Klow 80mg (Ekitabula) .

▎ BPC-157 kye ki?

BPC-157 ye peptide ekoleddwa nga erimu amino acids 15. Omutendera gwayo gusibuka mu kitundu kya Body Protection Compound (BPC) munda mu puloteyini z’omu lubuto lw’omuntu, nga kikola nga analog ey’obutonde eya endogenous gastrointestinal protective peptides. Ekintu ekikulu eky’ebiramu ekya peptide eno kiri mu busobozi bwayo obw’amaanyi obw’okulungamya okuddaabiriza ebitundu by’omubiri. Kitumbula okukula n’okusenguka kw’obutoffaali obukwatagana n’okuddaabiriza nga fibroblasts ne endothelial cells nga ekola ku tyrosine kinase receptors (okugeza, c-Met), ate nga kyanguya okusengejja n’okuddamu okukola ebitundu bya matrix eby’ebweru w’obutoffaali (okugeza, collagen, fibronectin). Ekikolwa kino kikakasiddwa mu bikolwa by’amabwa mu lubuto, okukutuka kw’emisuwa, n’obulema mu magumba. Mu bikolwa by’obuvune bw’omu lubuto, BPC 157 ekendeeza nnyo ku budde bw’okuwona amabwa n’okulongoosa omutindo gw’okuddamu okukola kw’omubiri.

BPC 157 ekola omulimu omukulu nga ekyusakyusa obutonde obutono obuzimba. Kiziyiza okuyingira kw’obusimu obuyitibwa neutrophil n’okulaga ennyo ensonga eziyamba okuzimba (nga IL-1β ne NF-κB), ate mu kiseera kye kimu n’okulinnyisa okufulumya ensonga eziziyiza okuzimba (nga IL-10). Kino kikendeeza ku kuddamu kw’okuzimba okw’amaanyi oluvannyuma lw’okulumwa era kiziyiza okwonooneka kw’ebitundu eby’okubiri okuva ku kuzimba okutafugibwa. Ebikolwa byayo eby’okukuuma emisuwa byeyoleka nnyo. Nga esitula okufulumya vascular endothelial growth factor (VEGF) ne angiopoietin, etumbula okutondebwawo kw’omukutu omupya ogw’emisuwa mu bitundu ebyonooneddwa, erongoosa okufuuwa omusaayi mu kitundu, era kiwa ebiriisa ebimala ne oxygen okuddaabiriza ebitundu.

▎ KPV kye ki?

KPV, tripeptide ekoleddwa lysine-proline-valine, esibuka mu kitundu kya C-terminal ekya α-melanocyte-stimulating hormone (α-MSH) era kitundu kya butonde nga kirimu emirimu mingi egy’ebiramu.

Mu kulungamya okuzimba, KPV eraga omulimu ogw’amaanyi ogw’okulwanyisa okuzimba. Kiziyiza bulungi ekkubo ly’obubonero erya nuclear factor-κB (NF-κB), ne kikendeeza ku kuwandiikibwa n’okufulumya cytokines eziyamba okuzimba (nga IL-1β, TNF-α, n’ebirala), bwe kityo ne kiziyiza ebiwujjo ebizimba ku nsibuko yaabyo. Mu bikolwa by’ebisolo eby’obulwadde bw’olubuto, okugaba KPV mu kamwa kikendeeza nnyo ku miwendo gy’okuzimba ekyenda era kikendeeza ku kwonooneka kw’omubiri. Ekikolwa kino kiva ku kulungamya kwayo okutuufu okw’obubonero obuzimba mu butoffaali bw’abaserikale b’omubiri mu byenda n’obutoffaali bw’omubiri obuyitibwa epithelial cells. KPV eyongera okukendeeza ku kuddamu kw’okuzimba okw’omu kitundu nga etebenkeza obutoffaali obuyitibwa mast cells n’okukendeeza ku kufulumya ebitabaganya ebizimba nga histamine, bwe kityo n’ekuuma obutonde bw’ebitundu.

Ku ddaala ly’obusimu obuziyiza endwadde, KPV eraga obusobozi bw’okukyusakyusa mu ngeri bbiri. Kyongera ku njawulo n’enkola y’obutoffaali bwa T, kitumbula okufulumya ensonga ezifuga obusimu obuziyiza endwadde nga IL-2 ne IFN-γ, era kitumbula okuddamu kw’abaserikale b’omubiri mu butoffaali. Mu bikolwa by’endwadde z’abaserikale b’omubiri, KPV etereeza bbalansi y’obutoffaali bwa Th1/Th2, ekendeeza ku nkola y’abaserikale b’omubiri esukkiridde, era eziyiza okwonooneka kw’abaserikale b’omubiri.

KPV era erina omugaso oguyinza okubaawo mu kukula kw’obutoffaali n’okuddaabiriza ebitundu by’omubiri. Nga ekola amakubo agakwatagana ag’obubonero mu butoffaali, kitumbula okukula n’okusenguka kw’obusimu obuyitibwa fibroblast, kyanguya okusengejja ebitundu bya matrix eby’ebweru w’obutoffaali nga kolagini, era kyanguyiza okuwona kw’ebiwundu mu bitundu ng’olususu n’ebinywa. Mu kugezesa okuddaabiriza olususu, ebiwundu ebyajjanjabwa KPV byalaga emiwendo egy’amangu ennyo egy’okuwona n’okukendeeza ku kutondebwa kw’enkovu, ekiraga nti bikwata bulungi ku mutindo gw’okuddaabiriza ebitundu by’omubiri. KPV era eyinza okusitula okwolesebwa kw’ensonga ezikwatagana n’okutondebwa kw’emisuwa nga ensonga y’okukula kw’emisuwa (VEGF), okutumbula okukola emisuwa emipya n’okulongoosa enkola y’omusaayi mu bifo ebifunye obuvune, bwe kityo n’ewa embeera enkulu ey’okuzza obuggya ebitundu by’omubiri.

▎ GHK-Cu kye ki?

GHK-Cu kizibu ekikolebwa glycyl-L-histidyl-L-lysine tripeptide ne copper ions. Nga ekozesa ekikolwa eky’okukwatagana ekya ion z’ekikomo ne tripeptide, kikola emirimu emikulu mingi mu mirimu gy’omubiri. Mu kuddaabiriza n’okuzza obuggya olususu, kikola nga signaling peptide okuleetera fibroblasts okukola collagen, elastin, ne glycosaminoglycans, okutumbula obugumu n’obugumu bw’olususu ate nga kitereeza ensonga z’olususu ezireetebwa okukaddiwa oba okukaddiwa kw’ekitangaala. Mu kiseera ky’okuwona ebiwundu, kisitula okukula kw’obutoffaali bwa stratum corneum okwanguya okuggalawo ate nga kitereeza okuzimba nga kinyigiriza IL-6 ne TNF-α expression ezisukkiridde. Era kitumbula okukuŋŋaanyizibwa kwa macrophage okufulumya ensonga ezikula, okuyamba okuddaabiriza ebitundu by’omubiri n’okuddamu okukola. Ebintu byayo eby’amaanyi ebiziyiza obuwuka obuleeta obulwadde n’okuzimba bitereeza emiwendo gya kikomo mu butoffaali, byongera ku busobozi bw’okuziyiza obuwuka obuleeta obulwadde, n’okulwawo okukaddiwa kw’obutoffaali. Mu bikolwa by’okuzimba amawuggwe, kikendeeza ku buvune obw’amaanyi obuva ku lipopolysaccharide era kitereeza embeera z’okuzimba ebitundu by’omubiri. GHK-Cu eyamba obulamu bw’enviiri ng’eyamba obutoffaali bw’enviiri okukola emirimu, okutumbula okukola melanin, okulungamya enkyukakyuka y’amaanyi, n’okuyamba mu kulongoosa enviiri ezigwa.

Mu bufunzi

Nga omugatte gwa TB 500, BPC-157, KPV, ne GHK-Cu, ebikolwa bya Klow eby’okukwatagana byeyoleka okuyita mu kulungamya okukwatagana n’okujjuliza emirimu gy’omubiri egy’ebitundu ebingi. TB 500 etumbula okutambula kw’obutoffaali n’okutondeka emisuwa, BPC-157 eyamba okuddaabiriza ebitundu by’omubiri n’okulungamya okuzimba, KPV essira erisinga kulissa ku bbalansi y’abaserikale b’omubiri n’okulwanyisa okuzimba mu kitundu, ate GHK-Cu ekola mu kuziyiza obuwuka obuleeta obulwadde, okuddamu okukola olususu, n’okulongoosa obutonde obutonotono. Wamu, zikola enkola ya closed-loop eya 'repair-anti-inflammation-immune modulation-microenvironment enhancement.'

Wansi w’enkolagana eno, TB 500 ne BPC-157 zanguya okukula kw’obutoffaali n’okusengejja matrix, ate KPV ekendeeza ku kuzimba okuyitiridde ng’eziyiza ekkubo lya NF-κB, ne likola embeera ennywevu okuddaabiriza. GHK-Cu’s antioxidant properties ekendeeza ku kwonooneka kwa free radical ku bitundu ebipya ebitondeddwa, era ebikolwa byayo eby’okukuuma emisuwa bikwatagana n’omulimu gwa TB 500 ogw’okukola emisuwa okutumbula omusaayi mu kitundu. KPV’s bidirectional immune modulation egerageranya enkola y’abaserikale b’omubiri etandikibwawo BPC-157 ne GHK-Cu, okuziyiza okutaataaganyizibwa kw’abaserikale b’omubiri. Enkolagana eno tekoma ku kukendeeza ku mitendera gy’okuddaabiriza ebitundu by’omubiri wabula era erongoosa omutindo gw’okuddaabiriza n’okukendeeza ku bulabe bw’okutondebwa kw’enkovu, okuwa enkizo enzijuvu mu kulungamya mu mbeera ng’okuwona ebiwundu, okuzimba okutambula obutasalako, n’okukaddiwa kw’olususu.

Ebikwata ku Muwandiisi

Ebintu ebyogeddwako waggulu byonna binoonyerezeddwako, birongooseddwa era ne bikung’aanyizibwa kkampuni ya Cocer Peptides.

EBINTU BYONNNA N’AMAWULIRE GW’EBINTU EBIweereddwa KU MUTINDO GUNO BIKOZESEBWA KU KUSASANYA AMAWULIRE N’EBIKOLWA BY’OKUSOMESA.  

Ebintu ebiweereddwa ku mukutu guno bigendereddwamu kunoonyereza mu kisenge (in vitro research) byokka. Okunoonyereza mu vitro (Olulattini: *mu ndabirwamu*, ekitegeeza mu bikozesebwa mu ndabirwamu) kukolebwa ebweru w’omubiri gw’omuntu. Ebintu bino si bya ddagala, tebikkiriziddwa kitongole kya Amerika ekivunaanyizibwa ku by’emmere n’eddagala (FDA), era tebirina kukozesebwa kuziyiza, kujjanjaba oba kuwonya mbeera yonna ya bujjanjabi, bulwadde oba bulwadde. Kikugirwa nnyo mu mateeka okuyingiza ebintu bino mu mubiri gw’omuntu oba ebisolo mu ngeri yonna.