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1kits (10Vials) .
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▎ Akɔbli-cu ƒe Dɔwɔɖoɖo
Dzɔtsoƒe: PubChem |
Nusiwo kplɔ wo nɔewo ɖo: Gly-His-Lys Molekyulãwo ƒe Mɔfiame: C 28H 46CuN 12O8 Molekyulã ƒe Kpekpeme: 742.3g/mol CAS ƒe xexlẽdzesi: 130120-56-8 PubChem ƒe CID: 9831891 Nya siwo sɔ kple wo nɔewo: Bisprezatide akɔbli;DL1TR6W6VM |
▎ Akɔbli-cu Numekuku
Nukae nye numekuku si wowɔ le Copper-cu ŋu?
Numekuku ƒe Ŋgɔyiyi si le Active Peptides ŋu:
Tso ƒe alafa 20 lia me la, wole numekuku si wowɔ tso peptide siwo wɔa dɔ le nugbagbeŋutinunya me ŋu le goglom ɖe edzi ɣesiaɣi. Dzɔdzɔmeŋutinunyalawo va kpɔe dze sii vivivi be peptidewo wɔa akpa vevi aɖe le nu gbagbewo me. Menye protein ƒe akpa aɖewo koe wonye o, ke woƒe nugbagbeŋusẽ ƒe dɔwɔwɔ le wo ɖokui si hã le wo si eye wokpɔa gome le nugbagbewo ƒe ŋutilã ƒe dɔwɔwɔ vovovowo, abe lãmenugbagbeviwo ƒe tsitsi, vovototodedeameme, kple dɔlélenutsiŋutete ƒe tɔtrɔ ene, dzi kpɔkpɔ me. Peptidewo gɔmesese deto sia naa nukpɔsusu ƒe gɔmeɖoanyi kple numekuku ƒe mɔfiame na Copper-cu didi kple nusɔsrɔ̃.
Plasma ƒe Akpawo Ŋuti Numekuku:
Le amegbetɔ ƒe ʋumenugbagbeviɣi ƒe akpawo ŋuti numekuku tsitotsito me la, dzɔdzɔmeŋutinunyalawo ɖoe kplikpaa be yewoaku nugbagbevi vovovo siwo le ʋumenugbagbevi dzĩ me ƒe wɔwɔme kple dɔwɔwɔ me. Esi wònye ŋutilã me tsi vevi aɖe le amegbetɔ ƒe ŋutilã me ta la, protein, peptide, lãmetsiŋusẽ, elektrikŋusẽ, kple nu bubuwo le ʋumenugbagbevi dzĩ me, eye enye mɔnu vevi aɖe si dzi woato alé amegbetɔ ƒe ŋutilã ƒe ŋutilã ƒe dɔwɔwɔ nyuie me ɖe asi. Le ƒe 1970-awo me la, numekulawo ke ɖe tripeptide tɔxɛ aɖe ŋu le vo me esime wonɔ plasma proteinwo me dzrom. Eƒe amino acid ƒe ɖoɖoe nye glycyl-histidyl-lysine, si nye GHK. Nu sia si ŋu woke ɖo la na dzɔdzɔmeŋutinunyalawo tsɔ ɖe le eme ŋutɔ eye wòna wogaku akpa si tripeptide sia wɔna le ʋumenugbagbevi dzĩ me kple eƒe nɔnɔmewo me yi ŋgɔe.
Akɔbli Ionwo ƒe Nu Gbagbewo ƒe Vevienyenye:
Le ɣeyiɣi ma ke me la, akpa vevi si akɔbli ions wɔna le nugbagbeŋutinunya me va he amewo ƒe susu vivivi. Akɔbli nye nu vevi siwo le amegbetɔ ƒe ŋutilã me dometɔ ɖeka eye wòkpɔa gome le nugbagbeŋusẽ ƒe dɔwɔwɔ geɖe me. Enye enzyme vevi geɖe ƒe akpa aɖe alo wowɔa dɔ eye wòwɔa akpa vevi aɖe le lãmenugbagbeviwo ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie, gbɔgbɔ, kple kolagen ƒe wɔwɔme me. Esi dzɔdzɔmeŋutinunyalawo nɔ numekuku wɔm tso akɔbli ions ƒe nugbagbeŋusẽ ƒe dɔwɔwɔ ŋu la, wokpɔe be akɔbli ions ate ŋu abla ɖe peptide nu aɖewo ŋu awɔ nusiwo me nugbagbeviwo ƒe dɔwɔwɔ tɔxɛwo le. Nusi ŋu woke ɖo sia na kpeɖodzi vevi aɖe si woatsɔ asrɔ̃ nu tso GHK kple akɔbli ions ƒe kadodo kple woƒe dɔwɔwɔ siwo woate ŋu awɔ ŋu.
Numekuku Siwo Ku Ðe Tsitsi Ŋu Dodo Ðe Ŋgɔ:
Esi hadomegbenɔnɔ le ŋgɔ yim eye amewo ƒe tsitsi ƒe kuxi si le dzedzem ɖe edzi ta la, numekuku siwo ku ɖe tsitsi ŋu va zu nyati vevi aɖe le agbeŋutinunya me. Dzɔdzɔmeŋutinunyalawo le agbagba dzem be yewoadi biomarkers kple ɖoɖowɔnu siwo do ƒome kplikplikpli kple tsitsi ƒe ɖoɖoa be woaɖe alesi tsitsi wɔa dɔe afia eye woaku mɔnu siwo dzi woato ahe tsitsi ɖe megbe la me. Le nya sia me la, wokpɔe be Copper-cu ƒe agbɔsɔsɔ si le amegbetɔ ƒe ŋutilã me dzi ɖena kpɔtɔna vivivi ne ame tsi, si fia be ate ŋu anye be kadodo aɖe le Copper-cu kple tsitsi ƒe ɖoɖoa dome. Nusi ŋu woke ɖo sia gaʋã numekulawo be woawɔ numekuku deto le Copper-cu ƒe dzɔtsoƒe, dɔwɔwɔ, kple eŋudɔwɔwɔ le tsitsi nutsitsi ƒe akpa dzi, eye wòdo numekuku siwo do ƒome kplii ƒe ŋgɔyiyi ɖaa ɖe ŋgɔ.
Nukae nye Akɔbli-cu ƒe dɔwɔwɔ ƒe mɔnu?
Lãmetsiwo Dzadzraɖo Kple Wo Gbugbɔgadzɔ Dodo Ðe Ŋgɔ:
Ʋukawo Kple Lãmetsiŋusẽwo ƒe Tsitsi Dodo Ðe Ŋgɔ:
Numekuku siwo li fifia ɖee fia be Copper-cu ate ŋu ana ʋukawo kple lãmekawo natsi. Ate ŋu akpɔ ŋusẽ sia to tsitsinu tɔxɛwo kple dzesimɔwo dzi kpɔkpɔ me. Le kpɔɖeŋu me, ate ŋu ado ʋukawo ƒe lãmenugbagbeviwo ƒe tsitsi ƒe akpa (VEGF) ƒe ɖeɖefia ɖe ŋgɔ, si ana ʋukawo nawɔ dɔ [1] . Le lãmekawo ƒe tsitsi gome la, ate ŋu ado lãmekawo ƒe lãmenugbagbeviwo ƒe agbetsitsi, woƒe dzidziɖedzi, kple woƒe axonal tsitsi ɖe ŋgɔ to ŋusẽkpɔkpɔ ɖe dzesi molecule siwo do ƒome kple lãmekawo ƒe tsitsi dzi.
Collagen, Elastin, Kple Glycosaminoglycans ƒe Dɔwɔwɔ Dzi Ðeɖe Akpɔtɔ:
Akɔbli-cu ate ŋu ana collagen, elastin, kple glycosaminoglycans ƒe wɔwɔme nadzi ɖe edzi. Collagen nye lãkusiwo abe ŋutigbalẽ kple ƒuwo ene ƒe akpa vevi aɖe, elastin naa lãkusiwo te ŋu nɔa te, eye glycosaminoglycans wɔa akpa vevi aɖe le lãmekawo ƒe tsidzadza kple woƒe ʋuʋu me. Mɔnu tɔxɛa ate ŋu abia be woaɖɔ domenyiŋusẽfianu siwo do ƒome kplii kple dzesimɔwo ƒe ɖeɖefia dzi akpɔtɔ, abe nuŋɔŋlɔ ƒe akpa tɔxɛ siwo le fibroblasts me ƒe dɔwɔwɔ be woado domenyiŋusẽfianu siwo do ƒome kple kolagen ƒe wɔwɔme ƒe ɖeɖefia ɖe ŋgɔ ene [1] ..
Kpekpeɖeŋunana Dermal Fibroblasts ƒe Dɔwɔwɔ:
Dermal fibroblasts wɔa akpa vevi aɖe le ŋutigbalẽa ƒe wɔwɔme kple dɔwɔwɔ me léle ɖe asi me. Akɔbli-cu ate ŋu ado alɔ ŋutigbalẽ me fibroblasts ƒe dɔwɔwɔ, si me lãmenugbagbeviwo ƒe dzidziɖedzi, ʋuʋu, kple lãmenugbagbeviwo godo ƒe matrix ƒe akpawo ƒe wɔwɔme dodo ɖe ŋgɔ hã le. Woate ŋu awɔ esia to dzesiwo ƒe mɔwo kple domenyiŋusẽfianu ƒe ɖeɖefia le fibroblasts me dzi kpɔkpɔ me.
Lãmenugbagbeviwo Takpɔkpɔ ƒe Ŋusẽkpɔɖeamedzi:
Dɔwɔna si Tsi Tre Ðe Kansa Ŋu:
Dɔ geɖe le akɔbli-cu ŋu si tsia kansa nu. Ate ŋu awɔ dɔ ɖe kansa dzi to mɔxexe ɖe kansa lãmenugbagbeviwo ƒe dzidziɖedzi nu, kansa lãmenugbagbeviwo ƒe tsɔtsrɔ̃, kple kansa lãmenugbagbeviwo ƒe amedzidzedze kple woƒe kaka nu. Mɔnu tɔxɛa ate ŋu anye be wòaɖɔ lãmenugbagbeviwo ƒe tsatsam ɖo, ana apoptosis ƒe dzesimɔa nawɔ dɔ, eye wòaxe mɔ na dzesimɔ siwo do ƒome kple dɔdzẽ [1] ..
Dɔléle si Tsi Tre Ðe Dzoxɔxɔ Ŋu:
Akɔbli-cu wɔa dɔ sẽŋu aɖe si tsia dɔdzẽ nu. Ate ŋu axe mɔ ɖe dɔdzẽ ƒe nusiwo nye tumor necrosis factor-α (TNF-α) kple interleukin-6 (IL-6) ƒe wɔwɔ nu, eye le ɣeyiɣi ma ke me la, ana dɔlékuiwutike siwo tsia dzoxɔxɔ nu abe superoxide dismutase (SOD) ene ƒe dɔwɔwɔ nadzi ɖe edzi. Eƒe dɔlékuiwutike ƒe mɔnu ate ŋu ado ƒome kple NF-κB p65 kple p38 MAPK dzesimɔwo ƒe mɔxexe, si wɔnɛ be dɔdzẽ ƒe ŋuɖoɖo dzi naɖe akpɔtɔ [2]..
Aklã ƒe Takpɔkpɔ Kple Aklãdɔléle si Tsi Tre Ðe Eŋu (COPD) ƒe Dzadzraɖo:
Akɔbli-cu kpɔa ŋusẽ ɖe lãkusiwo dzi eye wòɖɔa wo ɖo. Ate ŋu axe mɔ na dɔdzẽ ƒe ŋuɖoɖo le lãkusi me, aɖe lãkusi ƒe gbegblẽ kple fibrosis dzi akpɔtɔ. Le dɔnɔ siwo ŋu aklãdɔléle si xea mɔ na dɔlékuiwo (COPD) le ƒe lãkusi me lãkusiwo gome la, Copper-cu ate ŋu agbugbɔ woƒe dɔwɔwɔ aɖo anyi, ɖewohĩ to dzesimɔ siwo do ƒome kplii kple domenyiŋusẽfianu ƒe ɖeɖefia dzi kpɔkpɔ me [1]..
Dzimaɖitsitsi, Vevesesenutsitike, Kple Tsitretsitsi Ðe Amedzidzedze Ŋu ƒe Ŋusẽkpɔɖeamedzi:
Akɔbli-cu hã ƒe ŋusẽ tsia dzimaɖitsitsi, vevesesenutsitike, kple tsitretsitsi ɖe amedzidzedze ŋu, gake womese mɔnu tɔxɛ siwo wozãna gɔme bliboe haɖe o. Ate ŋu ado ƒome kple dzesimɔwo kple ahɔhɔ̃mekawo ƒe dɔwɔwɔ le lãmekawo me.
DNA Dzadzraɖo Kple Lãmenugbagbeviwo Dzadzraɖo:
DNA Dzadzraɖo:
Akɔbli-cu ƒe dɔe nye DNA dzadzraɖo. Ate ŋu adzra DNA si gblẽ ɖo to DNA ɖɔɖɔɖo ƒe enzyme tɔxɛwo alo dzesimɔwo zazã me. Esia le vevie ŋutɔ le lãmenugbagbeviwo ƒe dɔwɔwɔ nyuie me léle ɖe asi kple mɔxexe ɖe dɔlélewo abe tsitsi kple kansa ene ƒe dzɔdzɔ nu [1] ..
Lãmenugbagbeviwo Dzadzɛnyenye ƒe Dɔwɔwɔ (to Proteasome System dzi):
Akɔbli-cu ate ŋu ana lãmenugbagbeviwo ƒe proteasome-ɖoɖoa nawɔ dɔ, si ana lãmenugbagbeviwo me proteinwo nagblẽ eye woaɖe wo ɖa. Esia kpena ɖe lãmenugbagbeviwo me ƒe nɔnɔme ŋu wòli ke eye wòxea mɔ na protein ƒe ƒuƒoƒo kple lãmenugbagbeviwo ƒe dɔmawɔmawɔ nyuie [1] ..
Nukpɔsusu le Atikewɔwɔ ƒe Mɔnu Ŋu: Numekuku aɖewo do susua ɖa be woate ŋu akpɔ atikewɔwɔ ƒe dɔwɔwɔ ƒe mɔnu to Copper-cu dzi. Togbɔ be wogale nu srɔ̃m tso mɔnu tɔxɛa ŋu yi ŋgɔe hã la, esia na nukpɔsusu yeye aɖe mí be míase alesi Copper-cu wɔa dɔe gɔme [3]..
GHK ƒe agbɔsɔsɔ le ʋumenugbagbevi dzĩ me kple eƒe dɔdamɔnu ƒe vevienyenye le dɔnɔ siwo ŋu silicosis le me: A. Plasma GHK ƒe agbɔsɔsɔ le ame siwo le lãmesẽ me kple dɔnɔ siwo ŋu silicosis le me. B. Plasma GHK ƒe agbɔsɔsɔ le dɔnɔ siwo ŋu silicosis le le dɔlélea ƒe dɔdamɔnu vovovowo me. C. Aklã ƒe nɔnɔmetatawo ɖeɖefia ƒe dzesiwo kple GHK ƒe agbɔsɔsɔ le ʋumenugbagbevi dzĩ me le ameha si le lãmesẽ me si dzi wokpɔna kple dɔnɔ siwo le silicosis ƒe dɔdamɔnu vovovowo me. D. Kadodo si le plasma GHK ƒe agbɔsɔsɔ kple FEV1%pre dome le dɔnɔ siwo ŋu silicosis le me. E. Kadodo si le plasma GHK ƒe agbɔsɔsɔ kple DLCO%pre dome le dɔnɔ siwo ŋu silicosis le me.
Dzɔtsoƒe:PubMed [6] .
Nukae nye Copper-cu ƒe dɔwɔwɔ?
Ŋutilã Dzadzraɖo Kple Atsyɔ̃ɖoɖo:
Collagen ƒe Dɔwɔwɔ si Doa Ŋusẽ:
Akɔbli-cu ate ŋu aʋã collagen, elastin, kple glycosaminoglycans ƒe wɔwɔme. Collagen nye ŋutigbalẽa ƒe akpa vevi aɖe, si nana ŋutigbalẽa te ŋu nɔa te sesĩe eye wòsẽna [1] . Ne ame tsi la, collagen ƒe wɔwɔme dzi ɖena kpɔtɔna vivivi, si wɔnɛ be ŋutigbalẽa ɖea dzi ɖi eye wòdzena abe lãgbalẽ ene. To collagen wɔwɔ dodo ɖe ŋgɔ me la, Copper-cu ate ŋu ana ŋutigbalẽa nate ŋu aʋã eye wòali ke nyuie wu eye wòaɖe ɖa ƒe wɔwɔme dzi akpɔtɔ.
Ʋukawo Kple Lãmetsiŋusẽwo ƒe Tsitsi Dodo Ðe Ŋgɔ:
Ewɔa dɔ ɖe ʋukawo kple lãmekawo ƒe tsitsi dzi [1] . Ʋu ƒe sisi nyuie le vevie ŋutɔ na ŋutigbalẽa ƒe lãmesẽ. Ate ŋu ana nunyiame kple ɔksidzin si sɔ ŋutigbalẽ ƒe lãmenugbagbeviwo eye wòado ŋutigbalẽa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ɖe ŋgɔ. Tsɔ kpe ɖe eŋu la, lãmekawo ƒe tsitsi hã kpena ɖe ŋutigbalẽa ƒe seselelãme kple nuwɔwɔ ƒe ŋutete ŋu.
Kpekpeɖeŋunana Dermal Fibroblasts ƒe Dɔwɔwɔ:
Akɔbli-cu doa alɔ ŋutigbalẽ me fibroblasts ƒe dɔwɔwɔ. Fibroblasts nye lãmenugbagbevi ƒomevi vevi siwo le ŋutigbalẽa me dometɔ ɖeka, eye woƒe dɔe nye be wowɔa collagen, elastin, kple lãmenugbagbeviwo godo ƒe akpa bubu siwo le ŋutigbalẽa me [1] . Akɔbli-cu ate ŋu ana fibroblasts ƒe dɔwɔwɔ nanyo ɖe edzi eye woƒe ŋutete be woawɔ lãmenugbagbeviwo godo ƒe ƒuƒoƒoa nanyo ɖe edzi, si ana ŋutigbalẽa ƒe wɔwɔme kple dɔwɔwɔ nanɔ anyi.
Abi Dada:
Akɔbli-cu ɖea ŋusẽkpɔɖeamedzi veviwo fiana le abi ƒe dɔyɔyɔ me. Numekukuwo ɖee fia be ate ŋu ana abi nahaya kabakaba, ana lãmenugbagbevi siwo me abi le la natsi, eye wòana collagen nawɔ ahaƒo ƒu. Tsɔ kpe ɖe eŋu la, Copper-cu ate ŋu aɖɔ macrophages ƒe tɔtrɔ tso M2 ƒe akpaa me ɖo, axe mɔ ɖe dɔdzẽ ƒe nusiwo TNF-α kple IL-6 ƒe ɖeɖefia nu nyuie le lãmenugbagbeviwo me, aɖe asi le dɔlékuiwutikewo abe TGF-β kple iNOS ene ŋu, ana HIF-1α mɔ ƒe ɖeɖefia kabakaba, ado VEGF ƒe ɖeɖefia ɖe ŋgɔ be wòakpɔ ŋusẽ si doa ʋukawo ƒe dzɔdzɔ ɖe ŋgɔ, eye wòana lãmenugbagbeviwo ƒe ɖɔɖɔɖo kabakaba.
Tsitretsitsi ɖe tsitsi ŋu:
Akɔbli-cu wɔa dɔ geɖe le tsitsi ŋu. Ateŋu axe mɔ ɖe molecule abe NFκB ene ƒe dɔwɔwɔ nu, si wobu be enaa tsitsi ƒe dɔwɔwɔ kabakaba (Pickart L, 2018). Tsɔ kpe ɖe eŋu la, dzimaɖitsitsi, vevesesenutsitike, kple dɔlékuiwutikewo hã le esi, DNA ɖɔɖɔɖo, kple dɔwɔwɔ si naa lãmenugbagbeviwo kɔklɔ to proteasome ƒe ɖoɖoa dzi nawɔ dɔ.
Abe Atsyɔ̃ɖonuwo ene:
Le ŋusẽ si wòkpɔna ɖe ŋutigbalẽ dzadzraɖo kple tsitsi dzi ta la, wozãa Copper-cu geɖe le atsyɔ̃ɖonuwo me. Le kpɔɖeŋu me, woate ŋu azã liposomes siwo wotu ɖe anionic (AL) kple cationic (CL) hydrogenated lecithin dzi abe ŋutigbalẽ ƒe tsɔtsɔ yi na Copper-cu [4] . Liposomes siawo li ke, woƒe nusuewo ƒe lolome le sue (anɔ abe 100nm ene), eye woƒe bilayer fluidity lolo, si ate ŋu atsɔ Copper-cu ayi ŋutigbalẽa me nyuie. Abe atsyɔ̃ɖomi ene la, menye ɖeko Copper-cu ate ŋu ana ŋutigbalẽa ƒe dzedzeme nanyo ɖe edzi ko o, ke ate ŋu ana ŋutigbalẽa ƒe lãmesẽ hã nanyo ɖe edzi.
Atikewɔwɔ ƒe Agble:
Atikewɔwɔ na Aklã ƒe Nuveviwɔame Sesẽ:
Akɔbli-cu kpɔa ŋusẽ ɖe abi si woxɔna le lãkusi me vevie (ALI) dzi. Le dodokpɔ siwo wowɔ le RAW 264.7 macrophages siwo lipopolysaccharide (LPS) hena vɛ ŋu le vitro me kple le sisiblisi ƒe kpɔɖeŋu si wowɔ le abixɔxɔ sesẽ ƒe lãkusi me le vivo me la, Copper-cu dɔdamɔnu ɖe oxygen ƒomevi siwo wɔa dɔ (ROS) ƒe wɔwɔ dzi kpɔtɔ, dzi superoxide dismutase (SOD) ƒe dɔwɔwɔ ɖe edzi, eye le ɣeyiɣi ma ke me la, eɖe TNF-α kple IL-6 ƒe wɔwɔ dzi kpɔtɔ, si wɔa dɔ to mɔxexe ɖe wo nu me NF-κB p65 kple p38 MAPK ƒe dzesimɔwo [2] . Tsɔ kpe ɖe eŋu la, Copper-cu ate ŋu aɖe dɔléle ƒe tɔtrɔ siwo LPS hena vɛ le lãkusi me hã dzi akpɔtɔ eye wòaxe mɔ na lãmenugbagbevi siwo naa dɔdzẽ ƒe gege ɖe lãkusi me.
Aklã ƒe Dɔléle ƒe Atikewɔwɔ:
Copper-cu ɖe atikewɔwɔ ƒe ŋusẽkpɔɖeamedzi fia le sisiblisi ƒe kpɔɖeŋu si wowɔ le aklã me lãkusi si bleomycin (BLM) hena vɛ ŋu [5] . Idiopathic pulmonary fibrosis nye aklãdɔléle sesẽ aɖe, eye oxidative stress kple inflammation ye nye eƒe dɔlékuiwutike vevitɔwo. Akɔbli-cu ate ŋu awɔ akpa aɖe si akpɔ ame ta to nuteɖeamedzi si tsia dzoxɔxɔ nu kple mɔ siwo tsia dzoxɔxɔ nu me.
Silicosis ƒe Dɔdamɔnu:
Silicosis ye nye aklãdɔléle ƒomevi si bɔ wu, eye fifia la, atike aɖeke meli koŋ woatsɔ adae o. Numekukuwo ɖee fia be Copper-cu kpɔa ŋusẽ ɖe silicosis dzi le atikewɔwɔ me. Ateŋu aɖe aklã ƒe dɔdzẽ kple fibrosis dzi akpɔtɔ le silicosis mice me to taɖodzinu ɖoɖo ɖe peroxiredoxin 6 (PRDX6) ŋu me, eye eƒe akpa aɖe tso oxidative stress ƒe mɔxexe ɖe alveolar macrophages si crystalline silica hena vɛ gbɔ [6]..
Dɔ geɖe le akɔbli-cu ŋu eye vevienyenye gã aɖe le eŋu. Ate ŋu aʋã nusiwo le abe kolagen ene ƒe wɔwɔme, adzra ŋutigbalẽa ɖo, eye wòahe tsitsi ɖe megbe, si akpe ɖe amewo ŋu woati ŋutigbalẽ si le lãmesẽ me eye wònya kpɔ yome le atsyɔ̃ɖoɖo kple ŋutigbalẽ dzi kpɔkpɔ ƒe nyawo me. Le atikewɔwɔ gome la, enaa mɔfiame yeye aɖe na aɖuɖɔtoedɔlélewo abe abi si woxɔna le lãkusi me vevie kple aklã me fibrosis ene dada, eye wole mɔ kpɔm be ana dɔnɔwo ƒe lãmesẽ nanyo ɖe edzi. Le nusianu me la, Copper-cu kpena ɖe agbeŋutinunya, atikewɔwɔ, kple atsyɔ̃ɖoɖo ƒe dɔwɔƒewo ƒe ŋgɔyiyi ŋu, eye wòkpɔa ŋusẽ nyui ɖe amegbetɔ ƒe agbenɔnɔ ƒe nyonyome dzi.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Bian Y nye numekula si do ƒome kple habɔbɔ ɖedzesi geɖewo. Esiawo dometɔ aɖewoe nye State Key Lab Resp Hlth & Multimorbid, -Japan Xɔlɔ̃wɔwɔ Kɔdzi, Chinatɔwo ƒe Atikewɔwɔ Ŋuti Nusrɔ̃ƒe - Peking Union Atikewɔwɔ Kɔledzi, Natl Clin Res Ctr Resp Dis, Natl Ctr Resp Med, kple Tongji Yunivɛsiti. Eƒe habɔbɔ siwo do ƒome kplii ɖe atikewɔwɔ kple dzɔdzɔmeŋutinunya me numekuku ƒe nuteƒekpɔkpɔ geɖe fia.
Eƒe numekukua ku ɖe nyati vevi geɖewo ŋu. Eƒe nunya le Yagbɔgbɔ ƒe Dɔwɔɖoɖo, Dɔdzẽŋutinunya, Atikewɔwɔ Gbãtɔ & Ememe, Numekuku & Dodokpɔ ƒe Atikewɔwɔ, kple Biochemistry & Molecular Biology me. Dɔ si wòwɔ le go siawo me ɖe dzesi ŋutɔ le atikewɔwɔ ŋuti dzɔdzɔmeŋutinunya dodo ɖe ŋgɔ kple lãmesẽnyawo gbɔ kpɔkpɔ ƒe nyonyo me. Woŋlɔ Bian Y ɖe nyayɔyɔ ƒe numekugbalẽ me [6].
