By Cocer Peptides 
Watanni 1 da suka gabata
DUKKANIN LABARI DA BAYANIN KYAUTATAWA DA AKE BAYAR A WANNAN SHAFIN KAWAI DOMIN WATSA BAYANI NE DA MANUFOFIN ILIMI.
Kayayyakin da aka bayar akan wannan gidan yanar gizon an yi niyya ne kawai don binciken in vitro. Binciken in vitro (Latin: *a cikin gilashi*, ma'ana a cikin gilashin gilashi) ana gudanar da shi a wajen jikin mutum. Waɗannan samfuran ba magunguna ba ne, Hukumar Abinci da Magunguna ta Amurka (FDA) ba ta amince da su ba, kuma dole ne a yi amfani da su don hanawa, magani, ko warkar da duk wani yanayi na likita, cuta, ko cuta. Doka ta haramta shigar da waɗannan samfuran cikin jikin mutum ko dabba ta kowace hanya.
1 Bayani
Nau'in ciwon sukari na 2 (T2D) cuta ce ta rayuwa ta yau da kullun wacce ke da juriya na insulin da rashin isasshen insulin, wanda ke haifar da haɓakar matakan glucose na jini. Tare da hauhawar hauhawar kiba a duniya, al'amuran T2D na ci gaba da karuwa. Gudanar da nauyi yana da mahimmanci a cikin jiyya na T2D, saboda yawan kiba yana ƙara haɓaka juriya na insulin kuma yana ƙara lalata sarrafa glucose na jini. Haɓaka magungunan da za su iya daidaita matakan glucose na jini yadda ya kamata yayin da suke taimakawa wajen sarrafa nauyi ya zama mai da hankali kan bincike a fagen jiyya na T2D. Cagrilintide, a matsayin sabon magani, ya ƙara jawo hankali.
Hoto 1 Abubuwan da ke da alaƙa da ciwon sukari da kiba na GLP-1.
2 Matsayin Cagrilintide a cikin Tsarin Glucose na Jini
Tsarin Mulki
Cagrilintide shine glucagon-kamar peptide-1 (GLP-1) analog. GLP-1 shine hormone incretin wanda ke taka muhimmiyar rawa a cikin tsarin glucose na jini. Bayan cin abinci, ƙwayoyin endocrin na hanji suna ɓoye GLP-1, wanda ke motsa ƙwayar insulin ta hanyar dogaro da glucose, ta haka yana rage matakan glucose na jini. Cagrilintide yana da alaƙa mai girma ga masu karɓar GLP-1 kuma yana iya kwaikwayi tasirin ilimin lissafin jiki na GLP-1. Lokacin da matakan glucose na jini ya tashi, Cagrilintide yana ɗaure ga mai karɓar GLP-1, yana kunna jerin hanyoyin siginar intracellular waɗanda ke haɓaka haɓakar insulin da sakin, yana ba da damar glucose shiga cikin sel don amfani kuma ta haka yana rage yawan adadin glucose na jini. Hakanan yana hana fitowar glucagon kuma yana rage fitowar glucose na hanta, yana ƙara daidaita matakan glucose na jini.
Ingantaccen asibiti
Yawancin karatu na asibiti sun nuna cewa Cagrilintide yana nuna kyakkyawan tasirin tsarin glucose na jini a cikin marasa lafiya da nau'in ciwon sukari na 2. A cikin bazuwar, makafi biyu, gwajin gwaji na asibiti, an raba marasa lafiya na T2D zuwa rukunin jiyya na Cagrilintide da ƙungiyar placebo. Bayan makonni 12 na jiyya, an gano cewa marasa lafiya a cikin rukunin jiyya na Cagrilintide sun sami raguwa sosai a cikin matakan haemoglobin A1c (HbA1c) idan aka kwatanta da asali, tare da raguwa mai mahimmanci a cikin glucose na jini mai azumi da matakan glucose na jini na postprandial. HbA1c muhimmiyar alama ce ta sarrafa glucose na jini na dogon lokaci, kuma raguwar sa yana nuna cewa Cagrilintide na iya inganta ingantaccen sarrafa glucose na jini na marasa lafiya yadda ya kamata. Idan aka kwatanta da magungunan antidiabetic na gargajiya, Cagrilintide yana rage matakan glucose na jini yayin da yake haifar da ƙananan haɗarin hypoglycemia. Wannan ana danganta shi da tsarin sa na glucose wanda ke dogara da tsarin samar da siginar insulin, ma'ana yana motsa fitar insulin ne kawai lokacin da matakan glucose na jini ya tashi kuma baya rage yawan glucose na jini lokacin da suke al'ada.
3 Tsarin Ayyukan Cagrilintide a Gudanar da Weight
Cagrilintide yana rage cin abinci ta hanyar hana ci. Yana aiki akan tsarin kulawa na tsakiya, yana rinjayar cibiyar satiety a cikin hypothalamus don haifar da jin dadi, don haka rage cin abinci. Cagrilintide na iya jinkirta zubar da ciki, yana tsawaita lokacin da abinci ya rage a ciki, yana kara haɓaka koshi, da rage cin abinci na gaba. Hakanan yana iya yin tasiri akan metabolism na mai ta hanyar haɓaka oxidation mai mai da haɓaka kashe kuzari, ta haka yana taimakawa asarar nauyi.
4 Aikace-aikacen Cagrilintide a cikin Jiyya na Nau'in Ciwon sukari na 2
Alamu
Cagrilintide ya dace da yawancin marasa lafiya da ke da nau'in ciwon sukari na 2, musamman waɗanda ke da kiba ko kiba. Ga marasa lafiya waɗanda ke da ƙarancin sarrafa glycemic duk da abinci da motsa jiki kuma suna buƙatar sarrafa nauyi na lokaci ɗaya, Cagrilintide shine ingantaccen zaɓi na magani.
Haɗuwa da Sauran Magunguna
Ana iya amfani da Cagrilintide a hade tare da wasu magungunan antidiabetic na gargajiya, irin su metformin da sulfonylureas. Magungunan haɗin gwiwa na iya yin amfani da tasirin haɗin gwiwa na magunguna daban-daban don ƙarin sarrafa sukarin jini da nauyi sosai. Lokacin amfani da shi tare da metformin, metformin da farko yana rage sukarin jini ta hanyar inganta juriya na insulin da rage fitowar glucose na hanta, yayin da Cagrilintide yana rage sukarin jini da nauyi ta hanyoyi kamar haɓaka ƙwayar insulin da kuma hana ci. Haɗin waɗannan biyun na iya sarrafa matakan sukari na jini yadda ya kamata a cikin marasa lafiya na T2D kuma ya ƙara haɓaka matsayin nauyi ba tare da ƙara haɗarin halayen haɗari kamar hypoglycemia ba.
5 Kammalawa
A taƙaice, Cagrilintide, a matsayin sabon magani don maganin nau'in ciwon sukari na 2, yana nuna inganci mai kyau a cikin tsarin glucose na jini da sarrafa nauyi. Tsarin aikinsa ya sa ya zama babban darajar aikace-aikacen a cikin jiyya na T2D, yana ba da sabon zaɓi na jiyya ga marasa lafiya da nau'in ciwon sukari na 2.
Sources
[1] Abdulrahman A, Najjar S, Al-Zobaidy M. Tasirin liraglutide akan sarrafa nauyi da hawan jini a cikin nau'in ciwon sukari na 2. Jaridar Faculty of Medicine, Baghdad, 2023,64:2022.DOI:10.32007/jfacmedbagdad.6441971.
[2] Kurtzhals P, Flindt Kreiner F, Singh Bindra R. Matsayin kula da nauyi a cikin kula da nau'in ciwon sukari na 2: Hanyoyi akan semaglutide [J]. Binciken Ciwon sukari da Ayyukan Asibiti, 2023,203.DOI:10.1016/j.diabres.2023.110881.
[3] Shalahuddin I, Maulana I, Pebrianti S, et al. Dokokin Matakan Sugar Jini a cikin Marasa lafiya Nau'in Ciwon Ciwon sukari na 2 Ta Hanyar Gudanar da Abinci[J]. Jurnal Aisyah : Jurnal Ilmu Kesehatan, 2022. https://api.semanticscholar.org/CorpusID:251675212.
[4] McAdam-Marx C, Gaebler JA, Bellows BK, et al. Gudanar da zamani na marasa lafiya tare da nau'in ciwon sukari na 2 [J]. Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararru, 2010,8 (6): 767-770.DOI: 10.1586 / erc.10.62.
Samfura akwai don amfani da bincike kawai:
