Coremend (TB4, KPV, BPC157) 25mg + 10mg + 10mg (Kuvanga)

K KPV ni iki?

KPV ni tripeptide igizwe na lysine (Lys), proline (Pro), na valine (Val). Nibice bikora bya α-melanocyte-itera imisemburo (α-MSH) hamwe nibikorwa bitandukanye byibinyabuzima. KPV ikora ingaruka zayo binyuze mubikorwa byo kurwanya inflammatory no kuzamura tissue. Ihindura urwego rwa cytokine ikongeza, ikabuza kurekura abunzi kurekura, kandi ikagabanya ibisubizo byaho. Icyarimwe, iteza kwimuka kwakagari no gukwirakwira, kwihutisha gusana no kuvugurura mucosa cyangwa tissue byangiritse kugirango habeho ibidukikije byiza byo gukiza ibisebe. Agaciro kayo ko kuvura kavura indwara. Kurwara ibisebe, KPV yatanzwe neza cyangwa mu kanwa (akenshi ikongerwaho na nanocarrier cyangwa hydrogels kugirango igere ku ntego) igabanya cyane uburibwe bwa colonike, igasana ibyangiritse, ikagabanya ibimenyetso by’indwara, kandi igateza imbere kugarura imiterere y’imitsi. Muri dermatology, ubushakashatsi bwa KPV bwo kurwanya inflammatory n'ingaruka zongera melanocyte burimo gushakishwa kugirango bivure vitiligo. Sisitemu yo gutanga ibintu byingenzi itera synthesis ya melanin no gukwirakwiza selile, ifasha kwisubiraho kuruhu rwanduye. Byongeye kandi, ibikoresho byayo byo gusana bitanga ubushobozi bwo kuvura izindi nkomere zo mu mitsi cyangwa ibihe bijyanye no gutwika.

?BPC-157 ni iki

BPC-157 ikora ibikorwa byinshi byibinyabuzima muguhuza imvugo ya molekile zingenzi nkimikurire yimitsi iva mu mitsi, synthase ya nitric okiside ya endoteliyale, hamwe na reseptor ya hormone ikura, byerekana akamaro gakomeye mugusana no kurinda ingirangingo. Itera kwimuka kwa fibroblast hamwe na synthesis ya kolagen, yihutisha angiogenez, kandi igatanga ingirangingo zangiritse hamwe nintungamubiri zihagije hamwe no gusana imbaraga, bikagera kuri sisitemu zo kurinda selile.

Mubikorwa bya gastrointestinal, agaciro kayo ni ingirakamaro: isana neza ibyangiritse byo mu gifu, irwanya ibisebe biterwa n'inzoga cyangwa NSAIDs, igabanya ibisebe, kandi igatera gukira. Ku ndwara zifata amara nka colitis ulcerative na Indwara ya Crohn, igabanya ibintu bitera porotokore, igabanya uburibwe bwo mu mara, yihutisha gusana ahakorerwa anastomotique, kandi inoze imikorere y amara.

Muri sisitemu ya musculoskeletal, BPC-157 ikora inzira zijyanye no gukwirakwiza ingirabuzimafatizo no kwimuka, bigateza imbere gusana nyuma yo gukomeretsa imitsi ndetse no kugabanya igihe cyo gukira nyuma yo gukomeretsa siporo cyangwa kubagwa. Byihutisha kandi gukiza amagufwa no gukira kwa karitsiye, bigabanya gucana hamwe, kandi bigira ingaruka nziza kumiterere nka osteoarthritis.

Kubijyanye na neuroprotection, ihindura imiterere ya gene ya hippocampal muburyo bwo gukomeretsa umugongo kugirango ifashe imikorere ya moteri. Igabanya kwangirika kwubwonko buterwa nubwonko bwubwonko, igabanya defisit ya neurologiya nyuma yubwonko, ikanagabanya ibimenyetso mubyitegererezo byindwara ya Parkinson na sikizofreniya, byerekana ubushobozi bwa neuroprotective. BPC-157 iteza imbere gukira ibikomere byaka, ihahamuka, na nyuma yo kubagwa. Mugutezimbere amaraso mumitsi ya ischemic, itanga inyungu zo kuvura indwara ziterwa na ischemic.

Umwanzuro

Imikoranire ihuriweho na TB500, KPV, na BPC-157 mu ruvange rwa Coremend ishyiraho umuyoboro ngenderwaho wa casade ya 'anti-inflammatory - gusana - kuvugurura ' imiyoboro ngengamikorere ya caskade, igera ku ngaruka z’ibinyabuzima zidashobora kugerwaho n’ibice bimwe na bimwe. KPV ishyira imbere kugabanya ibibyimba byaho byangiza muguhagarika ibintu biterwa no kurekura ibintu, bikarema microen ibidukikije ikongejwe neza kugirango ikosorwe nyuma. Gutezimbere kwimyanya myakura no kwimuka bitangiza inzira yo gusana ahangiritse. Twubakiye kuri uru rufatiro, TB500 yihutisha kwimuka kwingirabuzimafatizo igenga imikorere ya actin mugihe icyarimwe itera angiogenez na synthesis ya kolagen, itanga ishingiro ryibikoresho byo gusana ingirabuzimafatizo. Itangizwa ryimyororokere ihuza ibice bigize uburinganire bukurikirana hamwe na KPV yo kugenzura ibyiciro byambere. BPC-157 yongerera imbaraga angiogenez muguhuza imiterere ya molekuline yerekana imikurire yimitsi iva mumitsi hamwe na nitric okiside ya nitric okiside, mugihe itezimbere ibikorwa bya fibroblast. Ibi byongerera imbaraga angiogenic ya TB500 kugirango itange intungamubiri kandi igabanye ibyangiritse mugihe cyo gusana binyuze mumikorere yayo ya cytoprotective. Ubushobozi bwayo bwo gusana ibice byinshi (inzira ya gastrointestinal, sisitemu ya musculoskeletal, sisitemu ya nervice) byuzuza imitekerereze ya TB500 hamwe no gusana imitsi ya KPV ikoresheje guhuza imbaraga. Iyo bihujwe, ibikorwa bya KPV birwanya inflammatory bikuraho inzitizi zo gusana, itangizwa rya TB500 rishyiraho urufatiro rwimiterere, kandi ibikorwa bya BPC-157 byongera imikorere no kurinda selile bizamura ubwiza no gukora neza. Hamwe na hamwe, byihutisha inzira yose kuva gukemura umuriro kugeza kwiyubaka no gukira kwimikorere mumyanya yangiritse, bitanga uburyo bwo guhuza imbaraga cyane kubikomere byimitsi hamwe nindwara ziterwa no gutwika.

Ibyerekeye Umwanditsi

Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.

INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.  

Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.