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1kits (Ebipipa 10) .
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▎ Enzimba ya Motc
Ensibuko: PubChem |
Omutendera: MRWQEMGYIFYPRKLR Ensengekera ya molekyu: C101H152N28O22S2 Obuzito bwa molekyu: 2174.6g/mol Ennamba ya CAS: 1627580-64-6 PubChem CID: 146675088. Enkola y’okukuuma eddagala lino Ebigambo ebikwatagana: UNII-A5CV6JFB78 |
▎ Motc Okunoonyereza kwa
Ensibuko y’okunoonyereza eya Motc eri etya?
Ensibuko y’okunoonyereza eya Motc yasibuka mu kunoonyereza ku kifo kya DNA ya mitochondrial mu bulamu bw’enkyukakyuka y’emmere n’okukaddiwa. Nga okutegeera enkola ya mitochondria kweyongera, kyazuulibwa nti mitochondria si kifo kyokka eky’okukyusakyusa amaanyi wabula era zeetaba mu mpuliziganya y’obutoffaali n’okukyusa obubonero. Nga zikola ekkubo lya AMPK, zeenyigira mu nkyukakyuka ya glucose ne lipid, ezikwatagana ennyo n’endwadde z’enkyukakyuka mu mubiri nga metabolism n’omugejjo, era zisuubiza ng’ebigendererwa ebipya eby’obujjanjabi eri embeera zino. Okusinziira ku kakwate akaliwo wakati w’enkola ya mitochondria n’endwadde ez’enjawulo, Motc era ebadde ekozesebwa mu mbeera nga chronic hepatitis B ne kookolo w’enkwaso. Okunoonyereza kulaga nti kiyinza okukola kinene mu nkola z’okukwatibwa akawuka. Dduyiro atumbula okusengejja n’okwolesebwa kwa Motc mu mubiri gw’omuntu, bwe kityo n’alongoosa enkyukakyuka y’ebinywa, okukola emirimu gy’omubiri, n’enkola y’omubiri okutwalira awamu, n’awa obujulizi ku bukodyo obuziyiza okukaddiwa obusinziira ku dduyiro n’okugaziya obuwanvu bw’okunoonyereza kwa Motc.
Enkola ya Motc ekola ki?
Okukola kw’ekkubo ly’obubonero bwa AICAR-AMPK:
Motc okusinga ekola emirimu gyayo egy’omubiri ng’ekola ekkubo ly’obubonero erya AICAR-AMPK. Kitaataaganya enzirukanya ya folate-methionine mu butoffaali, bwe kityo ne kikola ekkubo ly’obubonero erya AICAR-AMPK. Okugeza, mu nkola z’omubiri nga okulongoosa obuziyiza bwa insulini n’okuziyiza omugejjo, okukola ekkubo lino kikola kinene. Nga ekola ekkubo lino, Motc esobola okulungamya enkyukakyuka y’amasoboza g’obutoffaali, okutumbula okutwalibwa kw’obutoffaali n’okukozesa glucose, bwe kityo n’etereeza enkola y’okukyusakyusa emmere y’omubiri (systemic metabolic homeostasis) [1,2]..
Enkolagana n’amakubo ag’obubonero ag’enjawulo n’obuzaale:
Mu butoffaali bw’ebinywa, Motc ekwatagana ne signal transduction ne transcription activator 3 (STAT3) okuyita mu YIFY domain’s putative Src-homologous 2 (SH2) binding motif yaayo, okukendeeza ku STAT3’s transcriptional activity n’okutumbula okutondebwa kwa myotube. Mu bulwadde bwa radiation pneumonitis, Motc ekendeeza ku kwonooneka kw’ebitundu by’amawuggwe, okuzimba, n’okunyigirizibwa okw’okwokya (oxidative stress) ng’eyongera ku miwendo gya nuclear factor E2-related factor (Nrf2) n’okutumbula okukyusakyusa kwayo okwa nuclear, bwe kityo n’ekuuma enkola ya mitochondria. Okugatta ku ekyo, Motc ekola emirimu egy’enjawulo egy’omubiri ng’etereeza okwolesebwa kw’obuzaale nga GLUT4, STAT3, ne IL-10 [3]..
Okulungamya amakubo g’enkyukakyuka mu mubiri:
Motc yeetaba mu kulungamya enkola ez’enjawulo enkulu ez’enkyukakyuka mu mubiri, omuli enkyukakyuka ya glucose, enkyukakyuka y’amasavu, n’okukyusakyusa amagumba, okuyita mu nkola za autocrine ne paracrine. Mu nkyukakyuka ya glucose, alongoosa obuziyiza bwa insulini n’okutereeza emiwendo gya glucose mu musaayi; mu nkyukakyuka y’amasavu, kyongera ku thermogenesis y’amasavu ga kitaka, kitumbula amasavu amazungu okufuuka kitaka, era kiziyiza omugejjo n’obuzibu mu nkyukakyuka y’amasavu; mu nkyukakyuka y’amagumba, kitumbula okukula kw’amagumba, okwawukana, n’okufuuka eby’obugagga eby’omu ttaka, kiziyiza okutondebwa kw’amagumba, era kitereeza enkyukakyuka y’amagumba n’okuddamu okukola kw’amagumba [4,5]..
Ekifaananyi 1 Enkola n’enkola ya Motc [6]..
Emirimu n’enkozesa ya Motc bye biruwa?
Emirimu gya Motc
Ebikosa okulungamya ku nkyukakyuka y’emmere:
Motc esobola okulongoosa enkyukakyuka ya glucose ne lipid mu mubiri. Mu nkyukakyuka ya glucose, kikendeeza ku buziyiza bwa insulini, kiyamba okuziyiza enkyukakyuka y’ekika eky’okubiri, era kiyamba obutoffaali okutwala n’okukozesa obulungi glucose. Mu nkyukakyuka y’amasavu, kyongera ku thermogenesis y’amasavu ga kitaka, kitumbula okufuuka kitaka kw’amasavu amazungu, bwe kityo ne kitereeza enkyukakyuka y’amasavu, ne kiziyiza omugejjo, n’obuzibu obukwatagana mu nkyukakyuka y’amasavu. Era kikendeeza ku bulwadde bw’ekibumba ekirimu amasavu agatali ga mwenge era kitereeza enkyukakyuka y’amasavu mu kibumba [2]..
Ebikosa enkola y’obutoffaali:
Kitumbula enkola ya mitochondria era kikuuma obutoffaali obutakwonooneka. Okugeza, mu kifuba ekiva ku masanyalaze, kikendeeza ku kwonooneka kwa mitochondria mu butoffaali bw’amawuggwe, kikendeeza ku kufa kw’obutoffaali, era kikuuma enkola y’obutoffaali eya bulijjo. Mu butoffaali bw’olubuto, Motc ekwata ku kufulumya n’okwolesebwa kwa insulini ne glucagon, okulungamya enkola y’obutoffaali bw’olubuto, era era ekosa obulamu bw’obutoffaali n’okufa [4,5]..
Ebikosa ebinywa n’amagumba:
Mu binywa, Motc etumbula okwawukana kw’obutoffaali obusibuka mu binywa, eyongera ku kutondebwa kwa myotube, era ekuuma obutoffaali bw’ebinywa okuva ku kwonooneka okuva mu interleukin-6 (IL-6), ekiyinza okuziyiza okukendeera kw’ebinywa. Mu nsonga z’amagumba, kitumbula okukula, okwawukana, n’okufuuka eby’obulimi mu bitundu by’amagumba, kiziyiza okutondebwa kw’amagumba, kikuuma bbalansi y’enkyukakyuka y’amagumba, era kiyamba okulwawo okuzimba amagumba [1,5]..
Ebikolwa ebiziyiza okuzimba n’okukendeeza ku busimu obuziyiza endwadde:
Motc ekendeeza ku systemic chronic inflammatory responses era etereeza enkola y’abaserikale b’omubiri. Mu bikolwa by’obulumi bw’okuzimba, Motc ekendeeza ku bulumi obuyitiridde, ekendeeza ku kufulumya ensonga ezizimba, era eziyiza okukola kw’obutoffaali n’obusimu obuyitibwa glial cells, okulaga ebikolwa eby’okulwanyisa okuzimba n’okukendeeza obulumi [3]..
Okukozesa kwa Motc
Ebikosa endwadde z’enkyukakyuka mu mubiri:
Ebikolwa bya Motc ebifuga ku glucose ne lipid metabolism bigifuula ekigendererwa ekipya eky’obujjanjabi eri endwadde z’enkyukakyuka mu mubiri nga ekika kya 2 metabolism, omugejjo, n’obulwadde bw’ekibumba obw’amasavu obutali bwa mwenge [2]..
Okuziyiza n’okujjanjaba endwadde z’ebinywa n’amagumba:
Ebirungi by’ekola ku binywa n’amagumba bisobola okukozesebwa okuziyiza n’okujjanjaba endwadde ezeekuusa ku kukendeera kw’ebinywa n’endwadde z’amagumba ng’okuzimba amagumba. Ku balwadde abalina okuzimba ebinywa, kiyinza okulongoosa enkola y’ebinywa nga kitumbula okwawukana kw’obutoffaali bw’ebinywa n’okuziyiza okufa kw’obutoffaali bw’ebinywa; Ku balwadde abalina obulwadde bw’amagumba, busobola okutereeza bbalansi y’enkyukakyuka y’amagumba, okwongera ku density y’amagumba, n’okuziyiza n’okujjanjaba obulwadde bw’amagumba [1,5]..
Okukuuma okwonooneka kw’emisanvu:
Mu kunoonyereza ku bulwadde bw’ekifuba obuva ku masanyalaze, Motc eraga nti ekola bulungi ku kwonooneka kw’obusannyalazo bw’amawuggwe. Kiyinza okukozesebwa mu kiseera ky’obujjanjabi obw’amasannyalaze okukuuma ebitundu ebya bulijjo, okukendeeza ku kwonooneka kw’ebitundu ebiva ku masanyalaze, n’okutumbula obulungi bw’obujjanjabi obw’amasannyalaze [2] ..
Obujjanjabi bw’endwadde ezizimba:
Okusinziira ku buzibu bwayo obuziyiza okuzimba, Motc esobola okukozesebwa okujjanjaba endwadde ezizimba ng’obulumi obuzimba, okuwa endagiriro empya ez’okujjanjaba embeera ng’ezo [3]..
Mu bufunzi
Nga peptide evudde mu mitochondrial, Motc esobola okukola amakubo agalaga obubonero okulungamya enkyukakyuka ya glucose ne lipid, okulongoosa obuziyiza bwa insulini, n’okukendeeza ku bulabe bw’endwadde z’enkyukakyuka mu mubiri; era esobola okukuuma ebinywa n’amagumba okukola, okuziyiza ebinywa okuzimba n’okuzimba amagumba; era erina emirimu gy’okulwanyisa okuzimba n’okukuuma obutoffaali, ekola kinene mu kukuuma okwonooneka kw’obusannyalazo n’okujjanjaba endwadde ezizimba.
Ebikwata ku Muwandiisi
Ebintu ebyogeddwako waggulu byonna binoonyerezeddwako, birongooseddwa era ne bikung’aanyizibwa kkampuni ya Cocer Peptides.
Omuwandiisi wa Scientific Journal
Wan, Yanmin akwatagana n’ebibiina eby’ekitiibwa eby’enjawulo, omuli amalwaliro, ebifo eby’okunoonyereza, amatendekero, n’ebitongole nga Linping Hosp Integrated Tradit Chinese & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan Agricultural University, n’ebirala Eby’obutonde (Chemistry). Mu kisaawe kya Immunology Science & Technology, agenda mu maaso n’okunoonyereza ku nkola n’enkozesa y’abaserikale b’omubiri. Okunoonyereza kwe mu Virology kwesigamye ku mpisa z’akawuka, okusaasaana, n’okuziyiza. Mu kitundu kya Materials Science Chemistry, yeewaddeyo okutumbula eby’obugagga by’ebintu n’okukozesa enkola ya kemiko mu ngeri ey’obuyiiya, ekimufuula omuntu ow’amaanyi ng’afunye obuwanguzi obw’amaanyi mu kunoonyereza mu by’ensoma ebikwatagana. Wan, Yanmin awandiikiddwa mu kiwandiiko ekijuliziddwa mu kiwandiiko ekijuliziddwa [6].
