Na Cocer Peptides 
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INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
1. Incamake
Slu-PP-332, intungamubiri ya estrogene ya reseptor ifitanye isano n'imfubyi (ERR) agonist, irashobora kugira ingaruka nziza kubuzima bwabantu muburyo bwinshi. Uhereye ku miterere yimiti, ni mubyiciro byihariye bya molekile ntoya ishobora guhuza neza na reseptor ya ERR, bityo igakora urukurikirane rwibisubizo byumubiri. Bitandukanye nibiyobyabwenge gakondo cyangwa uburyo bwo kugenzura imikorere yumubiri, Slu-PP-332 ikoresha amabwiriza ya physiologiya yibasira reseptor ya ERR.
Igishushanyo 1 Imiterere yimiti ya Slu-PP-332.
2. Uburyo bwibikorwa
Amabwiriza yo Guhindura Ingufu: Slu-PP-332 yerekana ingaruka zikomeye zoguhindura imbaraga za metabolism. Ikora reseptor ya ERR, ikongerera ingufu ingufu. Kurwego rwa selile, byongera imikorere ya mitochondial kandi bigatezimbere imikorere yubuhumekero ya selile, bigatuma selile zihindura intungamubiri mumbaraga neza. Mu ngirangingo z'imitsi ya skeletale, Slu-PP-332 itera imvugo ya gen bifitanye isano, igatera okiside ya aside irike, bigatuma ibinure bikoreshwa neza nkisoko yingufu kandi bikagabanya kwirundanya kw'amavuta. Izi ngaruka zigana imbaraga za metabolisme yumubiri mugihe cyimyitozo ngororamubiri, ituma umubiri ukomeza gukoresha ingufu nyinshi ndetse no kuruhuka, bifasha kugumana ibiro byiza no kuzamura imiterere ya metabolike muri rusange.
Kunoza imikorere yimitsi ya skeletale: Kubijyanye n'imitsi ya skeletale, Slu-PP-332 yerekana ingaruka nziza. Irashobora gukora imyitozo ikaze ya aerobic imyitozo ngengabuzima, biterwa na reseptor ya ERRα. Ubushakashatsi bwerekanye ko nyuma yo guha Slu-PP-332 imbeba, habayeho kwiyongera kwa fibre yo mu bwoko bwa IIa oxydeide skeletal imitsi, byongera kwihanganira imitsi. Ubwoko bwa IIa fibre ifite imbaraga nyinshi za okiside, ituma ikoreshwa neza rya ogisijeni kugirango itange ingufu, bityo imitsi imara igihe kirekire. Kubantu, ibi byerekana ko Slu-PP-332 ishobora gufasha kunoza kwihangana kwimyitozo ngororamubiri, bikaba byungura inyungu abakinnyi bombi bashaka kuzamura imikorere nabantu bagamije kuzamura ubushobozi bwumubiri bwa buri munsi. Kwiyongera kwimitsi ya skeletale imikorere ya mitochondrial irashobora kandi gufasha kugabanya umunaniro wimitsi no kwihuta gukira nyuma yimyitozo.
Kubungabunga imikorere yumutima: Estrogene yakira imfubyi zijyanye no kwakira impfubyi ERRα na ERRγ ninzego zingenzi zigenga umutima. Imbeba zabuze ERRα na ERRγ zitera umutima wica umutima ndetse no kunanirwa k'umutima. Nka ERR agonist ikora neza, Slu-PP-332 igira uruhare runini mugukomeza imikorere yumutima. Abashakashatsi batewe no kunanirwa k'umutima ku mbeba z'abagabo bakuze binyuze muri aortic coarctation (TAC) hanyuma batanga Slu-PP-332 kugira ngo bavurwe. Ubuvuzi bwa Slu-PP-332 bwateje imbere cyane igice cyo gusohora imbeba, ikimenyetso cyingenzi cyimikorere yo kuvoma umutima, byerekana ubwiyongere bwumutima. Yateje imbere kandi ultrastructure ya mitochondrial, igabanya fiboside yumutima, kandi ihindura imvugo idasanzwe ya genes zifitanye isano. Izi mpinduka hamwe zigira uruhare mukubungabunga imiterere yimikorere yumutima. Slu-PP-332 kunoza imikorere yumutima biterwa no kongera imikorere ya mito-iyambere no kugenzura inzira ya metabolisme ya aside irike, itanga uburyo bushya bwo kuvura kunanirwa k'umutima.
3. Porogaramu
Imikino yubuvuzi bwa siporo: Mubuvuzi bwa siporo, Slu-PP-332 ifite amahirwe menshi yo gukoreshwa. Kubakinnyi, birashobora kuba nkibikorwa bishya byongera imikorere. Mugutezimbere kwihanganira imyitozo no kugabanya umunaniro wimitsi, abakinnyi barashobora kwitwara neza mugihe cy'imyitozo n'amarushanwa. Abiruka intera ndende barashobora kwimenyereza kwaguka kwimyitozo ngororamubiri no kunoza amarushanwa nyuma yo gukoreshwa. Kubakunda imyitozo ngororamubiri muri rusange, Slu-PP-332 irashobora kubafasha kugera kumikorere myiza yingufu za metabolisme mugihe cyimyitozo ngororamubiri, kunoza imikorere yimyitozo ngororamubiri, kugabanya ububabare bwimitsi nyuma yimyitozo ngororangingo nibindi bitameze neza, no guteza imbere gukira kumubiri, kubafasha kwitabira cyane mumyitozo namahugurwa. Kubadashoboye gukora imyitozo yimbaraga nyinshi kubera kugabanuka kwimikorere yumubiri, nkabasaza cyangwa abarwayi bafite indwara zimwe na zimwe zidakira, Slu-PP-332 itezimbere imikorere yimitsi hamwe ningufu za metabolisme, ibafasha gukora imyitozo yoroheje bityo bikazamura imibereho yabo.
Kuvura indwara ya metabolike: Mu kuvura indwara ziterwa na metabolike, Slu-PP-332 nayo yerekana ubushobozi bukomeye. Dufashe urugero rwumubyibuho ukabije, byongera ingufu zikoreshwa kandi bikagabanya kwegeranya ibinure, bitanga uburyo bushya bwo kuvura abarwayi bafite umubyibuho ukabije. Ubushakashatsi bwibanze bwerekana ko mubyokurya biterwa nimirire yabyibushye cyangwa imbeba ya ob / ob imbeba, imiyoborere ya Slu-PP-332 igabanya neza uburemere bwumubiri kandi ikanonosora insuline. Ibi kandi ni ingirakamaro ku barwayi barwaye diyabete yo mu bwoko bwa 2, kubera ko kurwanya insuline ari bumwe mu buryo bw'ingenzi bwa diyabete yo mu bwoko bwa 2. Slu-PP-332 itezimbere insuline, bityo igafasha kugenzura neza urugero rwa glucose yamaraso. Ku bantu barwaye syndrome de metabolike, Slu-PP-332 irashobora guteza imbere byimazeyo indwara nyinshi ziterwa na metabolike, nka dyslipidemiya na hypertension, bityo bikagabanya ibyago byingaruka nkindwara zifata umutima.
4. Umwanzuro
Kwirinda no kuvura indwara z'umutima: Bitewe n'ingaruka nziza za Slu-PP-332 ku mikorere y'umutima, ifite agaciro gakomeye mu rwego rwo kwirinda no kuvura indwara z'umutima. Ku barwayi bananirwa n'umutima, uburyo bwo kuvura ubu ni buke, ariko Slu-PP-332 itezimbere imikorere yumutima mu kongera imikorere ya mitochondrial no kugenzura metabolisme ya aside irike, itanga intego nshya yo kuvura kunanirwa k'umutima. Ku baturage bafite ibyago byo kurwara umutima, nk'abafite umuvuduko ukabije w'amaraso cyangwa indwara z'umutima, Slu-PP-332 irashobora kugira uruhare mu gukumira ikomeza metabolisme y'umutima n'imikorere isanzwe, bityo bikagabanya ibyago byo kurwara umutima. Muri make, Slu-PP-332, nkikomatanya hamwe nuburyo bwihariye bwibikorwa, birashobora kunoza imikorere yumubiri.
Inkomoko
[1] Nasri H. Ibyiringiro bishya kuri 'SLU-PP-332 ' nkumukozi mwiza wo kugabanya ibiro hamwe ningaruka zo kurinda impyiko zitaziguye; icyerekezo cya neprologiya [J]. Ikinyamakuru cya Endocrinology, 2024. https://api.semanticscholar.org/CorpusID:267189187.
[2] Billon C, Sitaula S, Banerjee S, n'abandi. Sintetike ERR $ alpha $ Agonist itera imyitozo ikaze yindege ya Aerobic kandi ikongerera ubushobozi imyitozo [J]. Biorxiv, 2022. https://api.semanticscholar.org/CorpusID:252819965.
[3] Xu W, Billon C, Li H, n'abandi. Ibisobanuro 9682: Ingaruka zo Kurinda Umutima Ingaruka za Sintezitike ya Pan-Estrogene ifitanye isano na Receptor Agoniste Slu-pp-332 na Slu-pp-915 [J]. Kuzenguruka, 2021,144.DOI: 10.1161 / umuzenguruko.144.suppl_1.9682.
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