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▎ GHK - Cu Structure
Isi mmalite: PubChem |
Usoro: Gly-His-Lys Usoro ihe omimi: C 28H 46CuN 12O8 Arọ molekụla: 742.3g/mol Nọmba CAS: 130120-56-8 PubChem CID: 9831891 Synonyms: Bisprezatide ọla kọpa;DL1TR6W6VM |
▎ GHK - Cu nyocha
Kedu ihe ndabere nyocha nke GHK-Cu?
Ọganihu nyocha nke Peptides na-arụ ọrụ:
Kemgbe narị afọ nke 20, nyocha nke peptides bioactive na ngalaba sayensị ndụ ka na-aga n'ihu. Ndị ọkà mmụta sayensị ejirila nwayọọ nwayọọ ghọta na peptides na-ekere òkè dị mkpa na ihe ndị dị ndụ. Ha abụghị naanị akụkụ nke protein mana ha nwekwara ọrụ ndụ onwe ha na-ekere òkè n'ịchịkwa usoro ọmụmụ physiological dị iche iche nke ihe dị ndụ, dị ka uto cell, ọdịiche, na immunomodulation. Nghọta a dị omimi nke peptides na-enye usoro ihe omimi na ntụziaka nyocha maka nchọpụta na ọmụmụ nke GHK-Cu.
Nyocha nke akụrụngwa Plasma:
N'ime nyocha zuru ezu nke ihe mejupụtara plasma mmadụ, ndị ọkà mmụta sayensị na-agba mbọ nyochaa nhazi na ọrụ nke biomolecules dị iche iche na plasma. Dị ka mmiri dị mkpa na ahụ mmadụ, plasma nwere ọtụtụ protein, peptides, hormones, electrolytes, na ihe ndị ọzọ, ọ bụkwa isi ihe na-eme ka ọ nọgide na-arụ ọrụ physiological nkịtị nke ahụ mmadụ. N'afọ ndị 1970, ndị nchọpụta chọpụtara na mberede pụrụ iche tripeptide n'oge nyocha nke proteins plasma. Usoro amino acid ya bụ glycyl-histidyl-lysine, ya bụ GHK. Nchọpụta a kpalitere mmasị dị ukwuu n'etiti ndị ọkà mmụta sayensị ma kpalie ha inyochakwu ọrụ na njirimara nke tripeptide a na plasma.
Mmetụta ndu nke ion ọla kọpa:
N'otu oge ahụ, ọrụ dị mkpa nke ions ọla kọpa na bayoloji ejirila nwayọọ nwayọọ dọta uche. Ọla kọpa bụ otu n'ime ihe ndị dị mkpa na-achọpụta na ahụ mmadụ ma na-ekere òkè na ọtụtụ mmeghachi omume biochemical. Ọ bụ akụkụ ma ọ bụ onye na-arụ ọrụ nke ọtụtụ enzymes isi ma na-arụ ọrụ dị mkpa n'ịkwado metabolism nkịtị nke mkpụrụ ndụ, iku ume, na njikọ nke collagen. N'oge ọmụmụ nke ọrụ ndu nke ion ọla kọpa, ndị ọkà mmụta sayensị chọpụtara na ions ọla kọpa nwere ike jikọta na ụfọdụ peptide bekee iji mepụta ogige nwere ọrụ pụrụ iche nke ndu. Nchọpụta a na-enye ihe ngosi dị mkpa maka ọmụmụ banyere njikọ nke GHK na ọla kọpa ion na ọrụ ha nwere ike ịrụ.
Nkwalite nyocha gbasara ịka nká:
Site na mmepe nke ọha mmadụ na nsogbu na-arịwanye elu nke ịka nká nke ọha mmadụ, nchọpụta metụtara ịka nká aghọwo isiokwu dị mkpa na ngalaba sayensị ndụ. Ndị ọkà mmụta sayensị na-agbalị ịchọta ndị na-ahụ maka ihe ndị na-emepụta ihe na ihe ndị na-achịkwa ihe ndị metụtara usoro ịka nká iji kpughee usoro ịka nká na ịchọpụta ụzọ iji gbuo oge ịka nká. N'okwu a, a chọpụtala na ntinye nke GHK-Cu na ahụ mmadụ ji nwayọọ nwayọọ na-ebelata ka ọ na-eto, nke pụtara na GHK-Cu nwere ike inwe njikọ ụfọdụ na usoro ịka nká. Nchọpụta a na-eme ka ndị na-eme nchọpụta na-eme nchọpụta miri emi banyere isi mmalite, ọrụ, na ntinye nke GHK-Cu n'ọhịa nke mgbochi ịka nká, ma na-akwalite ọganihu na-aga n'ihu nke nchọpụta metụtara ya.
Kedu ihe bụ usoro nke GHK-Cu?
Na-akwalite Mmezi na Mweghachi Tissue:
Ụgbọ mmiri na-akpali akpali na uto akwara:
Nnyocha e mere egosiwo na GHK-Cu nwere ike ịkpalite uto nke arịa ọbara na irighiri akwara. Ọ nwere ike nweta mmetụta a site n'ịhazi ihe ndị na-eto eto na ụzọ mgbaàmà. Dịka ọmụmaatụ, ọ nwere ike ịkwalite nkwupụta nke vascular endothelial growth factor (VEGF), si otú ahụ na-akpali angiogenesis [1] . N'ihe gbasara uto irighiri akwara, ọ nwere ike ịkwalite ndụ, mmụba, na uto axonal nke mkpụrụ ndụ akwara site na imetụta ụmụ irighiri ihe mgbaàmà metụtara uto akwara.
Na-abawanye njikọ nke Collagen, Elastin na Glycosaminoglycans:
GHK-Cu nwere ike ịbawanye njikọ nke collagen, elastin, na glycosaminoglycans. Collagen bụ akụkụ dị mkpa nke anụ ahụ dị ka akpụkpọ ahụ na ọkpụkpụ, elastin na-enye anụ ahụ na-agbanwe agbanwe, glycosaminoglycans na-ekerekwa òkè dị mkpa n'ịkwado mmiri na ngbanwe nke anụ ahụ. Usoro a kapịrị ọnụ nwere ike ịgụnye ịhazi okwu nke mkpụrụ ndụ ihe nketa metụtara ya na ụzọ akara, dị ka ịgbalite ihe ederede akọwapụtara na fibroblasts iji kwalite okwu mkpụrụ ndụ ihe nketa metụtara njikọ njikọ collagen [1].
Na-akwado ọrụ nke Dermal Fibroblasts:
Dermal fibroblasts na-arụ ọrụ dị mkpa n'ịkwado nhazi na ọrụ nke akpụkpọ ahụ. GHK-Cu nwere ike ịkwado ọrụ nke fibroblasts dermal, gụnyere ịkwalite mgbasawanye cell, mbugharị, na njikọ nke akụkụ matrix extracellular. Enwere ike nweta nke a site n'ịhazi ụzọ mgbaàmà na mkpụrụ ndụ ihe nketa n'ime fibroblasts.
Mmetụta Nchekwa Cell:
Ọrụ Anticancer:
GHK-Cu nwere ọtụtụ ọrụ mgbochi ọrịa kansa. Ọ nwere ike ịkpata mmetụta anticancer site na igbochi mmụba nke mkpụrụ ndụ kansa, na-ebute apoptosis nke mkpụrụ ndụ kansa, na igbochi mwakpo na metastasis nke mkpụrụ ndụ kansa. Usoro a kapịrị ọnụ nwere ike ịgụnye ịhazi okirikiri cell, ime ka ụzọ akara apoptosis rụọ ọrụ, na igbochi ụzọ mgbaàmà metụtara etuto [1].
Mmetụta mgbochi mkpali:
GHK-Cu nwere mmetụta mgbochi mkpali dị ike. Ọ nwere ike igbochi mmepụta nke ihe mkpali dị ka tumor necrosis factor-α (TNF-α) na interleukin-6 (IL-6), ma n'otu oge ahụ na-abawanye ọrụ nke enzymes antioxidant dị ka superoxide dismutase (SOD). Usoro mgbochi ya nwere ike jikọta ya na mgbochi nke NF-κB p65 na p38 MAPK ụzọ mgbaàmà, si otú ahụ belata nzaghachi mkpali [2]..
Nchekwa akpa ume na mmezi nke ọrịa na-egbochi akpa ume na-adịghị ala ala (COPD):
GHK-Cu nwere mmetụta nchebe na ngbanwe na anụ ahụ ngụgụ. Ọ nwere ike igbochi nzaghachi mkpali na anụ ahụ ngụgụ, belata mmebi na fibrosis nke anụ ahụ ngụgụ. Maka fibroblasts ngụgụ nke ndị ọrịa nwere ọrịa na-adịghị ala ala obstructive pulmonary (COPD), GHK-Cu nwere ike iweghachi ọrụ ha, ikekwe site n'ịhazi ụzọ mgbaàmà metụtara ya na okwu mkpụrụ ndụ ihe nketa [1]..
Mmetụta Anxiolytic, Analgesic, na Mgbochi iwe:
GHK-Cu nwekwara mmetụta anxiolytic, analgesic na mgbochi mkpasu iwe, mana usoro ndị a ka aghọtabeghị nke ọma. Ọ nwere ike jikọta ya na nhazi nke ụzọ mgbaàmà na neurotransmitters na usoro ụjọ ahụ.
Ndozi DNA na ihicha cell:
Ndozi DNA:
GHK-Cu nwere ọrụ nke nrụzi DNA. Ọ nwere ike ịrụzi DNA mebiri emebi site na ịgbalite enzymes mmezi DNA kpọmkwem ma ọ bụ ụzọ akara. Nke a dị oke mkpa maka ịnọgide na-arụ ọrụ nkịtị nke mkpụrụ ndụ yana igbochi omume nke ọrịa dịka ịka nká na ọrịa kansa [1].
Na-arụ ọrụ nhicha cell (site na Sistemụ Proteasome):
GHK-Cu nwere ike ime ka usoro sel nke proteasome rụọ ọrụ, na-akwalite mmebi na mkpochapụ nke protein intracellular. Nke a na-enyere aka idowe nkwụsi ike nke gburugburu intracellular ma gbochie nchịkọta protein na arụ ọrụ cell [1].
Echiche dị na usoro acupuncture: Ụfọdụ ọmụmụ atụpụtawo echiche na usoro nke acupuncture nwere ike nweta site na GHK-Cu. Ọ bụ ezie na a ka ga-amụkwu usoro a kapịrị ọnụ, nke a na-enye echiche ọhụrụ maka ịghọta usoro omume nke GHK-Cu [3].
Ọkwa plasma na mkpa ụlọ ọgwụ nke GHK na ndị ọrịa nwere silicosis: A. Plasma GHK ọkwa na ndị nwere ahụike na ndị ọrịa nwere silicosis. B. Plasma GHK ọkwa na ndị ọrịa nwere silicosis dị iche iche na-adakarị ọrịa nke ọrịa. C. Ngosipụta onyonyo nke akpa ume na ọkwa GHK plasma na ọnụ ọgụgụ ndị na-achịkwa ahụike na ndị ọrịa nọ n'ọkwa ụlọ ọgwụ dị iche iche nke silicosis. D. Mmekọrịta dị n'etiti ọkwa GHK plasma na FEV1% tupu ndị ọrịa nwere silicosis. E. Mmekọrịta dị n'etiti ọkwa GHK plasma na DLCO% pre na ndị ọrịa nwere silicosis.
Isi mmalite: PubMed [6]
Kedu ihe bụ ngwa GHK-Cu?
Mmezi akpụkpọ na ịma mma:
Nchịkọta Collagen na-akpali akpali:
GHK-Cu nwere ike kpalie njikọ nke collagen, elastin, na glycosaminoglycans. Collagen bụ akụkụ dị mkpa nke akpụkpọ ahụ, nke na-eme ka akpụkpọ ahụ dịkwuo mma na nkwụsi ike [1] . Site na mmụba nke afọ, njikọ nke collagen ji nwayọọ nwayọọ na-ebelata, na-eduga na ntụrụndụ anụ ahụ na ọdịdị nke wrinkles. Site n'ịkwalite mmepụta nke collagen, GHK-Cu nwere ike imeziwanye mgbanwe na nkwụsi ike nke akpụkpọ ahụ ma belata nhazi nke wrinkles.
Na-akwalite arịa ọbara na uto akwara:
Ọ nwere mmetụta nke na-akpali uto nke arịa ọbara na irighiri akwara [1] . Ezi mgbasa ọbara dị oke mkpa maka ahụike anụ ahụ. Ọ nwere ike inye nri zuru oke na oxygen maka mkpụrụ ndụ akpụkpọ ahụ ma kwalite metabolism nke akpụkpọ ahụ. Tụkwasị na nke ahụ, uto nke irighiri akwara na-enyekwa aka na ikike anụ ahụ na imeghachi omume nke akpụkpọ ahụ.
Na-akwado ọrụ nke Dermal Fibroblasts:
GHK-Cu na-akwado ọrụ nke fibroblasts dermal. Fibroblasts bụ otu n'ime ụdị sel bụ isi na akpụkpọ ahụ, ha na-ahụ maka ịmepụta collagen, elastin, na ihe ndị ọzọ matrix extracellular [1] . GHK-Cu nwere ike ime ka ọrụ nke fibroblasts dịkwuo elu ma melite ikike ha ịmepụta matrix extracellular, si otú a na-enyere aka ịnọgide na-enwe nhazi na ọrụ nke akpụkpọ ahụ.
Ọgwụgwọ ọnya:
GHK-Cu na-egosi mmetụta dị ịrịba ama na ọgwụgwọ ọnya. Nnyocha e mere egosiwo na ọ nwere ike ime ka usoro ọgwụgwọ ọnya ahụ dịkwuo ngwa ngwa, kwalite uto nke anụ ahụ granulation, na mmepụta na nchịkọta collagen. Tụkwasị na nke ahụ, GHK-Cu nwere ike ịhazi mgbanwe nke macrophages site na M2 oge, na-egbochi nkwupụta nke ihe ndị na-egbuke egbuke TNF-α na IL-6 na anụ ahụ, hapụ ihe ndị na-adịghị mma dị ka TGF-β na iNOS, mee ka nkwupụta nke ụzọ HIF-1a dịkwuo elu, na-akwalite nkwupụta nke VEGF iji nweta mmetụta nke anụ ahụ na-eme ka ọ dịkwuo elu, na-eme ka ọkpụkpụ na-eme ka ọ dịkwuo elu.
mgbochi ịka nká:
GHK-Cu nwere otutu mmetụta mgbochi ịka nká. Ọ nwere ike igbochi ọrụ nke ụmụ irighiri ihe dị ka NFκB, nke a na-ewere na ọ na-eme ka usoro ịka nká dịkwuo elu (Pickart L, 2018). Tụkwasị na nke ahụ, ọ nwekwara ọrụ anxiolytic, analgesic, na mgbochi mkpali, ịrụzi DNA, na ọrụ nke ime ka ihicha sel rụọ ọrụ site na usoro proteasome.
Dị ka ihe ịchọ mma:
N'ihi mmetụta ya na nrụzi akpụkpọ ahụ na mgbochi ịka nká, a na-eji GHK-Cu eme ihe na ịchọ mma. Dịka ọmụmaatụ, enwere ike iji liposomes dabere na anionic (AL) na cationic (CL) lecithin hydrogenated dị ka usoro nnyefe akpụkpọ anụ maka GHK-Cu [4] . Liposomes ndị a kwụsiri ike, nwere obere urughuru nha (ihe dị ka 100nm), yana mmiri mmiri bilayer dị elu, nke nwere ike ịnapụta GHK-Cu nke ọma n'ime akpụkpọ ahụ. Dị ka ihe ịchọ mma, GHK-Cu nwere ike ọ bụghị naanị ịkwalite ọdịdị akpụkpọ ahụ kamakwa ọ na-eme ka ahụ ike nke akpụkpọ ahụ dịkwuo mma.
Ebe ahụike:
Ọgwụgwọ nke nnukwu mmerụ ahụ nku ume:
GHK-Cu nwere mmetụta nchebe na nnukwu mmerụ ahụ nku ume (ALI). Nnwale in vitro na RAW 264.7 macrophages nke lipopolysaccharide (LPS) kpatara na n'ụdị òké nke nnukwu mmerụ ahụ nku ume na vivo, ọgwụgwọ GHK-Cu belatara mmepụta nke ụdị oxygen reactive (ROS), mụbara ọrụ nke superoxide dismutase (SOD), ma n'otu oge ahụ belata mmepụta nke TILNF na mmepụta nke 6. NF-κB p65 na p38 MAPK ụzọ akara [2] . Na mgbakwunye, GHK-Cu nwekwara ike ibelata mgbanwe mgbanwe nke anụ ahụ ngụgụ nke LPS na-ebute ma gbochie ntinye nke mkpụrụ ndụ mkpali n'ime parenchyma ngụgụ.
Ọgwụgwọ Fibrosis Pulmonary:
GHK-Cu egosila mmetụta ọgwụgwọ na ụdị òké nke fibrosis pulmonary na-ebute site na bleomycin (BLM) [5] . Idiopathic pulmonary fibrosis bụ ọrịa ngụgụ siri ike, na nrụgide oxidative na mbufụt bụ isi ihe na-akpata ọrịa ya. GHK-Cu nwere ike rụọ ọrụ nchebe site na nrụgide antioxidant na ụzọ mgbochi mkpali.
Ọgwụgwọ nke Silicosis:
Silicosis bụ ụdị pneumoconiosis a na-ahụkarị, ma ọ nweghị ọgwụ ọ bụla akọwapụtara maka ọgwụgwọ ya ugbu a. Nnyocha achọpụtala na GHK-Cu nwere mmetụta ọgwụgwọ na silicosis. Ọ nwere ike ibelata mbufụt nke akpa ume na fibrosis na ụmụ oke silicosis site na ịchụso peroxiredoxin 6 (PRDX6), akụkụ n'ihi mgbochi nke nrụgide oxidative na alveolar macrophages nke silica crystalline kpatara [6].
GHK-Cu nwere ọtụtụ ọrụ yana nnukwu uru. Ọ nwere ike kpalite njikọ nke ihe ndị dị ka collagen, rụzie akpụkpọ ahụ, na igbu oge ịka nká, na-enyere ndị mmadụ aka ịchụso akpụkpọ ahụ dị mma ma mara mma n'ọhịa nke ịma mma na nlekọta anụ ahụ. N'ọkwa ahụike, ọ na-enye ntụziaka ọhụrụ maka ọgwụgwọ ọrịa ngụgụ dị ka nnukwu mmerụ ahụ nku ume na fibrosis pulmonary, a na-atụkwa anya na ọ ga-eme ka ahụike nke ndị ọrịa dịkwuo mma. N'ozuzu, GHK-Cu na-enye aka na mmepe nke sayensị ndụ, nkà mmụta ọgwụ, na ụlọ ọrụ ịma mma, ma nwee mmetụta dị mma n'ịkwalite àgwà ndụ mmadụ.
Banyere Onye dere ya
Ihe niile a kpọtụrụ aha n'elu bụ Cocer Peptides na-enyocha, dezie ma chịkọta ya.
Onye ode akwụkwọ akụkọ sayensị
Bian Y bụ onye nyocha jikọtara ya na ọtụtụ ụlọ ọrụ ama ama. Ndị a gụnyere State Key Lab Resp Hlth & Multimorbid, -Japan Friendship Hospital, Chinese Academy of Medical Sciences - Peking Union Medical College, Natl Clin Res Ctr Resp Dis, Natl Ctr Resp Med, na Mahadum Tongji. Mmekọrịta ya na ụlọ ọrụ na-egosipụta nzụlite sara mbara na nyocha ahụike na sayensị.
Nchọpụta ya gbasara ọtụtụ isiokwu dị mkpa. O nwere nka na sistemu iku ume, Oncology, General & Internal Medicine, Research & Experimental Medicine, na Biochemistry & Molecular Biology. Ọrụ ya na mpaghara ndị a dị mkpa maka ịkwalite sayensị ahụike yana ịkwalite ahụike. Edepụtara Bian Y na ntụnye aka nke ntụaka [6].
