1 khoom (10Vials)
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▎ TB4
Raws li ib tug hluavtaws analogue ntawm Thymosin Beta-4 (Tβ4), TB4 yog ib tug polypeptide molecule nrog ntau yam kev ua ub no lom. Nws cov txheej txheem tseem ceeb ntawm kev ua tiav yog ua tiav los ntawm kev tswj hwm qhov sib npaug ntawm qhov sib npaug ntawm cov polymerization thiab depolymerization ntawm actin hauv cytoskeleton. Cov molecule no tuaj yeem txhawb nqa cell migration, proliferation, thiab sib txawv, yog li ua lub luag haujlwm tseem ceeb hauv cov txheej txheem kho cov ntaub so ntswg thiab rov tsim dua tshiab. Hauv kev kho qhov txhab ntawm daim tawv nqaij, TB4 tuaj yeem ua kom lub qhov txhab kaw, txhawb kev txiav txim siab ntawm collagen, thiab inhibit qhov txawv txav ntawm cov kab mob caws pliav. Nyob rau hauv lub tshav pob ntawm cov kab mob metabolic, nws alleviates o ntawm pathological txheej txheem xws li tsis-alcoholic fatty siab kab mob thiab pulmonary fibrosis los ntawm inhibiting kev tso tawm ntawm pro-inflammatory yam. Nyob rau hauv cov nqe lus ntawm kev tiv thaiv kab mob plawv, thaum lub sij hawm mob myocardial infarction, TB4 tuaj yeem tiv thaiv cov neeg muaj sia nyob cardiomyocytes, qhib cov txheej txheem endogenous angiogenesis, optimize myocardial microcirculation, thiab thaum kawg txhim kho lub plawv dhia ua haujlwm. Nws tsim nyog sau cia tias TB4 nthuav tawm bioavailability siab, muaj txiaj ntsig zoo ntawm ntau lub hom phiaj, thiab biocompatibility zoo heev. Nws qhov tshwj xeeb cov ntaub so ntswg-targeting cuab yeej ua rau nws ua ncaj qha rau microenvironment ntawm cov ntaub so ntswg puas. Thaum ua tiav cov kev kho mob zoo, nws txo qis qhov kev pheej hmoo ntawm kev raug mob, muab lub hauv paus theoretical thiab kev txhawb nqa rau kev siv tshuaj kho mob.
▎ PAB157
BPC 157 yog ib qho hluavtaws peptide uas tsim los ntawm kaum tsib amino acids, thiab nws lub npe tag nrho yog Lub Cev Tiv Thaiv Lub Cev 157. Cov molecule no tau pib los ntawm kev cais cov proteins los ntawm cov kua txiv hmab txiv ntoo thiab tom qab ntawd muab cov khoom sib xyaw ua ke. Kev tshawb fawb qhia tau hais tias BPC 157 muaj ntau yam kev ua haujlwm lom neeg, suav nrog kev txhawb nqa cov ntaub so ntswg kho, tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv kab mob, thiab tshuaj tiv thaiv antioxidant. Hauv kev kho cov ntaub so ntswg, BPC 157 tuaj yeem ua kom cov txheej txheem kho kom zoo ntawm cov ntaub so ntswg xws li daim tawv nqaij, cov leeg, thiab ligaments, tshwj xeeb tshaj yog qhia tau zoo heev hauv kev kho cov qhov txhab hlawv. Nws cov txheej txheem ntawm kev ua haujlwm suav nrog kev txhim kho kev loj hlob, kev tsiv teb tsaws, thiab tubule tsim muaj peev xwm ntawm cov hlwb endothelial, yog li txhawb nqa angiogenesis thiab cov ntaub so ntswg rov tsim dua. Nyob rau hauv cov nqe lus ntawm neuroprotection, BPC 157 plays lub luag hauj lwm zoo nyob rau hauv lub hauv paus paj hlwb system los ntawm kev tswj cov theem ntawm neurotransmitters xws li serotonin thiab dopamine, thiab tuaj yeem txhim kho cov teeb meem xws li plab zom mov, malabsorption, thiab kev tiv thaiv kab mob.
Tsis tas li ntawd, BPC 157 nthuav tawm cov tshuaj tiv thaiv kab mob tseem ceeb thiab cov tshuaj tiv thaiv kab mob, uas tuaj yeem tswj kev ncaj ncees ntawm lub plab hnyuv mucosa thiab tiv thaiv kev cuam tshuam ntawm cov kab mob thiab co toxins rau hauv txoj hnyuv. Hais txog kev tiv thaiv daim siab, cov molecule no muaj kev tiv thaiv tseem ceeb ntawm daim siab ua haujlwm los ntawm inhibiting qhov txawv txav ntawm cov cell proliferation, tswj cov txheej txheem ntawm hepatocytes, stabilizing enzymatic indices, txo cov theem ntawm inflammatory yam, thiab inhibiting cov txheej txheem ntawm daim siab fibrosis. Piv nrog rau lwm cov tshuaj, qhov zoo ntawm BPC 157 yog nyob rau hauv nws cov toxicity tsawg thiab tsis muaj cov kev phiv tseem ceeb, uas qhia tau hais tias muaj kev nyab xeeb thiab kam rau ua nyob rau hauv ntau yam tsiaj qauv. Tam sim no, BPC 157 tsis tsuas yog muaj cov txiaj ntsig tshwj xeeb hauv kev kho cov kab mob hauv plab hnyuv, tab sis kuj tseem qhia tau tias muaj txiaj ntsig zoo hauv kev txhawb nqa cov ntaub so ntswg, txhim kho kev ua haujlwm ntawm lub paj hlwb, thiab kev tiv thaiv kev laus.
▎ PAB157
Raws li ib txwm muab los ntawm tripeptide tooj liab chelate, GHK-Cu yog ib qho khoom siv bioactive molecule. Nws cov qauv tseem ceeb yog ib qho chaw ruaj khov uas tsim los ntawm tripeptide ntawm glycine-histidine-lysine thiab tooj liab ions. Los ntawm kev tswj cov txheej txheem metabolic dynamic ntawm tooj liab ions, cov molecule no nthuav tawm ntau yam kev ua haujlwm lom neeg, suav nrog antioxidant, tiv thaiv kev mob, thiab txhawb kev sib txuas ntawm collagen. Hauv kev lag luam ntawm kev zoo nkauj thiab kev tu tawv nqaij, GHK-Cu tuaj yeem txo cov tawv nqaij laus, ua kom cov txheej txheem kho qhov txhab, txhim kho daim tawv nqaij elasticity, thiab tib lub sijhawm siv cov tshuaj tiv thaiv kab mob thiab antioxidant. Tsis tas li ntawd, nws cov dej num lom neeg kuj tseem cuam tshuam txog kev txhawb cov plaub hau kev noj qab haus huv, tswj cov noob qhia, thiab pab kho cov kab mob tshwj xeeb. Raws li qhov tshwm sim bioactive molecule, GHK-Cu qhia tau hais tias muaj peev xwm siv tau zoo hauv kev ncua kev laus, txhim kho daim tawv nqaij microenvironment, thiab txhim kho cov ntaub so ntswg. Nws ntau lub hom phiaj ntawm kev nqis tes ua endows nws nrog dav daim ntawv thov kev cia siab hauv kev zoo nkauj, tiv thaiv kev laus, thiab kev kho mob. Kev tshawb fawb tam sim no qhia ntxiv tias GHK-Cu tuaj yeem paub txog nws txoj kev qhuab qhia tus nqi hauv biomedicine thiab tshuaj pleev ib ce los ntawm ntau lub tswv yim xws li kev tswj hwm txoj hauv kev ntawm tes, txhim kho cov metabolism hauv cell, thiab ua kom cov ntaub so ntswg microenvironment zoo dua.
▎ Cov ntsiab lus
Kev sib xyaw ua ke ntawm TB500, BPC157, thiab GHK-Cu muaj ntau yam muaj txiaj ntsig thiab txiaj ntsig hauv kev kho mob, kho cov nqaij mos, tiv thaiv kab mob, tiv thaiv kab mob, thiab kev noj qab haus huv ntawm daim tawv nqaij thiab kev zoo nkauj.
1. Kev noj qab haus huv ntawm daim tawv nqaij thiab kev zoo nkauj
Txhim kho daim tawv nqaij elasticity:
GHK-Cu tuaj yeem txhawb kev tsim cov collagen thiab elastin, ua rau daim tawv nqaij firmer thiab elastic dua. Collagen thiab elastin yog cov khoom tseem ceeb rau kev tswj cov tawv nqaij elasticity. Cov nyhuv ntawm GHK-Cu tuaj yeem ua rau daim tawv nqaij elasticity thiab txo cov tsos ntawm wrinkles thiab kab zoo. TB500 thiab BPC157 tuaj yeem txhawb kev kho thiab rov tsim dua tshiab ntawm daim tawv nqaij. Lawv tuaj yeem ua kom cov kab mob ntawm daim tawv nqaij zoo, txo cov caws pliav, thiab tib lub sijhawm txhawb cov metabolism hauv cov tawv nqaij, ua rau cov tawv nqaij noj qab haus huv.
Kev siv ua ke ntawm peb cov tshuaj no yuav muaj txiaj ntsig zoo hauv kev tiv thaiv kev laus thiab kev zoo nkauj ntawm daim tawv nqaij. Lawv ua rau ntawm daim tawv nqaij ua ke, txhim kho kev noj qab haus huv thiab zoo li ntawm daim tawv nqaij los ntawm ntau yam, ua rau cov tawv nqaij hluas thiab muaj zog dua.
Txhawb kev kho daim tawv nqaij:
Rau kev raug mob ntawm daim tawv nqaij xws li kub hnyiab, scalds, thiab txiav, peb cov tshuaj no tuaj yeem ua kom cov txheej txheem kho ntawm daim tawv nqaij thiab txo cov caws pliav. BPC157 tau pom tias muaj txiaj ntsig zoo hauv kev txhawb kev kho mob ntawm daim tawv nqaij hauv cov qauv nas ntawm alkali kub hnyiab. Nws tuaj yeem ua kom lub qhov txhab kaw thiab txhawb kev tsim cov ntaub so ntswg granulation, rov epithelialization, dermal remodeling, thiab collagen deposition [1] . TB500 thiab GHK-Cu kuj tseem tuaj yeem ua kom cov txheej txheem kho ntawm daim tawv nqaij los ntawm kev txhawb nqa kev loj hlob ntawm tes thiab kho, nrog rau kev tsim cov collagen.
2. Kho qhov txhab thiab kho daim ntaub so ntswg
Accelerating qhov txhab kho:
Ob leeg TB500 thiab BPC157 muaj txiaj ntsig los txhawb kev kho qhov txhab. TB500 tuaj yeem ua kom cov cell tsiv teb tsaws thiab kev loj hlob, txhawb kev tsim cov tshuaj angiogenesis, thiab ua kom cov collagen synthesis thiab kho cov ntaub so ntswg. BPC157 kuj ua tau zoo hauv qhov no. Nws tuaj yeem txhawb kev tsim cov nitric oxide thiab txhawb kev tsiv teb tsaws ntawm vascular endothelial hlwb, yog li ua kom lub qhov txhab zoo.
GHK-Cu pab cov tawv nqaij rov qab kho nws tus kheej lub peev xwm los ntawm kev txhawb nqa cov collagen thiab elastin. Collagen thiab elastin yog cov khoom tseem ceeb ntawm cov ntaub so ntswg ntawm daim tawv nqaij, thiab lawv cov khoom tsim tau pab rau qhov txhab thiab kho cov ntaub so ntswg.
Thaum peb cov tshuaj no tau siv ua ke, lawv cov nyhuv synergistic tuaj yeem ua kom lub qhov txhab kho sai thiab ua kom lub sijhawm kho kom luv. Peb yam khoom txhawb kev kho qhov txhab los ntawm qhov sib txawv. TB500 thiab BPC157 feem ntau txhawb kev tsiv teb tsaws ntawm tes, proliferation, thiab angiogenesis, thaum GHK-Cu txhawb kev tsim cov collagen thiab elastin. Raws li kev sib xyaw ua ke, qhov txhab tuaj yeem kho sai dua.
Txhim kho cov ntaub so ntswg zoo:
TB500 pab txhawb kev kho cov ntaub so ntswg. Nws tuaj yeem tswj hwm kev loj hlob ntawm tes thiab kev sib txawv thiab txhawb cov txheej txheem kho cov ntaub so ntswg, ua kom cov ntaub so ntswg kho kom zoo dua. BPC157 tuaj yeem txhim kho kev ncaj ncees thiab ruaj khov ntawm cov ntaub so ntswg. Piv txwv li, nyob rau hauv txoj kev tshawb no ntawm tendon kho, BPC157 txhawb txoj kev loj hlob ntawm tendon fibroblasts los ntawm tendon explants, nce cell ciaj sia nyob rau hauv cov kev ntxhov siab, thiab txhawb cell migration, uas yuav pab txhim khu kev ncaj ncees thiab stability ntawm cov ntaub so ntswg [2] . GHK-Cu tuaj yeem txhawb kev tsim kho ntawm daim tawv nqaij qia hlwb. Cov tawv nqaij qia hlwb ua lub luag haujlwm tseem ceeb hauv kev kho cov ntaub so ntswg. Lawv tuaj yeem sib txawv rau hauv ntau lub hlwb ntawm daim tawv nqaij, ua rau cov ntaub so ntswg kho kom zoo thiab elastic dua.
3. Anti-inflammatory nyhuv
Txo cov inflammatory teb:
Ob leeg BPC157 thiab TB500 muaj cov tshuaj tiv thaiv kab mob. Raws li cov tshuaj antioxidant, GHK-Cu tuaj yeem ua rau cov dawb radicals tsim tawm thaum lub sijhawm ua haujlwm, txo qhov mob ntxiv. Dawb radicals tuaj yeem ua rau cov ntaub so ntswg puas thaum lub sij hawm inflammatory txheej txheem, thiab cov nyhuv antioxidant ntawm GHK-Cu tuaj yeem txo cov tiam ntawm cov dawb radicals, yog li alleviating inflammatory teb.
Kev sib xyaw ua ke ntawm peb cov tshuaj no tuaj yeem muaj txiaj ntsig zoo dua hauv kev kho cov kab mob inflammatory xws li mob caj dab thiab mob leeg. Lawv siv cov tshuaj tiv thaiv kab mob los ntawm cov txheej txheem sib txawv, thiab thaum siv ua ke, lawv tuaj yeem tsim cov nyhuv synergistic thiab txo cov lus teb zoo dua.
4. Neuroprotection thiab kho paj hlwb
Txhawb kev kho paj hlwb:
BPC157 muaj kev tiv thaiv kab mob hauv lub paj hlwb, uas tuaj yeem txhawb kev loj hlob thiab kho cov paj hlwb thiab txhim kho cov paj hlwb. Piv txwv li, qee qhov kev tshawb fawb tau pom tias qhov kev tiv thaiv ntawm BPC157 ntawm lub paj hlwb yuav cuam tshuam rau nws txoj kev ua haujlwm ntawm Src-Cav-1-eNOS txoj kev [3] . GHK-Cu muab qhov chaw zoo rau kev loj hlob rau cov paj hlwb los ntawm kev txhawb nqa kev tsim cov collagen. Collagen kuj tseem ua lub luag haujlwm tseem ceeb hauv cov paj hlwb. Nws tuaj yeem muab kev txhawb nqa thiab cov khoom noj rau cov paj hlwb thiab txhawb kev loj hlob thiab kho cov paj hlwb.
Cov nyhuv synergistic ntawm peb yam khoom no yuav pab kho cov hlab ntsha raug mob thiab cov kab mob neurodegenerative xws li Parkinson's disease thiab Alzheimer's disease. Peb cov khoom txhawb kev kho paj hlwb los ntawm ntau lub kaum ntse ntse. BPC157 thiab TB500 ncaj qha ua rau cov paj hlwb los txhawb lawv txoj kev loj hlob thiab kho, thaum GHK-Cu ua haujlwm ncaj qha los ntawm kev txhim kho qhov chaw loj hlob ntawm cov paj hlwb.
Hais Txog Tus Sau
Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.
▎ Cov Lus Qhia Tseem Ceeb
[1] Huang T, Zhang K, Sun L, et al. Lub cev tiv thaiv compound-157 txhim kho alkali-hlawv qhov txhab kho hauv vivo thiab txhawb nqa kev loj hlob, kev tsiv teb tsaws, thiab angiogenesis hauv vitro. Drug Des Devel Ther 2015; 9: 2485-99.DOI: 10.2147/DDDT.S82030.
[2] Chang C, Tsai W, Lin M, Hsu Y, Pang JS. Kev txhawb nqa cov txiaj ntsig ntawm pentadecapeptide BPC 157 ntawm kev kho cov leeg muaj feem cuam tshuam txog kev loj hlob ntawm tes, kev muaj sia nyob ntawm tes, thiab kev tsiv teb tsaws ntawm tes. J APPL PHYSIOL 2011; 110(3): 774-80.DOI:10.1152/japplphysiol.00945.2010.
[3] Hsieh M, Lee C, Chueh H, et al. Modulatory teebmeem ntawm BPC 157 ntawm vasomotor tone thiab ua kom muaj Src-Caveolin-1-endothelial nitric oxide synthase txoj kev. SCI REP-UK 2020; 10(1): 17078.DOI:10.1038/s41598-020-74022-y.
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.