Cocer Peptides fɛ 
a bɛ kalo 1 bɔ
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Dilan pepitiriw ye sebaayaba jira farikolo yɔrɔw dilancogo ni u lasegincogo la. I n’a fɔ dilan pepitiri, Chonluten jɔyɔrɔ ka bon selilɛriw ka baara ɲɛnabɔli la ani ka farikolo yɔrɔw dilancogo sabati.
Jaa 1 Chonluten ka kemikaliya cogoya.
Kɔnlutɛni jɔyɔrɔ selilɛriw caya ni funu ɲɛnabɔli la
Kɔnɔnatumuw cayacogo ɲɛnabɔli : Kɔnlutɛni ni pepitiri caman minnu dɔnna Karamɔgɔ Khavinson fɛ kabini san 1973, olu bɛ se ka cayacogo jɔnjɔnw ɲɛnabɔ ni tirosini fosforilasi caya ye mitogène-activé proteine kinases la sitoplasma kɔnɔ. Kɔnlutɛni bɛ se ka nɔ bila selilu caya taabolo la, ka selilu tilacogo ni u bonya sabati, o la, a bɛ se ka selilɛriw jusigilan wajibiyalen di farikolo yɔrɔw dilancogo ma. Misali la, joginda kɛnɛyali waati, farikolokisɛw caya ye fɛɛrɛ nafamaba ye farikolo yɔrɔ kuraw dilanni na. Kɔnlutɛni bɛ o wale in sabati ni kinase minnu bɛ tali kɛ ɲɔgɔn na, olu ka baara ɲɛnabɔ.
Funu kunbɛnni : Kɔnlutɛni bɛ nafa kɛrɛnkɛrɛnnen jira funu kunbɛnni na. A bɛ bɔ fogonfogon la epiteliyali selilɛriw la, a bɛ tumor necrosis factor (TNF) sɔrɔli bali monositiw fɛ minnu bɛ banakisɛw ka lipopolysaccharide (LPS) sɔrɔ minnu bɛ banakisɛw kɛlɛ in vitro. Monocytes jɔyɔrɔ ka bon kosɛbɛ funu jaabiw la; ni LPS ye u lawuli, u bɛ sitokiniw bɔ minnu bɛ funu dɛmɛ i n’a fɔ TNF walasa ka funu daminɛ. Kɔnlutɛni bɛ dɔ bɔ funu jaabiw fanga la ni a bɛ TNF bɔli bali. Pepitidi minnu bɛɛ sɛgɛsɛgɛra, olu bɛɛ bɛ se ka TNF ni pro-inflammatory interleukin-6 (IL-6) sitokiniw jirali bali LPS-stimulated terminally differentiated THP-1 cellules kɔnɔ, o bɛ Chonluten jɔyɔrɔ ɲuman jira ka t’a fɛ funu sigida fitininw labɛnni na. Funu jaabi minnu bɛ sɔrɔ funubana fɛ walima farikolo yɔrɔw tiɲɛni fɛ, Kɔnlutɛni bɛ se ka farikolo yɔrɔw tiɲɛni wɛrɛw nɔgɔya funu fɛ o fɛɛrɛ in sababu fɛ, ka sigida ɲuman dilan farikolo yɔrɔw dilancogo la.
Jaa 2 Kɔnɔnatumu kɔkanna bɔgɔlanw jate bɛ kɛ ni sitofluorimɛtiri sɛgɛsɛgɛli ye monositɛriw (A) ni makɔrɔfagaw (B) kan.
Kɔnlutɛni tali farikolo yɔrɔw dilancogo danfaralenw na
Farikolo yɔrɔw dilancogo : Fari joginda dilancogo la, Chonluten ka banakisɛfagalanw ni farikolokisɛw caya sabatili nafa ka bon kosɛbɛ. I n’a fɔ hadamaden farikolo yɔrɔba ye, fari bɛ se ka jogin suguya caman sɔrɔ, i n’a fɔ jeninida ni tigɛ. Funu jaabiw bɛ baara kɛ joona fari jogin kɔfɛ, wa funu kojugu bɛ se ka joginda kɛnɛyali bila kɔfɛ ani ka kɛ sababu ye yɛrɛ ka joginda sɔrɔ. Konlutɛni bɛ se ka funufɛnw bɔli bali, ka funu jaabiw dɔgɔya, ani ka farikolo yɔrɔw caya o waati kelen na, o bɛ joginda kɛnɛyali teliya. Ni aw ye a suma ni laadala joginda sirilanw ye, Kɔnlutɛni bɛ minnu na, olu bɛ se ka joginda misɛnninw labɛn ka ɲɛ, ka farikolo yɔrɔw labɛn ka ɲɛ ani ka u dilan, ka se ka dɔ bɔ joginda sɔrɔli la, ani ka fari dilancogo ɲɛ.
Jaa 3 Cell–Cell Adhesion Assay: Confocal microscopy quantification ani ICAM-1 Western Blot sɛgɛsɛgɛli.
Kolotugudaw dilancogo : Ka ɲɛsin kolotugudaw dilancogo ma, hali ni ɲinini minnu kɛra sisan, olu ma ɲɛsin Kɔnlutɛni tali ma kolotugudaw dilancogo la, o dilan pepitiri suguya kelenw ye ɲɛtaa ɲuman jira. Pepitiri B2A dilannen bɛ se ka kɛ sababu ye ka jirisunw bila u ka danfara don u ni ɲɔgɔn cɛ ka kɛ kɔnɔbara basigilenw ye ani ka dɔ fara sosow ka kolotuguda tiɲɛnenw dilancogo kan. Kɔnlutɛni, n’a bɛ se ka farikolokisɛw caya ni u funucogo ɲɛnabɔ, hakilinata siratigɛ la, o fana bɛ se ka kɛ sababu ye ka kolotugudaw dilan. Kɔnɔnatumu jogin kɔfɛ, sigida funu bɛ kɛ, wa Kɔnlutɛni bɛ se ka funu bali, o bɛ dɔ bɔ a tiɲɛni na kolotugudaw la. A ka seliluw caya sabatili bɛ se ka kɛ sababu ye ka kolosinsinnanw caya ni u danfara nɔgɔya, ka kolotugudaw matirili labɛnni sabati, wa o bɛ se ka kolotugudaw dilan.
Jaa 4 B2A nɔ min bɛ MIA fɛ kolotugudaw la sosow gɛnɛgɛnɛ na.
Kolow dilancogo : Kolow dilancogo siratigɛ la, ɲinini minnu bɛ sen na sisan, olu sinsinnen bɛ fɔlɔ dilan pepitiri suguya wɛrɛw ni biyomateriyali kan. PCL sɛnɛfɛn dilannen min datugulen don ni pepitiriw ye minnu bɛ kolajɛ ladege GFOGER, o bɛ kolo dilancogo sabati sosow ka kolotugudaw la minnu bonya ka bon kosɛbɛ; paratayiroyidi ɔrimɔni bɔlenw PTHrP-1 min sirilen bɛ RADA16-I-formed self-assembled peptides P1R16 la, olu bɛ baara jira i n’a fɔ ka jirisunw caya, ka danfara ɲɛsin u ma, ka kolo labɛn kokura, ani ka joli siraw labɛn, o b’a jira ko sebaayaba bɛ kolotugudaw labɛncogo la kolotugudaw walima u karilenw dilancogo la. Kɔnlutɛni ka banakisɛfagalanw ni farikolokisɛw caya sabatili nɔw bɛ funu tiɲɛni nɔgɔya kolotugudaw la kolo dilancogo daminɛ na, ka kolotugudaw caya, ani ka kolotugudaw lasegincogo jusigilan sigi.
Kuncɛli
Kuma surun na, Chonluten, i n’a fɔ dilan pepitiri, o bɛ nɔba jira farikolokisɛw caya ni funu labɛnni na. A kɛcogo ani ɲinini minnu sɔrɔla dilan pepitiri wɛrɛw kan minnu bɛ tali kɛ ɲɔgɔn na, olu nafa ka bon farikolo yɔrɔw dilancogo la, fari, kolotugudaw ani kolo fana sen bɛ o la.
Sɛbɛn minnu bɛ tali kɛ o la
[1] Avolio F, Martinotti S, Khavinson V. K., ani mɔgɔ wɛrɛw. Pepitidi minnu bɛ caya baara ni funu siraw ɲɛnabɔ Monocyte/Macrophage THP-1 selilɛri la[J]. Duniya kɔnɔ, 2022,23(7).DOI:10.3390/ijms23073607.
[2] Lin X, Shanmugasundaram S, Liu Y, ani a ɲɔgɔnnaw. Pepitiri B2A bɛ danfara don kɔnɔbara la in vitro ani ka kolotugudaw dilancogo ɲɛ sosow la[J]. Ɲɛgɛnɛsiraw ɲinini gafe, 2012,30(8):1221-1228.DOI:10.1002/jor.22078.
[3] Wojtowicz A. M., Shekaran A., Oest M. E., ani a ɲɔgɔnnaw. Biyomateriyali sɛgɛsɛgɛlikɛlanw datuguli ni kolajɛni-mimɛtiki pepitiri GFOGER ye kolotugudaw dilancogo kama[J]. Biomateriels, 2010,31(9):2574-2582.DOI:10.1016/j.biyomateriyali.2009.12.008.
Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama:
