TB4 ni iki?
TB4 (Thymosin Beta-4) ni peptide ya endogenous peptide igizwe na acide 43 amine, ikomoka mukarere gakomeye ka thimosine yumuntu isanzwe ibaho β4. Yerekana amazi meza kandi akomeye, muburyo busanzwe buboneka mumyanya nkamaraso, imitsi, nuruhu, kandi birashobora kuboneka muburyo bwubukorikori. Ugereranije na thimosine idakomeye β4, TB4 igumana ibikorwa byingenzi byibinyabuzima mugihe byoroshye kwinjizwa ningirangingo hakoreshejwe inshinge. Irakora idasaba guhindura ibintu bigoye, ikabigira imwe muri molekile yize cyane peptide murwego rwo gusana ingirangingo.
TB4 iteza imbere kwimuka kwimitsi no kuvugurura ingirabuzimafatizo mugukoresha ubushobozi bwo kwimuka kwingirabuzimafatizo zijyanye no gusana nka selile endothelia na fibroblast. Byihutisha angiogenezi hamwe na kolagene yoherejwe, ifasha mugukosora ibikomere byimitsi ihuza imitsi, imitsi, ligaments, nuruhu. Icyarimwe, igenga matrice idasanzwe kugirango igabanye inkovu zikabije. Irerekana anti-inflammatory na cytoprotective ingaruka mukubuza kurekura ibintu bitera inflammatory nka TNF-α na IL-1β, bityo bikagabanya uburibwe bwimitsi no kuribwa. Byongeye kandi, byongera imbaraga za anti -xydeant anti -xydeant selile, bikagabanya ibyangiritse biterwa na ischemia nuburozi, kandi bigira uruhare runini muguhagarika ibidukikije byangiza umubiri.
Ikoreshwa nk'ubuvuzi bujyanye no gukomeretsa bijyanye na siporo nko kunanirwa imitsi, tendinitis, n'amarira ya ligament, bigabanya ukwezi gukira no gufasha mu kugarura imikorere ya siporo. Mu gukira ibikomere, byihutisha gufunga ibikomere bidakira bidakira (urugero, ibisebe bya diyabete ya diyabete) no gutwika ibikomere biteza imbere imikurire ya granulation hamwe na epiteliyale yimuka. Mubikorwa byo kwangirika kwinyama, birerekana kandi imbaraga mugukomeretsa imitsi (urugero, kwanduza imitsi ya periferique) hamwe nubushakashatsi bwo gusana nyuma ya myocardial ischemia.
Umwanzuro
Imvange ya BPC-157 / TB4 ni sisitemu igizwe na peptide ebyiri za endogenous hamwe nibikorwa byo gusana ingirangingo. BPC-157, ikomoka kuri poroteyine yo mu gifu ya muntu, irimo aside amine 15, mu gihe TB4 ari agace gakomeye ka thymosine β4, kagizwe na aside amine 43. Iyo bihujwe, bigira ingaruka zingirakamaro. BPC-157 iteza imbere ikwirakwizwa rya fibroblast, ikongerera ubudahangarwa bwa mucosal inzitizi, kandi igahagarika irekurwa rya por-inflammatory, mugihe TB4 igenga polimerisiyumu ya actin, yihutisha kwimuka kwa selile, kandi itera angiogenez. Hamwe na hamwe, byongera imbaraga zo kuvugurura no gusana neza, hamwe ningaruka zindi zo kurwanya inflammatory, kurinda ingingo zifata imyanya ndangagitsina, no guteza imbere ibidukikije bya selile. Ubushakashatsi bukoreshwa muri iki gihe bwibanze ku gukira imvune za siporo (urugero, tendinitis, imitsi, imvune); Kurinda gastrointestinal mucosal (urugero, ibisebe byo mu gifu, indwara zifata amara zifatanije); hamwe na tissue nyinshi yangiza kugarura imbaraga (urugero, ibikomere byuruhu, ibikomere byoroheje byinjira). Ubu buryo bwuzuzanya bugabanya inzitizi zo gusana, bugabanya ibisubizo byumuriro, kandi byoroshya kwivanga mubibazo byangiza imyenda.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorerwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
