▎ SNAP-8 Kev Tshawb Fawb
SNAP-8 yog dab tsi?
SNAP-8 yog ib qho hluavtaws peptide uas muaj 8 amino acids.
Kev tshawb fawb keeb kwm ntawm SNAP-8 yog dab tsi?
Kev tshawb fawb ntawm daim tawv nqaij laus:
Nrog rau kev loj hlob ntawm lub hnub nyoog, daim tawv nqaij qhia cov cim ntawm kev laus xws li wrinkles. Qhov tsim ntawm dynamic wrinkles yog ze ze rau qhov nquag contraction ntawm lub ntsej muag nqaij. Cov leeg nqaij contraction yog kho los ntawm neurotransmitters. Yog li ntawd, nrhiav tau ib yam khoom uas yuav tswj tau cov neurotransmitter tso tawm thiab txo cov leeg nqaij contraction tau dhau los ua ib qho tseem ceeb hauv kev tshawb fawb ntawm daim tawv nqaij los tiv thaiv kev laus.
Kev tshawb fawb txog Neuroscience:
Kev tshawb fawb ntawm cov txheej txheem ntawm kev tso tawm neurotransmitter tau tob zuj zus mus, thiab nws tau pom tias Soluble NSF Attachment Protein Receptor (SNARE) complex ua lub luag haujlwm tseem ceeb hauv nws. SNAP-25 yog ib qho tseem ceeb ntawm SNARE complex. Kev nkag siab txog nws cov qauv thiab kev ua haujlwm muab lub hauv paus theoretical rau kev tsim cov tshuaj uas tuaj yeem cuam tshuam nrog kev tso tawm neurotransmitter. Raws li cov kev tshawb fawb no, cov kws tshawb fawb vam tias yuav tsim cov tshuaj muaj txiaj ntsig zoo thiab muaj txiaj ntsig zoo uas tuaj yeem tsis tsuas yog ua lub luag haujlwm tiv thaiv kev ua kom tawv nqaij tab sis kuj muab cov cuab yeej tshiab thiab cov tswv yim rau kev tshawb fawb neuroscience. SNAP-8 tau tshwm sim nyob rau hauv cov ntsiab lus no thiab maj mam dhau los ua qhov kev tshawb fawb hotspot nyob rau hauv lwm qhov chaw.
Yuav ua li cas yog lub mechanism ntawm kev txiav txim ntawm SNAP-8?
1. Daim tawv nqaij tiv thaiv kev laus
Txo wrinkles:
SNAP-8 txo cov pob txha dynamic thiab zoo li qub ntawm daim tawv nqaij los ntawm kev txo cov leeg nqaij, txhim kho tag nrho cov tawv nqaij. Dynamic wrinkles yog tshwm sim los ntawm contraction ntawm lub ntsej muag qhia cov leeg, thaum zoo li qub wrinkles maj mam tsim nrog lub hnub nyoog thiab txo ntawm daim tawv nqaij elasticity. Lub mechanism ntawm kev txiav txim ntawm SNAP-8 tsis muaj zog cov leeg nqaij contractions, yog li txo cov tiam ntawm dynamic wrinkles. Nyob rau tib lub sijhawm, txij li nws txo cov paj hlwb stimulation rau ntawm daim tawv nqaij, nws kuj yuav pab kom qeeb ntawm daim tawv nqaij laus txheej txheem thiab txo qhov tsim ntawm static wrinkles.
Txhawb nqa collagen ntau lawm:
SNAP-8 kuj tseem tuaj yeem txhawb kev tsim cov collagen hauv daim tawv nqaij los ntawm kev tswj cov kab mob ntawm tes. Collagen yog cov txheej txheem tseem ceeb hauv daim tawv nqaij, uas ua rau cov tawv nqaij elasticity thiab toughness. Nrog lub hnub nyoog, cov ntsiab lus ntawm collagen hauv daim tawv nqaij maj mam txo, ua rau cov tawv nqaij so thiab cov tsos ntawm wrinkles. SNAP-8 tuaj yeem txhawb nqa collagen synthesis los ntawm kev ua kom muaj qee yam kev taw qhia, xws li TGF-β/Smad signaling pathway. Tsis tas li ntawd, SNAP-8 kuj tseem tuaj yeem nce cov ntsiab lus ntawm collagen hauv daim tawv nqaij los ntawm inhibiting collagen degradation.
2. Neuromuscular tswj
Kev cuam tshuam nrog SNARE complex:
SNAP-8 yog N-terminal mimic ntawm SNAP-25 thiab tuaj yeem sib tw nrog SNAP-25 rau nws txoj haujlwm hauv SNARE complex. SNARE complex plays lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm kev tso tawm neurotransmitter. Nquag, SNARE complex yog tsim los ntawm syntaxin ntawm presynaptic membrane, synaptobrevin, thiab SNAP-25 ntawm lub synaptic vesicle membrane. Thaum cov hlab ntsha impulse ncav cuag lub presynaptic daim nyias nyias, lub influx ntawm calcium ions ua rau lub fusion ntawm synaptic vesicles nrog lub presynaptic membrane, yog li tso tawm neurotransmitters. Txawm li cas los xij, thaum SNAP-8 sib tw nrog SNAP-25 rau txoj haujlwm hauv SNARE complex, nws cuam tshuam nrog kev tsim ntawm SNARE complex. Qhov no ua rau nws tsis yooj yim sua rau synaptic vesicles tso tawm neurotransmitters zoo, ua rau cov leeg tsis muaj zog.
Txo cov neurotransmitter tso tawm:
Los ntawm kev cuam tshuam nrog SNARE complex, SNAP-8 txo qhov tso tawm ntawm cov neurotransmitters. Neurotransmitters yog cov tshuaj lom neeg uas xa cov cim ntawm cov paj hlwb. Kev tso tawm ntau dhau ntawm cov neurotransmitter yuav ua rau cov leeg mob siab heev. Qhov kev txiav txim ntawm SNAP-8 txo cov paj hlwb stimulation ntawm cov leeg, yog li txo qhov tsim ntawm wrinkles.
3. Kev tshawb fawb txog Neurobiological
Regulating neurotransmitter tso tawm:
Vim yog qhov zoo sib xws ntawm cov qauv ntawm SNAP-8 thiab SNAP-25, nws yuav muaj peev xwm siv tau tus nqi hauv kev tshawb fawb neurobiological [1] . Hauv cov kab mob neurodegenerative, kev tso tawm ntau dhau ntawm neurotransmitter tuaj yeem ua rau muaj kev puas tsuaj rau neuronal.
Kev cuam tshuam rau neuroinflamation:
SNAP-8 tuaj yeem tswj hwm qhov tso tawm ntawm cov cytokines hauv lub cev tiv thaiv kab mob los ntawm kev cuam tshuam cov fusion ntawm synaptic vesicles, yog li muaj kev cuam tshuam rau cov lus teb inflammatory [1] . Neuroinflammation plays lub luag haujlwm tseem ceeb hauv ntau yam kab mob neurodegenerative. Kev ua kom lub cev tiv thaiv kab mob thiab kev tso tawm ntawm pro-inflammatory cytokines yuav ua rau kev puas tsuaj thiab kev tuag ntawm cov neurons. SNAP-8 tuaj yeem cuam tshuam rau kev tso tawm ntawm cov cytokines pro-inflammatory hauv lub cev tiv thaiv kab mob los ntawm kev tswj cov fusion ntawm synaptic vesicles, yog li txo cov lus teb neuroinflammatory.
Cov ntawv thov ntawm SNAP-8 yog dab tsi?
1. Anti-wrinkle nyhuv
Raws li hom tshiab ntawm octapeptide, SNAP-8 qhia tau hais tias muaj txiaj ntsig zoo los tiv thaiv kev ua haujlwm ntawm daim tawv nqaij. Nws txo qhov kev cog lus ntau dhau ntawm cov leeg ntawm lub ntsej muag los ntawm inhibiting kev tso tawm ntawm cov neurotransmitters, thiab tom qab ntawd txo qhov tsim ntawm dynamic thiab zoo li qub wrinkles. Ntau cov kev tshawb fawb tau pom tias SNAP-8 tuaj yeem ua tau zoo ntawm lub ntsej muag kab thiab wrinkles. Siv SNAP-8 ob zaug hauv ib hnub tuaj yeem txo cov kab lus qhia thiab wrinkles ntau txog 63% hauv 30 hnub, uas muab kev txhawb zog rau nws daim ntawv thov hauv daim tawv nqaij los tiv thaiv wrinkle. Qhov no anti-wrinkle mechanism yog txawv los ntawm tsoos anti-wrinkle txoj kev. Nws tsis siv lub cev filling lossis tshuaj tev tawm, tab sis pib los ntawm kev xav ntawm cov tshuaj neurotransmitter tso tawm, muab lub tswv yim tshiab rau daim tawv nqaij los tiv thaiv wrinkle.
2. Txhawb nqa collagen ntau lawm
SNAP-8 kuj tseem tuaj yeem txhawb nqa kev tsim cov collagen hauv daim tawv nqaij los ntawm kev tswj hwm cellular signaling pathways, yog li txhim kho cov qauv thiab elasticity ntawm daim tawv nqaij. Collagen yog ib qho tseem ceeb ntawm daim tawv nqaij, uas tuaj yeem tswj qhov firmness thiab elasticity ntawm daim tawv nqaij. Nrog lub hnub nyoog, collagen hauv daim tawv nqaij maj mam txo, ua rau cov tawv nqaij so thiab ntau wrinkles. Qhov txheej txheem ntawm kev ua ntawm SNAP-8 no muab txoj hauv kev tshiab los daws cov teeb meem ntawm daim tawv nqaij laus. Los ntawm kev txhawb kev tsim cov collagen, SNAP-8 tuaj yeem txhim kho qhov kev ntxhib los mos thiab pom ntawm daim tawv nqaij, ua rau daim tawv nqaij smoother thiab firmer.
3. Tsis-invasive lwm txoj
Raws li ib tug natural-derived, non-toxic, thiab non-invasive lwm txoj rau botulinum toxin, SNAP-8 tsis muaj kev phiv los ntawm txhaj tshuaj botulinum toxin. Txawm hais tias botulinum toxin muaj qee yam cuam tshuam los ntawm kev tiv thaiv wrinkle, nws txoj kev txhaj tshuaj yuav ua rau muaj kev phiv xws li mob, o, thiab nqaij tawv, thiab yuav tsum tau ua haujlwm ntawm tus kws kho mob. Hauv qhov sib piv, SNAP-8 muaj kev nyab xeeb dua thiab yooj yim dua thiab tuaj yeem siv los ua cov khoom tu tawv nqaij txhua hnub. Nws cov tsos muab kev xaiv tshiab rau cov neeg siv khoom uas txhawj xeeb txog cov khoom siv tshuaj pleev ib ce.
4. Tswj kev tso tawm neurotransmitter
Vim qhov zoo sib xws ntawm cov qauv ntawm SNAP-8 thiab SNAP-25, nws muaj peev xwm siv tus nqi hauv kev tshawb fawb neurobiological [1] . Hauv cov kab mob neurodegenerative, kev tso tawm ntau dhau ntawm neurotransmitter tuaj yeem ua rau muaj kev puas tsuaj rau neuronal. SNAP-8 tuaj yeem txo qhov kev puas tsuaj no los ntawm kev tswj cov tshuaj neurotransmitter tso tawm. Neurotransmitters ua lub luag haujlwm tseem ceeb hauv kev xa cov ntaub ntawv hauv lub paj hlwb, thiab kev tso tawm tsis zoo ntawm cov neurotransmitters tuaj yeem ua rau ntau yam kab mob hauv lub paj hlwb. Qhov txheej txheem ntawm kev ua ntawm SNAP-8 muab lub tswv yim tshiab rau kev kho cov kab mob neurodegenerative. Los ntawm kev tswj hwm kev tso tawm ntawm cov tshuaj neurotransmitters, SNAP-8 yuav tsum txo qis kev puas tsuaj ntawm cov hlab ntsha thiab ua rau cov kab mob qeeb zuj zus.
5. cuam tshuam rau neuroinflamation
SNAP-8 tuaj yeem tswj hwm qhov tso tawm ntawm cov cytokines hauv lub cev tiv thaiv kab mob los ntawm kev cuam tshuam cov fusion ntawm synaptic vesicles, yog li muaj kev cuam tshuam rau cov lus teb inflammatory [1] . Neuroinflammation plays lub luag haujlwm tseem ceeb hauv kev tshwm sim thiab kev loj hlob ntawm ntau yam kab mob paj hlwb. Qhov txheej txheem ntawm kev ua ntawm SNAP-8 no muab txoj hauv kev tshiab los tswj cov kab mob neuroinflamation. Los ntawm kev cuam tshuam cov fusion ntawm synaptic vesicles, SNAP-8 tuaj yeem tswj cov kev tso tawm ntawm pro-inflammatory cytokines hauv lub cev tiv thaiv kab mob, yog li txo cov inflammatory teb thiab tiv thaiv neurons.
Hauv kev xaus, SNAP-8 muaj ntau yam cuam tshuam thiab tseem ceeb heev. Hauv kev tu tawv nqaij, nws tuaj yeem txo cov leeg nqaij, txhawb kev tsim cov collagen, thiab pab cov tawv nqaij tiv thaiv wrinkles thiab ua kom khov kho; Hauv kev tshawb fawb txog neurobiological, nws tuaj yeem tswj cov tshuaj neurotransmitter tso tawm thiab cuam tshuam rau neuroinflamation.
Hais Txog Tus Sau
Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.
Scientific Journal Author
Lemos M yog txuam nrog ntau lub koom haum thiab cov kev kawm. Hais txog cov koom haum, lawv tau txuas nrog Cesumar Inst Sci Technol & Innovat, Cesumar Univ, Univ Cesumar, Cesumar Inst Sci, UniCesumar - Centro Universitario Cesumar, Universidade de Lisboa, North Lisbon Hosp Ctr, Ctr Hosp Univ Lisboa Norte, Centro Universitario Tsev Kho Mob Ntsib cov neeg Maringa. Hais txog cov ncauj lus kawm, Lemos M koom nrog Psychiatry, Physiology, Cardiovascular System & Cardiology, Oncology, thiab Respiratory System. Lemos M tau teev nyob rau hauv qhov kev siv ntawm cov ntaub ntawv pov thawj [1].
