▎ Ubushakashatsi bwa Bronch-g
Ni ubuhe bushakashatsi bwakozwe na Bronchogen?
Muri iki gihe cyubushakashatsi bwubuvuzi, indwara zubuhumekero zagiye zibandwaho kwisi yose. Dukurikije imibare yemewe, mu myaka yashize, umubare w'abantu bandura indwara zitandukanye z'ubuhumekero nk'indwara zidakira zifata indwara zidakira (COPD), asima, na bronhite idakira zagiye ziyongera uko umwaka utashye, bikaba byangiza ubuzima bw'abantu ndetse n'ubuzima bwabo. Iyo uhanganye nizi ndwara zigoye, uburyo gakondo bwo kuvura bukunze kugira ibibazo nkibisubizo byo gukiza indwara n'ingaruka mbi, bigatuma iterambere ryubuvuzi bushya, bunoze, kandi butekanye buteganya umurimo wihutirwa mubuvuzi.
Kuruhande rwibi, abashakashatsi bibanze ku gucukumbura ibintu bifite ibikorwa byihariye by’ibinyabuzima biva mu binyabuzima bitandukanye bishobora gusana no kurinda ingirangingo. Bakoresheje tekinoroji ya biyolojiya ya biologiya hamwe nuburyo bwimbitse bwo gusuzuma kugirango bakore ubushakashatsi butunganijwe kumubare munini wibinyabuzima. Nyuma yimbaraga zigihe kirekire, Bronchogen yavumbuwe. Irashobora guturuka ku bicuruzwa biva mu ngirabuzimafatizo by’ibinyabuzima bimwe na bimwe cyangwa bigasohorwa n’inyama zihariye mu bihe byihariye bya physiologiya, kandi bifite ubushobozi budasanzwe bwo kugenzura imikorere y’imiterere ijyanye na bronchi, ifungura icyerekezo gishya cy’ubushakashatsi mu kuvura indwara z’ubuhumekero kandi isezeranya kuba urufunguzo rwo guca mu ngorane zisanzwe zo kuvura.
Ni ubuhe buryo bwo gukora bwa Bronchogen?
1. Ingaruka muburyo bw'indwara zifata ibihaha
Kurwanya Ubushuhe: Muburyo budakira bwindwara zifata ibihaha (COPD), Bronchogen igira ingaruka kumiterere n'imikorere ya epitelium ya bronchial hamwe nibikorwa byo gutwika ibihaha. Mu gukora urugero rwa COPD mu mbeba mu minsi 60 yo guhura na dioxyde ya azote rimwe na rimwe, byagaragaye ko nyuma yo kuvurwa na peptide ya Bronchogen, ibikorwa byo gutwika neutrophile byagabanutse, hamwe n’utugingo ngengabuzima muri bronchoalveolar lavage fluid (BALF) no gukwirakwiza cytokine na enzymes zisubiza inyuma. Ibi byerekana ko Bronchogen ishobora guhagarika igisubizo cyo gutwika ibihaha [1, 2].
Kugarura Imiterere n'imikorere ya Epitelium ya Bronchial: Mugihe cyo gushinga moderi ya COPD, imiterere ya epitelium ya bronchial yangiritse, ariko kuvura hamwe na Bronchogen byagaruye iyi miterere, kandi ibikorwa byayo nabyo byaragaruwe. Ibi birashobora kugaragazwa no kwiyongera kwa immunoglobuline A (ikimenyetso cy’umudugudu waho) hamwe na poroteyine B ya surfactant B, ishinzwe kugabanya ubukana bw’imiterere ya alveoli [1, 2].
2. Ingaruka kuri Strmal Stabilite ya ADN
Guhindura imiterere ya ADN: Ubushakashatsi bwerekanye ko Bronchogen ishobora gukora nka stabilisateur ya ADN. Mubice bimwe byokwibandaho (igipimo cyimyororokere ya Bronch-g / ADN ibice bibiri ni 0.01 - 0.055), Bronchogen irashobora kongera ubushyuhe bwo gushonga kwa ADN kuva inyana ya thymus numwijima wimbeba kuri 3.1 ° C [3] . Ariko, gukomeza kongera iki gipimo ntabwo bihindura ubushyuhe bwo gushonga. Muri uru rwego, gushonga (ΔH (gushonga)) yikigo ntigihinduka, kandi ΔH (gushonga) ya ADN ituruka ku nyana thymus numwijima wimbeba ni 11.4 na 12.7 cal / g. Ibi birerekana ko Bronchogen atari adenine-thymine yihariye cyangwa guanine-cytosine yihariye ligand, kandi ubwoko bwayo buhuza ni uguhuza gukomeye kandi kubwimpanuka, cyane cyane guhuza imirongo ibiri ya ADN (cyane cyane ibishingwe bya azote) [3].
Ni ubuhe buryo bukoreshwa na Bronchogen?
1. Bronchite idakira
Bronchogen igira uruhare runini mu kuvura indwara ya bronhite idakira. Indwara ya bronhite idakira ni indwara y'ubuhumekero, kandi abarwayi bakunze kugaragaramo ibimenyetso nko gukorora, gusohora, na dyspnea [2] . Bronchogen irashobora kugabanya ibimenyetso byabarwayi mukugabanya igisubizo cyumuriro no kugabanya ubukana nindurwe ya mucosa bronchial. Mugihe kimwe, irashobora kandi guteza imbere gusana no kuvugurura ingirangingo za bronchial, bikongerera imbaraga n'imikorere ya bronchi. Mugihe cyo kuvura igihe kirekire, inshuro yo gukorora hamwe nubunini bwo gutegereza abarwayi bigenda bigabanuka buhoro buhoro, kandi urugero rwa dyspnea rugenda rwiyongera cyane.
Asima
Mu micungire ya asima, Bronchogen yerekanye ubushobozi bukomeye. Indwara ya asima ni indwara idakira yandurira mu mwuka, kandi inzira z'abarwayi zumva cyane ibintu bitandukanye bitera imbaraga, bikunze kugaragara ku bimenyetso nka bronchospasm na dyspnea. Bronchogen irashobora kunoza imikorere yumuyaga mugabanya uburibwe bwa bronchial no kugabanya hyperresponsiveness yumuyaga. Irashobora kugenga ubudahangarwa bw'umubiri, kugabanya kwinjira mu ngirabuzimafatizo no kurekura abunzi batera umuriro, bityo bikagabanya ibimenyetso by'abarwayi ba asima. Byongeye kandi, Bronchogen irashobora kandi kuzamura ubuzima bwibihaha no kunoza imikorere y ibihaha yabarwayi, ibafasha guhangana neza nibibazo bitandukanye mubuzima bwa buri munsi.
3. Indwara Zidakira Zifata Indwara (COPD)
Ku barwayi bafite indwara zidakira zifata ibihaha, Bronchogen nubuvuzi bwiza. COPD n'indwara y'ubuhumekero igenda itera imbere, kandi abarwayi bakunze kwerekana ibimenyetso nko gukorora, gusohora, no guhumeka neza. Ingaruka za Bronchogen mu barwayi ba COPD zirimo ahanini guteza imbere gusana ingirabuzimafatizo, kunoza imikorere ya bronchial, no kugabanya umuriro. Irashobora gutera imbaraga kuvugurura ingirabuzimafatizo ya epiteliyale, gusana ingirangingo zangiritse, no kunoza imikorere ya bronchi. Muri icyo gihe, Bronchogen irashobora kandi kugabanya igisubizo cyo gutwika, kugabanya ibyangiritse mu bihaha, no gutinza iterambere ry’indwara. Binyuze muri izo ngaruka, Bronchogen irashobora kuzamura imibereho yabarwayi, kugabanya umubare wokwiyongera gukabije, no kongera igihe cyo kubaho kwabarwayi.
4. Gukira nyuma yo kwandura gukabije
Nyuma yo kwandura gukabije k'ubuhumekero (nk'umusonga), Bronchogen irashobora gukoreshwa mu gufasha abarwayi gukira. Indwara zikomeye z'ubuhumekero zirashobora kwangiza cyane ingirangingo z'umubiri n'ibihaha, bikagira ingaruka ku mikorere y'ubuhumekero bw'abarwayi. Bronchogen irashobora kwihutisha gusana ingirangingo za bronchial, guteza imbere ingirabuzimafatizo zangiritse, no kugarura imiterere n'imikorere isanzwe ya bronchi [4] . Irashobora kandi kunoza imikorere yubuhumekero, kongera ubushobozi bwo guhererekanya gaze yibihaha, no kugabanya ibyago byo kwangirika igihe kirekire. Nyuma yo gukoresha Bronchogen, abarwayi bahumeka neza, bagarura imbaraga gahoro gahoro, kandi barashobora gusubira mubuzima busanzwe bagakora vuba.
5. Kurinda imikorere yibihaha mubanywa itabi
Ku banywa itabi cyangwa abantu bahuye n’umwanda w’ibidukikije, Bronchogen ifasha kurinda no gusana bronchi. Kunywa itabi no guhumanya ibidukikije birashobora kwangiza cyane sisitemu y'ubuhumekero no kongera ibyago byo kurwara ibihaha bidakira. Bronchogen irashobora kugabanya kwangiza ibintu byangiza ingirangingo za bronchial nu bihaha kandi bigateza imbere gusana no kuvugurura bronchi [5] . Irashobora kongera imikorere yo kwirwanaho ya bronchi, kugabanya igisubizo cyo gutwika, no kugabanya indwara z ibihaha. Byongeye kandi, Bronchogen irashobora kandi kunoza imikorere y ibihaha, ikongera ubwiza bwubuhumekero bwabanywa itabi, kandi ikadindiza umuvuduko witerambere ryindwara zidakira.
6. Uruhare rwabafasha mukuvura byose
Bronchogen irashobora gukoreshwa nkibishobora kuvurwa gakondo kugirango byongere ingaruka zo kuvura. Mu kuvura indwara nka syndrome ya inkorora, guhuza Bronchogen nuburyo bwo kuvura gakondo birashobora kunoza ingaruka zo kuvura muri rusange.
Bronchogen ni ingirakamaro kumatsinda akurikira:
Mu gusoza, Bronchogen yerekana agaciro gakomeye mubijyanye nubumenyi bwubuzima. Irashobora guhagarika imiterere ya ADN, itanga icyerekezo gishya cyo kwiga uburyo bujyanye na ADN. Mu kuvura indwara z'ubuhumekero, ku bihe nka bronhite idakira, asima, na COPD, irashobora kugabanya neza gutwika, guteza imbere gusana ingirabuzimafatizo, kuzamura cyane imyanya y'ubuhumekero y'abarwayi, kugabanya ibimenyetso, no kuzamura imibereho, ibyo bikaba bifite akamaro kanini mu gukumira no kuvura indwara z'ubuhumekero.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Caswell SJ ni umushakashatsi w'icyamamare ukorana n'inzego nyinshi zikomeye, nka AstraZeneca, ikigo cya Francis Crick Institute, TDHB, kaminuza ya Columbiya y'Ubwongereza, na ALVANLEY CLIN. Ubushakashatsi bwe bukubiyemo ibice byinshi, byerekana ubuhanga bwe butandukanye. Muri Biochemie & Molecular Biology, yagize uruhare mu guteza imbere imyumvire yimikorere ya selile n'imikoranire ya molekile. Ibikorwa bye muri rusange & Imbere mubuvuzi bifite ingaruka zo kunoza ubuvuzi no kuvura protocole.
Mu rwego rwa virusi, Caswell SJ yakoze ubushakashatsi ku buryo bwa virusi ndetse n’imikoranire yabakiriye, ari ngombwa mu gushyiraho ingamba zo kurwanya virusi. Uruhare rwe muri siyanse & tekinoloji - Izindi ngingo zerekana uruhare rwe muburyo bwa tekinoloji nubuhanga burenga imipaka yubumenyi gakondo. Byongeye kandi, ubushakashatsi yakoze muri Parasitology bwamuritse indwara za parasitike n'ingaruka zabyo ku buzima rusange. Binyuze mu bushakashatsi bwe butandukanye, Caswell SJ yagize uruhare runini mu bumenyi bwa siyansi, agira uruhare mu iterambere ry’imyumvire ndetse no mu bikorwa bifatika mu buvuzi na biyolojiya. Caswell SJ yanditse murutonde rwibisobanuro [4].
