Klow 80mg (Tsakae) .

▎ Nukae nye BPC-157?

BPC-157 nye peptide si wowɔ si me amino acid 15 le. Eƒe ɖoɖoa dzɔ tso Ŋutilã Takpɔnu (BPC) kakɛ si le amegbetɔ ƒe dɔgbo ƒe ʋuka me proteinwo me, si nye peptide siwo kpɔa dɔgboa ta le lãmenugbagbeviwo me ƒe kpɔɖeŋu si wowɔ kple asi. Nu gbagbewo ƒe nɔnɔme vevitɔ si le peptide sia ŋue nye eƒe lãmenugbagbeviwo ɖɔɖɔɖo ƒe ɖoɖowɔwɔ ƒe ŋutete sẽŋu. Edoa lãmenugbagbevi siwo do ƒome kple ɖɔɖɔɖo abe fibroblasts kple endothelial cells ƒe dzidziɖedzi kple ʋuʋu ɖe ŋgɔ to tyrosine kinase receptors (le kpɔɖeŋu me, c-Met) ƒe dɔwɔwɔ me, esime wònaa extracellular matrix components (le kpɔɖeŋu me, collagen, fibronectin) ƒe wɔwɔme kple wo gbugbɔgawɔ kabakaba. Woda asi ɖe ŋusẽkpɔɖeamedzi sia dzi le dɔgbo ƒe abi, lãkusi ƒe gbagbã, kple ƒu ƒe gbagbã ƒe kpɔɖeŋuwo me. Le dɔgbo ƒe abixɔxɔ ƒe kpɔɖeŋuwo me la, BPC 157 ɖea abi ƒe dɔyɔɣi dzi kpɔtɔna ŋutɔ eye wònaa lãkusi ƒe gbugbɔgadzɔ ƒe nyonyome nyona ɖe edzi.

BPC 157 wɔa akpa vevi aɖe to asitɔtrɔ le dɔdzẽ ƒe nuto suea ŋu me. Etsia neutrophil ƒe gege ɖe lãme na ame kple nusiwo doa ŋusẽ dɔdzẽ (abe IL-1β kple NF-κB ene) ƒe ɖeɖefia fũ akpa nu, eye le ɣeyiɣi ma ke me la, edoa nusiwo tsia dɔdzẽ nu (abe IL-10 ene) ƒe dodo ɖe ŋgɔ. Esia ɖea dɔdzẽ ƒe ŋuɖoɖo kpata le abixɔxɔ megbe dzi kpɔtɔna eye wòxea mɔ na lãmenugbagbeviwo ƒe gbegblẽ evelia si dɔdzẽ si dzi womeɖu o hena vɛ. Eƒe ʋukawo takpɔkpɔ ƒe ŋusẽkpɔɖeamedziwo dzena ŋutɔ. To ʋukawo me lãmenugbagbeviwo ƒe tsitsi ƒe akpa (VEGF) kple angiopoietin ƒe dodo me la, edoa ʋuka yeye ƒe wɔwɔme ɖe ŋgɔ le teƒe siwo gblẽ, enaa ʋu ƒe dodo le teƒea nyona ɖe edzi, eye wònaa nunyiame kple ɔksidzin si sɔ hena lãmenugbagbeviwo ɖɔɖɔɖo.

▎ Nukae nye KPV?

KPV, si nye peptide etɔ̃ si me lysine-proline-valine le, dzɔ tso α-melanocyte-stimulating hormone (α-MSH) ƒe C-nuwuƒe nuto me eye wònye kakɛ si le dzɔdzɔme nu si me nugbagbeviwo ƒe dɔwɔwɔ ɖedzesi aɖe le.

Le dɔdzẽ ƒe ɖoɖowɔwɔ me la, KPV ɖea dɔ sesẽ si tsia dɔdzẽ nu fiana. Etsia nuklia factor-κB (NF-κB) ƒe dzesimɔa nu nyuie, si ɖea pro-inflammatory cytokines (abe IL-1β, TNF-α, kple bubuawo ene) ƒe nuŋɔŋlɔ kple woƒe dodo dzi kpɔtɔna, si wɔnɛ be wòxea mɔ na inflammatory cascades le woƒe dzɔtsoƒe. Le lãwo ƒe dɔgbo ƒe kpɔɖeŋuwo me la, KPV nono ɖea dɔgbo ƒe dɔdzẽ ƒe agbɔsɔsɔ dzi kpɔtɔna ŋutɔ eye wòɖea lãkusi ƒe gbegblẽ dzi kpɔtɔna. Dɔwɔwɔ sia tsoa alesi wòɖɔa dɔdzẽ ƒe dzesiwo ɖo pɛpɛpɛ le dɔgboa ƒe dɔlélenutsiŋutete ƒe lãmenugbagbeviwo kple lãkusi me lãmenugbagbeviwo me gbɔ. KPV gaɖea teƒea ƒe dɔdzẽ ƒe ŋuɖoɖowo dzi kpɔtɔna to mast cells ƒe liƒolili kple dɔdzẽ ƒe domenɔlawo abe histamine ene ƒe dodo dzi ɖeɖe kpɔtɔ me, si wɔnɛ be lãmenugbagbeviwo ƒe homeostasis nɔa anyi.

Le dɔlélenutsiŋutete ƒe ɖoɖo nu la, KPV ɖea mɔ eve dzi tɔtrɔ ƒe ŋutetewo fiana. Edoa T-lãmenugbagbeviwo ƒe vovototodedeameme kple dɔwɔwɔ ɖe ŋgɔ, edoa dɔlélenutsiŋutete ƒe nusiwo le abe IL-2 kple IFN-γ ene ƒe dodo ɖe ŋgɔ, eye wòdoa lãmenugbagbeviwo ƒe dɔlélenutsiŋutete ƒe ŋuɖoɖo ɖe ŋgɔ. Le dɔlélenutsiŋutete ƒe dɔléle ƒe kpɔɖeŋuwo me la, KPV ɖɔa Th1/Th2 lãmenugbagbeviwo ƒe dadasɔ ɖo, eɖea dɔlélenutsiŋutete ƒe dɔwɔwɔ si gbɔ eme dzi kpɔtɔna, eye wòxea mɔ na dɔlélenutsiŋutete ƒe gbegblẽ.

Asixɔxɔ si ate ŋu anɔ KPV ŋu le lãmenugbagbeviwo ƒe dzidziɖedzi kple lãmenugbagbeviwo ɖɔɖɔɖo hã me. To lãmenugbagbeviwo me dzesimɔ siwo sɔ ƒe dɔwɔwɔ me la, edoa fibroblast ƒe dzidziɖedzi kple ʋuʋu ɖe ŋgɔ, enaa lãmenugbagbeviwo godo ƒe matrix ƒe akpawo abe collagen ene ƒe wɔwɔme kabakaba, eye wònaa abi ƒe dɔyɔyɔ nɔa lãmenugbagbeviwo abe ŋutigbalẽ kple lãmeka ene me nɔa bɔbɔe. Le ŋutigbalẽ ɖɔɖɔɖo dodokpɔwo me la, abi siwo wotsɔ KPV da dɔe ɖee fia be woƒe dɔyɔyɔ kabakaba ŋutɔ eye abi ƒe wɔwɔme dzi ɖe kpɔtɔ, si ɖe ŋusẽ nyui si wòkpɔna ɖe lãmenugbagbeviwo ɖɔɖɔɖo ƒe nyonyome dzi fia. KPV ate ŋu aʋã nusiwo do ƒome kple ʋukawo ƒe dzɔdzɔ abe ʋukawo ƒe lãmenugbagbeviwo ƒe tsitsi ƒe nuwɔna (VEGF) ene hã ƒe ɖeɖefia, si ado ʋuka yeyewo ƒe dɔwɔwɔ ɖe ŋgɔ eye wòana ʋu nayi teƒe siwo woxɔ abi la nanyo ɖe edzi, si ana nɔnɔme veviwo nasu lãmenugbagbeviwo ƒe gbugbɔgadzɔ me.

▎ Nukae nye GHK-Cu?

GHK-Cu nye nusi glycyl-L-histidyl-L-lysine tripeptide kple akɔbli ions wɔ. Esi wòwɔa akɔbli ions kple tripeptide ƒe dɔwɔwɔ aduadu ŋudɔ ta la, ewɔa dɔ vevi geɖe le ŋutilã ƒe dɔwɔwɔwo me. Le ŋutigbalẽ dzadzraɖo kple eƒe gbugbɔgadzɔ me la, ewɔa dɔ abe dzesi peptide ene be wòana fibroblasts nawɔ collagen, elastin, kple glycosaminoglycans, si wɔnɛ be ŋutigbalẽa sesẽna eye wòtena ɖe edzi esime wònaa ŋutigbalẽ ƒe nya siwo tsitsi alo foto ƒe tsitsi hena vɛ la nyona ɖe edzi. Le abi ƒe dɔyɔɣi la, eʋãa stratum corneum cell ƒe tsitsi be woatu kabakaba esime wòle dɔdzẽa ɖɔm ɖo to IL-6 kple TNF-α ƒe ɖeɖefia fũ dzi ɖeɖe kpɔtɔ me. Edoa macrophage ƒe ƒuƒoƒo hã ɖe ŋgɔ be wòaɖe tsitsinuwo ɖa, si kpena ɖe lãmekawo dzadzraɖo kple wo gbugbɔgaɖɔɖo ŋu. Eƒe dɔlékuiwutike sesẽ kple esi tsia dzodzodzoetsitsi nu nana akɔbli ƒe agbɔsɔsɔ le lãmenugbagbeviwo me, enaa antioxidant ƒe ŋutete dzina ɖe edzi, eye wòhea lãmenugbagbeviwo ƒe tsitsi ɖe megbe. Le aklã me dɔdzẽ ƒe kpɔɖeŋuwo me la, eɖea abi sesẽ si lipopolysaccharide hena vɛ dzi kpɔtɔna eye wònaa lãmenugbagbeviwo ƒe dɔdzẽ ƒe nɔnɔmewo nyona ɖe edzi. GHK-Cu ɖea vi na ɖa ƒe lãmesẽ to ɖa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dodo ɖe ŋgɔ, melanin wɔwɔ dodo ɖe ŋgɔ, ŋusẽ ƒe asitɔtrɔ le lãmenugbagbeviwo ŋu ƒe ɖoɖowɔwɔ, kple kpekpeɖeŋu nana be ɖa ƒe ŋeŋe nanyo ɖe edzi me.

Nyanuwuwuw

Abe TB 500, BPC-157, KPV, kple GHK-Cu ƒe tsakatsaka ene la, Klow ƒe dɔwɔwɔ aduadu ƒe ŋusẽkpɔɖeamedziwo dzena to ŋutilã ƒe dɔwɔwɔ siwo le akpa vovovowo ƒe ɖoɖowɔwɔ ɖe wo nɔewo dzi kple esiwo kpe ɖe wo nɔewo ŋu me. TB 500 doa lãmenugbagbeviwo ƒe ʋuʋu kple ʋukawo ƒe dzɔdzɔ ɖe ŋgɔ, BPC-157 doa lãmenugbagbeviwo ɖɔɖɔɖo kple dɔdzẽ ƒe ɖoɖowɔwɔ ɖe ŋgɔ, KPV léa ŋku ɖe dɔlélenutsiŋutete ƒe dadasɔ kple teƒea ƒe dɔdzẽ nutsitsi ŋu, esime GHK-Cu wɔa dɔ le antioxidant takpɔkpɔ, ŋutigbalẽ ƒe gbugbɔgadzɔ, kple microenvironment optimization me. Wo katã wowɔa 'dzraɖo-anti-inflammation-immune modulation-microenvironment enhancement.' ƒe ɖoɖo si wotu ɖe ʋuƒo dzi.'

Le nuwɔwɔ aduadu sia te la, TB 500 kple BPC-157 naa lãmenugbagbeviwo ƒe dzidziɖedzi kple matrix ƒe wɔwɔme kabakaba, gake KPV ya ɖea dɔdzẽ si gbɔ eme dzi kpɔtɔna to mɔxexe ɖe NF-κB mɔa nu me, si wɔnɛ be nɔnɔme si li ke be woadzra wo ɖo. GHK-Cu ƒe antioxidant ŋutetewo ɖea free radical ƒe nugbegblẽ le lãmenugbagbevi yeye siwo wowɔ ŋu dzi kpɔtɔna, eye eƒe ʋukawo takpɔnu wɔa dɔ aduadu kple TB 500 ƒe ʋukawo ƒe dzɔdzɔ ƒe dɔwɔwɔ be wòana ʋu si le nutoa me nadzi ɖe edzi. KPV ƒe dɔlélenutsiŋutete ƒe tɔtrɔ si yia mɔ eve dzi da sɔ le dɔlélenutsiŋutete ƒe dɔwɔwɔ si BPC-157 kple GHK-Cu ʋãna me, si xea mɔ na dɔlélenutsiŋutete ƒe dɔmawɔmawɔ nyuie. Menye ɖeko nuwɔwɔ aduadu sia nana lãmenugbagbeviwo ɖɔɖɔɖo ƒe ɣeyiɣiwo nɔa kpuie ko o, ke enaa nuwo ɖɔɖɔɖo ƒe nyonyome hã nyona ɖe edzi eye wòɖea abi ƒe dzɔdzɔ ƒe afɔkua dzi kpɔtɔna, si naa ɖoɖowɔwɔ ƒe viɖe gbogbo aɖewo le nɔnɔmewo abe abi ƒe dɔyɔyɔ, abi si nɔa anyi didi, kple ŋutigbalẽ ƒe tsitsi ene me.

Le Agbalẽŋlɔla La Ŋu

Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.

NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.  

Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.