Cocer Peptides fɛ 
a bɛ kalo 1 bɔ
BƐƐRƐ KUNNAFONIW NI FƐRƐW KUNNAFONIW BƐƐ MIN BƐ NI WEBSITE KAN NA, U BƐ KUNNAFONIW FƆLƆ DƆRƆN NI KALANSENW YE.
Fɛn minnu bɛ di nin siti in kan, olu dabɔra ɲininiw dɔrɔn kama in vitro. Sɛgɛsɛgɛli in vitro (latinkan na: *glasi kɔnɔ*, o kɔrɔ ye gilasi kɔnɔ) bɛ kɛ hadamaden farikolo kɔkan. Nin fura ninnu tɛ furaw ye, Ameriki ka dumuniko ni furako ɲɛmɔgɔso (FDA) ma sɔn u ma, wa u man kan ka kɛ ka furakɛli bana, bana walima bana si bali, k’a furakɛ, walima k’a furakɛ. A dagalen don kosɛbɛ sariya fɛ ka nin fɛn ninnu don hadamaden walima bagan farikolo la cogo o cogo.
Kuma bɛɛ lajɛlen
Bam15, n’o ye mitokondriyaw ka ɲɔgɔndan sugandilen ye, o kɛra farikoloɲɛnajɛ ɲininiw na nin san laban ninnu na, ka furakɛli suguya kura di farikoloɲɛnajɛ bana suguya caman ma. Mitokondriyaw jɔyɔrɔ ka bon selilɛriw ka fanga sɛnɛcogo la, minnu bɛ ATP dilan fosforilasi oksidan fɛ, o la, u bɛ fanga di selilɛriw ka baara suguya caman ma. Banakisɛ dɔw la, mitokondriyaw ka baara bɛ se ka tiɲɛ, o bɛ na ni farikoloɲɛnajɛ gɛlɛyaw ye ani ka kɛ sababu ye ka banaw daminɛni ni u taa ɲɛ i n’a fɔ fasa, sukarodunbana, ani sugunɛbilenni min tɛ dɔlɔ ye.
Bam15 bɛ mitokondriyaw laɲini kɛrɛnkɛrɛnnenya la, wa, a kɛcogo kɛrɛnkɛrɛnnen dɔ sababu fɛ, a bɛ jɛɲɔgɔnya gɛlɛn tiɲɛ ɛlektrɔnikiw tacogo ni ATP sɔrɔli cɛ. A bɛ porotɔnw kɔsegincogo sabati mitokondriyaw kɔnɔna na, o la, a bɛ porotɔnw jiginni tiɲɛ, o bɛ kɛ sababu ye mitokondriyaw ninakili cakɛda ka taa a fɛ ka baara kɛ nka a bɛ dɔ bɔ ATP dilanni nafa la. Nin ɲɔgɔndanbaliya nɔ in nafa ka bon farikolo ta fan fɛ, barisa a bɛ mitokondriyaw ninakili sabati, ka fanga ta caya, ka fanga tiɲɛ funteni cogo la, o la, a bɛ farikolo fanga sɛnɛcogo balansi labɛn.
Jaa 1 BAM15 ka fosforilasi oksidantali ɲɔgɔndanbaliya fɛɛrɛ.
A nɔfɛkow
Fanga sɛnɛcogo sabatili : Bam15 bɛ farikolo fanga sɛnɛcogo hakɛ caya kosɛbɛ mitokondriyaw ka ɲɔgɔndɛmɛ fɛɛrɛw fɛ. Ni farikolo cogoya bɛnnen don, selilɛriw ka fanga sɛnɛcogo bɛ to cogo la min bɛ sabati kosɛbɛ walasa ka farikolo baara kɛcogo ɲumanw sabati. Ni farikolo ye fanga caman dun min tɛ se ka dun joona, fanga tɛmɛnen bɛ mara i n’a fɔ tulu, o bɛ na ni girinya ni fasa ye. Bam15 bɛ o balansi tiɲɛ ni mitokondriyaw ninakili baara ye, o bɛ kɛ sababu ye ka farikolokisɛw kɔnɔfɛnw kɛ oksidan ye ani ka toli joona, o bɛ dɔ fara fanga musaka kan ani ka tulu dalajɛli dɔgɔya. Baganw ka kɛlɛli la, soso minnu furakɛra ni Bam15 ye, olu ye girinya damatɛmɛ kosɛbɛ hali ni tulumafɛnw bɛ dumuni na, o b’a jira ka jɛya ko Bam15 jɔyɔrɔ bɛ fanga falenfalenni sabatili la.
Insuline (insuline) kunbɛncogo ɲɛnabɔli : Insuline (insuline) tali ye banakisɛfagalanw ka fɛɛrɛ jɔnjɔn dɔ ye min bɛ sukarodunbana suguya 2 sɔrɔ. Ni inisɔndiya tɛ a la, farikolo yɔrɔw ka inisɔndiya bɛ dɔgɔya, o bɛ inisɔndi bali ka sukaro tali ni a baaracogo ɲɛ ka ɲɛ, o bɛ kɛ sababu ye ka sukaro hakɛ caya joli la. Bam15 bɛ se ka inisɔndiya sabati sira caman fɛ. A bɛ fanga sɛnɛcogo sabati, ka tulu caman dalajɛli dɔgɔya farikolo yɔrɔw la, kɛrɛnkɛrɛnnenya la kɔnɔnatumuw. Fasa kojugu bɛ funufɛnw ni adipokiniw caman bɔ, olu bɛ inisɔndiya taamasiɲɛw tali bali, o bɛ na ni inisɔndiya kunbɛnni ye. Tulumafɛnw dalajɛli dɔgɔyali kɔfɛ, Bam15 bɛ dɔ bɔ funu jaabiw la, o la, a bɛ inisɔndiya taamasiɲɛw sira baara ɲɛ. Bam15 bɛ se fana ka baara kɛ tigitigi inisɔndiya taamasiɲɛw molekiluw kan farikolo kɔnɔ, ka inisɔndiya taamasiɲɛw tali sabati ani ka dɔ fara selilɛriw ka inisɔndiya kan, o bɛ kɛ sababu ye ka farikolokisɛw dɛmɛ ka sukaro ta ka ɲɛ ani ka baara kɛ ni a ye, o la, sukaro hakɛ bɛ dɔgɔya joli la.
Mitokondriyaw ka otofaji sabatili : Mitokondriyaw ka otofaji ye fɛɛrɛ nafama ye farikolokisɛw fɛ walasa ka mitokondriyaw jogo ni u baara sabati. Ni mitokondriyaw tiɲɛna walima ni u tɛ baara kɛ, seliluw bɛ mitokondriyaw ka otofaji kɛcogo daminɛ, ka mitokondriyaw tiɲɛnenw datugu ka u bila lizozomuw la walasa u ka tiɲɛ walasa ka mitokondriyaw jamanadenw ka kɛnɛya sabati seli kɔnɔ. Banakisɛw la i n’a fɔ dumuni tuluma caman, mitokondriyaw ka teli ka tiɲɛ, o bɛ na ni mitokondriyaw baarakɛbaliya ye ani ka farikoloɲɛnajɛ gɛlɛyaw juguya ka taa a fɛ. Bam15 bɛ mitokondriyaw ka otofaji sabati kosɛbɛ, a kɛtɔ ka mitokondriyaw ka otofaji taamasiyɛn jamu Pink1 ni Parkin jiracogo kɔrɔta, o bɛ kɛ sababu ye ka seliluw bila ka mitokondriyaw tiɲɛnenw jɛya joona, ka mitokondriyaw jogoɲini ɲɛ, ka mitokondriyaw ka baara kɛcogo ɲuman segin a cogo kɔrɔ la, ani ka selilɛriw ka fanga sɛnɛcogo homɛostasi mara.
Lipid metabolism ɲɛnabɔli : Bam15 jɔyɔrɔ ka bon lipid metabolisme labɛnni na. A bɛ tulumafɛnw bɔli sabati sugunɛbilenni na, ka tulumafɛnw sɔrɔli bali, ka tulumafɛnw dalajɛli dɔgɔya sugunɛ na. Banabana cogoyaw la i n’a fɔ jolidɛsɛ hakɛ cayalenba, joli la tulumafɛnw hakɛ cayalenba bɛ na ni tulumafɛnw caya kojugu ye farikolo yɔrɔw la i n’a fɔ sugunɛ, o bɛ kɛ sababu ye ka tulumafɛnw sɔrɔ i n’a fɔ sɔgɔsɔgɔninjɛ. Bam15 bɛ anzimu minnu bɛ tulumafɛnw sɛnɛcogo la, olu ka baara sɛmɛntiya, i n’a fɔ a bɛ anzimuw jirali sabati minnu bɛ tali kɛ asidi fatɔw ka oksidan na ani ka asidi tulumafɛnw dilanni anzimuw ka baara bali, o la, a bɛ dɔ fara asidi fatɔw ka oksidan ni u tiɲɛni kan ka sɔrɔ ka dɔ bɔ u dilanni na. O bɛ tulumafɛnw hakɛ dɔgɔya sugunɛ ni joli la, ka tulumafɛnw falenfalenbaliya ɲɛ.
Aplikasiw (applications) minnu bɛ kɛ
Fasa furakɛli : Fasa kɛra diɲɛ foroba kɛnɛyako ye, wa a ni bana basigilen suguya caman daminɛni bɛ tali kɛ ɲɔgɔn na kosɛbɛ. K’a sababu kɛ a seko ye ka fanga sɛnɛcogo ɲɛ ani ka tulu dalajɛli dɔgɔya, Bam15 bɛ sebaayaba jira fasa furakɛli la. Baganw ka kɔrɔbɔli jaabiw y’a jira ko sogo fasalenw minnu furakɛra ni Bam15 ye, olu girinya dɔgɔyara kosɛbɛ, u farikolo labɛncogo ɲɛnabɔra, u tulu hakɛ dɔgɔyara, ani u farikolojidɛsɛ hakɛ cayara kosɛbɛ. O la, Bam15 bɛ se ka kɛ furakɛlifɛn ye min bɛ se ka kɛ fasa furakɛli la, a kɛtɔ ka fanga balansi labɛn, ka farikolo girinya dɔgɔyali dɛmɛ banabagatɔ fasalenw na, ani ka dɔ bɔ fasa gɛlɛyaw la.
Sukarodunbana furakɛli : Ni an y’a jateminɛ ko Bam15 jɔyɔrɔ ka bon inisɔndiya furakɛli la ani ka joli sukaro hakɛ labɛn, a ye jateminɛba sɔrɔ sukarodunbana furakɛli la. Sɛgɛsɛgɛli minnu kɛra ka kɔn kɛnɛyaso ɲɛ, olu y’a jira ko Bam15 bɛ se ka inisɔndiya sabati sukarodunbanabagatɔ baganw ka misaliw la, ka joli sukaro hakɛ dɔgɔya, ani ka sukaro muɲuni dɔgɔyali ɲɛ. O bɛ fɛɛrɛ kura di ani fura sugandilen bɛ se ka kɛ sukarodunbana furakɛli la. Ni an y’a suma ni sukarodunbana fura kɔrɔw ye, Bam15 bɛ farikoloɲɛnajɛ labɛn fɛɛrɛ kɛrɛnkɛrɛnnen dɔ fɛ, a bɛ joli sukaro hakɛ kɔlɔsi ka ɲɛ ka sɔrɔ a ma kɔlɔlɔ jugumanw lase u ma i n’a fɔ sukarodunbana, o la, a bɛ furakɛli kɛcogo ɲumanw di sukarodunbanabagatɔw ma.
Sugunɛbilenni min tɛ dɔlɔ ye, o furakɛli : Sugunɛbilenni min tɛ dɔlɔ ye, o ye sugunɛbana ye min ka teli ka sɔrɔ farikoloɲɛnajɛ la, a bɛ sɔrɔ tulumafɛnw caya kojugu sugunɛ na. Bam15 bɛ se ka sugunɛbilenni dɔgɔya kosɛbɛ ani ka sugunɛ baara ɲɛ ni a bɛ tulumafɛnw sɛnɛcogo ɲɛnabɔ ani ka mitokondriyaw ka otofaji sabati. Baganw ka kɛlɛli la, sugunɛbilenni misali bagan minnu tɛ dɔlɔ ye, minnu furakɛra ni Bam15 ye, olu ye sugunɛbilenni hakɛ dɔgɔya kosɛbɛ ani ka sugunɛ baara taamasiɲɛw ɲɛnabɔ.
Farankan
Bam15 bɛ mitokondriyaw ka farikoloɲɛnajɛ laɲini, a jɔyɔrɔ bɛ taabolo kolomaw la i n’a fɔ fanga balanbaliya, inisɔndiya, tulumafɛnw, ani mitokondriyaw jogoɲini, o la, a bɛ furakɛli fɛɛrɛ kuraw di farikoloɲɛnajɛ banaw ma i n’a fɔ fasa, sukarodunbana, ani sugunɛbilenni, ani u ni ɲɔgɔn cɛ gɛlɛyaw.
Sosow (Sɔrɔyɔrɔw).
[1] Xiong G, Zhang K, Ma Y, ani a ɲɔgɔnnaw. BAM15 i n’a fɔ mitokondriyali uncoupler: furakɛli fɛɛrɛ layidu talen bana suguya caman kama[J]. Dancɛw ka ɲɛsin Endocrinologie ma, 2023,14:1252141.DOI:10.3389/fendo.2023.1252141.
[1] Pari V, Alexopoulos S, H. U. Y, ani mɔgɔ wɛrɛw. Mitochondrial Uncoupler BAM15 bɛ PCOS metaboliki jogo minnu bɛ tali kɛ ɲɔgɔn na, olu ɲɛnabɔ PCOS sosɛti modɛli la min bɛ wele ko Hyperandrogenic[J]. Bange ni bange, 2022,04:208.DOI:10.1142/S266 13182227411 94.
Fɛn min bɛ sɔrɔ ɲininiw dɔrɔn kama:
