By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da kowane yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
1. Bayani
Slu-PP-332, mai karɓar mai karɓar isrogen na roba wanda ke da alaka da marayu mai karɓa (ERR), na iya samun tasiri mai kyau akan lafiyar ɗan adam ta hanyoyi da yawa. Daga yanayin tsarin sinadarai, yana cikin takamaiman aji na ƙananan ƙwayoyin ƙwayoyin cuta waɗanda za su iya ɗaure daidai ga masu karɓar ERR, don haka kunna jerin martanin ilimin lissafi. Ba kamar magungunan gargajiya ko hanyoyin daidaita ayyukan jiki ba, Slu-PP-332 yana aiwatar da ka'idojin ilimin lissafin jiki ta hanyar yin niyya ga mai karɓar sabon ERR.
Hoto 1 Tsarin sinadaran Slu-PP-332.
2. Tsarin Aiki
Ka'idojin Metabolism na Makamashi: Slu-PP-332 yana nuna tasiri mai mahimmanci akan metabolism na makamashi. Yana kunna mai karɓar ERR, yana haɓaka kashe kuzari. A matakin salon salula, yana ƙara aikin mitochondrial kuma yana inganta ingantaccen numfashi na salula, yana ba da damar sel su canza abubuwan gina jiki zuwa makamashi cikin inganci. A cikin ƙwayoyin ƙwanƙwasa ƙwanƙwasa, Slu-PP-332 yana haifar da maganganun kwayoyin halitta masu dangantaka, inganta haɓakar acid acid oxidation, ƙyale kitsen da za a yi amfani da shi sosai a matsayin tushen makamashi da rage yawan kitsen mai. Wadannan illolin suna kwaikwayi tsarin sarrafa kuzarin jiki yayin motsa jiki, yana baiwa jiki damar kula da yawan kashe kuzarin makamashi ko da a lokacin hutu, wanda ke taimakawa kula da lafiyayyen nauyi da inganta yanayin rayuwa gaba daya.
Inganta aikin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta, Slu-PP-332 yana nuna sakamako mai kyau. Zai iya kunna babban shirin motsa jiki na motsa jiki na motsa jiki, wanda ya dogara da mai karɓar ERRα. Nazarin ya nuna cewa bayan gudanar da Slu-PP-332 ga mice, an sami karuwa a nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in ƙwayar cuta na IIa, wanda ke inganta ƙarfin tsoka. Nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i) yana ba da damar yin amfani da iskar oxygen don samar da makamashi don haka yana tsawaita tsawon lokacin aikin tsoka. Ga mutane, wannan yana nuna cewa Slu-PP-332 na iya taimakawa wajen inganta juriya na motsa jiki, mai yiwuwa amfani da 'yan wasa biyu da ke neman haɓaka aiki da kuma daidaikun mutane da ke da nufin haɓaka ƙarfin jiki na yau da kullum. Haɓakarsa na aikin mitochondrial na ƙwanƙwasa na iya taimakawa rage gajiyar tsoka da hanzarta dawo da motsa jiki bayan motsa jiki.
Kula da aikin zuciya: ERRα da ERRγ masu karɓan marayu masu alaƙa da Estrogen mai karɓar isrogen sune maɓallai masu daidaita metabolism na zuciya. Berayen da ba su da ERRα da ERRγ suna haɓaka cututtukan zuciya da cututtukan zuciya. A matsayin ingantaccen agonist ERR, Slu-PP-332 yana taka muhimmiyar rawa wajen kiyaye aikin zuciya. Masu bincike sun haifar da gazawar zuciya a cikin manya maza na beraye ta hanyar haɗin gwiwa (TAC) sannan kuma an gudanar da Slu-PP-332 don magani. Maganin Slu-PP-332 ya inganta haɓaka juzu'in fitar da berayen, muhimmiyar alama ce ta aikin bugun zuciya, yana nuna haɓakar haɓakar zuciya. Hakanan ya inganta ultrastructure na mitochondrial, rage fibrosis na zuciya, da daidaita yanayin rashin daidaituwa na kwayoyin halitta. Waɗannan canje-canjen suna ba da gudummawa tare don kiyaye tsarin zuciya na yau da kullun da aikin. Slu-PP-332 na haɓakawa a cikin aikin zuciya yana da alaƙa da haɓaka aikin mitochondrial da daidaita hanyoyin hanyoyin metabolism na fatty acid, yana ba da sabuwar hanyar warkewa don gazawar zuciya.
3. Aikace-aikace
Filin Magungunan Wasanni: A cikin likitancin wasanni, Slu-PP-332 yana da babban yuwuwar aikace-aikace. Ga 'yan wasa, yana iya zama wakili mai haɓaka wasan kwaikwayo. Ta hanyar inganta ƙarfin motsa jiki da rage gajiyar tsoka, 'yan wasa za su iya yin aiki sosai a lokacin horo da gasa. Masu tsere masu nisa na iya fuskantar tsawaita iyakan juriya na motsa jiki da ingantaccen aikin gasa bayan amfani. Ga masu sha'awar motsa jiki na gabaɗaya, Slu-PP-332 na iya taimaka musu wajen samun ingantaccen yanayin makamashi na makamashi yayin motsa jiki, inganta haɓakar motsa jiki, rage raunin tsoka bayan motsa jiki da sauran rashin jin daɗi, da haɓaka dawo da jiki, yana ba su damar shiga cikin motsa jiki da horo. Ga wadanda ba su iya yin motsa jiki mai tsanani saboda raguwar aikin jiki, irin su tsofaffi ko marasa lafiya da wasu cututtuka na yau da kullum, Slu-PP-332 yana inganta aikin tsoka da makamashi na makamashi, yana ba su damar shiga tsaka-tsakin motsa jiki kuma don haka inganta rayuwarsu.
Magungunan cututtukan ƙwayar cuta: A cikin maganin cututtuka na rayuwa, Slu-PP-332 kuma yana nuna gagarumin yuwuwar. Ɗaukar kiba a matsayin misali, yana haɓaka kashe kuzarin kuzari da rage yawan kitse, yana ba da sabbin hanyoyin magani ga majinyata masu kiba. Nazarin preclinical ya nuna cewa a cikin nau'in berayen da ke haifar da abinci ko ob / ob linzamin kwamfuta, gudanar da Slu-PP-332 yana rage nauyin jiki yadda ya kamata kuma yana haɓaka haɓakar insulin. Wannan kuma yana da mahimmanci ga marasa lafiya da ke da nau'in ciwon sukari na 2, saboda juriya na insulin ɗaya ne daga cikin mahimman hanyoyin ilimin halittar jiki na nau'in ciwon sukari na 2. Slu-PP-332 yana haɓaka haɓakar insulin, don haka yana taimakawa mafi kyawun sarrafa matakan glucose na jini. Ga mutanen da ke fama da ciwo na rayuwa, Slu-PP-332 na iya haɓaka haɓaka rikice-rikice masu yawa na rayuwa, kamar dyslipidemia da hauhawar jini, don haka rage haɗarin rikitarwa kamar cututtukan zuciya.
4. Kammalawa
Rigakafin cututtukan zuciya da jiyya: Idan aka ba Slu-PP-332 ingantaccen tasiri akan aikin zuciya, yana da ƙimar aikace-aikace mai mahimmanci a fagen rigakafin cututtukan zuciya da jiyya. Ga marasa lafiya marasa lafiya na zuciya, zaɓuɓɓukan jiyya na yanzu suna iyakance, amma Slu-PP-332 yana inganta aikin zuciya ta hanyar haɓaka aikin mitochondrial da daidaita tsarin metabolism na fatty acid, yana ba da sabon maƙasudin magani don maganin cututtukan zuciya. Ga mutanen da ke cikin haɗarin cututtukan zuciya, irin su waɗanda ke da hauhawar jini ko cututtukan zuciya na zuciya, Slu-PP-332 na iya taka rawar kariya ta hanyar kiyaye metabolism na zuciya na yau da kullun da aiki, ta haka rage haɗarin cututtukan zuciya. A taƙaice, Slu-PP-332, a matsayin fili tare da tsarin aiki na musamman, na iya inganta ayyukan jiki.
Sources
[1] Nasri H. Sabon fata akan 'SLU-PP-332' a matsayin wakili mai tasiri don asarar nauyi tare da ingantaccen kariyar koda kai tsaye; ra'ayi nephrology [J]. Jaridar Renal Endocrinology, 2024. https://api.semanticscholar.org/CorpusID:267189187.
[2] Billon C, Sitaula S, Banerjee S, et al. A roba ERR$alpha$ Agonist Yana haifar da Babban Amsar Motsa Jiki na Aerobic kuma Yana Haɓaka Ƙarfin Motsa [J]. Biorxiv, 2022. https://api.semanticscholar.org/CorpusID:252819965.
[3] Xu W, Billon C, Li H, et al. Abstract 9682: Tasirin Kariya na Zuciya na Novel Synthetic Pan-Estrogen mai alaƙa Mai karɓar Agonists Slu-pp-332 da Slu-pp-915[J]. Zagayawa, 2021,144.DOI:10.1161/circ.144.suppl_1.9682.
Samfura akwai don amfani da bincike kawai:
