MOTS-C 20mg

▎ MOTs-CSstructure

▎ MOTS-C Nchọpụta

Kedu ihe ndabere nyocha nke MOTS-C?

Nchọpụta nyocha nke MOTs-C sitere na nyocha gbasara ọrụ mitochondrial DNA na ahụike metabolic na ịka nká. Ka nghota nke ọrụ mitochondrial na-abawanyewanye, a chọpụtara na mitochondria abụghị naanị ebe etiti nke ọrịa shuga ma na-ekerekwa òkè na nzikọrịta ozi cellular na ntụgharị mgbaàmà. Site na ịgbalite ụzọ AMPK, ha na-etinye aka na glucose na ọrịa shuga lipid, nwere njikọ chiri anya na ọrịa metabolic dị ka ọrịa shuga na oke ibu, ma na-ekwe nkwa dị ka ebumnuche ọgwụgwọ ọhụrụ maka ọnọdụ ndị a. Nyere njikọ dị n'etiti ọrụ mitochondrial na ọrịa dị iche iche, MOTs-C etinyekwara ya n'ọnọdụ dịka ịba ọcha n'anya B na ọrịa cancer ovarian. Nnyocha na-egosi na ọ nwere ike na-ekere òkè dị ukwuu na usoro ọrịa nje. Mmega ahụ na-akwalite njikọ na nkwupụta nke MOTs-C n'ime ahụ mmadụ, si otú ahụ na-eme ka ọrịa shuga dịkwuo elu, ịrụ ọrụ anụ ahụ, na ọrụ anụ ahụ dum, na-enye ihe akaebe maka usoro mgbochi ịka nká nke na-emega ahụ na ịgbasawanye nyocha nke MOTs-C.

Gịnị bụ usoro omume nke MOTS-C?

Ntinye nke ụzọ akara AICAR-AMPK: 

MOTs-C na-arụ ọrụ ya nke ọma site n'ịgbalite ụzọ akara AICAR-AMPK. Ọ na-akpaghasị okirikiri folate-methionine n'ime sel, si otú a na-eme ka ụzọ akara AICAR-AMPK rụọ ọrụ. Dịka ọmụmaatụ, na usoro physiological dị ka imeziwanye nguzogide insulin na igbochi oke ibu, ịgbalite ụzọ a na-arụ ọrụ dị mkpa. Site n'ime ka ụzọ a rụọ ọrụ, MOTs-C nwere ike ịchịkwa ọrịa shuga ike cell, welie nnabata cellular na iji glucose, si otú ahụ na-achịkwa usoro metabolic homeostasis ^[1,2]..

Mmekọrịta na ụzọ mgbama na mkpụrụ ndụ ihe nketa: 

N'ime mkpụrụ ndụ akwara, MOTs-C na-emekọrịta ihe na ntụgharị mgbaàmà na transcription activator 3 (STAT3) site na YIFY ngalaba putative Src-homologous 2 (SH2) binding motif, na-ebelata ọrụ ntụgharị STAT3 na ịkwalite nhazi myotube. Na pneumonitis radieshon, MOTs-C na-ebelata mmebi anụ ahụ nku ume, mbufụt, na nrụgide oxidative site n'ịbawanye ọkwa nke ihe metụtara nuklia E2 (Nrf2) na ịkwalite nsụgharị nuklia ya, si otú ahụ na-echebe ọrụ mitochondrial. Na mgbakwunye, MOTs-C na-arụ ọrụ dị iche iche nke anụ ahụ site na ịhazi ngosipụta nke mkpụrụ ndụ ihe nketa dịka GLUT4, STAT3, na IL-10 ^[3].

Usoro nke usoro metabolic: 

MOTS-C na-ekere òkè na nhazi nke usoro metabolic dị iche iche dị mkpa, gụnyere ọrịa shuga glucose, ọrịa shuga lipid, na ọrịa shuga ọkpụkpụ, site na usoro autocrine na paracrine. Na ọrịa shuga mellitus, ọ na-eme ka insulin na-eguzogide ma na-achịkwa ọkwa glucose ọbara; na ọrịa shuga lipid, ọ na-abawanye thermogenesis nke abụba agba aja aja, na-akwalite agba aja aja na-acha ọcha, ma na-egbochi oke ibu na ọrịa shuga lipid; na ọrịa shuga ọkpụkpụ, ọ na-akwalite mmụba osteoblast, ọdịiche, na mineralization, na-egbochi ọgbọ osteoclast, ma na-achịkwa ọrịa shuga ọkpụkpụ na ọkpụkpụ ọkpụkpụ ^[4,5]..

Ọgụgụ 1 Usoro na ọrụ nke MOTs-C ^[6].

Kedu ọrụ na ngwa nke MOTs-C?

Ọrụ nke MOTs-C

Mmetụta nchịkwa na ọrịa shuga: 

MOTS-C nwere ike imeziwanye glucose na ọrịa shuga lipid na ahụ. Na ọrịa shuga mellitus, ọ na-ebelata nguzogide insulin, na-enyere aka igbochi ụdị ọrịa shuga 2, na-eme ka nnabata sel na-arụ ọrụ nke ọma na glucose. N'ime ọrịa shuga lipid, ọ na-abawanye thermogenesis nke abụba agba aja aja, na-akwalite browning nke abụba ọcha, si otú ahụ na-achịkwa ọrịa shuga lipid, na-egbochi oke ibu, yana nsogbu metabolic metụtara lipid. Ọ na-ebelatakwa ọrịa imeju na-adịghị egbu egbu ma na-achịkwa ọrịa shuga imeju nke imeju ^[2].

Mmetụta na ọrụ cell: 

Ọ na-akwalite ọrụ mitochondrial ma na-echebe mkpụrụ ndụ site na mmebi. Dịka ọmụmaatụ, na oyi baa na-akpata radieshon, ọ na-ebelata mmebi mitochondrial na cell epithelial ngụgụ, na-ebelata apoptosis cell, ma na-ejigide ọrụ cellular nkịtị. N'ime mkpụrụ ndụ pancreatic, MOTs-C na-emetụta nzuzo na ngosipụta nke insulin na glucagon, na-achịkwa physiology cell pancreatic, ma na-emetụtakwa ndụ cell na apoptosis ^[4,5]..

Mmetụta na mọzụlụ na ọkpụkpụ: 

N'ime akwara, MOTs-C na-akwalite ọdịiche nke mkpụrụ ndụ progenitor muscle, na-eme ka nhazi nke myotube, ma na-echebe mkpụrụ ndụ akwara site na interleukin-6 (IL-6) mebiri emebi, nwere ike igbochi atrophy muscle. N'ihe gbasara ọkpụkpụ, ọ na-akwalite mmụba, ọdịiche, na mineralization nke osteoblasts, na-egbochi nhazi osteoclast, na-eme ka ọkpụkpụ metabolic nguzozi, ma na-enyere aka igbu oge osteoporosis ^[1,5]..

Mmetụta mgbochi mkpali na immunomodulatory: 

MOTs-C na-ebelata nzaghachi mkpali na-adịghị ala ala ma na-achịkwa ọrụ mgbochi. N'ụdị ihe mgbu na-egbuke egbuke, MOTs-C na-ebelata ihe mgbu hypersensitivity, na-ebelata ntọhapụ nke ihe ndị na-egbuke egbuke, ma na-egbochi ọrụ nke mkpụrụ ndụ glial na neurons, na-egosipụta mmetụta mgbochi mkpali na nkwụsị mgbu ^[3]..

Ngwa nke MOTs-C

Mmetụta na ọrịa metabolic: 

Mmetụta nchịkwa nke MOTs-C na glucose na ọrịa shuga lipid na-eme ka ọ bụrụ ebumnuche ọgwụgwọ ọhụrụ maka ọrịa metabolic dị ka ụdị ọrịa shuga 2, oke ibu, na ọrịa imeju na-adịghị egbu egbu ^[2].

Mgbochi na Ọgwụgwọ Ọrịa Musculoskeletal: 

Enwere ike iji mmetụta dị mma ya na mọzụlụ na ọkpụkpụ iji gbochie ma na-agwọ ọrịa ndị metụtara atrophy muscle na ọrịa skeletal dị ka osteoporosis. Maka ndị ọrịa nwere atrophy muscle, ọ nwere ike imeziwanye ọrụ anụ ahụ site n'ịkwalite ọdịiche dị n'etiti cell muscle na igbochi apoptosis cell muscle; Maka ndị ọrịa nwere osteoporosis, ọ nwere ike ịhazi nguzozi nke ọkpụkpụ, mee ka ọkpụkpụ ọkpụkpụ dịkwuo elu, ma gbochie ma na-emeso ọkpụkpụ ọkpụkpụ ^[1,5]..

Nchekwa mmebi radieshon: 

N'ime ọmụmụ banyere pneumonitis radieshon, MOTs-C egosila mmetụta nchebe megide mmebi radieshon nku ume. Enwere ike iji ya n'oge ọgwụgwọ redio iji kpuchido anụ ahụ nkịtị, belata mmebi anụ ahụ na-akpata radieshon, ma welie ịdị irè nke ọgwụgwọ redio ^[2].

Ọgwụgwọ ọrịa mkpali: 

Dabere na mmetụta mgbochi ya, MOTs-C nwere ike iji na-agwọ ọrịa ndị na-egbuke egbuke dị ka ihe mgbu na-egbuke egbuke, na-enye ntụziaka ọhụrụ maka ọgwụgwọ nke ọnọdụ ndị dị otú ahụ ^[3].

Mmechi

Dị ka peptide sitere na mitochondrial, MOTs-C nwere ike ịgbalite ụzọ mgbaàmà iji mezie glucose na ọrịa shuga lipid, melite nguzogide insulin, ma belata ihe ize ndụ nke ọrịa metabolic; ọ nwekwara ike ịnọgide na-arụ ọrụ akwara na ọkpụkpụ, gbochie atrophy muscle na osteoporosis; na ọ nwere ọrụ mgbochi mkpali na nchekwa cell, na-ekere òkè na nchebe mmebi radieshon na ọgwụgwọ nke ọrịa na-efe efe.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

Onye ode akwụkwọ akụkọ sayensị

Wan, Yanmin na-ejikọta ya na ụlọ ọrụ dị iche iche a ma ama, gụnyere ụlọ ọgwụ, ụlọ ọrụ nyocha, mahadum, na ụlọ ọrụ dị ka Linping Hosp Integrated Tradit Chinese & Western M, Shanghai Sci Tech Inno Ctr Infect & Immun, Yunnan Agricultural University, wdg. mmasị nyocha ya dị ukwuu, bụ isi na-elekwasị anya na isiokwu nke Immunology Science & Technology, Virology Chemiss, Virology, Chemistry, Chemistry, Chemistry, Chemistry, Chemistry na Immunology. N'ihe gbasara Immunology Science & Technology, ọ na-abanye n'ime usoro na ngwa nke usoro ahụ ji alụso ọrịa ọgụ. Ihe nyocha Virology ya gbadoro ụkwụ na njirimara nje, nnyefe, na mgbochi. N'ime ngalaba nke Materials Science Chemistry, ọ na-agba mbọ na mmepe nke ihe onwunwe na ngwa ọhụrụ nke kemistri, na-eme ka ọ bụrụ onye ama ama nke nwere nnukwu nchọpụta nyocha na ngalaba agụmakwụkwọ dị mkpa. Wan, Yanmin ka edepụtara n'akwụkwọ ntụaka [6].

▎ Okwu ndị dị mkpa

[1] García-Benlloch S, Revert-Ros F, Blesa JR, et al. MOTs-C na-akwalite ọdịiche dị n'ahụ ahụ na vitro [J]. Peptides, 2022,155:170840.DOI:10.1016/j.peptides.2022.170840.

[2] Zhang Y, Huang J, Zhang Y, et al. Peptide MOTs-C sitere na Mitochondrial na-ebelata Pneumonitis Radiation site na Nrf2-Dependent Mechanism[J]. Antioxidants, 2024,13.

[3] Wang Z, Yang L, Xu L, et al. Central na mpụta usoro nke MOTs-C na-ebelata ihe mgbu hypersensitivity na ụmụ oke ụdị mgbu mgbu [J]. Nnyocha nke akwara ozi, 2024,46 (2): 165-177.DOI: 10.1080/01616412.2023.2258584.

[4] Bień J, Pruszyńska-Oszmałek E, Kołodziejski P, et al. MOTs-C na-ahazi alfa pancreatic na ọrụ beta cell in vitro[J]. Akụkọ ihe mere eme na ihe ọmụmụ ihe ọmụmụ, 2024,161(6):449-460.DOI:10.1007/s00418-024-02274-0.

[5] Yi X, Hu G, Yang Y, et al. Ọrụ MOTs-C na nhazi nke ọrịa shuga ọkpụkpụ [J]. Oke na Physiology, 2023,14:1149120.DOI:10.3389/fphys.2023.1149120.

[6] Wan W, Zhang L, Lin Y, et al. Mitochondria-ewepụtara peptide MOTs-C: mmetụta na usoro metụtara nrụgide, ọrịa shuga na ịka nká [J]. Akwụkwọ akụkọ ọgwụ ntụgharị, 2023,21 (1): 36.DOI: 10.1186/s12967-023-03885-2.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.