GHK-Cu 100 mg

▎ GHK - Cu Structure

Source: PubChem

Sequence: Gly-His-Lys Molecular Formula: C 28H 46CuN 12O8 Molecular Luj: 742.3g/mol CAS Nr .: 130120-56-8 PubChem CID: 9831891 Synonyms: Bisprezatide tooj liab; DL1TR6W6VM

▎ GHK - Cu Research

Kev tshawb fawb keeb kwm ntawm GHK-Cu yog dab tsi?

Kev Tshawb Fawb Kev Txhim Kho ntawm Active Peptides: 

Txij li thaum xyoo pua 20th, kev tshawb fawb ntawm bioactive peptides hauv kev tshawb fawb txog lub neej tau txuas ntxiv mus. Cov kws tshawb fawb tau maj mam pom tias peptides ua lub luag haujlwm tseem ceeb hauv cov kab mob muaj sia. Lawv tsis yog cov ntsiab lus ntawm cov proteins nkaus xwb tab sis kuj muaj kev ywj pheej ntawm kev ua haujlwm lom neeg thiab koom nrog kev tswj hwm ntau yam txheej txheem physiological ntawm cov kab mob, xws li kev loj hlob ntawm tes, sib txawv, thiab immunomodulation. Qhov kev nkag siab tob tob ntawm peptides muab lub hauv paus theoretical thiab kev tshawb fawb qhia rau kev tshawb pom thiab kev kawm ntawm GHK-Cu.

Kev tshawb nrhiav ntawm Plasma Cheebtsam: 

Hauv kev tshawb fawb ntxaws ntxaws ntawm tib neeg plasma Cheebtsam, cov kws tshawb fawb tau cog lus los tshuaj xyuas qhov muaj pes tsawg leeg thiab kev ua haujlwm ntawm ntau yam biomolecules hauv plasma. Raws li lub cev tseem ceeb hauv tib neeg lub cev, plasma muaj ntau yam proteins, peptides, cov tshuaj hormones, electrolytes, thiab lwm yam khoom, thiab nws yog ib qho tseem ceeb nruab nrab ntawm kev tswj cov kev ua haujlwm ntawm tib neeg lub cev. Nyob rau xyoo 1970, cov kws tshawb fawb nrhiav tau ib qho tshwj xeeb tripeptide thaum lub sij hawm tsom xam cov plasma proteins. Nws cov amino acid sequence yog glycyl-histidyl-lysine, uas yog GHK. Qhov kev tshawb pom no ua rau muaj kev txaus siab ntawm cov kws tshawb fawb thiab ua rau lawv tshawb nrhiav ntxiv txog lub luag haujlwm thiab cov yam ntxwv ntawm cov tripeptide hauv plasma.

Lub ntsiab lus tseem ceeb ntawm tooj liab ions: 

Nyob rau tib lub sijhawm, lub luag haujlwm tseem ceeb ntawm tooj liab ions hauv biology tau maj mam nyiam. Tooj liab yog ib qho tseem ceeb ntawm cov kab mob hauv tib neeg lub cev thiab koom nrog ntau yam tshuaj lom neeg. Nws yog ib feem lossis activator ntawm ntau cov enzymes tseem ceeb thiab ua lub luag haujlwm tseem ceeb hauv kev tswj cov metabolism hauv lub cev, ua pa, thiab kev sib txuas ntawm collagen. Thaum kawm txog kev ua haujlwm lom neeg ntawm tooj liab ions, cov kws tshawb fawb pom tias tooj liab ions tuaj yeem khi rau qee yam peptide tshuaj los tsim cov complexes nrog cov haujlwm tshwj xeeb lom neeg. Qhov kev tshawb pom no muab cov ntsiab lus tseem ceeb rau kev kawm txog kev khi ntawm GHK thiab tooj liab ions thiab lawv lub peev xwm ua haujlwm.

Txhawb Kev Tshawb Fawb Txog Kev Laus: 

Nrog rau txoj kev loj hlob ntawm tib neeg thiab cov teeb meem tseem ceeb ntawm cov pej xeem kev laus, kev tshawb fawb txog kev laus tau dhau los ua ib lub ntsiab lus tseem ceeb hauv kev tshawb fawb txog lub neej. Cov kws tshawb fawb tab tom sim nrhiav cov biomarkers thiab cov kev tswj hwm zoo cuam tshuam nrog cov txheej txheem kev laus kom nthuav tawm cov txheej txheem ntawm kev laus thiab tshawb xyuas cov txheej txheem los ncua kev laus. Hauv cov ntsiab lus no, nws tau pom tias qhov concentration ntawm GHK-Cu hauv tib neeg lub cev maj mam txo qis nrog lub hnub nyoog, uas txhais tau hais tias GHK-Cu yuav muaj qee qhov kev sib txuas nrog cov txheej txheem kev laus. Qhov kev tshawb pom no ntxiv txhawb cov kws tshawb fawb los ua qhov kev tshawb fawb tob txog qhov chaw, kev ua haujlwm, thiab kev siv GHK-Cu hauv kev tiv thaiv kev laus, thiab txhawb kev txhim kho txuas ntxiv ntawm kev tshawb fawb ntsig txog.

Dab tsi yog qhov mechanism ntawm kev txiav txim ntawm GHK-Cu?

Txhawb nqa cov ntaub so ntswg kho thiab rov tsim dua tshiab:

Stimulating Blood Vessel thiab Nerve Growth: 

Cov kev tshawb fawb uas twb muaj lawm tau pom tias GHK-Cu tuaj yeem txhawb kev loj hlob ntawm cov hlab ntsha thiab cov hlab ntsha. Nws tuaj yeem ua tiav qhov txiaj ntsig no los ntawm kev tswj hwm cov xwm txheej loj hlob thiab cov kev taw qhia. Piv txwv li, nws tuaj yeem txhawb kev nthuav qhia ntawm vascular endothelial kev loj hlob zoo tshaj plaws (VEGF), yog li stimulating angiogenesis ^[1] . Hais txog kev loj hlob ntawm cov paj hlwb, nws tuaj yeem txhawb txoj kev ciaj sia, kev loj hlob, thiab kev loj hlob ntawm cov paj hlwb los ntawm kev cuam tshuam cov cim qhia txog kev loj hlob ntawm cov paj hlwb.

Ua kom cov Synthesis ntawm Collagen, Elastin, thiab Glycosaminoglycans: 

GHK-Cu tuaj yeem ua kom cov synthesis ntawm collagen, elastin, thiab glycosaminoglycans. Collagen yog ib qho tseem ceeb ntawm cov ntaub so ntswg xws li daim tawv nqaij thiab pob txha, elastin muab cov ntaub so ntswg elasticity, thiab glycosaminoglycans ua lub luag haujlwm tseem ceeb hauv kev tswj cov dej noo thiab elasticity ntawm cov ntaub so ntswg. Cov txheej txheem tshwj xeeb yuav koom nrog kev tswj hwm cov kev qhia ntawm cov noob muaj feem xyuam thiab cov kev taw qhia, xws li ua kom muaj cov txheej txheem hloov pauv hauv fibroblasts los txhawb kev qhia cov noob ntsig txog collagen synthesis ^[1].

Txhawb Kev Ua Haujlwm ntawm Dermal Fibroblasts: 

Dermal fibroblasts ua lub luag haujlwm tseem ceeb hauv kev tswj cov qauv thiab kev ua haujlwm ntawm daim tawv nqaij. GHK-Cu tuaj yeem pab txhawb kev ua haujlwm ntawm dermal fibroblasts, suav nrog kev txhawb nqa cell proliferation, kev tsiv teb tsaws, thiab kev sib txuas ntawm cov khoom sib txuas ntawm cov matrix extracellular. Qhov no tuaj yeem ua tiav los ntawm kev tswj cov kev taw qhia thiab cov noob qhia hauv fibroblasts.

Cell tiv thaiv teebmeem:

Anticancer Activity: 

GHK-Cu muaj ntau yam tshuaj tiv thaiv kab mob. Nws tuaj yeem siv cov tshuaj tiv thaiv kab mob los ntawm inhibiting kev loj hlob ntawm cov qog nqaij hlav cancer, inducing apoptosis ntawm cov qog nqaij hlav cancer, thiab inhibiting invasion thiab metastasis ntawm cov qog nqaij hlav cancer. Cov txheej txheem tshwj xeeb tuaj yeem koom nrog kev tswj hwm lub voj voog ntawm tes, ua kom lub apoptosis signaling txoj hauv kev, thiab inhibiting qog-txog kev taw qhia txoj hauv kev ^[1].

Anti-inflammatory nyhuv: 

GHK-Cu muaj lub zog tiv thaiv kab mob. Nws tuaj yeem cuam tshuam kev tsim cov inflammatory yam xws li qog necrosis factor-α (TNF-α) thiab interleukin-6 (IL-6), thiab tib lub sij hawm nce cov kev ua ntawm antioxidant enzymes xws li superoxide dismutase (SOD). Nws cov tshuaj tiv thaiv kab mob tuaj yeem cuam tshuam nrog kev cuam tshuam ntawm NF-κB p65 thiab p38 MAPK txoj kev taw qhia, yog li txo cov lus teb inflammatory ^[2].

Kev Tiv Thaiv Mob ntsws thiab Kho Cov Kab Mob Hlwb Obstructive Pulmonary (COPD): 

GHK-Cu muaj kev tiv thaiv thiab kho cov nyhuv ntawm lub ntsws. Nws muaj peev xwm inhibit qhov inflammatory teb nyob rau hauv lub ntsws cov ntaub so ntswg, txo qhov kev puas tsuaj thiab fibrosis ntawm lub ntsws cov ntaub so ntswg. Rau cov mob ntsws fibroblasts ntawm cov neeg mob uas muaj kab mob ntsws ntev (COPD), GHK-Cu tuaj yeem rov qab ua haujlwm ntawm lawv txoj haujlwm, tejzaum nws los ntawm kev tswj cov kev taw qhia txog kev qhia txog noob caj noob ces ^[1].

Anxiolytic, Analgesic, thiab Anti-aggression Effects: 

GHK-Cu kuj muaj anxiolytic, analgesic, thiab tiv thaiv kev ua phem, tab sis cov txheej txheem tshwj xeeb tseem tsis tau nkag siab tag nrho. Tej zaum nws yuav muaj feem xyuam rau cov kev cai ntawm kev taw qhia txoj kev thiab neurotransmitters hauv lub paj hlwb.

DNA kho thiab ntxuav tes:

DNA Kho: 

GHK-Cu muaj cov haujlwm ntawm kev kho DNA. Nws tuaj yeem kho DNA puas tau los ntawm kev ua kom cov DNA kho cov enzymes lossis cov kev taw qhia. Qhov no yog qhov tseem ceeb heev rau kev tswj hwm lub cev ua haujlwm ntawm cov hlwb thiab tiv thaiv qhov tshwm sim ntawm cov kab mob xws li kev laus thiab mob qog noj ntshav ^[1].

Activating Cell Cleaning (los ntawm Proteasome System): 

GHK-Cu tuaj yeem qhib cov kab ke proteasome ntawm cov hlwb, txhawb kev degradation thiab tshem tawm cov proteins hauv cov cell. Qhov no yuav pab kom muaj kev ruaj ntseg ntawm ib puag ncig intracellular thiab tiv thaiv kev sib sau ntawm cov protein thiab kev ua haujlwm ntawm tes ^[1].

Hypothesis on the Mechanism of Acupuncture: Qee cov kev tshawb fawb tau tawm tswv yim tias cov txheej txheem ntawm kev ua ntawm acupuncture yuav ua tiav los ntawm GHK-Cu. Txawm hais tias cov txheej txheem tshwj xeeb tseem yuav tau kawm ntxiv, qhov no muab qhov kev xav tshiab rau kev nkag siab txog kev ua haujlwm ntawm GHK-Cu ^[3].

Cov qib ntshav plasma thiab qhov chaw kho mob ntawm GHK hauv cov neeg mob silicosis: A. Plasma GHK qib hauv cov neeg noj qab haus huv thiab cov neeg mob silicosis. B. Plasma GHK qib hauv cov neeg mob uas muaj cov kab mob silicosis nyob rau theem sib txawv ntawm tus kab mob. C. Cov tsos mob ntawm lub ntsws thiab plasma GHK qib hauv cov neeg tswj kev noj qab haus huv thiab hauv cov neeg mob hauv cov theem sib txawv ntawm silicosis. D. Kev sib raug zoo ntawm qib plasma GHK thiab FEV1% ua ntej hauv cov neeg mob silicosis. E. Kev sib raug zoo ntawm qib plasma GHK thiab DLCO% ua ntej hauv cov neeg mob silicosis.

Source: PubMed ^[6]

GHK-Cu yog dab tsi?

Daim tawv nqaij kho thiab kev zoo nkauj:

Stimulating Collagen Synthesis: 

GHK-Cu tuaj yeem txhawb nqa cov synthesis ntawm collagen, elastin, thiab glycosaminoglycans. Collagen yog ib qho tseem ceeb ntawm daim tawv nqaij, uas muab cov tawv nqaij elasticity thiab firmness ^[1] . Nrog lub hnub nyoog nce, cov synthesis ntawm collagen maj mam txo, ua rau cov tawv nqaij so thiab cov tsos ntawm wrinkles. Los ntawm kev txhawb kev tsim cov collagen, GHK-Cu tuaj yeem txhim kho elasticity thiab firmness ntawm daim tawv nqaij thiab txo qhov tsim ntawm wrinkles.

Txhawb nqa cov hlab ntsha thiab paj hlwb loj hlob:

 Nws muaj cov nyhuv stimulating kev loj hlob ntawm cov hlab ntsha thiab paj hlwb ^[1] . Cov ntshav khiav zoo yog qhov tseem ceeb rau kev noj qab haus huv ntawm daim tawv nqaij. Nws tuaj yeem muab cov as-ham txaus thiab oxygen rau cov hlwb ntawm daim tawv nqaij thiab txhawb cov metabolism hauv daim tawv nqaij. Tsis tas li ntawd, kev loj hlob ntawm cov hlab ntsha kuj tseem txhawb nqa lub peev xwm ntawm daim tawv nqaij thiab kev hnov ​​​​lus.

Txhawb Kev Ua Haujlwm ntawm Dermal Fibroblasts: 

GHK-Cu txhawb kev ua haujlwm ntawm dermal fibroblasts. Fibroblasts yog ib qho ntawm cov xov tooj tseem ceeb hauv daim tawv nqaij, thiab lawv muaj lub luag haujlwm rau kev sib txuas ntawm collagen, elastin, thiab lwm yam khoom siv hauv matrix extracellular ^[1] . GHK-Cu tuaj yeem txhim kho kev ua haujlwm ntawm fibroblasts thiab txhim kho lawv lub peev xwm los ua ke ntawm extracellular matrix, yog li pab tswj cov qauv thiab kev ua haujlwm ntawm daim tawv nqaij.

Kev Kho Mob: 

GHK-Cu qhia cov teebmeem tseem ceeb hauv kev kho qhov txhab. Cov kev tshawb fawb tau pom tias nws tuaj yeem ua kom cov txheej txheem kho qhov txhab, txhawb kev loj hlob ntawm cov ntaub so ntswg granulation, thiab tsim thiab tsub zuj zuj ntawm collagen. Tsis tas li ntawd, GHK-Cu tuaj yeem tswj hwm kev hloov pauv ntawm macrophages los ntawm theem M2, ua haujlwm zoo inhibit qhov kev qhia ntawm cov kab mob TNF-α thiab IL-6 hauv cov ntaub so ntswg, tso tawm cov tshuaj tiv thaiv kab mob xws li TGF-β thiab iNOS, ua kom cov lus qhia ntawm HIF-1α txoj hauv kev, txhawb kev qhia ntawm VEGF kom ua tiav cov txiaj ntsig ntawm kev kho cov ntaub so ntswg.

Anti-aging: 

GHK-Cu muaj ntau yam kev tiv thaiv kev laus. Nws tuaj yeem cuam tshuam cov kev ua ntawm cov molecules xws li NFκB, uas tau txiav txim siab ua kom cov txheej txheem kev laus (Pickart L, 2018). Tsis tas li ntawd, nws kuj muaj anxiolytic, analgesic, thiab tiv thaiv kev ua phem, kho DNA, thiab kev ua haujlwm ntawm kev ua kom huv ntawm tes los ntawm cov kab mob proteasome.

Raws li Cosmetic Ingredient: 

Vim nws cov teebmeem ntawm kev kho daim tawv nqaij thiab tiv thaiv kev laus, GHK-Cu yog dav siv hauv tshuaj pleev ib ce. Piv txwv li, liposomes raws li anionic (AL) thiab cationic (CL) hydrogenated lecithin tuaj yeem siv los ua cov txheej txheem ntawm daim tawv nqaij rau GHK-Cu ^[4] . Cov liposomes no ruaj khov, muaj qhov me me me me (li 100nm), thiab lub siab bilayer fluidity, uas tuaj yeem xa GHK-Cu rau hauv daim tawv nqaij. Raws li cov khoom xyaw kom zoo nkauj, GHK-Cu tuaj yeem tsis tsuas yog txhim kho cov tsos ntawm daim tawv nqaij, tab sis kuj txhim kho kev noj qab haus huv ntawm daim tawv nqaij.

Kev Kho Mob Field:

Kev kho mob ntsws mob ntsws: 

GHK-Cu muaj kev tiv thaiv kev mob ntsws mob ntsws (ALI). Hauv kev sim hauv vitro ntawm RAW 264.7 macrophages tshwm sim los ntawm lipopolysaccharide (LPS) thiab hauv tus qauv nas ntawm kev mob ntsws mob hauv vivo, GHK-Cu kev kho mob txo qis kev tsim cov pa oxygen reactive (ROS), nce kev ua haujlwm ntawm superoxide dismutase (SOD), thiab tib lub sijhawm txo cov khoom ntawm TNF-α thiab inhibition ntawm TNF-α, TNF-α thiab inhibition ntawm TNF6. p65 thiab p38 MAPK kev taw qhia ^[2] . Tsis tas li ntawd, GHK-Cu tseem tuaj yeem txo cov kev hloov pauv ntawm lub ntsws ntawm cov nqaij mos los ntawm LPS thiab inhibit qhov infiltration ntawm inflammatory cells rau hauv lub ntsws parenchyma.

Kev Kho Mob Pulmonary Fibrosis: 

GHK-Cu tau qhia txog kev kho mob hauv tus nas qauv ntawm pulmonary fibrosis tshwm sim los ntawm bleomycin (BLM) ^[5] . Idiopathic pulmonary fibrosis yog kab mob ntsws loj, thiab oxidative kev nyuaj siab thiab o yog nws cov txheej txheem tseem ceeb ntawm cov kab mob. GHK-Cu tuaj yeem ua lub luag haujlwm tiv thaiv los ntawm kev ntxhov siab antioxidant thiab kev tiv thaiv kab mob.

Kev Kho Mob Silicosis: 

Silicosis yog hom kab mob pneumoconiosis feem ntau, thiab tam sim no tsis muaj tshuaj tshwj xeeb rau nws txoj kev kho. Cov kev tshawb fawb tau pom tias GHK-Cu muaj kev kho mob ntawm silicosis. Nws tuaj yeem txo qhov mob ntsws thiab fibrosis hauv silicosis nas los ntawm kev tsom peroxiredoxin 6 (PRDX6), ib nrab vim yog inhibition ntawm oxidative kev nyuaj siab hauv alveolar macrophages induced los ntawm crystalline silica ^[6].

GHK-Cu muaj ntau lub luag haujlwm thiab tseem ceeb heev. Nws tuaj yeem txhawb nqa cov synthesis ntawm cov khoom xws li collagen, kho daim tawv nqaij, thiab ncua kev laus, pab tib neeg nrhiav kev noj qab haus huv thiab zoo nkauj ntawm daim tawv nqaij hauv kev zoo nkauj thiab kev tu tawv nqaij. Nyob rau theem kho mob, nws muab cov kev taw qhia tshiab rau kev kho mob ntsws xws li mob ntsws mob ntsws thiab mob ntsws ntsws, thiab xav tias yuav txhim kho kev noj qab haus huv ntawm cov neeg mob. Zuag qhia tag nrho, GHK-Cu pab txhawb rau kev txhim kho kev tshawb fawb ntawm lub neej, tshuaj, thiab kev lag luam kev zoo nkauj, thiab muaj txiaj ntsig zoo rau kev txhim kho tib neeg lub neej zoo.

Hais Txog Tus Sau

Cov ntaub ntawv hais saum toj no yog txhua yam tshawb fawb, kho thiab sau los ntawm Cocer Peptides.

Scientific Journal Author

Bian Y yog tus kws tshawb fawb koom nrog ntau lub koom haum tseem ceeb. Cov no suav nrog State Key Lab Resp Hlth & Multimorbid, -Japan Friendship Hospital, Chinese Academy of Medical Sciences - Peking Union Medical College, Natl Clin Res Ctr Resp Dis, Natl Ctr Resp Med, thiab Tongji University. Nws cov koom haum koom nrog cuam tshuam txog keeb kwm dav dav hauv kev kho mob thiab kev tshawb fawb tshawb fawb.

Nws txoj kev tshawb fawb nthuav dav ntau yam tseem ceeb. Nws muaj kev txawj ntse nyob rau hauv Kev Ua Phem Ua Phem, Oncology, General & Internal Medicine, Kev Tshawb Fawb & Kev Siv Tshuaj, thiab Biochemistry & Molecular Biology. Nws txoj haujlwm hauv cov haujlwm no yog qhov tseem ceeb rau kev nce qib kev kho mob thiab txhim kho kev noj qab haus huv. Bian Y tau teev nyob rau hauv qhov kev siv ntawm kev hais tawm [6].

▎ Cov Lus Qhia Tseem Ceeb

[1] Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the light of the New Gene Data[J]. International Journal of Molecular Sciences, 2018,19(7).DOI:10.3390/ijms19071987.

[2] Park JR, Lee H, Kim S, et al. Lub tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced mob ntsws raug mob hauv nas[J]. Oncotarget, 2016,7(36):58405-58417.DOI:10.18632/oncotarget.11168.

[3] Molt O Ripoll JP, Cointry G. Hypothesis ntawm lub tswv yim ntawm kev txiav txim ntawm acupuncture los ntawm GHK-Cu[J]. International Journal of Health Science, 2024. DOI: 10.22533/at.ed. 15942024150 26

[4] Dymek M, Olechowska K, Hąc-Wydro K, et al. Liposomes li Carriers ntawm GHK-Cu Tripeptide rau Cosmetic Application[J]. Pharmaceutics, 2023,15(10).DOI:10.3390/pharmaceutics15102485.

[5] Ma W, Li M, Ma H, et al. Kev tiv thaiv los ntawm GHK-Cu hauv bleomycin-induced pulmonary fibrosis ntawm kev tiv thaiv oxidative kev nyuaj siab thiab kev tiv thaiv kab mob [J]. Life Sciences, 2020,241:117139.DOI:10.1016/j.lfs.2019.117139.

[6] Bian Y, Deng M, Liu J, et al. Cov glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex ua rau lub ntsws o thiab fibrosis hauv silicosis los ntawm kev tsom peroxiredoxin 6 [J]. Redox Biology, 2024,75:103237.DOI:10.1016/j.redox.2024.103237.

Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.  

Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.