Los ntawm Cocer Peptides 
1 month ago
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
1 Txheej txheem cej luam
Hom 2 mob ntshav qab zib mellitus (T2D) yog ib hom kab mob metabolic uas tshwm sim los ntawm kev tiv thaiv insulin thiab tsis txaus cov tshuaj insulin, ua rau cov ntshav qabzib nce siab. Nrog rau lub ntiaj teb nce hauv kev rog rog, qhov tshwm sim ntawm T2D tseem nce ntxiv. Kev tswj qhov hnyav yog qhov tseem ceeb hauv kev kho T2D, vim tias rog rog feem ntau ua rau cov tshuaj insulin tsis kam thiab ua rau cov ntshav qabzib ntau ntxiv. Tsim cov tshuaj uas tuaj yeem tswj hwm cov ntshav qabzib zoo thaum pab tswj qhov hnyav tau dhau los ua kev tshawb fawb tsom hauv kev kho T2D. Cagrilintide, raws li cov tshuaj tshiab, tau nce ntxiv.
Daim duab 1 Kev mob ntshav qab zib thiab kev rog muaj feem cuam tshuam ntawm GLP-1.
2 Lub luag haujlwm ntawm Cagrilintide hauv Kev Cai Ntshav Qab Zib
Regulatory Mechanism
Cagrilintide yog glucagon zoo li peptide-1 (GLP-1) analog. GLP-1 yog ib qho tshuaj incretin uas ua lub luag haujlwm tseem ceeb hauv kev tswj cov ntshav qabzib. Tom qab noj zaub mov, cov kab mob hauv plab hnyuv tso tawm GLP-1, uas ua rau cov tshuaj insulin tso tawm hauv cov piam thaj hauv cov ntshav, yog li txo qis cov ntshav qabzib. Cagrilintide muaj affinity siab rau GLP-1 receptors thiab tuaj yeem ua raws li cov teebmeem ntawm lub cev ntawm GLP-1. Thaum cov ntshav qabzib nce siab, Cagrilintide khi rau GLP-1 receptor, ua kom muaj cov kab ke ntawm cov kab mob hauv lub cev uas txhawb kev tsim cov tshuaj insulin thiab tso tawm, ua kom cov piam thaj nkag mus rau hauv cov hlwb rau kev siv thiab yog li txo cov ntshav qabzib ntau. Nws kuj inhibits glucagon secretion thiab txo cov ntshav qabzib hauv siab, ntxiv stabilizing cov ntshav qabzib.
Clinical kev ua tau zoo
Ntau qhov kev tshawb fawb soj ntsuam tau pom tias Cagrilintide nthuav tawm cov txiaj ntsig zoo ntawm cov ntshav qabzib hauv cov neeg mob ntshav qab zib hom 2. Hauv kev sim tshuaj ntsuam xyuas randomized, ob-dig muag, tshuaj placebo-tswj, cov neeg mob T2D tau muab faib ua pawg kho mob Cagrilintide thiab pab pawg placebo. Tom qab 12 lub lis piam ntawm kev kho mob, nws tau pom tias cov neeg mob hauv pab pawg kho mob Cagrilintide muaj qhov txo qis hauv hemoglobin A1c (HbA1c) qib piv rau cov hauv paus, nrog kev txo qis hauv cov ntshav qabzib ceev thiab cov ntshav qabzib tom qab. HbA1c yog qhov taw qhia tseem ceeb ntawm kev tswj cov ntshav qabzib mus ntev, thiab nws qhov txo qis qhia tau tias Cagrilintide tuaj yeem txhim kho cov neeg mob cov ntshav qabzib tswj tau zoo. Piv nrog rau cov tshuaj antidiabetic tshuaj, Cagrilintide txo cov ntshav qabzib thaum ua rau muaj kev pheej hmoo ntawm hypoglycemia. Qhov no yog vim nws cov piam thaj concentration-dependant insulin secretion-txhim kho mechanism, txhais tau tias nws tsuas yog txhawb nqa insulin secretion thaum cov ntshav qabzib nce siab thiab tsis txo cov ntshav qabzib ntau dhau thaum lawv nyob li qub.
3 Mechanism of Action of Cagrilintide in Weight Management
Cagrilintide txo cov zaub mov noj los ntawm kev txo qis qab los noj mov. Nws ua rau lub hauv paus paj hlwb, cuam tshuam lub chaw satiety nyob rau hauv lub hypothalamus kom induce lub siab ntawm fullness, yog li txo cov zaub mov noj. Cagrilintide tuaj yeem ncua kev ua pa ntawm plab, ua kom lub sijhawm cov zaub mov tseem nyob hauv plab, ntxiv dag zog rau satiety, thiab txo cov khoom noj tom ntej. Nws kuj tseem tuaj yeem cuam tshuam cov roj metabolism los ntawm kev txhawb nqa cov roj oxidation thiab nce kev siv zog, yog li pab kom poob phaus.
4 Kev Siv Cagrilintide hauv Kev Kho Mob Ntshav Qab Zib Hom 2
Cov lus qhia
Cagrilintide yog tsim rau feem ntau cov neeg mob uas muaj ntshav qab zib hom 2, tshwj xeeb tshaj yog cov neeg rog rog lossis rog. Rau cov neeg mob uas tswj tsis tau glycemic txawm tias noj zaub mov thiab tawm dag zog thiab xav tau kev tswj hwm qhov hnyav, Cagrilintide yog qhov kev xaiv zoo tshaj plaws.
Kev sib xyaw nrog lwm cov tshuaj
Cagrilintide tuaj yeem siv ua ke nrog ntau yam tshuaj tiv thaiv kab mob, xws li metformin thiab sulfonylureas. Kev sib xyaw ua ke tuaj yeem ua rau muaj kev sib koom ua ke ntawm cov tshuaj sib txawv kom tswj tau cov ntshav qab zib thiab qhov hnyav dua. Thaum siv nrog metformin, metformin feem ntau txo cov ntshav qab zib los ntawm kev txhim kho cov tshuaj insulin thiab txo cov piam thaj hauv siab, thaum Cagrilintide txo cov ntshav qab zib thiab qhov hnyav los ntawm cov txheej txheem xws li kev txhawb nqa insulin secretion thiab suppressing qab los noj mov. Kev sib xyaw ua ke ntawm ob tuaj yeem tswj tau cov ntshav qab zib kom zoo dua hauv cov neeg mob T2D thiab txhim kho qhov hnyav ntxiv yam tsis muaj kev pheej hmoo ntawm kev phiv xws li hypoglycemia.
5 Kev xaus
Hauv cov ntsiab lus, Cagrilintide, raws li cov tshuaj tshiab rau kev kho mob ntshav qab zib hom 2, ua kom pom qhov ua tau zoo hauv kev tswj ntshav qabzib thiab tswj qhov hnyav. Nws cov txheej txheem ntawm kev ua haujlwm ua rau nws muaj txiaj ntsig tseem ceeb hauv kev kho T2D, muab kev kho tshiab rau cov neeg mob ntshav qab zib hom 2.
Qhov chaw
[1] Abdulrahman A, Najjar S, Al-Zobaidy M. Cov teebmeem ntawm liraglutide ntawm kev tswj qhov hnyav thiab ntshav siab hauv hom 2 ntshav qab zib Cov teebmeem ntawm liraglutide ntawm kev tswj qhov hnyav thiab ntshav siab hauv hom 2 mob ntshav qab zib mellitus Iraqi cov neeg mob [J]. Phau ntawv Journal ntawm Kws Kho Mob, Baghdad, 2023,64:2022.DOI:10.32007/jfacmedbagdad.6441971.
[2] Kurtzhals P, Flindt Kreiner F, Singh Bindra R. Lub luag haujlwm ntawm kev tswj qhov hnyav hauv kev tswj hwm hom 2 mob ntshav qab zib mellitus: Kev pom ntawm semaglutide[J]. Diabetes Research and Clinical Practice, 2023,203.DOI:10.1016/j.diabres.2023.110881.
[3] Shalahuddin I, Maulana I, Pebrianti S, et al. Ntshav Qab Zib Cov Kev Cai Lij Choj hauv Ntshav Qab Zib Hom 2 Cov Neeg Mob Los Ntawm Kev Tswj Noj Qab Haus Huv [J]. Jurnal Aisyah : Phau Ntawv Teev Ntuj Ilmu Kesehatan, 2022. https://api.semanticscholar.org/CorpusID:251675212.
[4] McAdam-Marx C, Gaebler JA, Bellows BK, et al. Kev tswj hwm niaj hnub ntawm cov neeg mob uas muaj ntshav qab zib hom 2 [J]. Kws tshuaj ntsuam xyuas ntawm Kev Kho Mob Kho Mob, 2010,8(6):767-770.DOI:10.1586/erc.10.62.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
