzi. Le ɣeyiɣi ma ke me la, Epitalon ateŋu aɖe teƒe si le ʋumenugbagbeviɣi ƒe ŋuɖoɖo ƒe ʋuʋudedi te dzi akpɔtɔ, adzi sukli ƒe 'bu' ƒe agbɔsɔsɔ ɖe edzi, eye wòana ʋumenugbagbeviɣi ƒe insulin ƒe ʋuʋu nasɔ ɖe ɖoɖo nu le sukli dodo ƒe ŋuɖoɖo me. Esia ɖee fia be Epitalon nye nusi ŋugbe wodo be wòagbugbɔ lãmenugbagbeviwo ƒe dɔmawɔmawɔ nyuie si tso tsitsi gbɔ le primatewo me [7] ..
Alesi woate ŋu azã Epitalon le lãmekawo ƒe dɔlélewo dada me
Alzheimer ƒe dɔléle: Alzheimer ƒe dɔléle nye ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie, si ƒe dzesi vevitɔe nye be eƒe susu ƒe dɔwɔwɔ dzi ɖena kpɔtɔna eye wògaɖoa ŋku nu dzi nyuie o. Numekuku siwo wowɔ fifia ɖee fia be Alzheimer ƒe dɔlélea do ƒome kple ahɔhɔ̃mekawo ƒe vovototodedeameme ƒe gbegblẽ. Ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe xexlẽme dzi ɖena kpɔtɔna le Alzheimer-dɔlélawo ƒe ahɔhɔ̃ me, eye woxea mɔ na woƒe vovototodedeameme ŋutete hã. Epitalon ate ŋu ado ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme ɖe ŋgɔ, ana ahɔhɔ̃mekawo nadzi ɖe edzi, eye wòana Alzheimer-dɔlélawo ƒe susu ƒe dɔwɔwɔ nanyo ɖe edzi. Tsɔ kpe ɖe eŋu la, Epitalon ate ŋu aɖɔ ahɔhɔ̃mekawo ƒe dodo hã ɖo, si ana Alzheimer-dɔlélawo ƒe ŋkuɖoɖonudzi kple nusɔsrɔ̃ ŋutete nanyo ɖe edzi [8]..
Parkinson ƒe dɔléle: Parkinson ƒe dɔléle nye ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie si ƒe dzesi koŋue nye lãmekawo ƒe dɔwɔwɔ ƒe kuxiwo. Eƒe dɔlélenutsiŋutete vevitɔe nye dopaminergic ahɔhɔ̃meka siwo bu le substantia nigra me. Atikewɔwɔmɔnu siwo li fifia koŋ ɖea dzesiawo dzi kpɔtɔna to dopamine tsɔtsɔ kpe ɖe eŋu alo mɔxexe ɖe dopamine ƒe gbegblẽ nu me, gake mɔnu siawo mate ŋu atɔ te dɔlélea ƒe ŋgɔyiyi o. Ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo dodo na ame nye atikewɔwɔmɔnu si woate ŋu azã, gake ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe dzɔtsoƒe kple woƒe vovototodedeameme ŋutete gakpɔtɔ nye kuxi. Epitalon ate ŋu ado ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme ɖe ŋgɔ, ana dopaminergic ahɔhɔ̃mekawo ƒe xexlẽme nadzi ɖe edzi, eye wòana Parkinson dɔléle dɔnɔwo ƒe dɔwɔwɔ nanyo ɖe edzi [8] ..
Ʋusɔgbɔdɔ kple ahɔhɔ̃mekawo ƒe abixɔxɔ: Ʋusɔgbɔdɔ nye ahɔhɔ̃mekawo ƒe dɔléle si bɔ, eye emetsonu vevitɔe nye ahɔhɔ̃mekawo ƒe ku kple ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie. Ahɔhɔ̃ ƒe abixɔxɔ hã ate ŋu ana ahɔhɔ̃mekawo nabu eye wòagawɔ dɔ nyuie o. Ahɔhɔ̃mekawo wɔa akpa vevi aɖe le nuwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ me le ʋusɔgbɔdɔ kple ahɔhɔ̃ ƒe abixɔxɔ megbe. Epitalon ate ŋu ado ahɔhɔ̃mekawo ƒe lãmenugbagbeviwo ƒe dzidziɖedzi kple vovototodedeameme ɖe ŋgɔ, ana ahɔhɔ̃mekawo ƒe xexlẽme nadzi ɖe edzi, eye wòana ahɔhɔ̃mekawo ƒe dɔwɔwɔ nanyo ɖe edzi na dɔnɔ siwo ŋu ʋusɔgbɔdɔ kple ahɔhɔ̃ me abi le [8] ..
Le nyataƒoƒo me la, abe tetrapeptide si wowɔ ene la, Epitalon ƒe tsitsi ƒe mɔnu vevitɔe nye be wòana telomerase reverse transcriptase subunit (TERT) domenyiŋusẽfianu ƒe ɖeɖefia nawɔ dɔ, akeke telomeres ƒe didime ɖe enu eye wòalé telomerase ƒe dɔwɔwɔ me ɖe asi, si wɔnɛ be wòdea nu lãmenugbagbeviwo ƒe tsitsi ƒe ɖoɖo vevitɔ me. Eƒe vevienyenye le tsitsi ƒe nudede dɔa me kpɔkpɔ zi gbãtɔ tso telomere ƒe nugbagbeŋutinunya ƒe nukpɔsusu nu, eto seɖoƒe si le antioxidants xoxo siwo tɔa ŋku free radicals ko dzi la me, eye wòna taɖodzinu yeye na tsitsi ƒe dɔlélewo abe Alzheimer ƒe dɔléle kple dzitodzito me dɔlélewo ene hehe ɖe megbe. Togbɔ be egahiã kokoko be woaɖo kpe eƒe dedienɔnɔ si anɔ anyi ɣeyiɣi didi (vevietɔ kansa ƒe afɔku) dzi le afɔɖeɖe III ƒe dɔdamɔnu dodokpɔwo me hã la, abe numekuku kple ŋgɔyiyi ƒe kpɔɖeŋu na telomerase activator-ƒomevi ƒe atike gbãtɔ si tsia tsitsi nu ene hã la, ede dzesi tɔtrɔ gã aɖe le tsitsi ƒe nudede eme tso dzesiwo ƒe nyonyo dzi va ɖo molecule ƒe dɔwɔwɔ dzi kpɔkpɔ dzi eye wole mɔ kpɔm be ado amegbetɔ ƒe lãmesẽ ƒe agbenɔƒe didi ɖe ŋgɔ.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Nyadzɔdzɔgbalẽŋlɔla Vladimir Khavinson nye Russiatɔ nugbagbeŋutinunyala xɔŋkɔ aɖe kple peptide ƒe nugbagbeŋutinunyalawo ŋuti numekula. Enye St. Petersburg ƒe Nu Gbagbewo Ŋuti Nusrɔ̃ƒe ƒe Dɔdzikpɔla eye wònye Russiatɔwo ƒe Atikewɔwɔ Ŋuti Nusrɔ̃ƒe me tɔ. Khavinson wɔ akpa vevi aɖe le tsitsi ŋuti numekuku me eye wòŋlɔ agbalẽ geɖewo ɖe magazine xɔŋkɔwo abe 'Molecular Biology of Aging' kple 'Journal of Anti-Aging Medicine' me. Eƒe dɔa ku ɖe peptide bioregulators ƒe wɔwɔ kple wo zazã ŋu koŋ be woatsɔ awɔ avu kple tsitsi ƒe dɔlélewo eye woana lãmesẽ nanyo ɖe edzi. Khavinson ƒe numekukua kpɔ ŋusẽ ɖe ame tsitsiwo ŋuti nunya dzi, eye wòna gɔmesese yeyewo kple atikewɔwɔmɔnu siwo woatsɔ ada tsitsi le lãmesẽ me. Woŋlɔ Vladimir Khavinson ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [5].
