Klow 80mg (ngwakọta)

▎ Gịnị bụ BPC-157?

BPC-157 bụ peptide sịntetịt nke mejupụtara amino acid iri na ise. Usoro ya sitere na mpempe akwụkwọ nchekwa ahụ (BPC) dị n'ime protein mucosal nke afọ mmadụ, na-eje ozi dị ka analog artificial nke peptides nchebe eriri afọ. Isi njirimara ndu ndu nke peptide a dabere na ikike nrụzi anụ ahụ ya nwere ike ịhazi. Ọ na-akwalite mmụba na mbugharị nke sel ndị metụtara nrụzi dị ka fibroblasts na sel endothelial site n'ịkwalite ndị na-anabata tyrosine kinase (dịka, c-Met), ebe ọ na-eme ngwa ngwa na nhazi nke ihe ndị ọzọ matrix extracellular (dịka, collagen, fibronectin). A kwadoro mmetụta a n'ụdị ọnya afọ, mgbawa akwara, na ntụpọ ọkpụkpụ. N'ụdị mmerụ ahụ mucosal gastric, BPC 157 na-ebelata oge ọgwụgwọ ọnya ma na-emeziwanye ogo mucosal mucosal.

BPC 157 na-arụ ọrụ dị mkpa site n'ịgbanwe microenvironment na-akpasu iwe. Ọ na-egbochi infiltration neutrophil na nkwubi okwu nke ihe ndị na-akpata mkpali (dị ka IL-1β na NF-κB), ebe n'otu oge na-emezi ihe nzuzo nke ihe mgbochi mkpali (dị ka IL-10). Nke a na-ebelata mmeghachi omume mkpali dị ukwuu na-esochi mmerụ ahụ ma gbochie mmebi anụ ahụ nke abụọ nke mbufụt na-achịkwaghị achịkwa kpatara. A na-akpọkarị mmetụta vasoprotective ya. Site na-akpali akpali ntọhapụ nke vaskụla endothelial growth factor (VEGF) na angiopoietin, ọ na-akwalite nhazi nke netwọk vaskụla ọhụrụ na mpaghara ndị mebiri emebi, na-eme ka nsị ọbara dị n'ógbè ahụ dịkwuo mma, ma na-enye nri zuru oke na ikuku oxygen maka ịrụzi anụ ahụ.

▎ Gịnị bụ KPV?

KPV, tripeptide nke mejuputara lysine-proline-valine, sitere na mpaghara C-terminal nke α-melanocyte-stimulating hormone (α-MSH) ma bụrụ akụkụ na-apụta n'okike nke nwere nnukwu ọrụ ndu.

Na nchịkwa mbufụt, KPV na-egosipụta ọrụ mgbochi mkpali dị ike. Ọ na-egbochi ụzọ ihe ngosi nuklia-κB (NF-κB), na-ebelata nsụgharị na ntọhapụ nke cytokines pro-inflammatory (dị ka IL-1β, TNF-α, wdg), si otú ahụ na-egbochi mkpali cascades na isi iyi ha. N'ụdị anụmanụ nke colitis, nchịkwa ọnụ nke KPV na-ebelata oke mbufụt nke eriri afọ ma na-ebelata mmebi mucosal. Mmetụta a sitere na nhazi ya ziri ezi nke nrịbama mkpali na sel mgbochi eriri afọ na sel epithelial. KPV na-ebelata nzaghachi mkpali mpaghara site na ime ka mkpụrụ ndụ mast guzosie ike na ibelata ntọhapụ nke ndị mgbasa ozi mkpali dị ka histamine, si otú a na-ejigide homeostasis anụ ahụ.

N'ọkwa immunoregulatory, KPV na-egosiputa ikike modulation bidirectional. Ọ na-eme ka ọdịiche na ọrụ T-cell dịkwuo mma, na-akwalite ihe nzuzo nke immunoregulatory ihe dị ka IL-2 na IFN-γ, ma na-akwalite nzaghachi mgbochi cellular. N'ụdị ọrịa autoimmune, KPV na-achịkwa nguzozi cell Th1/Th2, na-ebelata mmeghachi omume autoimmune gabigara ókè, ma gbochie mmebi ahụ.

KPV na-ejikwa uru nwere ike ime n'ịbawanye cellular na nrụzi anụ ahụ. Site n'ịgbalite ụzọ mgbaàmà intracellular dị mkpa, ọ na-akwalite mmụba na mbugharị fibroblast, na-eme ka njikọ nke akụkụ matrix extracellular dị ka collagen dị ngwa, ma na-enyere aka ịgwọ ọnya na anụ ahụ dị ka anụ ahụ na akwara. N'ime nnwale nrụzi akpụkpọ ahụ, ọnya ndị KPV gwọchara gosipụtara ọnụego ọgwụgwọ gbagoro nke ọma yana mbelata ọnya, na-egosipụta mmetụta dị mma ọ na-enwe na nrụzi anụ ahụ. KPV nwekwara ike kpalie nkwupụta nke ihe metụtara angiogenesis dị ka vascular endothelial growth factor (VEGF), na-akwalite neovascularization na imeziwanye ọbara na saịtị ndị merụrụ ahụ, si otú ahụ na-enye ọnọdụ dị mkpa maka ịmaliteghachi anụ ahụ.

▎ Gịnị bụ GHK-Cu?

GHK-Cu bụ mgbagwoju anya nke glycyl-L-histidyl-L-lysine tripeptide na ion ọla kọpa mebere. N'iji ọrụ synergistic nke ions ọla kọpa na tripeptide na-arụ ọrụ, ọ na-arụ ọtụtụ ọrụ dị oke mkpa na mmemme physiological. Na nrụzi akpụkpọ ahụ na ịmaliteghachi, ọ na-arụ ọrụ dị ka peptide na-egosi na ọ na-eme ka fibroblasts na-emepụta collagen, elastin, na glycosaminoglycans, na-eme ka akpụkpọ ahụ dịkwuo ike ma na-agbanwe agbanwe ma na-eme ka nsogbu akpụkpọ anụ kpatara site na ịka nká ma ọ bụ fotoaging. N'oge ọgwụgwọ ọnya, ọ na-akpali uto mkpụrụ ndụ stratum corneum iji mee ka mmechi dị ngwa ngwa ka ọ na-achịkwa mbufụt site na igbochi oke IL-6 na okwu TNF-α. Ọ na-akwalite nchịkọta macrophage iji hapụ ihe ndị na-eto eto, na-enyere aka nrụzi anụ ahụ na nhazigharị. Ngwongwo ya nke nwere ike na-eme ihe na-egbochi mkpali na-achịkwa ọkwa ọla kọpa intracellular, na-akwalite ikike antioxidant, na-egbu oge ịka nká. N'ụdị mbufụt nke akpa ume, ọ na-ebelata oke mmerụ ahụ nke lipopolysaccharide na-ebute ma na-akwalite steeti mkpali anụ ahụ. GHK-Cu na-erite uru ahụike ntutu site na ịkpali ọrụ cell follicle ntutu, na-akwalite mmepụta melanin, na-achịkwa metabolism ike, na inye aka n'ịkwalite ntutu isi.

Mmechi

Dị ka ngwakọta nke TB 500, BPC-157, KPV, na GHK-Cu, mmetụta mmekọrịta nke Klow na-egosipụta site na nchikota na nhazi usoro nke ọrụ physiological multidimensional. TB 500 na-akwalite mbugharị cell na angiogenesis, BPC-157 na-eme ka nrụzi anụ ahụ na iwu mkpali, KPV na-elekwasị anya na nguzozi mgbochi na mgbochi mbufụt nke mpaghara, ebe GHK-Cu na-arụ ọrụ na nchebe antioxidant, mmepụta anụ ahụ, na njikarịcha microenvironment. Ha jikọtara ọnụ, ha na-etolite usoro mechiri emechi nke ' mmezi-mgbochi-inflammation-immune modulation-microenvironment enhancement.'

N'okpuru mmekọrịta a, TB 500 na BPC-157 na-eme ka mmụba cell na njikọ nke matrix, ebe KPV na-ebelata oke ọkụ site na igbochi ụzọ NF-κB, na-emepụta ebe kwụsiri ike maka nrụzi. Ngwongwo antioxidant nke GHK-Cu na-ebelata mmebi nke radical n'efu na anụ ahụ emepụtara ọhụrụ, yana mmetụta vasoprotective ya na-arụkọ ọrụ angiogenesis nke TB 500 iji welie ọkọnọ ọbara mpaghara. Mgbanwe usoro mgbochi mgbochi nke KPV na-eme ka mgbaka mgbochi ọrịa butere site na BPC-157 na GHK-Cu, na-egbochi ndakpọ nke mgbochi. Mmekọrịta a abụghị naanị na-ebelata usoro nrụzi anụ ahụ kamakwa ọ na-eme ka nrụzi dị mma ma na-ebelata ihe ize ndụ akpụ akpụ, na-enye uru usoro iwu zuru oke na ọnọdụ dị ka ọgwụgwọ ọnya, mbufụt na-adịghị ala ala, na ịka nká anụ ahụ.

Banyere Onye dere ya

Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.

Edemede na ozi ngwaahịa niile enyere na webụsaịtị a bụ naanị maka mgbasa ozi na ebumnuche mmụta.  

Ngwaahịa ndị enyere na webụsaịtị a bụ naanị maka nyocha in vitro. A na-eme nyocha in vitro (Latin: * na iko *, nke pụtara na ihe eji enyo) na mpụga ahụ mmadụ. Ngwaahịa ndị a abụghị ọgwụ, ndị US Food and Drug Administration (FDA) akwadoghị ya, ha agaghịkwa eji ya gbochie, gwọọ, ma ọ bụ gwọọ ọnọdụ ahụike ọ bụla, ọrịa, ma ọ bụ ọrịa. Iwu amachibidoro nke ọma iwebata ngwaahịa ndị a n'ime ahụ mmadụ ma ọ bụ anụmanụ n'ụdị ọ bụla.