Bronch-g 20 mg

▎ Bronch-g Qauv

Source: PubChem

Sequence: Ala-Glu-Asp-Leu (AEDL) Molecular Formula: C 18H 30N 4O9 Molecular Luj: 446.45g / mol

▎ Bronch-g Kev Tshawb Fawb

Kev tshawb fawb keeb kwm ntawm Bronchogen yog dab tsi?

Hauv kev tshawb fawb txog kev kho mob tam sim no, cov kab mob ua pa ib txwm yog qhov tseem ceeb ntawm kev saib xyuas thoob ntiaj teb. Raws li cov ntaub ntawv pov thawj, nyob rau xyoo tas los no, qhov tshwm sim ntawm ntau yam kab mob ua pa xws li mob ntsws obstructive pulmonary (COPD), mob hawb pob, thiab mob ntsws ntev tau nce zuj zus txhua xyoo, ua rau tib neeg kev noj qab haus huv thiab lub neej zoo. Thaum cuam tshuam nrog cov kab mob nyuaj no, cov kev kho mob ib txwm muaj feem ntau muaj teeb meem xws li curative effect bottlenecks thiab phiv, ua rau txoj kev loj hlob tshiab, zoo, thiab kev nyab xeeb kev kho mob yog ib txoj hauj lwm ceev hauv kev kho mob.

Tawm tsam qhov keeb kwm yav dhau los no, cov kws tshawb fawb tau tsom mus rau kev tshawb nrhiav cov tshuaj lom neeg tshwj xeeb los ntawm ntau yam khoom siv lom neeg uas tuaj yeem kho thiab tiv thaiv cov ntaub so ntswg bronchial. Lawv tau siv cov txheej txheem qib siab molecular biology thiab kev tshuaj ntsuam xyuas siab los ua cov kev tshawb fawb txog ntau yam ntawm cov khoom siv bioactive. Tom qab kev siv zog ntev ntev, Bronchogen tau pom. Nws tuaj yeem tshwm sim los ntawm cov khoom lag luam metabolic ntawm cov hlwb tshwj xeeb hauv qee yam kab mob lossis raug zais los ntawm cov ntaub so ntswg tshwj xeeb hauv lub cev tshwj xeeb, thiab nws muaj lub peev xwm tshwj xeeb los tswj cov kev ua haujlwm ntawm lub cev muaj feem xyuam rau lub bronchi, qhib kev tshawb fawb tshiab rau kev kho mob ntawm cov kab mob ua pa thiab cog lus tias yuav yog tus yuam sij rau kev rhuav tshem cov kev kho mob uas twb muaj lawm.

Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm Bronchogen?

1. Cov teebmeem hauv cov qauv mob ntsws

Inhibiting Inflamation: Nyob rau hauv tus qauv mob obstructive pulmonary disease (COPD), Bronchogen muaj kev cuam tshuam rau cov txheej txheem thiab kev ua haujlwm ntawm bronchial epithelium thiab kev ua haujlwm ntawm lub ntsws. Los ntawm kev tsim cov qauv COPD hauv cov nas mus txog 60 hnub ntawm kev sib cuam tshuam ntawm nitrogen dioxide, nws tau pom tias tom qab kev kho mob nrog Bronchogen peptide, inflammatory kev ua ntawm neutrophils txo, thiab cov cell muaj pes tsawg leeg nyob rau hauv bronchoalveolar lavage kua (BALF) thiab kev faib cov pro-inflammatory cytokines thiab enzymes rov qab mus rau qhov qub. Qhov no qhia tau hais tias Bronchogen muaj peev xwm inhibit qhov inflammatory teb nyob rau hauv lub ntsws ^{[1, 2]}.

Txhim kho cov qauv thiab kev ua haujlwm ntawm Bronchial Epithelium: Thaum lub sij hawm tsim cov qauv COPD, cov qauv ntawm bronchial epithelium tau puas lawm, tab sis kev kho mob nrog Bronchogen tau kho cov qauv no, thiab nws cov haujlwm ua haujlwm kuj tau rov qab los. Qhov no tuaj yeem pom tau los ntawm kev nce hauv secretory immunoglobulin A (ib lub cim tiv thaiv kab mob hauv zos) thiab surfactant protein B, uas yog lub luag haujlwm rau txo qhov nro ntawm lub alveoli ^{[1, 2]}.

2. Qhov cuam tshuam rau thermal stability ntawm DNA

Stabilizing DNA Structure: Cov kev tshawb fawb tau pom tias Bronchogen tuaj yeem ua raws li DNA stabilizer. Nyob rau hauv ib tug tej yam concentration ntau (lub molar piv ntawm Bronch-g / DNA puag khub yog 0.01 - 0.055), Bronchogen tuaj yeem ua rau kom kub kub ntawm DNA los ntawm calf thymus thiab nas daim siab los ntawm 3.1 ° C ^[3] . Txawm li cas los xij, ntxiv qhov sib piv no tsis hloov qhov kub ntawm qhov melting. Nyob rau hauv no ntau yam, lub melting enthalpy (ΔH (melt)) ntawm lub complex tseem tsis hloov, thiab ΔH (melt) ntawm DNA los ntawm calf thymus thiab nas daim siab yog 11.4 thiab 12.7 cal / g raws li. Qhov no qhia tau hais tias Bronchogen tsis yog ib qho adenine-thymine-specific lossis guanine-cytosine-specific ligand, thiab hom ntawm nws txoj hlua khi yog qhov ruaj khov thiab tsis sib xws, feem ntau khi rau ob txoj hlua ntawm DNA (tsuas yog cov hauv paus nitrogenous) ^[3].

Cov kev siv ntawm Bronchogen yog dab tsi?

1. Mob ntsws ntsws

Bronchogen plays lub luag haujlwm tseem ceeb hauv kev kho mob bronchitis. Mob ntsws ntsws ntev yog ib yam kab mob ua pa, thiab cov neeg mob feem ntau muaj cov tsos mob xws li hnoos, expectoration, thiab dyspnea ^[2] . Bronchogen tuaj yeem txo cov tsos mob ntawm cov neeg mob los ntawm kev txo cov inflammatory teb thiab alleviating congestion thiab edema ntawm bronchial mucosa. Nyob rau tib lub sijhawm, nws tseem tuaj yeem txhawb kev kho thiab rov tsim cov ntaub so ntswg bronchial, txhim kho elasticity thiab kev ua haujlwm ntawm bronchi. Thaum lub sij hawm kev kho mob mus ntev, qhov hnoos ntau zaus thiab expectoration ntim ntawm cov neeg mob maj mam txo, thiab cov degree ntawm dyspnea yog ho txhim kho.

2. Mob hawb pob

Hauv kev tswj kev mob hawb pob, Bronchogen tau pom muaj peev xwm zoo. Mob hawb pob yog ib yam kab mob inflammatory ntawm txoj hlab pa, thiab cov hlab ntsws ntawm cov neeg mob yog cov rhiab heev rau ntau yam stimuli, nws muaj cov tsos mob xws li bronchospasm thiab dyspnea. Bronchogen tuaj yeem txhim kho txoj kev ua pa ntawm txoj hlab ntsws los ntawm kev txo qis bronchial o thiab txo qis kev ua pa ntawm txoj hlab pa. Nws tuaj yeem tswj hwm lub cev tiv thaiv kab mob, txo cov infiltration ntawm cov hlwb inflammatory thiab tso tawm cov inflammatory mediators, yog li alleviating cov tsos mob ntawm cov neeg mob hawb pob. Tsis tas li ntawd, Bronchogen tseem tuaj yeem txhim kho lub ntsws noj qab haus huv thiab txhim kho lub ntsws ua haujlwm ntawm cov neeg mob, ua kom lawv zoo dua nrog ntau yam kev cov nyom hauv lub neej txhua hnub.

3. Tus Kab Mob Hlwb Obstructive Pulmonary (COPD)

Rau cov neeg mob uas muaj kab mob pulmonary obstructive, Bronchogen yog ib qho kev kho mob zoo. COPD yog kab mob ua pa nyuaj, thiab cov neeg mob feem ntau muaj cov tsos mob xws li hnoos, expectoration, thiab ua tsis taus pa. Cov teebmeem ntawm Bronchogen hauv cov neeg mob COPD feem ntau suav nrog kev txhawb nqa cov ntaub so ntswg kho, txhim kho bronchial muaj nuj nqi, thiab txo qhov mob. Nws tuaj yeem txhawb kev tsim kho ntawm bronchial epithelial hlwb, kho cov ntaub so ntswg bronchial puas, thiab txhim kho patency ntawm bronchi. Nyob rau tib lub sijhawm, Bronchogen tseem tuaj yeem txo cov lus teb inflammatory, alleviate inflammatory puas nyob rau hauv lub ntsws, thiab ncua kev loj hlob ntawm tus kab mob. Los ntawm cov teebmeem no, Bronchogen tuaj yeem txhim kho lub neej zoo ntawm cov neeg mob, txo tus naj npawb ntawm cov mob hnyav, thiab txuas ntxiv lub sijhawm muaj sia nyob ntawm cov neeg mob.

4. Rov qab los tom qab mob ua pa nyuaj

Tom qab mob ua pa nyuaj (xws li mob ntsws), Bronchogen tuaj yeem siv los txhawb kev rov zoo ntawm cov neeg mob. Cov kab mob ua pa hnyav tuaj yeem ua rau muaj kev puas tsuaj loj rau cov ntaub so ntswg bronchial thiab ntsws, cuam tshuam rau kev ua pa ntawm cov neeg mob. Bronchogen tuaj yeem ua kom nrawm kho cov ntaub so ntswg bronchial, txhawb kev tsim kho ntawm cov hlwb puas, thiab kho cov qauv qub thiab kev ua haujlwm ntawm bronchi ^[4] . Nws tseem tuaj yeem txhim kho txoj kev ua pa, txhim kho lub peev xwm pauv roj ntawm lub ntsws, thiab txo qhov kev pheej hmoo ntawm kev puas tsuaj mus ntev. Tom qab siv Bronchogen, cov neeg mob ua pa zoo dua, rov ua kom lawv lub zog maj mam, thiab tuaj yeem rov qab mus rau lub neej zoo thiab ua haujlwm sai dua.

5. Kev tiv thaiv lub ntsws ua haujlwm hauv cov neeg haus luam yeeb

Rau cov neeg haus luam yeeb lossis cov neeg raug kev phem ib puag ncig, Bronchogen pab tiv thaiv thiab kho lub bronchi. Kev haus luam yeeb thiab ib puag ncig muaj kuab paug tuaj yeem ua rau muaj kev puas tsuaj loj rau lub ntsws thiab ua rau muaj kev pheej hmoo ntawm cov kab mob ntsws ntev. Bronchogen tuaj yeem txo qhov kev puas tsuaj ntawm cov tshuaj phem rau cov ntaub so ntswg bronchial thiab ntsws thiab txhawb kev kho thiab rov tsim dua tshiab ntawm bronchi ^[5] . Nws tuaj yeem txhim kho kev tiv thaiv kev ua haujlwm ntawm bronchi, txo cov lus teb inflammatory, thiab txo qhov tshwm sim ntawm cov kab mob ntsws. Tsis tas li ntawd, Bronchogen tseem tuaj yeem txhim kho lub ntsws ua haujlwm, txhim kho kev ua pa ntawm cov neeg haus luam yeeb, thiab txo qis kev loj hlob ntawm cov kab mob ntsws ntev.

6. Lub luag haujlwm pabcuam hauv kev kho mob

Bronchogen tuaj yeem siv los ua ib qho kev kho mob rau kev kho mob ib txwm siv los txhim kho cov nyhuv kho. Nyob rau hauv kev kho mob ntawm cov kab mob xws li hnoos syndrome, combining Bronchogen nrog ib txwm siv txoj kev kho mob yuav txhim kho tag nrho cov curative nyhuv.

Bronchogen muaj txiaj ntsig zoo rau cov neeg hauv qab no:

Hauv kev xaus, Bronchogen qhia tau hais tias muaj txiaj ntsig tseem ceeb hauv kev tshawb fawb txog lub neej. Nws tuaj yeem txhim kho cov qauv DNA, muab cov kev taw qhia tshiab rau kev kawm txog DNA ntsig txog cov txheej txheem. Hauv kev kho cov kab mob ua pa, rau cov mob xws li mob ntsws ntsws, mob ntsws asthma, thiab COPD, nws tuaj yeem txo qhov mob, txhawb kev kho cov ntaub so ntswg, ua kom cov neeg mob ua pa zoo, txo cov tsos mob, thiab txhim kho lub neej zoo, uas yog qhov tseem ceeb heev rau kev tiv thaiv thiab kho cov kab mob ua pa.

Hais Txog Tus Sau

Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.

Scientific Journal Author

Caswell SJ yog tus kws tshawb fawb tshwj xeeb koom nrog ntau lub tsev tseem ceeb, suav nrog AstraZeneca, Francis Crick Institute, TDHB, University of British Columbia, thiab ALVANLEY CLIN. Nws txoj kev tshawb fawb nthuav dav ntau thaj chaw, qhia txog nws txoj kev txawj ntse. Hauv Biochemistry & Molecular Biology, nws tau pab txhawb kev nkag siab txog cov txheej txheem ntawm tes thiab kev sib cuam tshuam ntawm molecular. Nws txoj haujlwm hauv General & Internal Medicine muaj qhov cuam tshuam rau kev txhim kho cov neeg mob thiab kho cov txheej txheem.

Hauv thaj tsam ntawm Virology, Caswell SJ tau tshawb nrhiav cov kab mob sib kis thiab kev sib cuam tshuam ntawm tus tswv tsev, uas yog qhov tseem ceeb rau kev tsim cov tswv yim tiv thaiv kab mob. Nws txoj kev koom tes hauv Kev Tshawb Fawb & Tshuab - Lwm Cov Ntsiab Lus qhia nws txoj kev koom tes nrog cov txheej txheem tshiab thiab thev naus laus zis uas dhau los ua ib thaj tsam ntawm kev tshawb fawb. Tsis tas li ntawd, nws txoj kev tshawb fawb hauv Parasitology tau pom cov kab mob parasitic thiab lawv cuam tshuam rau kev noj qab haus huv ntawm pej xeem. Los ntawm nws txoj kev tshawb fawb ntau yam, Caswell SJ tau ua haujlwm tseem ceeb rau kev tshawb fawb hauv zej zog, cuam tshuam rau ob qho tib si theoretical kev nce qib thiab kev siv tswv yim hauv tshuaj thiab biology. Caswell SJ tau teev nyob rau hauv kev siv ntawm cov ntaub ntawv pov thawj [4].

▎ Cov Lus Qhia Tseem Ceeb

[1] Kuzubova NA, Lebedeva ES, Dvorakovskaya IV, et al. Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology[J]. Bulletin of Experimental Biology and Medicine, 2015,159(5):685-688.DOI:10.1007/s10517-015-3047-x.

[2] Titova ON, Kuzubova NA, Lebedeva ES, et al. Antiinflammatory thiab regenerative nyhuv ntawm peptide kho nyob rau hauv tus qauv ntawm obstructive ntsws pathology [J]. Ross Fiziol Zh Im IM Sechenova, 2017,103(2):201-208. https://pubmed.ncbi.nlm.nih.gov/30199201/.

[3] Monaselidze JR, Khavinson VK, Gorgoshidze MZ, et al. Cov nyhuv ntawm peptide bronch-g (Ala-Asp-Glu-Leu) ntawm DNA thermostability [J]. Bulletin of Experimental Biology and Medicine, 2011,150(3):375-377.DOI:10.1007/s10517-011-1146-x.

[4] Caswell SJ, Thomson AH, Ashmore SP, et al. latent rhiab heev rau cov kab mob ua pa syncytial thaum mob bronchiolitis thiab lub ntsws ua haujlwm tom qab rov zoo [J]. Archives of disease in Childhood, Archives of Disease in Childhood, 1990,65(9):946-952.DOI:10.1136/adc.65.9.946.

[5] Yoshida M, Kaneko Y, Ishimatsu A, et al. Cov teebmeem ntawm tiotropium ntawm lub ntsws ua haujlwm hauv cov neeg haus luam yeeb tam sim no thiab tsis haus luam yeeb nrog bronchial hawb pob [J]. Pulmonary Pharmacology & Therapeutics, 2017,42:7-12.DOI:10.1016/j.pupt.2016.11.004.

Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.  

Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.