▎ SNAP-8 Ubushakashatsi
SNAP-8 ni iki?
SNAP-8 ni peptide ya syntetique igizwe na acide 8 amine.
Ni ubuhe bushakashatsi bwakozwe na SNAP-8?
Ubushakashatsi bwo gusaza k'uruhu:
Hamwe no kwiyongera kwimyaka, uruhu rwerekana ibimenyetso byo gusaza nkiminkanyari. Imiterere yiminkanyari ifite imbaraga zifitanye isano rya bugufi no kugabanuka kwimitsi yo mumaso. Kugabanuka kw'imitsi byahujwe na neurotransmitters. Kubwibyo, kubona ikintu gishobora kugenga irekurwa rya neurotransmitter no kugabanya kugabanuka kwimitsi byahindutse icyerekezo cyingenzi mubushakashatsi bwo kurwanya gusaza.
Ubushakashatsi bwa Neuroscience:
Ubushakashatsi ku buryo bwo kurekura neurotransmitter bwarushijeho kwiyongera, kandi byagaragaye ko ikigo cya Soluble NSF Attachment Protein Receptor (SNARE) kigira uruhare runini muri cyo. SNAP-25 nikintu cyingenzi kigize SNARE. Gusobanukirwa imiterere n'imikorere byayo bitanga ishingiro ryiterambere ryibintu bishobora kubangamira irekurwa rya neurotransmitter. Hashingiwe kuri ubwo bushakashatsi, abashakashatsi bizeye ko bazakora ibintu byizewe kandi bifite akamaro bidashobora gusa kugira uruhare mu kurwanya uruhu mu kwita ku ruhu ahubwo binatanga ibikoresho n'ibitekerezo bishya ku bushakashatsi bw’imitsi. SNAP-8 yagaragaye muriki gice kandi buhoro buhoro ihinduka ahantu h'ubushakashatsi mubice bifitanye isano.
Ni ubuhe buryo bwo gukora bwa SNAP-8?
1. Uruhu rurwanya gusaza
Kugabanya iminkanyari:
SNAP-8 igabanya imyunyu ngugu kandi ihagaze hejuru yuruhu igabanya kugabanuka kwimitsi, kunoza isura rusange yuruhu. Iminkanyari idahwitse iterwa no kugabanuka kwimitsi yo mumaso, mugihe iminkanyari ihagaze buhoro buhoro uko imyaka igenda ishira no kugabanuka kwuruhu. Uburyo bwibikorwa bya SNAP-8 bigabanya imitsi kugabanuka, bityo bikagabanya ibisekuruza byimitsi. Muri icyo gihe, kubera ko bigabanya imitsi itera uruhu, bifasha kandi kugabanya umuvuduko wo gusaza kwuruhu no kugabanya iminkanyari ihagaze.
Guteza imbere umusaruro wa kolagen:
SNAP-8 irashobora kandi guteza imbere umusaruro wa kolagene muruhu muguhuza inzira zerekana ibimenyetso. Kolagen ni poroteyine nyamukuru yubaka mu ruhu, itanga uruhu rworoshye kandi rukomeye. Hamwe n'imyaka, ibigize kolagen mu ruhu bigenda bigabanuka buhoro buhoro, biganisha ku kuruhura uruhu no kugaragara kw'iminkanyari. SNAP-8 irashobora guteza imbere synthesis ya kolagen mugukoresha inzira zimwe zerekana ibimenyetso, nka TGF-β / Smad yerekana inzira. Byongeye kandi, SNAP-8 irashobora kandi kongera ibirimo bya kolagene muruhu muguhagarika kwangirika kwa kolagen.
2. Amabwiriza ya Neuromuscular
Kwivanga hamwe na SNARE complex:
SNAP-8 ni N-terminal yigana SNAP-25 kandi irashobora guhangana na SNAP-25 kumwanya wacyo murwego rwa SNARE. Uruganda rwa SNARE rufite uruhare runini mugikorwa cyo kurekura neurotransmitter. Mubisanzwe, SNARE igizwe na syntaxin kuri presynaptic membrane, synaptobrevin, na SNAP-25 kuri synaptic vesicle membrane. Iyo impyisi itera igeze kuri presinaptic membrane, iyinjira rya calcium ion itera guhuza imitsi ya synaptique hamwe na presinaptic membrane, bityo ikarekura neurotransmitter. Ariko, iyo SNAP-8 irushanwe na SNAP-25 kumwanya uri murwego rwa SNARE, ibangamira ishingwa rya SNARE. Ibi bituma bidashoboka ko imitsi ya synaptic irekura neza neurotransmitter neza, bigatuma imitsi igabanuka.
Kugabanya irekurwa rya neurotransmitter:
Kubangamira urwego rwa SNARE, SNAP-8 igabanya irekurwa rya neurotransmitter. Neurotransmitter ni ibintu byimiti itanga ibimenyetso hagati yingirangingo. Kurekura gukabije kwa neurotransmitter bizatuma habaho imitsi ikabije yimitsi. Igikorwa cya SNAP-8 kigabanya imitsi yimitsi yimitsi, bityo bikagabanya iminkanyari.
3. Ubushakashatsi bwa Neurobiologiya
Kugenga irekurwa rya neurotransmitter:
Bitewe nuburyo busa hagati ya SNAP-8 na SNAP-25, irashobora kugira agaciro gakoreshwa mubushakashatsi bwa neurobiologique [1] . Mu ndwara zifata ubwonko, irekurwa ryinshi rya neurotransmitter rishobora gutera kwangirika kwa neuronal.
Ingaruka kuri neuroinflammation:
SNAP-8 irashobora kugenga ururenda rwa cytokine itera poroteyine mu ngirabuzimafatizo z'umubiri bigira ingaruka ku guhuza imitsi ya synaptic, bityo bikagira ingaruka ku gisubizo cy’umuriro [1] . Neuroinflammation igira uruhare runini mu ndwara nyinshi zifata ubwonko. Gukora kwingirangingo z'umubiri hamwe no gusohora cytokine itera inflammatory bizatera kwangirika no gupfa kwa neuron. SNAP-8 irashobora kugira ingaruka ku gusohora kwa cytokine itera inflammatory mu ngirabuzimafatizo z'umubiri mu kugenzura guhuza imitsi ya synaptic, bityo bikagabanya igisubizo cya neuroinflammatory.
Ni ubuhe buryo bukoreshwa muri SNAP-8?
1. Ingaruka zo kurwanya inkari
Nubwoko bushya bwa octapeptide, SNAP-8 yerekana ingaruka zikomeye zo kurwanya inkari mu rwego rwo kwita ku ruhu. Igabanya kugabanuka gukabije kwimitsi yo mumaso ibuza irekurwa rya neurotransmitter, hanyuma igabanya imiterere yiminkanyari kandi ihagaze. Ubushakashatsi butari buke bwerekanye ko SNAP-8 ishobora gukora neza kumirongo yo mumaso no muminkanyari. Gukoresha SNAP-8 kabiri kumunsi birashobora kugabanya cyane imirongo yerekana n'iminkanyari kugera kuri 63% mugihe cyiminsi 30, itanga inkunga ikomeye yo kuyikoresha murwego rwo kurwanya uruhu. Ubu buryo bwo kurwanya inkeke butandukanye nuburyo gakondo bwo kurwanya inkari. Ntabwo ikoresha kwuzuza umubiri cyangwa gukuramo imiti, ariko itangirira muburyo bwo kurekura neurotransmitter, itanga igitekerezo gishya cyo kurwanya uruhu.
2. Guteza imbere umusaruro wa kolagen
SNAP-8 irashobora kandi guteza imbere umusaruro wa kolagene muruhu muguhuza inzira zerekana ibimenyetso bya selile, bityo bikazamura imiterere nubworoherane bwuruhu. Kolagen ni ikintu cyingenzi cyuruhu, rushobora gukomeza gukomera no gukomera kwuruhu. Hamwe n'imyaka, kolagene mu ruhu igenda igabanuka buhoro buhoro, biganisha ku kuruhura uruhu ndetse n'iminkanyari nyinshi. Ubu buryo bwibikorwa bya SNAP-8 butanga uburyo bushya bwo gukemura ikibazo cyo gusaza kwuruhu. Mugutezimbere umusaruro wa kolagen, SNAP-8 irashobora kunoza neza imiterere nisura yuruhu, bigatuma uruhu rworoha kandi rukomera.
3. Ubundi buryo budatera
Nkibisanzwe bikomoka kuri kamere, bidafite uburozi, kandi ntibishobora gutera ubundi burozi bwa botuline, SNAP-8 nta ngaruka mbi ziterwa nuburozi bwa botuline. Nubwo uburozi bwa botuline bugira ingaruka zimwe na zimwe mu kurwanya inkari, uburyo bwo gutera inshinge bushobora gutera ingaruka mbi nko kubabara, kubyimba, no gukomeretsa, kandi bisaba ko hakorwa umuganga wabigize umwuga. Ibinyuranye, SNAP-8 ifite umutekano kandi yoroshye kandi irashobora gukoreshwa nkigicuruzwa cyita ku ruhu rwa buri munsi. Isura yacyo itanga amahitamo mashya kubakoresha bahangayikishijwe no kwisiga.
4. Kugenga irekurwa rya neurotransmitter
Bitewe nuburyo busa hagati ya SNAP-8 na SNAP-25, ifite agaciro gakoreshwa mubushakashatsi bwa neurobiologique [1] . Mu ndwara zifata ubwonko, irekurwa ryinshi rya neurotransmitter rishobora gutera kwangirika kwa neuronal. SNAP-8 irashobora kugabanya ibyangiritse mugutegeka irekurwa rya neurotransmitter. Neurotransmitters igira uruhare runini mugukwirakwiza amakuru muri sisitemu y'imitsi, kandi irekurwa ridasanzwe rya neurotransmitter rishobora gutera indwara zitandukanye za sisitemu. Ubu buryo bwibikorwa bya SNAP-8 butanga igitekerezo gishya cyo kuvura indwara zifata ubwonko. Mugutegeka irekurwa rya neurotransmitter, SNAP-8 biteganijwe ko igabanya kwangirika kwimitsi no kudindiza iterambere ryindwara.
5. Kugira ingaruka kuri neuroinflammation
SNAP-8 irashobora kugenga ururenda rwa cytokine itera poroteyine mu ngirabuzimafatizo z'umubiri bigira ingaruka ku guhuza imitsi ya synaptic, bityo bikagira ingaruka ku gisubizo cy’umuriro [1] . Neuroinflammation igira uruhare runini mu kubaho no guteza imbere indwara zinyuranye za sisitemu. Ubu buryo bwibikorwa bya SNAP-8 butanga uburyo bushya bwo kugenzura neuroinflammation. Mu kugira ingaruka ku guhuza imitsi ya synaptique, SNAP-8 irashobora kugenga ururenda rwa cytokine itera porotokore mu ngirabuzimafatizo, bityo bikagabanya igisubizo cy’umuriro no kurinda neuron.
Mu gusoza, SNAP-8 ifite ingaruka zitandukanye ningirakamaro. Mu kwita ku ruhu, irashobora kugabanya kugabanuka kwimitsi, guteza imbere umusaruro wa kolagen, no gufasha uruhu kurwanya iminkanyari no gukomera; mubushakashatsi bwa neurobiologique, burashobora kugenga irekurwa rya neurotransmitter kandi bikagira ingaruka kuri neuroinflammation.
Ibyerekeye Umwanditsi
Ibikoresho byavuzwe haruguru byose byakorewe ubushakashatsi, byahinduwe kandi byakozwe na Cocer Peptides.
Umwanditsi w'ikinyamakuru
Lemos M ifitanye isano nimiryango itandukanye nibyiciro. Ku bijyanye n’amashyirahamwe, bahujwe na Cesumar Inst Sci Technol & Innovat, Cesumar Univ, Univ Cesumar, Cesumar Inst Sci, UniCesumar - Centro Universitario Cesumar, Universidade de Lisboa, Amajyaruguru ya Lissabon Hosp Ctr, Ctr Hosp Univ Lisboa Norte, Centro Hosp, Estadual de Maringa. Kubyerekeye ibyiciro, Lemos M igira uruhare mubuvuzi bwo mu mutwe, Physiologiya, Sisitemu Yumutima Yumutima & Cardiology, Oncology, na Sisitemu yubuhumekero. Lemos M iri kurutonde rwerekanwe [1].
