▎ SNAP-8 Numekuku
Nukae nye SNAP-8?
SNAP-8 nye peptide si wowɔ si me amino acid 8 le.
Nukae nye numekuku si wowɔ le SNAP-8 ŋu?
Ŋutilã ƒe tsitsi ŋuti numekuku:
Ne ame tsi la, ŋutigbalẽa ɖea tsitsi ƒe dzesiwo abe ɖaƒoƒo ene fiana. Ʋuʋudedi siwo ŋu ŋusẽ le ƒe wɔwɔme do ƒome kplikplikpli kple mo ƒe lãmekawo ƒe tete enuenu. Ahɔhɔ̃mekawoe nyea domenɔlawo na lãmekawo ƒe tete. Eyata nusi ate ŋu aɖɔ ahɔhɔ̃mekawo ƒe dodo ɖo eye wòaɖe lãmekawo ƒe tete dzi akpɔtɔ didi va zu mɔfiame vevi aɖe le ŋutigbalẽ ƒe tsitsi ŋuti numekuku me.
Ahɔhɔ̃ŋutinunya me numekuku:
Wole numekuku si wowɔ tso ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe mɔnu si woɖena ɖe go ŋu la de to ɖe edzi ɣesiaɣi, eye wokpɔe be Soluble NSF Attachment Protein Receptor (SNARE) complex wɔa akpa vevi aɖe le eme. SNAP-25 nye SNARE ƒe akpa vevi aɖe. Eƒe wɔwɔme kple dɔwɔwɔ gɔmesese naa nukpɔsusu ƒe gɔmeɖoanyi na nusiwo ate ŋu ado kplamatse ahɔhɔ̃mekawo ƒe dodo. Numekulawo nɔ te ɖe numekuku siawo dzi le mɔ kpɔm be yewoato atike si le dedie eye wòwɔa dɔ nyuie vɛ si menye ɖeko wòate ŋu awɔ akpa aɖe le ŋutigbalẽdzikpɔkpɔ me be wòatsi ʋuʋudedi nu ko o, ke ana dɔwɔnu yeyewo kple susu yeyewo hã na ahɔhɔ̃ŋutinunya me numekuku. SNAP-8 do le nɔnɔme sia me eye vivivi la, eva zu numekuku ƒe teƒe vevi aɖe le go siwo do ƒome kplii me.
Nukae nye SNAP-8 ƒe dɔwɔwɔ ƒe mɔnu?
1. Ŋutilã ƒe tsitretsitsi ɖe tsitsi ŋu
Ʋuʋudedi dzi ɖeɖe kpɔtɔ:
SNAP-8 ɖea ƒunukpeƒetetedɔ siwo le ʋuʋum kple esiwo nɔa teƒe ɖeka dzi kpɔtɔna to lãmekawo ƒe tete dzi ɖeɖe kpɔtɔ me, si wɔnɛ be ŋutigbalẽa ƒe dzedzeme bliboa nyona ɖe edzi. Mo ƒe dzedzeme ƒe lãmekawo ƒe tete gbɔe ʋuʋudedi siwo le ŋusẽ kpɔm tsona, gake ʋuʋudedi siwo nɔa teƒe ɖeka la va nɔa vivivi ne ame tsi eye ŋutigbalẽ ƒe tete dzi ɖena kpɔtɔna. Alesi SNAP-8 wɔa dɔe la gbɔdzɔa lãmekawo ƒe tete, si wɔnɛ be ʋuʋudedi siwo ŋu ŋusẽ le ƒe dzidzi dzi ɖena kpɔtɔna. Le ɣeyiɣi ma ke me la, esi wòɖea lãmeka siwo ʋãa ŋutigbalẽa dzi kpɔtɔna ta la, ekpena ɖe ame ŋu hã be ŋutigbalẽa ƒe tsitsi dzi ɖena kpɔtɔna eye wòɖea ʋuʋudedi siwo meʋãna o ƒe wɔwɔ dzi kpɔtɔna.
Collagen wɔwɔ dodo ɖe ŋgɔ:
SNAP-8 ate ŋu ado kolagen wɔwɔ ɖe ŋutigbalẽa me hã ɖe ŋgɔ to lãmenugbagbeviwo ƒe dzesimɔwo dzi kpɔkpɔ me. Collagen ye nye protein vevitɔ si wɔa ŋutigbalẽa, si naa ŋutigbalẽa te ŋu nɔa te sesĩe eye wòsesẽna. Ne ame tsi la, collagen si le ŋutigbalẽa me dzi ɖena kpɔtɔna vivivi, si wɔnɛ be ŋutigbalẽa ɖea dzi ɖi eye wòdzena le ŋutigbalẽa me. SNAP-8 ate ŋu ado kolagen ƒe wɔwɔ ɖe ŋgɔ to dzesimɔ aɖewo abe TGF-β/Smad dzesimɔ ene, ƒe dɔwɔwɔ me. Tsɔ kpe ɖe eŋu la, SNAP-8 ate ŋu ana kolagen si le ŋutigbalẽa me hã nadzi ɖe edzi to mɔxexe ɖe kolagen ƒe gbegblẽ nu me.
2. Ahɔhɔ̃mekawo ƒe dɔwɔwɔ nyuie
Dodo ɖe SNARE ƒe ƒuƒoƒoa me:
SNAP-8 nye SNAP-25 ƒe N-nuwuƒe srɔ̃la eye ateŋu aʋli ho kple SNAP-25 ɖe eƒe nɔƒe le SNARE ƒe ƒuƒoƒoa me ta. SNARE ƒe ƒuƒoƒoa wɔa akpa vevi aɖe le ahɔhɔ̃mekawo ƒe dɔwɔwɔ me. Zi geɖe la, SNARE ƒe ƒuƒoƒoa nyea syntaxin si le presynaptic membrane dzi, synaptobrevin, kple SNAP-25 si le synaptic vesicle membrane dzi. Ne lãmeka ƒe ʋuʋu ɖo preynaptic membrane la, calcium ions ƒe gege ɖe lãme nana synaptic vesicles ƒe tsakatsaka kple presynaptic membrane, si wɔnɛ be ahɔhɔ̃mekawo dona. Gake ne SNAP-8 le ho ʋlim kple SNAP-25 ɖe nɔƒe si le SNARE ƒe ƒuƒoƒoa me ta la, edoa kplamatse SNARE ƒe ƒuƒoƒoa ƒe wɔwɔ. Esia wɔnɛ be manya wɔ be synaptic vesicles naɖe asi le ahɔhɔ̃mekawo ŋu nyuie o, si wɔnɛ be lãmekawo ƒe tete gbɔdzɔna.
Ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi ɖeɖe kpɔtɔ:
To nudede SNARE ƒe ƒuƒoƒoa me la, SNAP-8 ɖea ahɔhɔ̃mekawo ƒe dodo dzi kpɔtɔna. Ahɔhɔ̃mekawo nye atike siwo ɖoa dzesiwo ɖe lãmekawo dome. Ahɔhɔ̃mekawo ƒe dɔwɔwɔ fũ akpa ana lãmekawo ƒe lãmekawo naʋã fũ akpa. SNAP-8 ƒe dɔwɔwɔ ɖea lãmekawo ƒe lãmekawo ƒe dɔwɔwɔ dzi kpɔtɔna, si wɔnɛ be ʋuʋudediwo ƒe wɔwɔme dzi ɖena kpɔtɔna.
3. Ahɔhɔ̃mekawo ŋuti numekuku
Ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi kpɔkpɔ:
Le SNAP-8 kple SNAP-25 ƒe wɔwɔme ƒe sɔsɔ ta la, ate ŋu anye be asixɔxɔ si ate ŋu azãe le ahɔhɔ̃mekawo ŋuti numekuku me [1] . Le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie me la, ahɔhɔ̃mekawo ƒe dodo fũ ate ŋu ana ahɔhɔ̃mekawo nagblẽ.
Ŋusẽkpɔɖeamedzi ɖe ahɔhɔ̃mekawo ƒe dɔdzẽ ŋu:
SNAP-8 ate ŋu aɖɔ pro-inflammatory cytokines ƒe dodo le dɔlélenutsiŋutete ƒe lãmenugbagbeviwo me ɖo to ŋusẽkpɔkpɔ ɖe synaptic vesicles ƒe ƒoƒo dzi, si ana wòakpɔ ŋusẽ ɖe inflammatory ƒe ŋuɖoɖo dzi [1] . Ahɔhɔ̃mekawo ƒe dɔléle wɔa akpa vevi aɖe le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie ƒe dɔléle geɖe me. Dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ kple pro-inflammatory cytokines ƒe dodo ana ahɔhɔ̃mekawo nagblẽ eye woaku. SNAP-8 ate ŋu akpɔ ŋusẽ ɖe pro-inflammatory cytokines ƒe dodo le dɔlélenutsiŋutete ƒe lãmenugbagbeviwo me dzi to asitɔtrɔ le synaptic vesicles ƒe ƒoƒo ŋu me, si ana ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi naɖe akpɔtɔ.
Nukae nye SNAP-8 ƒe dɔwɔwɔ?
1. Anti-wrinkle ŋusẽkpɔɖeamedzi
Abe octapeptide ƒomevi yeye ene la, SNAP-8 ɖea ŋusẽ vevi aɖe si tsi tre ɖe ʋuʋudedi ŋu fiana le ŋutigbalẽdzikpɔkpɔ ƒe akpa dzi. Eɖea mo ƒe lãmekawo ƒe tete fũ dzi kpɔtɔna to mɔxexe ɖe ahɔhɔ̃mekawo ƒe dodo nu me, eye emegbe eɖea ʋuʋudedi siwo le ŋusẽ kpɔm kple esiwo nɔa teƒe ɖeka ƒe wɔwɔ dzi kpɔtɔna. Numekuku geɖe ɖee fia be SNAP-8 ate ŋu awɔ dɔ nyuie ɖe mo ƒe dzedzeme ƒe fliwo kple flitetewo dzi. SNAP-8 zazã zi eve gbesiagbe ate ŋu aɖe nyagbɔgblɔ ƒe fliwo kple flitetewo dzi akpɔtɔ ŋutɔ va ɖo 63% le ŋkeke 30 me, si naa kpekpeɖeŋu sẽŋu na eƒe zazã le ŋutigbalẽ ƒe ʋuʋudedi nutsitsi ƒe akpa dzi. Mɔ̃ sia si wozãna tsɔ tsia ʋuʋudedi nu la to vovo na mɔnu xoxo siwo wozãna tsɔ tsia ʋuʋudedi nu. Mezãa ŋutilã me nusiwo wotsɔ yɔa nu alo atikewo ƒe ʋuʋu o, ke boŋ edzea egɔme tso ahɔhɔ̃mekawo ƒe dodo ƒe nukpɔsusu dzi, si naa susu yeye aɖe le ŋutigbalẽ ƒe ʋuʋu nu.
2. Collagen wɔwɔ dodo ɖe ŋgɔ
SNAP-8 ate ŋu ado kolagen ƒe wɔwɔ ɖe ŋgɔ le ŋutigbalẽa me hã to lãmenugbagbeviwo ƒe dzesimɔwo dzi kpɔkpɔ me, si ana ŋutigbalẽa ƒe wɔwɔme kple eƒe tete ɖe edzi nanyo ɖe edzi. Collagen nye ŋutigbalẽa ƒe akpa vevi aɖe, si ate ŋu ana ŋutigbalẽa nali ke ahanɔ te sesĩe. Ne ame tsi la, kolagen si le ŋutigbalẽa me dzi ɖena kpɔtɔna vivivi, si wɔnɛ be ŋutigbalẽa ɖea dzi ɖi eye wòƒoa ƒu geɖe wu. SNAP-8 ƒe dɔwɔwɔ ƒe mɔnu sia naa mɔnu yeye aɖe si dzi woato akpɔ ŋutigbalẽ ƒe tsitsi ƒe kuxia gbɔ. To collagen wɔwɔ dodo ɖe ŋgɔ me la, SNAP-8 ate ŋu ana ŋutigbalẽa ƒe nɔnɔme kple eƒe dzedzeme nanyo ɖe edzi nyuie, si ana ŋutigbalẽa nanɔ blɔ eye wòali ke.
3. Mɔnu bubu si me womedea ame dzi o
Esi wònye be SNAP-8 nye atike si wokpɔna le dzɔdzɔme nu, si me aɖi mele o, eye medzea ame dzi o ɖe botulinum aɖi teƒe ta la, botulinum aɖi si wodona ɖe lãme na ame ƒe nugbegblẽ aɖeke mele eŋu o. Togbɔ be aɖi si nye botulinum kpɔa ŋusẽ aɖewo ɖe ʋuʋudedi dzi hã la, eƒe dodo ate ŋu ahe nu gbegblẽwo abe vevesese, abi, kple abi ene vɛ, eye ahiã be ɖɔkta bibi nawɔ dɔ nɛ. To vovo na ema la, SNAP-8 le dedie wu eye wòsɔ wu eye woate ŋu azãe abe ŋutigbalẽtakpɔnu gbesiagbe ene. Eƒe dzedzeme naa tiatia yeye nuƒlela siwo tsia dzi ɖe atsyɔ̃ɖomi siwo wodona ɖe lãme na ame ŋu.
4. Ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi kpɔkpɔ
Le SNAP-8 kple SNAP-25 ƒe wɔwɔme ƒe sɔsɔ ta la, asixɔxɔ si ate ŋu azãe le ahɔhɔ̃mekawo ŋuti numekuku me [1] . Le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie me la, ahɔhɔ̃mekawo ƒe dodo fũ ate ŋu ana ahɔhɔ̃mekawo nagblẽ. SNAP-8 ate ŋu aɖe nusiwo gblẽ le ame ŋu sia dzi akpɔtɔ to ahɔhɔ̃mekawo ƒe dɔwɔwɔ dzi kpɔkpɔ me. Ahɔhɔ̃mekawo wɔa akpa vevi aɖe le nyatakakawo ɖoɖo ɖe lãmekawo me, eye ahɔhɔ̃mekawo ƒe dodo le mɔ si mesɔ o nu ate ŋu ahe lãmekawo ƒe dɔléle vovovowo vɛ. SNAP-8 ƒe dɔwɔwɔ ƒe mɔnu sia na susu yeye aɖe va le ahɔhɔ̃mekawo ƒe dɔmawɔmawɔ nyuie dada ŋu. To ahɔhɔ̃mekawo ƒe dodo dzi kpɔkpɔ me la, wokpɔ mɔ be SNAP-8 aɖe ahɔhɔ̃mekawo ƒe gbegblẽ dzi akpɔtɔ eye wòana dɔlélea ƒe ŋgɔyiyi nagbɔdzɔ.
5. Ŋusẽkpɔɖeamedzi ɖe ahɔhɔ̃mekawo ƒe dɔdzẽ ŋu
SNAP-8 ate ŋu aɖɔ pro-inflammatory cytokines ƒe dodo le dɔlélenutsiŋutete ƒe lãmenugbagbeviwo me ɖo to ŋusẽkpɔkpɔ ɖe synaptic vesicles ƒe ƒoƒo dzi, si ana wòakpɔ ŋusẽ ɖe inflammatory ƒe ŋuɖoɖo dzi [1] . Ahɔhɔ̃mekawo ƒe dɔléle wɔa akpa vevi aɖe le lãmekawo ƒe dɔléle vovovowo ƒe dzɔdzɔ kple woƒe dzɔdzɔ me. SNAP-8 ƒe dɔwɔwɔ ƒe mɔnu sia naa mɔnu yeye aɖe si dzi woato aɖɔ ahɔhɔ̃mekawo ƒe dɔdzẽ ɖo. To ŋusẽkpɔkpɔ ɖe synaptic vesicles ƒe ƒoƒo dzi me la, SNAP-8 ate ŋu aɖɔ pro-inflammatory cytokines ƒe dodo le dɔlélenutsiŋutete ƒe lãmenugbagbeviwo me ɖo, si wɔnɛ be dɔdzẽ ƒe ŋuɖoɖo dzi naɖe akpɔtɔ eye wòakpɔ ahɔhɔ̃mekawo ta.
Le nyataƒoƒo me la, SNAP-8 ƒe ŋusẽkpɔɖeamedzi vovovowo le eŋu eye vevienyenye gã aɖe le eŋu. Le ŋutigbalẽdzikpɔkpɔ me la, ate ŋu aɖe lãmekawo ƒe tete dzi akpɔtɔ, ana collagen nawɔ, eye wòakpe ɖe ŋutigbalẽa ŋu wòatsi tre ɖe ʋuʋudedi ŋu eye wòali ke; le ahɔhɔ̃mekawo ŋuti numekuku me la, ate ŋu aɖɔ ahɔhɔ̃mekawo ƒe dodo ɖo eye wòakpɔ ŋusẽ ɖe ahɔhɔ̃mekawo ƒe dɔdzẽ dzi.
Le Agbalẽŋlɔla La Ŋu
Nusiwo míeyɔ ɖe etame la katã nye esiwo ŋu Cocer Peptides wɔ numekuku le, trɔ asi le wo ŋu eye woƒo wo nu ƒu.
Dzɔdzɔmeŋutinunya ƒe Agbalẽŋlɔla
Lemos M do ƒome kple habɔbɔ vovovowo kple nusɔsrɔ̃ ƒe hatsotsowo. Le habɔbɔwo gome la, wodo ƒome kple Cesumar Inst Sci Technol & Innovat, Cesumar Univ, Univ Cesumar, Cesumar Inst Sci, UniCesumar - Centro Universitario Cesumar, Universidade de Lisboa, Dziehe Lisbon Hosp Ctr, Ctr Hosp Univ Lisboa Norte, Centro Hospitalar de Lisboa Ocidental, EPE, kple Universidade Estadual de Maringa. Le nusɔsrɔ̃ ƒe hatsotsowo gome la, Lemos M kpɔa gome le Tagbɔdɔléle, Lãmesẽŋutinunya, Dzitodzitoŋutinunya & Dzidɔŋutinunya, Kansaŋutinunya, kple Yagbɔgbɔŋutinunya me. Woŋlɔ Lemos M ŋkɔ ɖe nyayɔyɔ ƒe numekugbalẽ [1] me.
