Mgbochi 20mg

▎ Ọdịdị Motc

▎ Motc Nchọpụta

Kedu ihe ndabere nyocha nke Motc?

Nchọpụta nyocha nke Motc sitere na nyocha gbasara ọrụ mitochondrial DNA na ahụike metabolic na ịka nká. Ka nghota nke ọrụ mitochondrial na-abawanyewanye, a chọpụtara na mitochondria abụghị naanị ebe etiti metabolism ike kamakwa na-ekere òkè na nkwurịta okwu cellular na ntụgharị mgbaàmà. Site na ịgbalite ụzọ AMPK, ha na-etinye aka na glucose na metabolism lipid, nwere njikọ chiri anya na ọrịa metabolic dị ka metabolism na oke ibu, ma na-ekwe nkwa dị ka ebumnuche ọgwụgwọ ọhụrụ maka ọnọdụ ndị a. Nyere njikọ dị n'etiti ọrụ mitochondrial na ọrịa dị iche iche, a na-etinyekwa Motc na ọnọdụ ndị dị ka ịba ọcha n'anya B na ọrịa cancer ovarian. Nnyocha na-egosi na ọ nwere ike na-ekere òkè dị ukwuu na usoro ọrịa nje. Mmega ahụ na-akwalite njikọ na nkwupụta nke Motc n'ime ahụ mmadụ, si otú ahụ na-emeziwanye metabolism nke anụ ahụ, ịrụ ọrụ anụ ahụ, na ọrụ anụ ahụ dum, na-enye ihe akaebe maka usoro mgbochi ịka nká na-emega ahụ na ịgbasawanye nyocha nke Motc.

Gịnị bụ usoro omume nke Motc?

Ntinye nke ụzọ akara AICAR-AMPK: 

Motc na-arụ ọrụ ya nke ọma site n'ịgbalite ụzọ akara AICAR-AMPK. Ọ na-akpaghasị okirikiri folate-methionine n'ime sel, si otú a na-eme ka ụzọ akara AICAR-AMPK rụọ ọrụ. Dịka ọmụmaatụ, na usoro physiological dị ka imeziwanye nguzogide insulin na igbochi oke ibu, ịgbalite ụzọ a na-arụ ọrụ dị mkpa. Site n'ime ka ụzọ a rụọ ọrụ, Motc nwere ike ịhazi metabolism ike cellular, welie nnabata cellular na iji glucose, si otú ahụ na-achịkwa usoro metabolic homeostasis ^[1,2]..

Mmekọrịta na ụzọ mgbama na mkpụrụ ndụ ihe nketa: 

N'ime mkpụrụ ndụ akwara, Motc na-emekọrịta ihe na ntụgharị mgbaàmà na transcription activator 3 (STAT3) site na ngalaba YIFY ya na-ejikọta Src-homologous 2 (SH2) binding motif, na-ebelata ọrụ ntụgharị STAT3 na ịkwalite nhazi myotube. Na pneumonitis radieshon, Motc na-ebelata mmebi anụ ahụ nku ume, mbufụt, na nrụgide oxidative site n'ịbawanye ọkwa nke ihe metụtara nuklia E2 (Nrf2) na ịkwalite nsụgharị nuklia ya, si otú ahụ na-echebe ọrụ mitochondrial. Ọzọkwa, Motc na-arụ ọrụ dị iche iche physiological site n'ịchịkwa okwu nke mkpụrụ ndụ ihe nketa dị ka GLUT4, STAT3, na IL-10 ^[3].

Usoro nke usoro metabolic: 

Motc na-ekere òkè na nhazi nke usoro metabolic dị iche iche dị mkpa, gụnyere glucose metabolism, lipid metabolism, na ọkpụkpụ, site na autocrine na paracrine usoro. Na metabolism nke glucose, ọ na-eme ka insulin na-eguzogide ma na-achịkwa ọkwa glucose ọbara; na lipid metabolism, ọ na-abawanye thermogenesis abụba agba aja aja, na-akwalite ọcha abụba browning, na-egbochi oke ibu na lipid metabolism ọrịa; na ọkpụkpụ ọkpụkpụ, ọ na-akwalite mmụba osteoblast, ọdịiche, na mineralization, na-egbochi ọgbọ osteoclast, ma na-achịkwa ọkpụkpụ ọkpụkpụ na ọkpụkpụ ọkpụkpụ ^[4,5]..

Ọgụgụ 1 Usoro na ọrụ nke Motc ^[6].

Kedu ọrụ na ngwa nke Motc?

Ọrụ nke Motc

Mmetụta nke usoro metabolic: 

Motc nwere ike melite glucose na lipid metabolism na ahụ. Na metabolism nke glucose, ọ na-ebelata nguzogide insulin, na-enyere aka igbochi ụdị 2 metabolism, na-eme ka nnabata sel na-arụ ọrụ nke ọma na glucose. Na lipid metabolism, ọ na-abawanye thermogenesis abụba agba aja aja, na-akwalite browning nke abụba ọcha, si otú na-achịkwa lipid metabolism, na-egbochi oke ibu, na metụtara lipid metabolic ọrịa. Ọ na-ebelatakwa ọrịa imeju abụba na-adịghị egbu egbu ma na-achịkwa imeju lipid metabolism ^[2].

Mmetụta na ọrụ cell: 

Ọ na-akwalite ọrụ mitochondrial ma na-echebe mkpụrụ ndụ site na mmebi. Dịka ọmụmaatụ, na oyi baa na-akpata radieshon, ọ na-ebelata mmebi mitochondrial na cell epithelial ngụgụ, na-ebelata apoptosis cell, ma na-ejigide ọrụ cellular nkịtị. N'ime mkpụrụ ndụ pancreatic, Motc na-emetụta nzuzo na ngosipụta nke insulin na glucagon, na-achịkwa physiology cell pancreatic, ma na-emetụtakwa ndụ cell na apoptosis ^[4,5]..

Mmetụta na mọzụlụ na ọkpụkpụ: 

N'ime akwara, Motc na-akwalite ọdịiche nke progenitor cell muscle, na-eme ka ọdịdị myotube dịkwuo elu, ma na-echebe mkpụrụ ndụ akwara site na interleukin-6 (IL-6) mebiri emebi, nwere ike igbochi atrophy muscle. N'ihe gbasara ọkpụkpụ, ọ na-akwalite mmụba, ọdịiche, na mineralization nke osteoblasts, na-egbochi nhazi osteoclast, na-eme ka ọkpụkpụ metabolic nguzozi, ma na-enyere aka igbu oge osteoporosis ^[1,5]..

Mmetụta mgbochi mkpali na immunomodulatory: 

Motc na-ebelata nzaghachi mkpali na-adịghị ala ala ma na-achịkwa ọrụ mgbochi. N'ụdị ihe mgbu na-egbuke egbuke, Motc na-ebelata ihe mgbu hypersensitivity, na-ebelata ntọhapụ nke ihe ndị na-egbuke egbuke, ma na-egbochi ọrụ nke mkpụrụ ndụ glial na neurons, na-egosipụta mmetụta mgbochi mkpali na nkwụsị mgbu ^[3]..

Ngwa nke Motc

Mmetụta na ọrịa metabolic: 

Mmetụta nchịkwa nke Motc na glucose na metabolism lipid na-eme ka ọ bụrụ ebumnuche ọgwụgwọ ọhụrụ maka ọrịa metabolic dị ka ụdị 2 metabolism, oke ibu, na ọrịa imeju na-adịghị egbu egbu ^[2].

Mgbochi na Ọgwụgwọ Ọrịa Musculoskeletal: 

Enwere ike iji mmetụta dị mma ya na mọzụlụ na ọkpụkpụ iji gbochie ma na-agwọ ọrịa ndị metụtara atrophy muscle na ọrịa skeletal dị ka osteoporosis. Maka ndị ọrịa nwere atrophy muscle, ọ nwere ike imeziwanye ọrụ anụ ahụ site n'ịkwalite ọdịiche dị n'etiti cell muscle na igbochi apoptosis cell muscle; Maka ndị ọrịa nwere osteoporosis, ọ nwere ike ịhazi nguzozi nke ọkpụkpụ, mee ka ọkpụkpụ ọkpụkpụ dịkwuo elu, ma gbochie ma na-emeso ọkpụkpụ ọkpụkpụ ^[1,5]..

Nchekwa mmebi radieshon: 

N'ime ọmụmụ banyere pneumonitis radieshon, Motc egosila mmetụta nchebe megide mmebi radieshon nku ume. Enwere ike iji ya n'oge ọgwụgwọ redio iji kpuchido anụ ahụ nkịtị, belata mmebi anụ ahụ na-akpata radieshon, ma welie ịdị irè nke ọgwụgwọ redio ^[2].

Ọgwụgwọ ọrịa mkpali: 

Dabere na mmetụta mgbochi ya, Motc nwere ike iji na-agwọ ọrịa ndị na-egbuke egbuke dị ka mgbu na-egbuke egbuke, na-enye ntụziaka ọhụrụ maka ọgwụgwọ nke ọnọdụ ndị dị otú ahụ ^[3].

Mmechi

Dị ka peptide sitere na mitochondrial, Motc nwere ike ịgbalite ụzọ mgbaàmà iji mezie glucose na metabolism lipid, melite nguzogide insulin, ma belata ihe ize ndụ nke ọrịa metabolic; ọ nwekwara ike ịnọgide na-arụ ọrụ akwara na ọkpụkpụ, gbochie atrophy muscle na osteoporosis; na ọ nwere ọrụ mgbochi mkpali na nchekwa cell, na-ekere òkè na nchebe mmebi radieshon na ọgwụgwọ nke ọrịa na-efe efe.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

Onye ode akwụkwọ akụkọ sayensị

Wan, Yanmin na-ejikọta ya na ụlọ ọrụ dị iche iche a ma ama, gụnyere ụlọ ọgwụ, ụlọ ọrụ nyocha, mahadum, na ụlọ ọrụ dị ka Linping Hosp Integrated Tradit Chinese & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan Agricultural University, wdg. mmasị nyocha ya dị ukwuu, bụ isi na-elekwasị anya na isiokwu nke Immunology Science & Technology, Virology Chemiss, Virology, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry na Immunology. N'ihe gbasara Immunology Science & Technology, ọ na-abanye n'ime usoro na ngwa nke usoro ahụ ji alụso ọrịa ọgụ. Ihe nyocha Virology ya gbadoro ụkwụ na njirimara nje, nnyefe, na mgbochi. N'ime ngalaba nke Materials Science Chemistry, ọ na-agba mbọ na mmepe nke ihe onwunwe na ngwa ọhụrụ nke kemistri, na-eme ka ọ bụrụ onye ama ama nke nwere nnukwu nchọpụta nyocha na ngalaba agụmakwụkwọ dị mkpa. Wan, Yanmin ka edepụtara n'akwụkwọ ntụaka [6].

▎ Okwu ndị dị mkpa

[1] García-Benlloch S, Revert-Ros F, Blesa JR, et al. Motc na-akwalite ọdịiche anụ ahụ na vitro[J]. Peptides, 2022,155:170840.DOI:10.1016/j.peptides.2022.170840.

[2] Zhang Y, Huang J, Zhang Y, et al. Peptide Motc nke sitere na Mitochondrial na-eme ka Pneumonitis Radiation na-ebelata site na Nrf2-Dependent Mechanism[J]. Antioxidants, 2024,13.

[3] Wang Z, Yang L, Xu L, et al. Central na mpụta usoro nke Motc attenuates mgbu hypersensitivity na a ụmụ oke ụdị nke mkpali mgbu [J]. Nnyocha nke akwara ozi, 2024,46 (2): 165-177.DOI: 10.1080/01616412.2023.2258584.

[4] Bień J, Pruszyńska-Oszmałek E, Kołodziejski P, et al. Motc na-ahazi alfa pancreatic na ọrụ beta cell na vitro[J]. Akụkọ ihe mere eme na ihe ọmụmụ ihe ọmụmụ, 2024,161(6):449-460.DOI:10.1007/s00418-024-02274-0.

[5] Yi X, Hu G, Yang Y, et al. Ọrụ nke Motc na nhazi nke ọkpụkpụ metabolism[J]. Oke na Physiology, 2023,14:1149120.DOI:10.3389/fphys.2023.1149120.

[6] Wan W, Zhang L, Lin Y, et al. Mitochondria-ewepụtara peptide Motc: mmetụta na usoro metụtara nrụgide, metabolism na ịka nká [J]. Akwụkwọ akụkọ ọgwụ ntụgharị, 2023,21 (1): 36.DOI: 10.1186/s12967-023-03885-2.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.