▎ BPC-157 kye ki?
BPC-157 ekola emirimu gy’ebiramu egy’enjawulo ng’etereeza okwolesebwa kwa molekyu enkulu nga ensonga y’okukula kw’emisuwa, endothelial nitric oxide synthase, n’ebikwata obusimu bw’okukula, ekiraga obulungi obw’enjawulo mu kuddaabiriza n’okukuuma ebitundu. Kitumbula okutambula kwa fibroblast n’okukola kolagini, kyanguya okukola emisuwa, era kiwa ebitundu ebyonooneddwa n’obuyambi obw’emmere obumala n’okuddaabiriza amaanyi, okutuuka ku bikolwa eby’okukuuma obutoffaali mu nkola.
Mu nkola z’omu lubuto, omugaso gwayo munene: eddaabiriza bulungi okwonooneka kw’omubiri gw’olubuto, eziyiza amabwa agava ku mwenge oba eddagala lya NSAID, ekendeeza ku kitundu ky’amabwa, era etumbula okuwona. Ku ndwadde z’ekyenda ezizimba nga ulcerative colitis ne Crohn’s disease, kikendeeza ku pro-inflammatory factor release, kikendeeza ku kuzimba kw’ekyenda, kyanguya okuddaabiriza mu bifo ebiyitibwa anastomotic sites, n’okulongoosa enkola y’ekyenda.
Munda mu nkola y’ebinywa n’amagumba, BPC-157 ekola amakubo agakwatagana n’okukula n’okusenguka kw’obutoffaali bw’emisuwa, okutumbula okuddaabiriza okuddamu okukola oluvannyuma lw’obuvune bw’emisuwa n’emisuwa n’okukendeeza ku biseera by’okuwona oluvannyuma lw’obuvune mu mizannyo oba okulongoosebwa. Era kyanguya okuwona obulema bw’amagumba n’okuddamu okukola kw’amagumba, kikendeeza ku kuzimba kw’ennyondo, era kikwata bulungi embeera ng’obulwadde bw’amagumba.
Ku bikwata ku kukuuma obusimu, ekyusakyusa okwolesebwa kw’obuzaale bwa hippocampal mu bikolwa by’obuvune bw’omugongo okuyamba okuddamu okukola emirimu gy’omubiri. Kikendeeza ku kwonooneka kw’obusimu obuleetebwa omusaayi mu bwongo, kikendeeza ku bbula ly’obusimu oluvannyuma lw’okusannyalala, era kikendeeza ku bubonero mu bikolwa by’obulwadde bwa Parkinson n’obulwadde bw’okutabuka emitwe, ekiraga obusobozi bw’okukuuma obusimu. BPC-157 etumbula okuwona mu biwundu eby’okwokya, ebizibu, n’eby’oluvannyuma lw’okulongoosebwa. Nga erongoosa entambula y’omusaayi mu bitundu by’omubiri ebiyitibwa ischemic tissues, kiwa emigaso egy’obujjanjabi eri endwadde z’omusaayi.
Mu bufunzi
Enkolagana ey'okukwatagana eya TB500, KPV, ne BPC-157 munda mu Coremend blend eteekawo omukutu gw'okulungamya cascade ogwa 'anti-inflammatory - repair - regeneration' cascade regulatory network, okutuuka ku bikolwa ebijjuvu eby'ebiramu ebitatuukibwako bitundu ssekinnoomu. KPV ekulembeza okukendeeza ku kuzimba kw’ebitundu by’omubiri mu kitundu nga eziyiza okufulumya ensonga eziyamba okuzimba, okutondawo embeera entonotono ey’okuzimba entono eyamba okuddaabiriza okuddirira. Okutumbula kwayo okukula kw’obutoffaali bw’omubiri (mucosal cell proliferation) n’okusenguka kutandika enkola y’okuddaabiriza mu bitundu ebyonooneddwa. Nga ezimba ku musingi guno, TB500 eyanguya okutambula kw’obutoffaali ng’etereeza enkyukakyuka ya actin ate mu kiseera kye kimu n’esitula angiogenesis ne collagen synthesis, n’ewa omusingi gw’ebintu okuddaabiriza ebitundu by’enzimba. Okutandika kwayo okuddamu okukola ebitundu ebiyunga kikola enkolagana ey’omuddiring’anwa n’okufuga okuzimba okwa KPV okw’omutendera ogusooka. BPC-157 eyongera ku bulungibwansi bw’okutondeka emisuwa nga etereeza molekyu okulaga ensonga y’okukula kw’emisuwa n’endothelial nitric oxide synthase, ate nga etumbudde emirimu gya fibroblast. Kino kigaziya TB500’s angiogenic effects okukakasa nti ebiriisa biweebwa era kikendeeza ku kwonooneka okw’okubiri mu kiseera ky’okuddaabiriza okuyita mu mulimu gwayo ogw’okukuuma obutoffaali. Obusobozi bwayo obw’okuddaabiriza ebitundu by’omubiri ebingi (omusuwa gw’omu lubuto, enkola y’ebinywa n’amagumba, enkola y’obusimu) bujjuliza TB500’s connective tissue regeneration ne KPV’s mucosal repair through tissue-targeted synergy. Bwe kikwatagana, ekikolwa kya KPV eky’okulwanyisa okuzimba kimalawo ebiziyiza okuddaabiriza, okutandika okuddamu okukola kwa TB500 kuteekawo emisingi gy’enzimba, ate okutumbula emirimu gya BPC-157 n’okukuuma obutoffaali bisitula omutindo gw’okuddaabiriza n’obulungi. Wamu, zanguya enkola yonna okuva ku kugonjoola okuzimba okutuuka ku kuddamu okuzimba enzimba n’okuddamu okukola mu bitundu ebyonooneddwa, nga ziwa enkola ey’okuyingira mu nsonga ezikwatagana ennyo ku buvune bw’ebitundu ebizibu n’endwadde ezeekuusa ku kuzimba.
Ebikwata ku Muwandiisi
Ebintu ebyogeddwako waggulu byonna binoonyerezeddwako, birongooseddwa era ne bikung’aanyizibwa kkampuni ya Cocer Peptides.
EBINTU BYONNNA N’AMAWULIRE GW’EBINTU EBIweereddwa KU MUTINDO GUNO BIKOZESEBWA KU KUSASANYA AMAWULIRE N’EBIKOLWA BY’OKUSOMESA.
Ebintu ebiweereddwa ku mukutu guno bigendereddwamu kunoonyereza mu kisenge (in vitro research) byokka. Okunoonyereza mu vitro (Olulattini: *mu ndabirwamu*, ekitegeeza mu bikozesebwa mu ndabirwamu) kukolebwa ebweru w’omubiri gw’omuntu. Ebintu bino si bya ddagala, tebikkiriziddwa kitongole kya Amerika ekivunaanyizibwa ku by’emmere n’eddagala (FDA), era tebirina kukozesebwa kuziyiza, kujjanjaba oba kuwonya mbeera yonna ya bujjanjabi, bulwadde oba bulwadde. Kikugirwa nnyo mu mateeka okuyingiza ebintu bino mu mubiri gw’omuntu oba ebisolo mu ngeri yonna.
