▎ Bronch-g Numekuku
Nukae nye Bronchogen ƒe numekuku?
Le atikewɔwɔ ŋuti numekuku si wole wɔwɔm fifia me la, gbɔgbɔmedɔlélewo nye nusiwo ŋu xexeame katã ƒe susu nɔna ɣesiaɣi. Le nyatakaka siwo ŋu ŋusẽ le nu la, le ƒe ʋɛ siwo va yi me la, gbɔgbɔtsixe ƒe dɔléle vovovowo abe aklãdɔléle si xea mɔ na dɔlékuiwo (COPD), asrã, kple aɖuɖɔtoedɔléle si nɔa anyi didi ene ƒe dzɔdzɔ le dzidzim ɖe edzi ƒe sia ƒe, si de amegbetɔ ƒe lãmesẽ kple agbenɔnɔ ƒe nyonyome afɔku gã aɖe me. Ne wole dɔléle sesẽ siawo gbɔ kpɔm la, zi geɖe la, kuxiwo abe dɔyɔyɔ ƒe ŋusẽkpɔɖeamedzi kple nugbegblẽ le ame ŋu ene nɔa atikewɔwɔmɔnu xoxowo ŋu, si wɔnɛ be atikewɔwɔmɔnu yeye siwo wɔa dɔ nyuie, eye wole dedie ƒe toto vɛ nyea dɔ kpata le atikewɔwɔ me.
Le nɔnɔme sia ta la, numekulawo ƒe susu le nusiwo ŋu nugbagbeŋusẽ tɔxɛwo le la didi tso nugbagbevi vovovo siwo ate ŋu adzra aɖuɖɔtoe ƒe lãkusiwo ɖo ahakpɔ wo ta me. Wozã molecule biology ƒe mɔnu deŋgɔwo kple dodokpɔmɔnu siwo wɔa dɔ nyuie tsɔ wɔ numekuku ɖe ɖoɖo nu le nugbagbewo ƒe akpa gbogbo aɖewo ŋu. Le agbagbadzedze madzudzɔmadzudzɔe ɣeyiɣi didi aɖe megbe la, woke ɖe Bronchogen ŋu. Ate ŋu atso lãmenugbagbevi tɔxɛ siwo le nugbagbevi aɖewo me ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ me alo lãmenugbagbevi aɖewo koŋ naɖee ɖa le ŋutilã ƒe nɔnɔme tɔxɛwo me, eye ŋutete tɔxɛ le esi be wòaɖɔ ŋutilã ƒe dɔwɔwɔ siwo do ƒome kple aɖuɖɔtoewo ɖo, si ʋua numekuku ƒe mɔfiame yeye aɖe ɖi na gbɔgbɔmedɔlélewo dada eye wòdo ŋugbe be yeanye nu vevitɔ si ana woato atikewɔwɔ ƒe kuxi siwo li fifia me.
Nukae nye Bronchogen ƒe dɔwɔwɔ ƒe mɔnu?
1. Ŋusẽkpɔɖeamedzi le Aklãdɔléle ƒe Kpɔɖeŋuwo Me
Mɔxexe Ðe Dɔdzẽ Nu: Le aklãdɔléle si xea mɔ na dɔléle si nɔa anyi didi (COPD) ƒe kpɔɖeŋu me la, Bronchogen kpɔa ŋusẽ ɖe aklã ƒe lãkusi ƒe wɔwɔme kple dɔwɔwɔ ƒe nɔnɔme kple aklã ƒe dɔdzẽ ƒe dɔwɔwɔ dzi. To COPD ƒe kpɔɖeŋu aɖe wɔwɔ le sisiblisiwo me to ŋkeke 60 ƒe nitrogen dioxide zazã ɣeaɖewoɣi me la, wokpɔe be le atikewɔwɔ kple Bronchogen peptide megbe la, neutrophils ƒe dɔdzẽ ƒe dɔwɔwɔ dzi ɖena kpɔtɔna, eye lãmenugbagbeviwo ƒe wɔwɔme le bronchoalveolar lavage fluid (BALF) me kple pro-inflammatory cytokines kple enzymes ƒe mama trɔna yia nɔnɔme si sɔ me. Esia ɖee fia be Bronchogen ate ŋu axe mɔ ɖe dɔdzẽ ƒe dɔwɔwɔ nu le lãkusiwo me [1, 2]..
Aɖuɖɔtoe ƒe Dɔwɔɖoɖo Kple Dɔwɔwɔ Gbugbɔgaɖoanyi: Le COPD ƒe kpɔɖeŋua wɔwɔ me la, aɖuɖɔtoe me lãkusi ƒe wɔwɔme gblẽ, gake atikewɔwɔ kple Bronchogen na nuwo ƒe wɔwɔme sia gaɖo anyi, eye eƒe dɔwɔwɔ hã gadze egɔme. Woate ŋu aɖe esia afia to adzame immunoglobulin A (si nye dɔlélenutsiŋutete ƒe dzesi si le nutoa me) kple protein B si wɔa dɔ ɖe anyigba dzi, si nana ʋukawo ƒe gotagome tete dzi ɖena kpɔtɔna ƒe dzidziɖedzi me [1, 2]..
2. Ŋusẽkpɔɖeamedzi ɖe DNA ƒe Dzoxɔxɔ ƒe Liƒo Dzi
DNA ƒe Dɔwɔɖoɖoa ƒe Lili ke: Numekukuwo ɖee fia be Bronchogen ate ŋu awɔ dɔ abe DNA ƒe liƒolili ene. Le agbɔsɔsɔ aɖe me (Bronch-g/DNA gɔmeɖoanyi eveawo ƒe molar ratio nye 0.01 - 0.055), Bronchogen ateŋu adzi DNA si tso nyitsu ƒe thymus kple sisiblisi ƒe aklã me ƒe dzoxɔxɔ ɖe edzi 3.1°C [3] . Gake ne wogadzi xexlẽme sia ɖe edzi la, metrɔa dzoxɔxɔ si le tsia me o. Le dometsotso sia me la, nusiwo le ʋeʋẽm ƒe enthalpy (ΔH (melt)) metrɔna o, eye DNA si tso nyitsu ƒe thymus kple sisiblisi ƒe aklã me ƒe ΔH (melt) nye 11.4 kple 12.7 cal/g. Esia ɖee fia be Bronchogen menye adenine-thymine-koŋ alo guanine-cytosine-koŋ ƒe ligand o, eye eƒe kadodo ƒomevi nye kadodo sesẽ aɖe si dzɔna le vo me, vevietɔ ebla ɖe DNA ƒe ka eveawo ŋu (vevietɔ nitrogen ƒe gɔmeɖoanyiwo) [3]..
Nukae nye Bronchogen ƒe dɔwɔwɔ?
1. Aɖuɖɔtoedɔléle si nɔa anyi didi
Bronchogen wɔa akpa vevi aɖe le aɖuɖɔtoedɔléle si nɔa anyi didi dada me. Aɖuɖɔtoedɔléle si nɔa anyi didi nye gbɔgbɔmedɔléle si bɔ, eye zi geɖe la, dɔnɔwo ƒe dzesiwo abe kɔdzidɔ, aɖuɖɔtoe, kple gbɔgbɔtsixe tsia ame ŋu [2] . Bronchogen ate ŋu aɖe dɔnɔwo ƒe dzesiwo dzi akpɔtɔ to dɔdzẽ ƒe ŋuɖoɖo dzi ɖeɖe kpɔtɔ kple aɖuɖɔtoe ƒe ʋukawo ƒe ʋuʋu kple ʋuʋu dzi ɖeɖe kpɔtɔ me. Le ɣeyiɣi ma ke me la, ate ŋu ado aɖuɖɔtoewo ƒe lãmenugbagbeviwo ɖɔɖɔɖo kple wo gbugbɔgadzɔ hã ɖe ŋgɔ, si ana aɖuɖɔtoeawo nate ŋu aʋã eye woƒe dɔwɔwɔ nanyo ɖe edzi. Le atikewɔwɔ ɣeyiɣi didi me la, dɔnɔwo ƒe kɔdzidede zi gbɔ zi geɖe kple woƒe aɖuɖɔtoe ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna vivivi, eye alesi gbegbe gbɔgbɔtsixe tsia wo me la nyona ɖe edzi ŋutɔ.
2. Asrãdɔ
Le asrãdɔ dzi kpɔkpɔ me la, Bronchogen ɖe ŋutete gã aɖe fia. Asrã nye yaƒoƒomɔ̃ ƒe dɔléle si nɔa anyi didi, eye dɔnɔwo ƒe yaƒoƒomɔ̃wo sea veve ɖe nu vovovowo nu ŋutɔ, eye dzesiwo abe aɖuɖɔtoe me ʋuʋu kple gbɔgbɔtsixetsixe ene dzena bɔbɔe. Bronchogen ate ŋu ana yaƒoƒomɔ̃ ƒe dɔwɔwɔ nanyo ɖe edzi to yaƒoƒo ƒe dɔdzẽ dzi ɖeɖe kpɔtɔ kple yaƒoƒomɔ̃a ƒe dɔwɔwɔ fũ akpa dzi ɖeɖe kpɔtɔ me. Ate ŋu aɖɔ dɔlélenutsiŋutete ɖo, aɖe dɔdzẽ ƒe lãmenugbagbeviwo ƒe gege ɖe lãme kple dɔdzẽ ƒe domenɔlawo ƒe dodo dzi akpɔtɔ, si ana asrã dɔnɔwo ƒe dzesiwo dzi naɖe akpɔtɔ. Tsɔ kpe ɖe eŋu la, Bronchogen ate ŋu ana dɔnɔwo ƒe lãkusi ƒe lãmesẽ hã nanyo ɖe edzi eye wòana dɔnɔwo ƒe lãkusi ƒe dɔwɔwɔ nanyo ɖe edzi, si ana woate ŋu anɔ te ɖe kuxi vovovowo nu nyuie wu le gbesiagbegbenɔnɔ me.
3. Aklãdɔléle si Nɔa Anyi Didi (COPD) .
Le dɔnɔ siwo ŋu aklãdɔléle si xea mɔ na dɔléle si nɔa anyi didi le gome la, Bronchogen nye atike nyui aɖe. COPD nye gbɔgbɔmedɔléle si yia edzi ɖaa, eye zi geɖe la, dɔnɔwo ƒe dzesiwo abe kɔdzi, aɖuɖɔtoe, kple gbɔgbɔtsixe tsia ame ƒo ene. Bronchogen ƒe ŋusẽkpɔɖeamedzi ɖe COPD dɔnɔwo dzi koŋ dometɔ aɖewoe nye lãmenugbagbeviwo ɖɔɖɔɖo dodo ɖe ŋgɔ, aɖuɖɔtoe ƒe dɔwɔwɔ nyuie wu, kple dɔdzẽ dzi ɖeɖe kpɔtɔ. Ate ŋu ana aɖuɖɔtoe me lãmenugbagbeviwo nagbugbɔ awɔ, adzra aɖuɖɔtoe ƒe lãkusi siwo gblẽ ɖo, eye wòana aɖuɖɔtoeawo nate ŋu aʋu nyuie wu. Le ɣeyiɣi ma ke me la, Bronchogen ate ŋu aɖe dɔdzẽ ƒe dɔwɔwɔ dzi akpɔtɔ hã, aɖe dɔdzẽ ƒe nugbegblẽ le lãkusiwo me dzi akpɔtɔ, eye wòahe dɔlélea ƒe ŋgɔyiyi ɖe megbe. To ŋusẽkpɔɖeamedzi siawo dzi la, Bronchogen ate ŋu ana dɔnɔwo ƒe agbenɔnɔ nanyo ɖe edzi, aɖe dɔléle sesẽwo ƒe xexlẽme dzi akpɔtɔ, eye wòana dɔnɔwo ƒe agbenɔƒe nadidi ɖe edzi.
4. Haya le Yagbɔgbɔdɔléle Sesẽwo megbe
Le gbɔgbɔtsixe ƒe dɔléle sesẽwo (abe aklãdɔ ene) megbe la, woate ŋu azã Bronchogen atsɔ ado alɔ dɔnɔwo ƒe hayahaya. Yagbɔgbɔdɔléle sesẽwo ate ŋu agblẽ nu le aɖuɖɔtoe kple lãkusi ƒe lãkusiwo ŋu vevie, si agblẽ nu le dɔnɔwo ƒe gbɔgbɔtsixe ƒe dɔwɔwɔ ŋu. Bronchogen ateŋu ana aɖuɖɔtoe ƒe lãkusiwo naɖɔ ɖo kabakaba, ado lãmenugbagbevi siwo gblẽ ƒe gbugbɔgadzɔ ɖe ŋgɔ, eye wòana aɖuɖɔtoeawo ƒe wɔwɔme kple dɔwɔwɔ nasɔ [4] . Ate ŋu ana gbɔgbɔtsixe ƒe dɔwɔwɔ nanyo ɖe edzi hã, ana lãkusiwo ƒe gas ɖɔliɖɔli ƒe ŋutete nanyo ɖe edzi, eye wòaɖe afɔku si le eme be wòagblẽ nu le ame ŋu ɣeyiɣi didi la dzi akpɔtɔ. Ne dɔnɔwo zã Bronchogen vɔ la, wogbɔa ya nyuie wu, ŋusẽ gaɖoa wo ŋu vivivi, eye woate ŋu atrɔ ayi agbe si sɔ me ahawɔ dɔ kabakaba wu.
5. Aklã ƒe Dɔwɔwɔ Takpɔkpɔ le Atamanolawo Me
Le atamanolawo alo amesiwo do go ɖiƒoƒo nutome gome la, Bronchogen kpena ɖe ame ŋu be woakpɔ aɖuɖɔtoewo ta ahadzra wo ɖo. Sigaretnono kple ɖiƒoƒo nutome ate ŋu agblẽ nu le gbɔgbɔtsixe ŋu vevie eye wòana aɖuɖɔtoedɔléle siwo nɔa anyi didi ƒe afɔkua nadzi ɖe edzi. Bronchogen ateŋu aɖe nusiwo gblẽa nu le aɖuɖɔtoe kple lãkusi ƒe lãkusiwo ŋu dzi akpɔtɔ eye wòado aɖuɖɔtoeawo ɖɔɖɔɖo kple wo gbugbɔgawɔ ɖe ŋgɔ [5] . Ate ŋu ana aɖuɖɔtoewo ƒe ametakpɔkpɔ ƒe dɔwɔwɔ nanyo ɖe edzi, aɖe dɔdzẽ ƒe dɔwɔwɔ dzi akpɔtɔ, eye wòaɖe aɖuɖɔtoedɔlélewo ƒe dzɔdzɔ dzi akpɔtɔ. Tsɔ kpe ɖe eŋu la, Bronchogen ate ŋu ana lãkusi ƒe dɔwɔwɔ nanyo ɖe edzi hã, ana atamanolawo ƒe gbɔgbɔ nanyo ɖe edzi, eye wòana aɖuɖɔtoedɔléle siwo nɔa anyi didi ƒe dzɔdzɔ nagbɔdzɔ.
6. Kpekpeɖeŋunana le Atikewɔwɔ Blibo me
Woate ŋu azã bronchogen abe kpeɖeŋutɔ na atikewɔwɔ si wozãna tsã ene be wòana atikewɔwɔ ƒe ŋusẽkpɔɖeamedzia nadzi ɖe edzi. Le dɔlélewo abe kɔdzidɔ ene dada me la, Bronchogen tsɔtsɔ tsaka kple atikewɔwɔmɔnu xoxowo ate ŋu ana dɔyɔyɔ ƒe ŋusẽkpɔɖeamedzi bliboa nanyo ɖe edzi.
Bronchogen ɖea vi na amewo ƒe hatsotso siwo gbɔna:
Le nyataƒoƒo me la, Bronchogen ɖe asixɔxɔ vevi aɖe fia le agbeŋutinunya me. Ate ŋu ana DNA ƒe wɔwɔme nali ke, si ana mɔfiame yeye nasu amewo si be woasrɔ̃ nu tso mɔnu siwo do ƒome kple DNA ŋu. Le gbɔgbɔmedɔlélewo dada me la, le nɔnɔmewo abe aɖuɖɔtoedɔléle si nɔa anyi didi, asrã, kple COPD ene gome la, ate ŋu aɖe abi dzi akpɔtɔ nyuie, ado lãmenugbagbeviwo ƒe ɖɔɖɔɖo ɖe ŋgɔ, ana dɔnɔwo ƒe gbɔgbɔtsixe ƒe nɔnɔme nanyo ɖe edzi ŋutɔ, aɖe dzesiwo dzi akpɔtɔ, eye wòana agbenɔnɔ nanyo ɖe edzi, si le vevie ŋutɔ le mɔxexe ɖe gbɔgbɔtsixe ƒe dɔlélewo nu kple wo dada me.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Caswell SJ nye numekula xɔŋkɔ aɖe si do ƒome kple dɔwɔƒe xɔŋkɔ geɖewo, siwo dometɔ aɖewoe nye AstraZeneca, Francis Crick Institute, TDHB, British Columbia Yunivɛsiti, kple ALVANLEY CLIN. Eƒe numekukua ku ɖe dɔ vovovowo ŋu, si ɖe eƒe nunya le nusɔsrɔ̃ vovovowo me fia. Le Biochemistry & Molecular Biology me la, ewɔ akpa aɖe le lãmenugbagbeviwo ƒe dɔwɔwɔ kple molecule ƒe kadodo gɔmesese dodo ɖe ŋgɔ me. Dɔ si wòwɔ le General & Internal Medicine me la, ekpɔ ŋusẽ ɖe dɔnɔdzikpɔkpɔ kple atikewɔwɔ ƒe ɖoɖowo dzi.
Le Dɔlékuiŋutinunya ƒe akpa dzi la, Caswell SJ ku dɔlékui ƒe mɔnuwo kple amedzrowo ƒe kadodo me, si le vevie ŋutɔ na dɔlékuiwutikewo toto vɛ. Eƒe gomekpɔkpɔ le Dzɔdzɔmeŋutinunya & Mɔ̃ɖaŋununya - Tanya Bubuwo me ɖee fia be eƒo eɖokui ɖe mɔnu yeyewo kple mɔ̃ɖaŋununya siwo ƒo dzɔdzɔmeŋutinunya ƒe liƒo xoxowo ta. Gawu la, numekuku si wòwɔ le Parasitology me na kekeli klẽ ɖe dɔlékuiwo ƒe dɔlélewo kple ŋusẽ si wokpɔna ɖe dukɔa ƒe lãmesẽ dzi ŋu. To eƒe numekuku si me wòto le go geɖe me la, Caswell SJ wɔ akpa vevi aɖe le dzɔdzɔmeŋutinunyalawo ƒe habɔbɔa me, eye wòkpɔ ŋusẽ ɖe nukpɔsusu ƒe ŋgɔyiyiwo kple wo zazã ŋutɔŋutɔ le atikewɔwɔ kple nugbagbeŋutinunya me siaa dzi. Woŋlɔ Caswell SJ ŋkɔ ɖe nyayɔyɔ ƒe nyatakaka me [4].
