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1 kits (10 Vials)
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▎ Tsarin Motc
Source: PubChem |
Jeri: MRWQEMGYIFYPRKLR Tsarin kwayoyin halitta: C101H152N28O22S2 Nauyin Kwayoyin Halitta: 2174.6g/mol Lambar CAS: 1627580-64-6 Kamfanin CID na PubChem: 146675088 Synonyms: UNII-A5CV6JFB78 |
▎ Motc Binciken
Menene asalin bincike na Motc?
Asalin bincike na Motc ya samo asali ne daga bincike kan rawar mitochondrial DNA a cikin lafiyar rayuwa da tsufa. Yayin da fahimtar aikin mitochondrial ya zurfafa, an gano cewa mitochondria ba kawai cibiyar makamashi ba ne amma kuma suna shiga cikin sadarwar salula da watsa sigina. Ta hanyar kunna hanyar AMPK, suna shiga cikin glucose da metabolism na lipid, masu alaƙa da alaƙa da cututtukan rayuwa kamar metabolism da kiba, kuma suna ɗaukar alƙawarin azaman sabbin dabarun warkewa don waɗannan yanayi. Idan aka ba da haɗin kai tsakanin aikin mitochondrial da cututtuka daban-daban, Motc kuma an yi amfani da shi a cikin yanayi kamar na kullum hepatitis B da ciwon daji na ovarian. Bincike ya nuna yana iya taka muhimmiyar rawa a cikin hanyoyin kamuwa da cuta. Motsa jiki yana haɓaka haɓakawa da bayyanar Motc a cikin jikin mutum, don haka inganta haɓakar ƙwayar tsoka, aikin jiki, da aikin jiki gabaɗaya, yana ba da shaida ga dabarun rigakafin tsufa na tushen motsa jiki da faɗaɗa iyakokin bincike na Motc.
Menene tsarin aikin Motc?
Kunna hanyar siginar AICAR-AMPK:
Motc da farko yana aiwatar da ayyukan sa na jiki ta hanyar kunna hanyar siginar AICAR-AMPK. Yana rushe zagayowar folate-methionine a cikin sel, ta haka yana kunna hanyar siginar AICAR-AMPK. Misali, a cikin tsarin ilimin halittar jiki kamar inganta juriya na insulin da hana kiba, kunna wannan hanyar yana taka muhimmiyar rawa. Ta hanyar kunna wannan tafarki, Motc na iya daidaita metabolism na makamashin salula, haɓaka ɗaukar wayar salula da amfani da glucose, ta haka ne ke daidaita tsarin metabolism homeostasis [1,2].
Ma'amala tare da takamaiman hanyoyin sigina da kwayoyin halitta:
A cikin ƙwayoyin tsoka, Motc yana hulɗa tare da siginar siginar da mai kunnawa 3 (STAT3) ta hanyar YIFY domain's putative Src-homologous 2 (SH2) daure motif, rage STAT3's transcriptional aiki da kuma inganta myotube samuwar. A cikin cutar pneumonitis na radiation, Motc yana rage lalacewar nama na huhu, kumburi, da damuwa na oxidative ta hanyar haɓaka matakan makamashin E2-related factor (Nrf2) da kuma inganta fassarar nukiliya, don haka kare aikin mitochondrial. Bugu da ƙari, Motc yana aiwatar da ayyuka daban-daban na ilimin lissafi ta hanyar daidaita maganganun kwayoyin halitta kamar GLUT4, STAT3, da IL-10 [3].
Tsarin hanyoyin metabolism:
Motc yana shiga cikin tsari na matakai daban-daban masu mahimmanci na rayuwa, gami da metabolism na glucose, metabolism na lipid, da metabolism na kashi, ta hanyar hanyoyin autocrine da paracrine. A cikin metabolism na glucose, yana inganta juriya na insulin kuma yana daidaita matakan glucose na jini; a cikin metabolism na lipid, yana haɓaka thermogenesis mai launin ruwan kasa, yana haɓaka launin fata mai launin fata, kuma yana hana kiba da rikicewar metabolism na lipid; a cikin metabolism na kashi, yana inganta haɓakar osteoblast, bambance-bambance, da ma'adinai, yana hana tsararrun osteoclast, kuma yana daidaita ƙasusuwan kashi da gyaran kashi [4,5]..
Hoto 1 Injiniyanci da aikin Motc [6].
Menene ayyuka da aikace-aikacen Motc?
Ayyukan Motc
Abubuwan da aka tsara akan metabolism:
Motc na iya inganta glucose da lipid metabolism a cikin jiki. A cikin metabolism na glucose, yana rage juriya na insulin, yana taimakawa hana nau'in metabolism na nau'in 2, kuma yana haɓaka ɗaukar salula da ingantaccen amfani da glucose. A cikin lipid metabolism, yana ƙara launin ruwan kasa thermogenesis mai launin ruwan kasa, yana haɓaka launin fata mai launin fata, ta haka yana daidaita metabolism na lipid, yana hana kiba, da rikice-rikice na rayuwa mai alaƙa. Hakanan yana rage yawan cututtukan hanta mai kitse mara-giya kuma yana daidaita metabolism na lipid na hanta [2].
Tasiri kan aikin salula:
Yana inganta aikin mitochondrial kuma yana kare sel daga lalacewa. Alal misali, a cikin ciwon huhu da ke haifar da radiation, yana rage lalacewar mitochondrial a cikin huhu epithelial cell, yana rage apoptosis cell, kuma yana kula da aikin salula na al'ada. A cikin sel na pancreatic, Motc yana rinjayar ɓoyewa da bayyanar insulin da glucagon, yana daidaita ilimin halittar jikin pancreatic, kuma yana rinjayar iyawar salula da apoptosis [4,5]..
Tasiri akan tsokoki da kasusuwa:
A cikin tsokoki, Motc yana haɓaka bambance-bambancen ƙwayoyin tsoka na ƙwayoyin tsoka, yana haɓaka haɓakar myotube, kuma yana kare ƙwayoyin tsoka daga lalacewa ta hanyar interleukin-6 (IL-6), mai yuwuwar hana atrophy na tsoka. Dangane da kasusuwa, yana haɓaka haɓakawa, bambance-bambance, da ma'adinai na osteoblasts, yana hana haɓakar osteoclast, yana kula da ma'auni na ƙasusuwa, kuma yana taimakawa jinkirta osteoporosis [1,5]..
Anti-mai kumburi da immunomodulatory effects:
Motc yana rage martanin kumburi na tsarin na yau da kullun kuma yana daidaita aikin rigakafi. A cikin nau'ikan ciwo mai kumburi, Motc yana rage jin zafi, yana rage sakin abubuwan da ke haifar da kumburi, kuma yana hana kunna ƙwayoyin glial da neurons, yana nuna tasirin kumburi da rage zafi [3].
Aikace-aikace na Motc
Tasiri kan cututtuka na rayuwa:
Abubuwan da aka tsara na Motc akan glucose da metabolism na lipid sun sa ya zama sabon makasudin warkewa don cututtukan rayuwa kamar nau'in 2 metabolism, kiba, da cututtukan hanta mara-giya [2].
Rigakafi da Maganin Cututtukan Musculoskeletal:
Ana iya amfani da ingantaccen tasirinsa akan tsokoki da ƙasusuwa don hanawa da kuma magance cututtukan da ke da alaƙa da ciwon tsoka da cututtukan kwarangwal kamar osteoporosis. Ga marasa lafiya tare da atrophy na tsoka, zai iya inganta aikin tsoka ta hanyar inganta bambance-bambancen ƙwayar tsoka da kuma hana apoptosis na ƙwayar tsoka; Ga marasa lafiya tare da osteoporosis, zai iya daidaita ma'auni na rayuwa na kashi, ƙara yawan kashi, da kuma hanawa da magance osteoporosis [1,5].
Kariyar lalata radiyo:
A cikin binciken kan cutar pneumonitis na radiation, Motc ya nuna tasirin kariya daga lalacewar huhu. Ana iya amfani da shi yayin aikin rediyo don kare kyallen takarda na yau da kullun, rage lalacewar nama da ke haifar da radiation, da haɓaka ingancin aikin rediyo [2].
Maganin cututtuka masu kumburi:
Dangane da tasirin anti-mai kumburi, Motc za a iya amfani dashi don magance cututtuka masu kumburi irin su ciwon kumburi, samar da sababbin hanyoyin magance irin waɗannan yanayi [3].
Kammalawa
A matsayin peptide wanda aka samu mitochondrial, Motc na iya kunna hanyoyin sigina don daidaita glucose da lipid metabolism, inganta juriya na insulin, da rage haɗarin cututtukan rayuwa; yana kuma iya kula da aikin tsoka da kashi, hana atrophy na tsoka da osteoporosis; kuma tana da ayyukan kariya da ƙwayoyin cuta da ƙwayoyin cuta, suna taka rawa wajen kariya daga lalacewar radiation da kuma magance cututtukan kumburi.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Wan, Yanmin yana da alaƙa da ƙungiyoyi masu daraja iri-iri, ciki har da asibitoci, cibiyoyin bincike, jami'o'i, da masana'antu irin su Linping Hosp Integrated Tradit Chinese & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan Agricultural University, da dai sauransu. Bukatun bincikensa suna da yawa, da farko yana mai da hankali kan nau'ikan nau'ikan ilimin Immunology Science & Technology, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry da Chemistry. A fagen Kimiyya da Fasaha na Immunology, ya shiga cikin hanyoyin da aikace-aikace na tsarin rigakafi. Cibiyar bincikensa ta Virology ta dogara ne akan halayen ƙwayoyin cuta, watsawa, da rigakafi. A cikin fannin Chemistry na Materials Science Chemistry, ya himmatu wajen haɓaka kaddarorin kayan aiki da sabbin aikace-aikacen sinadarai, yana mai da shi sanannen mutum wanda ya sami nasarorin bincike a fagagen ilimi masu dacewa. Wan, Yanmin an jera a cikin ma'anar ambato [6].
