▎ DSIP Sɛgɛsɛgɛli
DSIP ka ɲininiw kɛcogo ye mun ye?
San 1970 waatiw la, sunɔgɔ ɲininiw cayara kosɛbɛ, wa dɔnnikɛlaw tun b’a fɛ kosɛbɛ ka sunɔgɔ labɛnni gundo ɲɛfɔ. San 1977, Suwisi jamana ka furakɛlikɛla Schönenberg n’a ka kulu ye DSIP sɔrɔ bala la k’u to laɲɔw ka sunɔgɔcogo sɛgɛsɛgɛli la. O ye pepitiri tɛ min na, a bɛ sɔrɔ asidi aminiki kɔnɔntɔn fɛ, o bɛ sɔrɔ hipotalamus ni pituitaire glande la. O waati kɔnɔ, ɲɛtaa caman kɛra pepitiri dɔnniya la. Ameriki dɔnnikɛla Kastin ni Hollande dɔnnikɛla de Wied ye hakilina dɔ jira ko pepitiriw bɛ se ka joli ni kunkolo cɛsira tigɛ, o kɛra sababu ye ka ɲinini nataw jusigilan sigi DSIP kan. O bɛɛ kɔfɛ, kunkolo lakananen don kosɛbɛ joli ni kunkolo barikalan fɛ, wa fɛn fanba donni ka gɛlɛn. Ni DSIP bɛ se ka o gɛlɛya in tɛmɛ, o bɛna nɔba bila a jɔyɔrɔ la hakili ka sunɔgɔ labɛnni fɛɛrɛ la.
Kalan minnu kɛra o kɔfɛ, olu y’a jira ko DSIP tɛ sɔrɔ kunsɛmɛ yɔrɔ kɛrɛnkɛrɛnnenw dɔrɔn na, nka a bɛ sɔrɔ fana limbic system kɔnɔ cogo la min bɛ hɔrɔnya walima a sirilen na, ani fana a bɛ sɔrɔ farikolo yɔrɔ suguya caman na, farikolo yɔrɔw la ani farikolojiw la. Misali la, sɔgɔsɔgɔninjɛ la, a bɛ sigi ɲɔgɔn fɛ ni pepitiri suguya caman ye ani pepitiri tɛ cɛmancɛlafɛnw ye i n’a fɔ adɛrɛnokɔritikotropi ɔrimɔni. Banakɔtaa gundolafɛnw ni kɔnɔbara la, a ni glucagon bɛ ɲɔgɔn fɛ. Nin tilali jɛnsɛnnen in b’a jira ko DSIP bɛ se ka baara suguya caman kɛ ani ka gɛlɛn. A daminɛ na, DSIP tun bɛ jate sunɔgɔ pepitiri ye. Ni ɲininiw juguyara, a jirala ko a nɔ min bɛ farikolo la, o tɛ dan sunɔgɔ dɔrɔn ma. Kalan dɔw y’a jira ko a bɛ se ka jɔyɔrɔba ta degun jaabi ni dimi faamuyali la, wa a bɛ se ka kɛ sababu ye ka jɔrɔnanko lajɔ ani ka dimi dɔgɔya, nka hali bi o nɔ ninnu ka kan ka sɛgɛsɛgɛ ɲinini caman fɛ.
DSIP ka baarakɛcogo ye mun ye?
Sunɔgɔ ni kununni labɛnni
Sunɔgɔ ni kununni taabolo nɔ bilali la: Kalan damadɔ y’a jira ko DSIP bɛ nɔba bila sunɔgɔ ni kununni na ka ɲɛsin sariyaw ma. Misali la, sɛgɛsɛgɛli dɔ la, cɛ min si bɛ san 35 la, o pikiri kɛra ni DSIP ye siɲɛ caman, wa a jateminɛna a yɛrɛ ka fɔta fɛ, baarakɛcogo sɛgɛsɛgɛli fɛ, sunɔgɔ latɛmɛni sɛgɛsɛgɛli caman fɛ, ani su bɛɛ polisomnografi fɛ. A jirala ko DSIP ye dɔ bɔ sunɔgɔ binkanniw caya la, ka dɔ fara tile baara kan, ka kɔlɔsili kɛ ani ka baara kɛ [1] . DSIP ye sunɔgɔ waati degun ani ka ɲɛ lamaga teliya (REM) sunɔgɔ bonya. Jateminɛw y’a jira ko nin nɔ ninnu bɛ bɔ DSIP ka circadian rhythm ni ultradian rhythm fanga bonya. DSIP bɛ se ka farikolo yɔrɔw labɛncogo sabati minnu bɛ tali kɛ sunɔgɔ daminɛ na.
Sunɔgɔ cogoya labɛnni : DSIP tɛ nɔ bila sunɔgɔ kɛcogo ni a kuntaala dɔrɔn na, nka a bɛ nɔ bila sunɔgɔ cogoya fana na. A bɛ se ka REM sunɔgɔ bonya, o b’a jira ko a jɔyɔrɔ ka bon sunɔgɔ taabolo suguya wɛrɛw labɛnni na.
Farikoloɲɛnajɛ nɔ minnu bɛ sɔrɔ
A bɛ nɔ minnu bila funteni hakɛ la, dusukun tantanni, tansiyɔn, dimi hakɛ ani farikolojidɛsɛbanakisɛw la: Ka fara sunɔgɔ sabatili kan baganw na cogo kɛrɛnkɛrɛnnenw na, DSIP bɛ nɔ suguya caman kɛ farikolo la. Misali la, DSIP bɛ se ka nɔ bila funteni hakɛ la, dusukun tantanni na, tansiyɔn na, dimi hakɛ la, ani farikolojidɛsɛ la [2] . DSIP nɔ ninnu bɛ bɔ waati kɔnɔna na, wa a nɔ dɔw bɛ bɔ ka kɔn sunɔgɔ taamasiɲɛw ɲɛ minnu bɛ sɔrɔ senfagabana walima kɛwalew fɛ. O b’a jira ko DSIP bɛ se ka farikolo labɛncogo daminɛ sani sunɔgɔ ka daminɛ.
Antioxydant (banakisɛfagalan) nɔ
Kɔlɔsiliw y’a jira ko DSIP kɛnɛma pikiri (100μg/kg farikolo girinya, pikiri kɛli tile 5 tugu-tugulen) fari jukɔrɔ sosow la minnu si bɛ kalo 2 - 24 la, o bɛ se ka tulumafɛnw tiɲɛni oksidan ni malondialdehyde dalajɛli bali kosɛbɛ sosow la minnu si tɛ kelen ye, olu farikolo yɔrɔw ni u joli la DSIP bɛ ni farikolo tangalan fanga ye, o bɛ sɔrɔ ni farikolo tangalan lakanani fɛɛrɛ suguya caman kɛli ye farikolo kɔnɔ farikolo kɔnɔ ani selilu ni ɲɔgɔn cɛ ji la. DSIP bɛ nɔ bila superoxide dismutase, catalase ani ceruloplasmin ka baara la, wa a bɛ nɔ bila farikolo tangalanw hakɛ la minnu tɛ anzimu ye i n’a fɔ urea ni asidi uriki. Ni fɛnɲɛnamaw farikolo kɔrɔbayara, farikolo tangalanw bɛna bali, ka sɔrɔ DSIP bɛ se ka dɔ fara farikolo tangalan kɔnɔna nafa kan farikolo yɔrɔw ni joli la, kɛrɛnkɛrɛnnenya la ni a bɛ farikolo tangalan farikolo yɔrɔw lawuli, kɛrɛnkɛrɛnnenya la, mɔgɔ kelen-kelen bɛɛ ka yiriwali kɔfɛ.
DSIP ka baarakɛcogo ye mun ye?
Sunɔgɔbaliya furakɛli
Kalan dɔ kɔnɔ, DSIP pikiri furakɛli kɛra sunɔgɔbaliya banabagatɔw kan. Jateminɛw y’a jira ko DSIP pikiri kelen kɛli ni a hakɛ ye 25nmol/kg farikolo girinya ye sani sunɔgɔ ka se, o bɛ se ka sunɔgɔ ɲɛ. Ni aw ye a tali siɲɛ caman, o y’a jira ko sunɔgɔ cogoya bɛ kɛ cogo la, a tali naani kɔfɛ. Pikiri segin-segin sɔgɔmada fɛ, ka fara tile baara caya kan, o tun bɛ nɔ ɲumanba bila sufɛ sunɔgɔ la hali bi, nka a tali siɲɛ fila tile kɔnɔ, o nɔ tun man ɲi. Sunɔgɔbaliya min bɛ sɔrɔ kunsɛmɛnasumaya fɛ, DSIP hakɛ caman bɛ jaabi ɲuman di [1] ..
Nɔgɔbana furakɛli
Cɛ min si bɛ san 35 la, o ye DSIP pikiri kɛ siɲɛ caman sɛgɛsɛgɛli dɔ kɔnɔ. DSIP nɔ minnu bɛ kununni ni sunɔgɔ la, olu jateminɛna yɛrɛlafasali fɛ, baarakɛcogo sɛgɛsɛgɛli fɛ, sunɔgɔ latɛmɛni sɛgɛsɛgɛli caman fɛ, ani su bɛɛ polisomnografi fɛ. Jateminɛw y’a jira ko DSIP ye dɔ bɔ sunɔgɔ binkanniw caya la, ka dɔ fara tile baara kan, ka kɔlɔsili kɛ ani ka baara kɛ. DSIP ye sunɔgɔ waati degun ani ka REM sunɔgɔ bonya. Kalan in jaabiw y’a jira ko nin nɔ ninnu bɛ bɔ DSIP la min bɛ sinsin circadian rhythm ni ultradian rhythm kan [1] ..
Dɔlɔ ni opiyɔmu tali banaw furakɛli
Dɔgɔtɔrɔso furakɛli nɔw : Ka da baganw ka sɛgɛsɛgɛliw jaabiw kan, o kɔrɔ ye ko mɔrini, dɔlɔ, pentobarbital ani DSIP pikiri tilennen kɛli bulboreticular formation-midbrain-thalamus recruitment system kɔnɔ, o bɛ se ka kɛ sababu ye ka sunɔgɔ dɔɔni dɔɔni ani ka spindle wave caman kɛ, wa o nɔ bɛ se ka kɔsegin ni naloxone ye. A jateminɛna ko DSIP bɛ baara kɛ ni agoniste ye opioid talikɛlaw kan, wa a bɛ se ka kɛ nafa bɛ a la fura tali la[3]. DSIP pikiri kɛlen kɔfɛ jolisira fɛ walasa ka banabagatɔ 107 furakɛ minnu bɛ dɔgɔtɔrɔso la, dɔlɔmin taamasiɲɛw bɛ u la (n = 47) walima opiyɔmu (n = 60), dɔgɔtɔrɔw ni dɔgɔtɔrɔw ka kɛnɛyaso jateminɛw y’a jira ko opiyɔmu ni dɔlɔminnaw 97% ni 87%, u ka kɛnɛyako taamasiɲɛw ni u taamasiɲɛw tununna walima u ɲɛnabɔra kosɛbɛ DSIP kɔfɛ tali, ani jɔrɔnanko taamasiɲɛw lajɔli tun bɛ kɛ dɔɔni dɔɔni. Opiyɔmu talikɛlaw ka kɛnɛyaso taamasiɲɛw tun bɛ mɛn ani u tun ka kan ka DSIP pikiri caman kɛ [3] ..
DSIP bɛ se ka dɛmɛnanw di banabagatɔ jumɛnw ma?
Sunɔgɔbaliya bɛ banabagatɔ minnu na: DSIP bɛ se ka sunɔgɔ bila mɔgɔ la ani ka a labɛn. Sunɔgɔbaliya bɛ banabagatɔ minnu na, hali minnu ka sunɔgɔ ka gɛlɛn, minnu ka sunɔgɔ ka nɔgɔn, ani minnu kununni ka nɔgɔn, o bɛ se ka dɛmɛ don ka sunɔgɔcogo ɲɛ, ka sunɔgɔ waati janya, ani ka u dɛmɛ ka sunɔgɔ joona ani ka sunɔgɔ sabatilen to. Ka fara o kan, mɔgɔ minnu ka sunɔgɔcogo bɛ tiɲɛ ka a sababu kɛ jet lag ye, shift baara, a ɲɔgɔnnaw, DSIP bɛ se ka dɛmɛ fana ka sunɔgɔcogo ladilan ani ka sunɔgɔcogo ɲuman segin u cogo kɔrɔ la.
Banabagatɔ minnu bɛ ni farikolojidɛsɛbanaw ye : Farikoloɲɛnajɛ dɔw i n’a fɔ Parkinson ni Alzheimer bana, olu ka teli ka kɛ ni sunɔgɔbaliya ni farikolojidɛsɛ ye. Ka fara sunɔgɔ ɲɛnabɔli kan, DSIP bɛ se ka kɛ sababu ye fana ka farikolo tangacogo dɔ kɛ farikolojidɛsɛbanakisɛw la, ka dɛmɛ don ka farikolojidɛsɛ taamasiɲɛ dɔw lajɔ ani ka banabagatɔw ka ɲɛnamaya kɛcogo ɲɛ. Misali la, Parkinson banabagatɔw la, ni u ye sunɔgɔ ka ɲɛ, o bɛ se ka dɛmɛ don ka tile sɛgɛn ni lamaga-lamagali gɛlɛyaw dɔgɔya.
Banabagatɔ minnu bɛ sɔrɔ degun fɛ : Mɔgɔ minnu bɛ degun kuntaalajan kɔnɔ, i n’a fɔ hakili ni hakilibana bɛ banabagatɔ minnu na i n’a fɔ jɔrɔnanko ni degun, olu ka teli ka sunɔgɔ gɛlɛyaw sɔrɔ ani u farikolo bɛ degun basigilen na. DSIP bɛ se ka farikolo ka degun jaabi labɛn ni sunɔgɔ labɛnni ye, ka dɛmɛ don ka dusukunnataw taamasiɲɛw lajɔ i n’a fɔ jɔrɔnanko ni degun ani ka banabagatɔw bɛɛ ka cogoya ɲɛ. O waati kelen na, farikoloɲɛnajɛ gɛlɛya dɔw la minnu bɛ sɔrɔ degun fɛ, i n’a fɔ dumunikɛbaliya ani farikolo tangacogo dɔgɔyali, DSIP bɛ se ka dɛmɛ jɔyɔrɔ dɔ fana ta ka ɲɛtaa sabati ni sunɔgɔ ɲɛnabɔli ye ani ka degun jaabi labɛn.
Kuncɛli la, DSIP jɔyɔrɔ ka bon sunɔgɔ labɛnni siratigɛ la. A bɛ se ka sunɔgɔbaliya banabagatɔw ka sunɔgɔcogo ɲɛ ka ɲɛ ani ka u ka sunɔgɔ waati janya. Nakɔbanabagatɔw fɛ, a bɛ se ka dɔ bɔ sunɔgɔbaliya la ani ka tile baara ni u ɲɛmajɔli ɲɛ.
A sɛbɛnbaga ko la
Fɛn minnu kofɔlen dòn san fɛ, olu bɛɛ ɲinini Kɛra, k’u Labɛn ani k’u Lajɛ Cocer Peptides fɛ.
Dɔnniya gafe sɛbɛnbaga
Schneider-Helmert D ye ɲininikɛla ŋana ye sunɔgɔbaliya ni furakɛli minnu bɛ tali kɛ o la. a ka baara kɛra ni baarada tɔgɔba suguya caman ye i n’a fɔ kirschgarten dimi furakɛli, dimi dɔgɔtɔrɔso, dimi furakɛli kirschgarten, med ctr mariastein, amsterdam iniwɛrisite, hakiliɲagami dɔgɔtɔrɔso kanton aargau, kantonsspital aarau ag (ksa), hakiliɲagami dɔgɔtɔrɔso, hakiliɲagami klin konigsfelden, hakiliɲagami klin kt aargau, ani hakililabaarakɛla klin rt aargau ye. a ka ɲininiw ɲɛsinnen bɛ fɔlɔ neurosciences & neurology, psychiatry, general & internal medicine, pharmacology & pharmacy, ani psychology kan. a ye dɛmɛba don sunɔgɔbaliya ni sunɔgɔbaliya wɛrɛw faamuyali n’u furakɛli la, k’a mago don kɛrɛnkɛrɛnnenya la dsip (delta-sleep-inducing-peptide) nɔ minnu bɛ hadamadenw ka sunɔgɔ la.
A ka kalanw ye dsip ka hakili-la-ko-kɛcogo caman sɛgɛsɛgɛ ka tɛmɛ a jɔyɔrɔ kan sunɔgɔ dacogo la, o la, a nɔ bɛ hadamadenw ka sunɔgɔbaliya la ani a seko ka sunɔgɔbaliya sɔrɔ sunɔgɔbaliya la. ka fara o kan, a ye sɛgɛsɛgɛli kɛ kununni hakɛw kan minnu bɛ kɛ ni hakili ye ani minnu bɛ kɛ ni hakili ye, mɔgɔ minnu ka kɛnɛ ani minnu tɛ sunɔgɔbaliya sɔrɔ, ka fara sunɔgɔbaliya hakilina kan min tɛ taamasiɲɛ ye. a ka baara bɔra kalanko gafe suguya caman kɔnɔ, i n'a fɔ 'sunɔgɔ,' 'eur neurol,' 'experientia,' ani 'neuropsychobiology,' ani dɔw wɛrɛw. Schneider-Helmert D tɔgɔ sɛbɛnnen bɛ citation (citation) kɔnɔ [1].
