Coremend (TB4, KPV, BPC157) 25mg+10mg+10mg (ngwakọta)

▎ Gịnị bụ KPV?

KPV bụ ngwongwo tripeptide mejupụtara lysine (Lys), proline (Pro), na valine (Val). Ọ bụ akụkụ na-arụ ọrụ nke α-melanocyte-stimulating hormone (α-MSH) nwere ọrụ ndu pụrụ iche. KPV na-arụ ọrụ ya site na mgbochi mkpali na nkwalite nrụzi anụ ahụ. Ọ na-agbanwe ọkwa cytokine na-egbu egbu, na-egbochi mwepụta onye mgbasa ozi pro-inflammatory, ma na-ebelata nzaghachi mkpali mpaghara. N'otu oge ahụ, ọ na-akwalite ịkwaga cell na ịba ụba, na-eme ka nrụzi na ịmaliteghachi mucosa ma ọ bụ anụ ahụ mebiri emebi iji mepụta ebe dị mma maka ọgwụgwọ ọnya. Uru ọgwụgwọ ya bụ isi bụ n'ịgwọ ọrịa mkpali. Maka ulcerative colitis, a na-enye KPV n'ọnụ ma ọ bụ ọnụ (nke a na-akwalite ya na ndị nanocarriers ma ọ bụ hydrogels maka ebumnobi ka mma) na-ebelata mbufụt nke colon, na-edozi mmebi nke mucosal, na-ebelata ọrụ ọrịa, ma na-akwalite mweghachi nke colonic morphology. Na dermatology, a na-enyocha ihe mgbochi mkpali nke KPV na mmetụta na-akwalite melanocyte maka ọgwụgwọ vitiligo. Usoro nnyefe dị n'elu na-akwalite njikọ nke melanin na mmụba cell, na-enyere aka ngbanwe nke akpụkpọ ahụ metụtara. Na mgbakwunye, ihe nrụzi anụ ahụ ya na-enye ike ọgwụgwọ maka mmerụ ahụ mucosal ndị ọzọ ma ọ bụ ọnọdụ metụtara mbufụt.

▎ Gịnị bụ BPC-157?

BPC-157 na-arụ ọrụ dị iche iche nke ndụ site n'ịchịkwa okwu nke ụmụ irighiri ihe dị ka vaskụla endothelial growth factor, endothelial nitric oxide synthase, na hormone nke na-eto eto, na-egosipụta ọrụ dị mkpa na nrụzi na nchebe anụ ahụ. Ọ na-akwalite mbugharị fibroblast na njikọ collagen, na-eme ka angiogenesis dịkwuo elu, ma na-enye anụ ahụ mebiri emebi na nkwado nri na nrụzi zuru oke, na-enweta mmetụta nchebe cellular sistemu.

N'ime ngwa eriri afọ, uru ya bara uru: ọ na-arụzi mmebi nke mucosal gastric nke ọma, na-egbochi ọnya mmanya na-egbu egbu ma ọ bụ NSAID, na-ebelata ọnya afọ, na-akwalite ọgwụgwọ. Maka ọrịa afọ na-egbuke egbuke dị ka ọrịa ulcerative colitis na ọrịa Crohn, ọ na-ebelata ntọhapụ pro-inflammatory, na-ebelata mbufụt nke eriri afọ, na-emezi mmezi na saịtị anastomotic, ma na-eme ka ọrụ bowel dịkwuo mma.

N'ime usoro anụ ahụ, BPC-157 na-arụ ọrụ ụzọ ndị metụtara mmụba cell tendon na ịkwaga, na-akwalite nrụzi nrụpụta mgbe ọnyá na nkwonkwo akwara na-ebelata oge mgbake na-esote mmerụ egwuregwu ma ọ bụ ịwa ahụ. Ọ na-emekwa ka ọgwụgwọ ntụpọ ọkpụkpụ dị ngwa ngwa na nrụpụta cartilage, na-ebelata mbufụt nke nkwonkwo, ma na-emetụta ọnọdụ dị ka ọrịa ogbu na nkwonkwo.

Banyere neuroprotection, ọ na-agbanwe okwu mkpụrụ ndụ hippocampal na ụdị mmerụ ahụ nke azụ azụ iji nyere aka mgbake ọrụ moto. Ọ na-ebelata mmebi akwara ozi nke ụbụrụ ischemia na-akpata, na-ebelata ụkọ akwara ozi mgbe ọrịa strok gasịrị, ma na-ebelata akara ngosi na ụdị ọrịa Parkinson na schizophrenia, na-egosipụta ikike neuroprotective. BPC-157 na-akwalite ọgwụgwọ na ọkụ, traumatic, na ọnya posta. Site n'ịkwalite mmụba ọbara na anụ ahụ ischemic, ọ na-enye uru ọgwụgwọ maka ọrịa ischemic.

Mmechi

Mmekọrịta mmekọrịta nke TB500, KPV, na BPC-157 n'ime ngwakọta Coremend na-ewepụta netwọọkụ nchịkwa nke 'mgbochi mgbochi mkpali - nrụzi-mmezigharị' netwọk nchịkwa cascade, na-enweta mmetụta dị ndụ zuru oke nke a na-apụghị inweta site n'otu n'otu. KPV na-ebute ụzọ ibelata mbufụt anụ ahụ dị na mpaghara site na igbochi ntọhapụ ihe na-akpata pro-inflammatory, na-emepụta microenvironment dị ala na-adịghị mma na-enyere aka nrụzi na-esote. Nkwalite ya na mgbasa nke mucosal cell na ịkwaga na-ebute usoro nrụzi na ebe ndị mebiri emebi. N'ịrụ n'elu ntọala a, TB500 na-eme ka ịkwaga cell dịkwuo elu site n'ịchịkwa mmetụta actin mgbe ọ na-akpalite angiogenesis na collagen synthesis, na-enye ihe ndabere maka nrụzi anụ ahụ. Mmalite ya nke nweghachi anụ ahụ jikọrọ ọnụ na-etolite mmekọrịta n'usoro na njikwa mbufụt nke mmalite nke KPV. BPC-157 na-eme ka arụmọrụ angiogenesis dịkwuo elu site n'ịkwalite nkwupụta mkpụrụ ndụ nke vascular endothelial growth factor na endothelial nitric oxide synthase, ebe na-akwalite ọrụ fibroblast. Nke a na-abawanye mmetụta angiogenic nke TB500 iji hụ na ihe oriri na-edozi ahụ na-ebelata mmebi nke abụọ n'oge mmezi site na ọrụ cytoprotective ya. Ikike nrụzi anụ ahụ dị iche iche (oghere eriri afọ, sistem musculoskeletal, sistem ụjọ) na-eme ka TB500 na-emezigharị anụ ahụ jikọrọ ọnụ yana nrụzi mucosal nke KPV site na njikọta anụ ahụ ezubere iche. Mgbe emekọrịtara ọnụ, ihe mgbochi mkpali nke KPV na-ewepụ ihe mgbochi nrụzi, mmalite mmalite nke TB500 na-ewepụta ntọala ntọala, yana nkwalite ọrụ BPC-157 na nchekwa cell na-ebuli ogo nrụzi na arụmọrụ. Ọnụ, ha na-eme ka usoro ahụ dum dịkwuo elu site na mkpebi mbufụt na nhazi nhazi na mgbake na-arụ ọrụ na anụ ahụ mebiri emebi, na-enye usoro ntinye aka nke ukwuu maka mmerụ anụ ahụ dị mgbagwoju anya na ọrịa ndị metụtara mbufụt.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.