Glow 70mg (agwakọta)

▎ Bpc157

BPC 157 bụ peptide sịntetị nke mejupụtara amino acid iri na ise, aha ya n'uju bụ Body Protection Compound 157. E nwetara molecule a na mbụ site n'iwepụ protein na ihe ọṅụṅụ gastric wee mepụta ha n'ụzọ artificially. Nnyocha na-egosi na BPC 157 nwere ọtụtụ ọrụ dị ndụ, gụnyere ịkwalite nrụzi anụ ahụ, neuroprotection, mgbochi ọnya, mgbochi mkpali, na mmetụta antioxidant. N'ihe gbasara nrụzi anụ ahụ, BPC 157 nwere ike mee ka usoro ọgwụgwọ nke anụ ahụ jikọtara dị ka akpụkpọ anụ, akwara, na ligaments dịkwuo ngwa ngwa, karịsịa na-egosi arụmọrụ dị mma na nrụzi nke ọnya ọkụ. Usoro ya na-arụ ọrụ gụnyere ịkwalite mmụba, mbugharị, na ikike imepụta tubule nke mkpụrụ ndụ endothelial, si otú ahụ na-akwalite angiogenesis na imeghachi anụ ahụ. N'ihe gbasara neuroprotection, BPC 157 na-arụ ọrụ dị mma na usoro nhụjuanya nke etiti site n'ịhazi ọkwa nke neurotransmitters dị ka serotonin na dopamine, ma nwee ike melite nsogbu ndị dị ka mgbakasị ahụ, malabsorption, na immunodeficiency.

Na mgbakwunye, BPC 157 na-egosiputa ihe mgbochi ọnya na mgbochi mkpali, nke nwere ike ịnọgide na-eguzosi ike n'ezi ihe nke mucosa eriri afọ ma gbochie mwakpo nke nje na nsị n'ime eriri afọ. N'ihe banyere nchebe imeju, molecule a nwere mmetụta nchebe dị ịrịba ama na ọrụ imeju site na igbochi mgbasa nke cell na-adịghị mma, na-edobe iguzosi ike n'ezi ihe nke hepatocytes, na-eme ka indices enzymatic guzosie ike, na-ebelata ọkwa nke ihe ndị na-egbuke egbuke, na-egbochi usoro nke imeju fibrosis. N'iji ya tụnyere ọgwụ ndị ọzọ, uru nke BPC 157 dị na obere nsị ya na enweghị mmetụta dị ịrịba ama, na-egosi ezi nchekwa na nnabata na ụdị anụmanụ dị iche iche. Ka ọ dị ugbu a, BPC 157 ọ bụghị nanị na ọ nwere mmetụta ọgwụgwọ pụrụ iche na ọgwụgwọ nke ọrịa eriri afọ ma na-egosipụtakwa ụkpụrụ ngwa ngwa nwere ike ịkwalite nkwalite anụ ahụ, meziwanye ọrụ nke usoro nhụjuanya nke etiti, na ubi nke mgbochi ịka nká.

 ▎ Bpc157

Dịka chelate ọla kọpa tripeptide sitere n'okike, GHK-Cu bụ molekul bioactive multifunctional. Nhazi ya bụ ihe mgbagwoju anya kwụsiri ike site na tripeptide nke glycine-histidine-lysine na ion ọla kọpa. Site n'ịhazi usoro metabolic dị ike nke ion ọla kọpa, molecule a na-egosipụta ọtụtụ ọrụ ndu, gụnyere antioxidant, mgbochi mkpali, na ịkwalite njikọ nke collagen. N'ihe banyere ịma mma na nlekọta anụ ahụ, GHK-Cu nwere ike belata ịka nká nke anụ ahụ nke ọma, mee ka usoro ọgwụgwọ ọnya dịkwuo ngwa, mee ka akpụkpọ ahụ dịkwuo mma, ma n'otu oge ahụ na-egosipụta mmetụta mgbochi mkpali na antioxidant. Tụkwasị na nke ahụ, a na-egosipụtakwa ihe omume ya n'ịkwalite ahụike ntutu, ịchịkwa mkpụrụ ndụ ihe nketa, na inye aka n'ịgwọ ọrịa ụfọdụ. Dị ka ihe na-apụta bioactive molecule, GHK-Cu na-egosi nnukwu ngwa ngwa na-egbu oge ịka nká, melite microenvironment akpụkpọ, na ịkwalite ikike nrụzi anụ ahụ. Usoro ihe omume ya nwere ọtụtụ ebumnuche na-enye ya atụmanya ngwa ngwa n'akụkụ ịma mma, mgbochi ịka nká, na nlekọta ahụike. Nnyocha e mere ugbu a n'ihu na-egosi na GHK-Cu nwere ike ghọta uru ntinye aka ya na biomedicine na sayensị ịchọ mma site n'ọtụtụ usoro dị ka ịchịkwa ụzọ mgbaàmà cell, ịkwalite ọrụ metabolic cell, na ịkwalite microenvironment anụ ahụ.

▎ Nchịkọta

Ngwakọta ejikọtara ọnụ nke TB4, BPC157, na GHK-Cu nwere ọtụtụ mmetụta na uru dị na ọgwụgwọ ọnya, nrụzi anụ ahụ, mgbochi mbufụt, neuroprotection, na ahụike anụ ahụ na ịma mma.

1. Ahụ Ike Skin na Mma

Na-emeziwanye nhịahụ akpụkpọ: 

GHK-Cu nwere ike ịkwalite mmepụta nke collagen na elastin, na-eme ka akpụkpọ ahụ dịkwuo ike ma na-agbanwe. Collagen na elastin bụ ihe dị mkpa na-eme ka akpụkpọ ahụ dịkwuo mma. Mmetụta nke GHK-Cu nwere ike ime ka akpụkpọ ahụ dịkwuo mma ma belata ọdịdị nke wrinkles na ahịrị dị mma. TB4 na BPC157 nwere ike ịkwalite nrụzi na imegharị mkpụrụ ndụ akpụkpọ ahụ. Ha nwere ike mee ka ọgwụgwọ nke ọnyá akpụkpọ ahụ dịkwuo ngwa ngwa, belata ọkpụkpụ ọkpụkpụ, ma n'otu oge ahụ na-akwalite metabolism nke mkpụrụ ndụ akpụkpọ anụ, na-eme ka akpụkpọ ahụ dịkwuo mma.

Ejikọta ihe atọ ndị a nwere ike inwe mmetụta dị ukwuu na mgbochi ịka nká na nlekọta anụ ahụ mara mma. Ha na-emekọ ọnụ na akpụkpọ ahụ, na-eme ka ahụ ike na ọdịdị nke akpụkpọ ahụ dị iche iche dịkwuo mma, na-eme ka akpụkpọ ahụ dị obere ma na-egbuke egbuke.

Na-akwalite mmezi anụ ahụ: 

Maka mmerụ ahụ akpụkpọ ahụ dị ka ọkụ, ọkụ, na mbepụ, ihe atọ ndị a nwere ike ime ka usoro ọgwụgwọ anụ ahụ dịkwuo ngwa ma belata ọkpụkpụ ọkpụkpụ. BPC157 egosila mmetụta dị ukwuu n'ịkwalite ọgwụgwọ ọnya anụ ahụ n'ụdị oke oke ọkụ alkali. Ọ nwere ike mee ka mmechi ọnya dịkwuo ngwa ma kwalite nhazi anụ ahụ granulation, re-epithelialization, dermal remodeling, na collagen deposition ^[1] . TB4 na GHK-Cu nwekwara ike mee ka usoro ọgwụgwọ anụ ahụ dịkwuo ngwa site n'ịkwalite uto na nrụzi cell, yana mmepụta nke collagen.

2. Ọgwụgwọ ọnya na mmezi anụ ahụ

Na-eme ka ọgwụgwọ ọnya dị ngwa ngwa: 

Ma TB4 na BPC157 nwere mmetụta nke ịkwalite ọgwụgwọ ọnya. TB4 nwere ike mee ka mbugharị cell na mmụba dịkwuo elu, na-akwalite angiogenesis, ma mee ka njikọ collagen dịkwuo elu na nrụzi anụ ahụ. BPC157 na-arụkwa ọrụ nke ọma na nke a. Ọ nwere ike ịkpalite mmepụta nke nitric oxide ma kwalite mbugharị nke sel endothelial vaskụla, si otú a na-eme ka ọgwụgwọ ọnya dịkwuo ngwa.

GHK-Cu na-enyere akpụkpọ ahụ aka iweghachi ikike imezi onwe ya site n'ịkwalite mmepụta nke collagen na elastin. Collagen na elastin bụ akụkụ dị mkpa nke anụ ahụ anụ ahụ, mmepụta ha na-enye aka maka ọgwụgwọ ọnya na nrụzi anụ ahụ.

Mgbe a na-eji ihe atọ ndị a na-ejikọta ọnụ, mmetụta synergistic ha nwere ike ime ka ọnyá ahụ dịkwuo ngwa ngwa ma belata oge ọgwụgwọ. Ihe atọ ahụ na-akwalite ọgwụgwọ ọnya site n'echiche dị iche iche. TB4 na BPC157 na-akwalite mbugharị cell, mmụba, na angiogenesis, ebe GHK-Cu na-akwalite mmepụta nke collagen na elastin. N'okpuru ihe ejikọtara ọnụ, ọnya ahụ nwere ike ịgwọ ngwa ngwa.

Imelite ogo nrụzi anụ ahụ: 

TB4 na-atụnye ụtụ na nrụzi anụ ahụ n'usoro. Ọ nwere ike ịhazi uto cell na ọdịiche dị iche iche ma kwalite usoro nrụzi nkịtị nke anụ ahụ, na-eme ka anụ ahụ na-edozi ahụ dịkwuo n'usoro. BPC157 nwere ike ịkwalite iguzosi ike n'ezi ihe na nkwụsi ike nke anụ ahụ. Dịka ọmụmaatụ, n'ọmụmụ ihe gbasara ọgwụgwọ akwara, BPC157 kwalitere ọganihu nke fibroblasts tendon site na mkpịsị aka ọkpụkpụ, ịba ụba cell ndụ n'okpuru ọnọdụ nrụgide, na ịkwalite ịkwaga cell, nke nwere ike inye aka mee ka iguzosi ike n'ezi ihe na nkwụsi ike nke anụ ahụ ^[2] . GHK-Cu nwere ike kwalite mmụgharị nke sel steepụ akpụkpọ ahụ. Mkpụrụ ndụ akpụkpọ anụ na-arụ ọrụ dị mkpa n'imezi anụ ahụ. Ha nwere ike ịwapụta n'ime mkpụrụ ndụ akpụkpọ ahụ dị iche iche, na-eme ka anụ ahụ ndị a na-edozi ahụ dịkwuo mma ma dịkwuo mma.

3. Mmetụta mgbochi mkpali

Na-ebelata nzaghachi mkpali: 

Ma BPC157 na TB4 nwere ihe mgbochi mkpali. Dị ka antioxidant, GHK-Cu nwekwara ike kwụsịlata radicals free emepụtara n'oge usoro mkpali, na-ebelata mbufụt. Ndị na-emepụta ihe na-emepụta ihe nwere ike imebi anụ ahụ n'oge usoro mkpali, na mmetụta antioxidant nke GHK-Cu nwere ike ibelata ọgbọ nke free radicals, si otú ahụ na-ebelata nzaghachi mkpali.

Ijikọta ihe atọ ndị a nwere ike inwe mmetụta ọgwụgwọ ka mma n'ịgwọ ọrịa ndị na-akpasu iwe dị ka ogbu na nkwonkwo na ahụ ọkụ. Ha na-egosipụta mmetụta mgbochi mkpali site na usoro dị iche iche, na mgbe ejiri ya mee ihe, ha nwere ike ịmepụta mmetụta synergistic ma mee ka ọ dịkwuo irè belata nzaghachi mkpali.

4. Neuroprotection na Nrụzi akwara

Na-akwalite mmezi akwara: 

BPC157 nwere mmetụta nchebe na usoro ụjọ ahụ, nke nwere ike ịkwalite uto na mmezi nke mkpụrụ ndụ akwara ma melite ọrụ akwara. Dịka ọmụmaatụ, ụfọdụ ọmụmụ egosila na mmetụta nchebe nke BPC157 na usoro ụjọ ahụ nwere ike jikọta ya na ntinye nke ụzọ Src-Cav-1-eNOS ^[3] . GHK-Cu na-enye ọnọdụ uto dị mma maka mkpụrụ ndụ akwara site n'ịkwalite mmepụta nke collagen. Collagen na-arụkwa ọrụ dị mkpa na anụ ahụ akwara. Ọ nwere ike inye nkwado na nri maka mkpụrụ ndụ akwara ma kwalite uto na mmezi nke mkpụrụ ndụ akwara.

Mmetụta synergistic nke ihe atọ a nwere ike inye aka na-agwọ mmerụ ahụ akwara na ọrịa neurodegenerative dị ka ọrịa Parkinson na ọrịa Alzheimer. Ihe atọ ndị a na-akwalite nrụzi akwara site n'akụkụ dị iche iche. BPC157 na TB4 na-arụ ọrụ ozugbo na mkpụrụ ndụ akwara iji kwalite uto na nrụzi ha, ebe GHK-C na-arụ ọrụ na-apụtaghị ìhè site n'ịkwalite gburugburu uto nke mkpụrụ ndụ akwara.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

▎ Okwu ndị dị mkpa

[1] Huang T, Zhang K, Sun L, et al. Ngwakọta nchekwa ahụ-157 na-eme ka ọgwụgwọ ọnya alkali na-ere ọkụ na vivo ma na-akwalite mmụba, mbugharị, na angiogenesis na vitro. Drug Des Devel Ther 2015; 9: 2485-99.DOI:10.2147/DDDT.S82030.

[2] Chang C, Tsai W, Lin M, Hsu Y, Pang JS. Mmetụta na-akwalite pentadecapeptide BPC 157 na ọgwụgwọ akwara gụnyere mpụta akwara, ịlanarị cell, na mbugharị cell. J APPL PHYSIOL 2011; 110 (3): 774-80.DOI:10.1152/japplphysiol.00945.2010.

[3] Hsieh M, Lee C, Chueh H, et al. Mmetụta modulatory nke BPC 157 na ụda vasomotor na ntinye nke Src-Caveolin-1-endothelial nitric oxide synthase ụzọ. SCI REP-UK 2020; 10(1): 17078.DOI:10.1038/s41598-020-74022-y.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadobeghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.