▎ SNAP-8 Bincike
Menene SNAP-8?
SNAP-8 shine peptide na roba wanda ya ƙunshi amino acid 8.
Menene asalin bincike na SNAP-8?
Binciken tsufa na fata:
Tare da karuwar shekaru, fata yana nuna alamun tsufa irin su wrinkles. Samuwar wrinkles mai ƙarfi yana da alaƙa da kusanci da yawan murƙushewar fuska. Ƙunƙarar tsoka yana tsaka-tsaki ta hanyar neurotransmitters. Sabili da haka, gano wani abu wanda zai iya daidaita sakin neurotransmitter da rage ƙwayar tsoka ya zama muhimmiyar jagora a cikin binciken rigakafin tsufa na fata.
Binciken Kimiyyar Neuro:
An ci gaba da zurfafa bincike game da tsarin sakin neurotransmitter, kuma an gano cewa hadadden Protein Receptor (SNARE) mai Soluble NSF Attachment Protein Receptor (SNARE) yana taka muhimmiyar rawa a ciki. SNAP-25 wani muhimmin sashi ne na hadaddun SNARE. Fahimtar tsarinsa da aikinsa yana ba da tushen ka'idar don haɓaka abubuwan da zasu iya tsoma baki tare da sakin neurotransmitter. Dangane da waɗannan karatun, masu bincike suna fatan haɓaka wani abu mai aminci da inganci wanda ba zai iya taka rawar anti-wrinkle kawai a cikin kulawar fata ba amma kuma yana ba da sabbin kayan aiki da ra'ayoyi don bincike na neuroscience. SNAP-8 ya fito a cikin wannan mahallin kuma a hankali ya zama wurin bincike a fannonin da ke da alaƙa.
Menene tsarin aikin SNAP-8?
1. Skin maganin tsufa
Rage wrinkles:
SNAP-8 yana rage ƙwanƙwasa ƙwanƙwasa da tsayin daka akan farfajiyar fata ta hanyar rage raunin tsoka, haɓaka bayyanar fata gaba ɗaya. Ana haifar da wrinkles mai ƙarfi ta hanyar raguwar tsokoki na fuskar fuska, yayin da tsummoki mai tsayi a hankali yana tasowa tare da shekaru da raguwar elasticity na fata. Tsarin aikin SNAP-8 yana raunana raunin tsoka, don haka rage haɓakar wrinkles masu ƙarfi. A lokaci guda kuma, tun da yake yana rage karfin jijiya ga fata, yana taimakawa wajen rage tsarin tsufa na fata da kuma rage samuwar wrinkles a tsaye.
Inganta samar da collagen:
SNAP-8 na iya haɓaka samar da collagen a cikin fata ta hanyar daidaita hanyoyin siginar salula. Collagen shine babban sunadaran tsari a cikin fata, wanda ke baiwa fata da elasticity da tauri. Tare da shekaru, abun ciki na collagen a cikin fata yana raguwa a hankali, yana haifar da shakatawa na fata da bayyanar wrinkles. SNAP-8 na iya haɓaka haɗin haɗin gwiwa ta hanyar kunna wasu hanyoyin sigina, kamar hanyar siginar TGF-β/Smad. Bugu da ƙari, SNAP-8 na iya ƙara yawan abun ciki na collagen a cikin fata ta hanyar hana lalata collagen.
2. Tsarin tsarin neuromuscular
Tsangwama tare da hadaddun SNARE:
SNAP-8 mimic ne na N-terminal na SNAP-25 kuma yana iya yin gasa tare da SNAP-25 don matsayin sa a cikin hadaddun SNARE. Ƙungiyar SNARE tana taka muhimmiyar rawa wajen aiwatar da sakin neurotransmitter. Yawanci, hadaddun SNARE ya ƙunshi syntaxin akan membrane na presynaptic, synaptobrevin, da SNAP-25 akan membrane vesicle synaptic. Lokacin da jijiyar jijiyar ta kai ga membrane na presynaptic, kwararar ions na calcium yana haifar da haɗuwa da vesicles na synaptic tare da membrane na presynaptic, don haka ya saki neurotransmitters. Koyaya, lokacin da SNAP-8 yayi gasa tare da SNAP-25 don matsayi a cikin hadaddun SNARE, yana tsoma baki tare da samuwar hadaddun SNARE. Wannan ya sa ba zai yiwu ba ga vesicles na synaptic don saki masu amfani da neurotransmitters yadda ya kamata, yana haifar da raunin tsoka.
Rage sakin neurotransmitter:
Ta hanyar tsoma baki tare da hadaddun SNARE, SNAP-8 yana rage sakin masu watsawa. Neurotransmitters sune sinadarai da ke watsa sigina tsakanin ƙwayoyin jijiya. Yawan sakin neurotransmitter zai haifar da wuce gona da iri na jijiyoyi na tsokoki. Ayyukan SNAP-8 yana rage haɓakar jijiyar tsokoki, don haka rage samuwar wrinkles.
3. Binciken Neurobiological
Gudanar da sakin neurotransmitter:
Saboda tsarin kamanni tsakanin SNAP-8 da SNAP-25, yana iya samun yuwuwar ƙimar aikace-aikacen a cikin binciken neurobiological [1] . A cikin cututtukan neurodegenerative, yawan sakin neurotransmitter na iya haifar da lalacewar neuronal.
Yana shafar neuroinflammation:
SNAP-8 na iya tsara ɓoyayyiyar cytokines na pro-inflammatory a cikin ƙwayoyin rigakafi ta hanyar yin tasiri da haɗuwa da vesicles na synaptic, don haka yana da tasiri akan amsawar kumburi [1] . Neuroinflammation yana taka muhimmiyar rawa a yawancin cututtukan neurodegenerative. Kunna ƙwayoyin rigakafi da kuma ɓoyewar cytokines masu kumburi zai haifar da lalacewa da mutuwar ƙwayoyin cuta. SNAP-8 na iya rinjayar ɓoyewar cytokines masu kumburi a cikin ƙwayoyin rigakafi ta hanyar daidaita tsarin haɗin gwiwar synaptic vesicles, don haka rage amsawar neuroinflammatory.
Menene aikace-aikacen SNAP-8?
1. Anti-alama sakamako
A matsayin sabon nau'in octapeptide, SNAP-8 yana nuna mahimman tasirin maganin lanƙwasa a fagen kula da fata. Yana rage wuce gona da iri na tsokoki na fuska ta hanyar hana sakin neurotransmitters, sa'an nan kuma ya rage samuwar gyaggyarawa da kuma a tsaye. Yawancin karatu sun nuna cewa SNAP-8 na iya yin aiki yadda ya kamata akan layukan fuska da wrinkles. Yin amfani da SNAP-8 sau biyu a rana zai iya rage yawan layukan magana da wrinkles har zuwa 63% a cikin kwanaki 30, wanda ke ba da goyon baya mai karfi don aikace-aikacensa a fagen maganin fata. Wannan tsari na hana yawu ya sha bamban da na gargajiya na al'ada. Ba ya amfani da cika jiki ko kwasfa na sinadarai, amma yana farawa daga hangen nesa na sakin neurotransmitter, yana ba da sabon ra'ayi don rigakafin kumburin fata.
2. Inganta samar da collagen
SNAP-8 na iya haɓaka samar da collagen a cikin fata ta hanyar daidaita hanyoyin siginar salula, ta haka inganta tsari da elasticity na fata. Collagen wani abu ne mai mahimmanci na fata, wanda zai iya kula da tsauri da elasticity na fata. Tare da shekaru, collagen a cikin fata yana raguwa a hankali, yana haifar da shakatawa na fata da ƙarin wrinkles. Wannan tsarin aikin SNAP-8 yana ba da sabuwar hanya don magance matsalar tsufa na fata. Ta hanyar inganta samar da collagen, SNAP-8 na iya inganta yanayin fata da bayyanar fata yadda ya kamata, yana sa fata ta zama mai laushi da ƙarfi.
3. Madadin mara lalacewa
A matsayin abin da aka samu na halitta, mara guba, da kuma maye gurbin maye gurbin botulinum toxin, SNAP-8 ba shi da wani tasiri na toxin botulinum injectable. Ko da yake botulinum toxin yana da wasu sakamako masu illa a cikin maganin lanƙwasa, tsarin allurar sa na iya haifar da munanan halayen kamar zafi, kumburi, da ƙumburi, kuma yana buƙatar aikin ƙwararrun likita. Sabanin haka, SNAP-8 ya fi aminci kuma ya fi dacewa kuma ana iya amfani dashi azaman kayan kula da fata na yau da kullun. Bayyanar sa yana ba da sabon zaɓi ga masu amfani waɗanda suka damu da samfuran kayan kwalliyar allura.
4. Daidaita sakin neurotransmitter
Saboda tsarin kamanni tsakanin SNAP-8 da SNAP-25, yana da yuwuwar ƙimar aikace-aikacen a cikin binciken neurobiological [1] . A cikin cututtukan neurodegenerative, yawan sakin neurotransmitter na iya haifar da lalacewar neuronal. SNAP-8 na iya rage wannan lalacewa ta hanyar daidaita sakin neurotransmitter. Neurotransmitters suna taka muhimmiyar rawa wajen watsa bayanai a cikin tsarin juyayi, kuma rashin daidaituwa na ƙananan ƙwayoyin cuta na iya haifar da cututtuka iri-iri. Wannan tsarin aikin SNAP-8 yana ba da sabon ra'ayi don maganin cututtuka na neurodegenerative. Ta hanyar daidaita sakin masu amfani da ƙwayoyin cuta, ana sa ran SNAP-8 zai rage lalacewar neuronal da rage ci gaban cutar.
5. Yana shafar neuroinflammation
SNAP-8 na iya tsara ɓoyayyiyar cytokines na pro-inflammatory a cikin ƙwayoyin rigakafi ta hanyar yin tasiri da haɗuwa da vesicles na synaptic, don haka yana da tasiri akan amsawar kumburi [1] . Neuroinflammation yana taka muhimmiyar rawa a cikin abin da ya faru da kuma ci gaba da cututtuka daban-daban na tsarin juyayi. Wannan tsarin aikin SNAP-8 yana ba da sabuwar hanya don daidaita neuroinflammation. Ta hanyar yin tasiri da haɗuwa da vesicles na synaptic, SNAP-8 na iya tsara ƙaddamar da ƙwayoyin cytokines masu kumburi a cikin ƙwayoyin rigakafi, don haka rage amsawar kumburi da kare ƙwayoyin cuta.
A ƙarshe, SNAP-8 yana da tasiri mai yawa da mahimmanci. A cikin kula da fata, zai iya rage ƙwayar tsoka, inganta samar da collagen, da kuma taimakawa fata ta tsayayya da wrinkles kuma ta zama m; a cikin binciken neurobiological, yana iya daidaita sakin neurotransmitter kuma yana shafar neuroinflammation.
Game da Marubuci
Abubuwan da aka ambata a sama duk bincike ne, gyara su kuma Cocer Peptides ne suka haɗa su.
Mawallafin Jaridar Kimiyya
Lemos M yana da alaƙa da ƙungiyoyi daban-daban da nau'ikan batutuwa. In terms of organizations, they are linked to Cesumar Inst Sci Technol & Innovat, Cesumar Univ, Univ Cesumar, Cesumar Inst Sci, UniCesumar - Centro Universitario Cesumar, Universidade de Lisboa, North Lisbon Hosp Ctr, Ctr Hosp Univ Lisboa Norte, Centro Hospitalar de Lisboa Ocidental, EPE, and Universidade Estadual de Maringa. Game da nau'ikan batutuwa, Lemos M yana da hannu a cikin Likitan tabin hankali, Physiology, Cardiovascular System & Cardiology, Oncology, and Respiratory System. An jera Lemos M a cikin ambaton ambaton [1].
