Klow 80mg lend Kuvanga）

?BPC-157 ni iki

BPC-157 ni peptide ya syntetique igizwe na acide 15 amine. Urukurikirane rwarwo rukomoka ku gice cyo gukingira umubiri (BPC) kiri muri poroteyine zo mu gifu zo mu nda, zikora nk'ikigereranyo gihimbano cya peptide irinda gastrointestinal. Intangiriro yibinyabuzima iranga iyi peptide iri mubushobozi bwayo bwo gusana ingirabuzimafatizo. Itera ikwirakwizwa no kwimuka kwingirabuzimafatizo zijyanye no gusana nka fibroblast na selile endothelia ukoresheje reseptor ya tyrosine kinase (urugero, c-Met), mugihe wihutisha synthesis hamwe no kuvugurura ibice bigize matrice idasanzwe (urugero, kolagen, fibronectine). Izi ngaruka zemejwe mubyitegererezo by'ibisebe byo mu gifu, guturika kw'imitsi, hamwe n'amagufwa. Mu buryo bwo gukomeretsa mu gifu, BPC 157 igabanya cyane igihe cyo gukira ibisebe kandi ikanahindura ubwiza bwimitsi.

BPC 157 igira uruhare runini muguhindura ibidukikije byangiza. Irwanya neutrophil infiltration hamwe no gukabya gukabije kwibintu bitera umuriro (nka IL-1β na NF-κB), mugihe icyarimwe bigenga gusohora ibintu birwanya inflammatory (nka IL-10). Ibi bigabanya igisubizo gikaze nyuma yo gukomeretsa kandi bikarinda kwangirika kwinyuma zatewe no gutwikwa kutagenzuwe. Ingaruka za vasoprotective zigaragara cyane. Mugukangurira kurekura ibintu bikura byamaraso (VEGF) na angiopoietin, biteza imbere gushiraho urusobe rushya rwimitsi mumyanya yangiritse, bigateza imbere amaraso, kandi bigatanga intungamubiri zihagije hamwe na ogisijeni yo gusana ingirangingo.

K KPV ni iki?

KPV, tripeptide igizwe na lysine-proline-valine, ikomoka mu karere ka C-term ya hormone itera α-melanocyte (α-MSH) kandi ni igice gisanzwe kibaho gifite ibikorwa byingenzi byibinyabuzima.

Mu kugenzura umuriro, KPV yerekana ibikorwa bikomeye byo kurwanya inflammatory. Irahagarika neza ibintu bya kirimbuzi-κB (NF-κB) byerekana inzira yerekana inzira, bigabanya kwandukura no kurekura cytokine itera umuriro (nka IL-1β, TNF-α, nibindi), bityo ikagabanya kasake yumuriro aho ikomoka. Mubyitegererezo byinyamanswa ya colitis, gukoresha umunwa wa KPV bigabanya cyane urugero rwo gutwika amara kandi bikagabanya kwangirika kwimitsi. Izi ngaruka zikomoka kumabwiriza yazo yerekana ibimenyetso byerekana umuriro mu ngirabuzimafatizo z'umubiri no mu ngirabuzimafatizo. KPV irushaho kugabanya ibisubizo byaho byangiza muguhindura ingirabuzimafatizo no kugabanya irekurwa ryabunzi batera nka histamine, bityo bikomeza urugo rwa homeostasis.

Kurwego rwubudahangarwa, KPV yerekana ubushobozi bwo guhindura ibyerekezo byombi. Itezimbere T-selile itandukanye nimikorere, iteza imbere gusohora ibintu byikingira nka IL-2 na IFN-γ, kandi ikongera ubudahangarwa bw'umubiri. Mubyitegererezo byindwara ziterwa na autoimmune, KPV igenga ingirabuzimafatizo ya Th1 / Th2, igabanya reaction ya autoimmune ikabije, kandi ikarinda kwangirika kwumubiri.

KPV ifite kandi agaciro gashoboka mugukwirakwiza selile no gusana ingirangingo. Mugukoresha inzira yerekana ibimenyetso bifatika byerekana inzira, itera fibroblast ikwirakwizwa no kwimuka, byihutisha guhuza ibice bigize matrice idasanzwe nka kolagen, kandi byorohereza gukira ibikomere mumyanya nkuruhu n imitsi. Mu bushakashatsi bwo gusana uruhu, ibikomere bivurwa na KPV byagaragaje umuvuduko wihuse wo gukira no kugabanya inkovu, byerekana ingaruka nziza ku bwiza bwo gusana ingirangingo. KPV irashobora kandi gushimangira imvugo yibintu bifitanye isano na angiogenezi nkimikurire yimitsi iva mu mitsi (VEGF), guteza imbere imitsi yimitsi no kunoza itangwa ryamaraso ahantu hakomeretse, bityo bigatanga ibyangombwa byingenzi kugirango umubiri wongere uhindurwe.

GHK -Cu ni iki?

GHK-Cu ni urwego rugizwe na glycyl-L-histidyl-L-lysine tripeptide na ion z'umuringa. Gukoresha ibikorwa byo guhuza ibikorwa byumuringa ion na tripeptide, ikora imirimo myinshi ikomeye mubikorwa bya physiologique. Mu gusana uruhu no kuvugurura, ikora nka peptide yerekana ibimenyetso bya fibroblast kugirango ihuze collagen, elastin, na glycosaminoglycans, byongera uruhu rukomeye hamwe na elastique mugihe utezimbere ibibazo byuruhu biterwa no gusaza cyangwa gufotora. Mugihe cyo gukira ibikomere, itera gukura kwa stratum corneum selile kugirango yihute gufunga mugihe igenga umuriro muguhagarika imvugo ikabije ya IL-6 na TNF-α. Itera kandi guteranya macrophage kugirango irekure ibintu bikura, ifasha gusana ingirabuzimafatizo no kuvugurura. Imiti ikomeye ya antioxydeant na anti-inflammatory igenga urwego rwumuringa rudasanzwe, rwongera ubushobozi bwa antioxydeant, kandi rugatinda gusaza kwa selile. Muburyo bwo gutwika ibihaha, bigabanya lipopolysaccharide iterwa no gukomeretsa cyane ibihaha kandi bikanonosora imiterere yumubiri. GHK-Cu ifasha ubuzima bwimisatsi itera ibikorwa byimikorere yimisatsi, guteza imbere umusaruro wa melanin, kugenzura imbaraga za metabolisme, no gufasha kunoza umusatsi.

Umwanzuro

Nkuruvange rwa TB 500, BPC-157, KPV, na GHK-Cu, ingaruka za Klow zigaragarira muburyo bwo guhuzagurika no kuzuzanya kumikorere yimikorere myinshi. TB 500 iteza imbere kwimuka kwa selile hamwe na angiogenez, BPC-157 yongerera imbaraga gusana ingirabuzimafatizo no kugenzura ibicanwa, KPV yibanda ku buringanire bw’umubiri no kurwanya indwara zanduza, mu gihe GHK-Cu ikora mu kwirinda antioxydeant, kuvugurura uruhu, no kuzamura ibidukikije. Hamwe na hamwe, bashiraho sisitemu ifunze-ya 'gusana-kurwanya-gutwika-immun modulisiyo-kuzamura ibidukikije. '

Muri ubu bufatanye, TB 500 na BPC-157 byihutisha ikwirakwizwa rya selile hamwe na synthesis ya matrix, mugihe KPV igabanya ubukana bukabije muguhagarika inzira ya NF-κB, bigashyiraho ibidukikije bihamye byo gusana. Indwara ya antioxydeant ya GHK-Cu igabanya kwangirika kwubusa ku ngingo nshya zashizweho, kandi ingaruka zayo za vasoprotective zifatanya nigikorwa cya angiogenezi ya TB 500 kugirango itange amaraso yaho. KPV ihindagurika ry'ubudahangarwa bw'umubiri iringaniza ibikorwa byo gukingira indwara byatewe na BPC-157 na GHK-Cu, birinda indwara idakira. Iyi mikoranire ntabwo igabanya gusa ingengabihe yo gusana ingirabuzimafatizo ahubwo inatezimbere ubwiza bwo gusana kandi igabanya ibyago byo guterwa inkovu, itanga inyungu zuzuye zo kugenzura ibintu nko gukira ibikomere, gutwika indwara zidakira, no gusaza kwuruhu.

Ibyerekeye Umwanditsi

Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.

INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.  

Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.