Cocer Peptides fɛ 
a bɛ kalo 1 bɔ
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Kuma bɛɛ lajɛlen
Ni jamanadenw kɔrɔbayara teliya la bi jamana kɔnɔ, bana minnu bɛ tali kɛ kɔnɔboli baara la, i n’a fɔ sukarodunbana suguya 2 ani sukaro muɲuni dɔgɔyali, olu kɛra ka caya ka taa a fɛ. Pancragen, n’o ye tetarapɛtidi ye, o ye jateminɛba sɔrɔ nin san laban ninnu na pankreyasi kɛnɛyako ɲinini siratigɛ la.
Jaa 1 Pancragen ka kemikaliya cogoya.
Pancragen ka sariyaw ka nɔ bila Pankreyasi endocrine baarakɛcogo la
Glucose (Glucose) ka baarakɛcogo
Sɛgɛsɛgɛli minnu kɛra rhesus sonsannin kɔrɔbaw kan, a jirala ko sukaro hakɛ dantigɛlen dɔ tali kɔfɛ, sukaro 'tunni' hakɛ tun ka dɔgɔn bagankɔrɔbaw la ni i ye a suma ni bagan fitininw ye, o b’a jira ko sukaro bɔli seko dɔgɔyara. Nka, ni Pancragen pikiri kɛra rhesus sonsannin kɔrɔbaw la farikolo la (50 μg/bagan/tile tile 10 kɔnɔ), sukaro 'tunni' hakɛ cayara kosɛbɛ. O b’a jira ko Pancragen bɛ se ka farikolo ka farikoloɲɛnajɛ seko bonya sukaro la, ka joli sukaro bɔli teliya ani ka joli sukaro hakɛ sabati. Nin wale kɛcogo in bɛ tali kɛ Pancragen ka pankreyasi kɔnɔnatumuw labɛnni na, barisa a bɛ se ka inisɔndiya bɔli lawuli walima ka inisɔndiya sabati, o la, a bɛ dɔ fara farikolo yɔrɔw ka sukaro tali ni a baara kan ani ka sukaro hakɛ dɔgɔya joli la.
Inisɔn ni C-peptide hakɛw labɛnni
Nin ɲinini in y’a jira fana ko sukaro tali kɔfɛ, inisɔndiya ni C-peptide hakɛ dantɛmɛnen (miniti 5 ani 15 sukaro pikiri kɛlen kɔfɛ) tun ka ca bagan kɔrɔbaw la ka tɛmɛ bagan fitininw kan. O b’a jira ko inisɔndiya bɔli kɛcogo bagan kɔrɔbaw la, o tɛ cogo la. Pancragen tali bɛ joli la insuline ni C-peptide kinetiques normales lasegin. C-peptide bɛ bɔ molari hakɛ kelen na ni inisɔndiya ye, wa a hakɛ caman yeli bɛ pankreyasi β-cellw ka baara jira. Pankrazɛni bɛ inisɔndiya ni C-peptide hakɛ bɛnnenw segin u cogo kɔrɔ la, o b’a jira ko a bɛ nɔ ɲuman bila pankreyasi β-cell baara la, o min bɛ dɛmɛ ka inisɔndiya bɔli kɛcogo ɲuman sabati. O nafa ka bon kosɛbɛ joli sukaro hakɛ sabatili la ani ka sukaro sɛnɛcogo ɲuman sabati farikolo la.
Pancragen ani Glucose muɲuni dɔgɔyali ɲɛnabɔli
Baganw ka kɔrɔbɔli jaabiw
Rhesus sonsannin kɔrɔba 9 minnu kɛnɛyara kɛnɛyaso la, minnu si bɛ san 20–25 la, olu kɛra kalan kɛbagaw ye. o la, 5 pikiri kɛra ni Pancragen ye (miligaramu 0,05/bagan/tile, pikiri kɛli farikolo la, tile 10 kɔnɔ), ani 4 ye sukarodunbana fura min bɛ kɛ ka caya, n’o ye glimepiride ye (miligaramu 4/bagan/tile, a tali da la, tile 10 kɔnɔ). Pancragen ni glimepiride fila bɛɛ ye dɔ bɔ sonsannin kɔrɔbaw ka joli sukaro hakɛ basigilen na. Pancragen tɛ joli sukaro dɔrɔn dɔgɔya, nka a bɛ inisɔndiya ni C-peptide hakɛ segin a cogo kɔrɔ la, o bɛ a jira ko a bɛ se ka sukaro muɲuni dɔgɔya bagan kɔrɔw la. Pankrazɛni bɛ nafa kɛrɛnkɛrɛnnenw jira sukaro muɲuni dɔgɔyali la, barisa a tɛ joli sukaro hakɛ dɔgɔya dɔrɔn, nka min nafa ka bon kosɛbɛ, a bɛ o sababu ju ɲɛnabɔ ni a bɛ pankreyasi kɔnɔnatumuw baaracogo ɲɛnabɔ, o la, a bɛ farikolo ka se ka sukaro muɲu.
Kɛnɛyako siratigɛ la, a bɛ se ka kɛ a la
Sukaro muɲuni dɔgɔyali ye sukarodunbana suguya 2 taamasiɲɛ ye sani sukarodunbana ka sɔrɔ, wa ni a ma ɲɛnabɔ, a bɛ se ka taa ɲɛ nɔgɔya la ka kɛ sukarodunbana ye. Pancragen ka se ka sukaro muɲuni ɲɛ bagan kɔrɔbaw la, o bɛ hakilina kura di sukarodunbana suguya 2 kunbɛnni n’a furakɛli ma. Mɔgɔ minnu bɛ sukaro muɲunibaliya la, kɛrɛnkɛrɛnnenya la mɔgɔkɔrɔbaw, Pancragen bɛ se ka kɛ fɛɛrɛ ye min tɛ mɔgɔ tɔɔrɔ ani min bɛ se ka kɛ walasa ka sukarodunbana bila kɔfɛ walima ka a bali.
Pankrazɛni ka nɔ min bɛ se ka kɛ sababu ye ka pankreyasi selilɛriw danfara
Selilu danfara taamasiɲɛw jiracogo ɲɛnabɔli
Sɛgɛsɛgɛliw y’a jira ko ni pankreyasi selilɛriw bɛ kɔrɔbaya, danfara taamasiɲɛw jirali bɛ dɔgɔya. Nka, Pancragen bɛ se ka pankreyasi danfaralanw jirali lawuli (i n’a fɔ PDX1 ani PTFLA) ani gunw selilɛri taamasiɲɛw (PDX1, PAX6, PAX4, FOXA2, ani NKX2.2) 'kanbele' ni 'kɔrɔ' ladamu fila bɛɛ la. Nin danfara ninnu nafa ka bon kosɛbɛ danfaracogo ɲuman na ani pankreyasi selilɛriw ka baarakɛcogo sabatili la. PDX1 ye kɔnɔboli yiriwali ni pankreyasi β-cell baara ɲɛnabɔbaga jɔnjɔn ye, wa a jirali caya bɛ dɛmɛ ka pankreyasi β-cellw danfara ni u baarakɛcogo seginni sabati. Pankrazɛni bɛ pankreyasi selilɛriw danfara sabati ka kɛ farikolokisɛw ye minnu bɛ baara kɛ cogo la, a kɛtɔ ka o danfara taamasiɲɛw jiracogo kɔrɔta.
Danfara kɛcogo ani kɛnɛyako nɔfɛkow
Pankrazɛni bɛ pankreyasi gun ni asinari selilɛriw danfara bila mɔgɔ la, o ye wale ye min ye fɛɛrɛ jɔnjɔn dɔ ye min bɛ a ka sukarodunbana ni funu kɛlɛli nɔw sinsin. Ni a bɛ selilɛriw ka danfara sabati, Pancragen bɛ dɛmɛ ka pankreyasi farikolo yɔrɔw jɔcogo ni u baarakɛcogo dafalen sabati, ka pankreyasi seko bonya ka joli sukaro hakɛ labɛn, ani ka dɔ bɔ funu tiɲɛni na kɔnɔboli la. Nin pankreyasi selilɛriw danfara yiriwali in bɛ furakɛli laɲini dɔ di min bɛ se ka kɛ kɔnɔboli banaw furakɛli la i n’a fɔ sukarodunbana ni kɔnɔboli.
Pancragen baarakɛcogo seko jamanaden kɔrɔbaw la
Pankreyasi ka baarakɛbaliya min bɛ sɔrɔ si hakɛ fɛ, o ɲɛnabɔli
Bi jamanaden hakɛ sigicogo la, mɔgɔkɔrɔbaw hakɛ cayalenba ye sababu fɔlɔ dɔ ye min bɛ sukarodunbana suguya 2 banabagatɔw hakɛ caya ani ka sukaro muɲuni dɔgɔya. Pancragen bɛ nɔ ɲuman minnu bila pankreyasi endocrine baarakɛcogo la, fɛnɲɛnama kɔrɔbaw la minnu tɛ hadamadenw ye, olu b’a jira ko a bɛ se ka kɛ ka caya mɔgɔkɔrɔbaw la. A bɛ se ka mɔgɔkɔrɔbaw ka kɔnɔbara basigilenw ɲɛnabɔ ka ɲɛ ani ka u ɲɛ, ka u dɛmɛ ka joli sukaro hakɛ ni kɔnɔboli baara kɛcogo ɲuman sabati.
Kuncɛli
Kuma surun na, Pancragen ye nɔ ɲuman caman jira pankreyasi kɛnɛyako siratigɛ la. A bɛ se ka pankreyasi endocrine baarakɛcogo ɲɛnabɔ, ka joli sukaro hakɛ ɲɛ ka ɲɛ ani ka inisɔndiya ni C-peptide bɔli kɛcogo ɲɛ; a bɛ nɔ ɲuman bila sukaro muɲuni dɔgɔyali la, ka fɛɛrɛ kuraw di sukarodunbana suguya 2 kunbɛnni n’a furakɛli ma; ni a bɛ pankreyasi selilɛriw danfara sabati, a bɛ pankreyasi farikolo yɔrɔw jɔcogo n’u baara sabatili sabati, a jɔyɔrɔ ka bon banaw furakɛli la i n’a fɔ sukarodunbana ni kɔnɔboli.
Sosow (Sɔrɔyɔrɔw).
[1] Goncharova N. D., Ivanova L. G., Oganyan T. E., ani mɔgɔ wɛrɛw. [Sukaro muɲuni dɔgɔyali latilenni ni tetarapɛtidi (Pancragen) ye rhesus sonsannin muso kɔrɔw la][J]. Ɲɛtaa minnu kɛra mɔgɔkɔrɔbaw ka kɛnɛyako la, 2015,28(3):579-585.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=28509500&query_hl=1
[2] Goncharova ND, Ivanova LG, Oganian T É, ani mɔgɔ wɛrɛw. [Tetrapeptide pancragen ka nɔ bila pankreyasi endocrine baara la sonsannin kɔrɔw la][J]. Ɲɛtaa minnu kɛra mɔgɔkɔrɔbaw ka kɛnɛyako la, 2014,27(4):662-667.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=25946840&query_hl=1
[3] Khavinson V, Durnova A. O., Polyakova V. O., ani a ɲɔgɔnnaw. Pankrazɛni nɔ minnu bɛ pankreyasi banakisɛw danfara la u kɔrɔbaya waati[J]. Bulletin de biologie expérimentale et médecine, 2013,154(4):501-504.DOI:10.1007/s10517-013-1987-6.
Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama:
