Na Cocer Peptides 
ukwezi gushize
INGINGO ZOSE N'AMAKURU Y’IBICURUZWA BITANZWE KURI URU RUBUGA BISANZWE KUBONA AMAKURU N'INTEGO Z'UBUREZI.
Ibicuruzwa byatanzwe kururu rubuga bigenewe gusa mubushakashatsi bwa vitro. Mu bushakashatsi bwa vitro (Ikilatini: * mu kirahure *, bisobanura mu bikoresho by'ibirahure) bikorwa hanze y'umubiri w'umuntu. Ibicuruzwa ntabwo ari imiti, ntabwo byemejwe n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), kandi ntigomba gukoreshwa mu gukumira, kuvura, cyangwa gukiza indwara iyo ari yo yose y’ubuvuzi, indwara, cyangwa indwara. Birabujijwe rwose n'amategeko kwinjiza ibyo bicuruzwa mumubiri wabantu cyangwa inyamaswa muburyo ubwo aribwo bwose.
Incamake
Bam15, nkumuntu utoranya mitochondrial unoupler, yakoreshejwe mubushakashatsi bujyanye na metabolike mumyaka yashize, atanga uburyo bushya bwo kuvura indwara zitandukanye. Mitochondriya igira uruhare runini mu guhinduranya ingufu za selile, ishinzwe kubyara ATP ikoresheje fosifori ya okiside, bityo igatanga ingufu mu bikorwa bitandukanye bya selile. Mu bihe bimwe na bimwe by’indwara, imikorere ya mitochondial irashobora kwangirika, biganisha ku ihungabana ry’imikorere kandi bifitanye isano rya bugufi no gutangira no gutera indwara nk’umubyibuho ukabije, diyabete, n’indwara y’umwijima idafite inzoga.
Bam15 yibasira cyane mitochondriya kandi, binyuze muburyo bwihariye bwibikorwa, ihagarika guhuza gukomeye hagati yubwikorezi bwa electron hamwe na synthesis ya ATP. Itezimbere gusubira inyuma kwa proton hirya no hino imbere ya mitochondrial imbere, bityo ikwirakwiza proton gradient, bigatuma urunigi rwubuhumekero rwa mitochondrial rukomeza gukora ariko bikagabanya imikorere ya synthesis ya ATP. Izi ngaruka zidahwitse zifite akamaro gakomeye ka physiologique, kuko itera guhumeka mitochondial, kongera ingufu, kandi ikwirakwiza ingufu muburyo bwubushyuhe, bityo bikagenga imbaraga zingirakamaro zumubiri.
Igishushanyo 1 Uburyo bwa BAM15 buterwa no gukuramo fosifori ya okiside.
Ingaruka
Guteza imbere imbaraga za metabolisme: Bam15 yongerera cyane imbaraga imbaraga za metabolisme yumubiri binyuze muburyo bwa mitochondrial unoupling. Mubihe bisanzwe byimiterere yumubiri, ingufu za selile metabolisme ikomeza kumera neza kugirango ikomeze imikorere isanzwe ya physiologiya. Iyo umubiri ufashe imbaraga zikabije zidashobora gukoreshwa vuba, ingufu zisagutse zibikwa nkibinure, biganisha ku kongera ibiro n'umubyibuho ukabije. Bam15 ihungabanya ubwo buringanire ikora ihumeka rya mitochondial, ituma insimburangingo ziri mu ngirabuzimafatizo ziba okiside kandi zikangirika vuba, bityo kongera ingufu zikoreshwa no kugabanya ibinure. Mu bushakashatsi bw’inyamaswa, imbeba zavuwe na Bam15 zagaragaje cyane kongera ibiro ndetse no mu ndyo yuzuye amavuta, byerekana neza uruhare rwa Bam15 mu guteza imbere metabolism.
Kunoza kurwanya insuline: Kurwanya insuline ni bumwe mu buryo bwingenzi bwa patrophysiologique bushingiye ku iterambere rya diyabete yo mu bwoko bwa 2. Mugihe kirwanya insuline, ibyiyumvo byumubiri byumubiri kuri insuline bigabanuka, bikarinda insuline gutera neza gufata glucose no kuyikoresha, bityo bigatuma glucose yiyongera. Bam15 irashobora kunoza insuline ikoresheje inzira nyinshi. Itera imbaraga za metabolism, igabanya ibinure byinshi mumyanya, cyane cyane ibinure. Ibinure byinshi byamavuta arekura ibintu byinshi bitera na adipokine, bibangamira kwanduza bisanzwe inzira ya insuline yerekana inzira, biganisha ku kurwanya insuline. Nyuma yo kugabanya ibinure, Bam15 igabanya ibisubizo byokongoka, bityo igatezimbere imikorere yinzira ya insuline. Bam15 irashobora kandi gukora muburyo butaziguye kuri insuline yo mu bwoko bwa insuline yerekana ibimenyetso bya molekile, ikongerera ibimenyetso bya insuline no kongera ibyiyumvo bya selile kuri insuline, bigatuma selile zifata neza kandi zigakoresha glucose, bityo bikagabanya urugero rwa glucose.
Gutezimbere autophagy ya mitochondrial: Mitochondrial autophagy nuburyo bwingenzi bwingirabuzimafatizo kugirango ibungabunge ubuziranenge bwimikorere. Iyo mitochondriya yangiritse cyangwa idakora neza, selile zitangiza inzira ya mitochondrial autophagy, ikubiyemo mitochondriya yangiritse ikayijyana muri lysosomes kugirango yangirike kugirango ubuzima bwabaturage ba mitochondial bube mu kagari. Mu bihe by’indwara nko kurya ibinure byinshi, mitochondriya ikunze kwangirika, bigatuma imikorere mibi ya mito-iyambere ndetse ikarushaho gukaza umurego. Bam15 iteza imbere cyane autophagy ya mitochondrial muguhuza imvugo ya mitochondrial autophagy marker genes Pink1 na Parkin, bigatuma ingirabuzimafatizo zihita zangiza mitochondriya yangiritse, kunoza igenzura ryimiterere ya mitochondial, kugarura imikorere isanzwe ya mito-iyambere, no gukomeza ingufu za selile metabolike homeostasis.
Kugena metabolisme ya lipide: Bam15 igira uruhare runini mugutunganya metabolisme ya lipide. Itera lipolysis muri hepatocytes, ikabuza synthesis ya lipide, kandi igabanya kwirundanya kwa lipide mu mwijima. Mubibazo byindwara nka hyperlipidemiya, kuzamuka kwa lipide mu maraso biganisha ku kwirundanya kwa lipide cyane mu ngingo nkumwijima, bigatera indwara ziterwa na lipide nka steatose. Bam15 ihindura ibikorwa byimisemburo igira uruhare muri metabolisme ya lipide, nko guteza imbere imvugo yimisemburo ijyanye na okiside ya aside irike no guhagarika ibikorwa byimisemburo ya aside irike, bityo bikongera okiside ya aside irike no kubora mugihe bigabanya synthesis. Ibi bigabanya urugero rwa lipide mu mwijima no mu maraso, bigatera indwara ya lipide metabolism.
Porogaramu
Kuvura umubyibuho ukabije: Umubyibuho ukabije wabaye ikibazo cy’ubuzima rusange ku isi kandi ufitanye isano rya bugufi no gutangira indwara zitandukanye zidakira. Bitewe nubushobozi bwayo bwo guteza imbere metabolism yingufu no kugabanya ibinure, Bam15 yerekana imbaraga zikomeye mukuvura umubyibuho ukabije. Ibisubizo byubushakashatsi bwibikoko byerekana ko imbeba zifite umubyibuho ukabije zavuwe na Bam15 zagize ibiro byinshi, gutakaza umubiri neza, kugabanya ibinure, no kwiyongera kwimitsi. Rero, Bam15 irashobora kuba uburyo bwo kuvura umubyibuho ukabije muguhuza ingufu zingana, gufasha kugabanya ibiro kubarwayi bafite umubyibuho ukabije, no kugabanya ibyago byatewe numubyibuho ukabije.
Umuti wa Diyabete: Urebye uruhare Bam15 yagize mu kunoza insuline no kugabanya urugero rwa glucose mu maraso, rwitabiriwe cyane mu kuvura diyabete. Ubushakashatsi bwibanze bwerekanye ko Bam15 ishobora kongera insuline mu buryo bw’inyamaswa za diyabete, kugabanya glucose y’amaraso, no kunoza kwihanganira glucose. Ibi bitanga uburyo bushya hamwe nibishobora kuvura imiti yo kuvura diyabete. Ugereranije n'imiti gakondo ya diyabete, Bam15 igenga metabolism ikoresheje uburyo bwihariye, igenzura neza urugero rwa glucose mu maraso idateye ingaruka zikomeye nka hypoglycemia, bityo igatanga ibisubizo byiza byo kuvura abarwayi ba diyabete.
Kuvura indwara zumwijima zidafite inzoga: Indwara yumwijima itari inzoga ni indwara yumwijima ikunze kurangwa no kwirundanya kwa lipide nyinshi mu mwijima. Bam15 irashobora kugabanya neza indwara ya hepatike no kunoza imikorere yumwijima muguhindura metabolisme ya lipide no guteza imbere autophagy mitochondrial. Mu bushakashatsi bw’inyamaswa, inyamaswa z’umwijima zidafite inzoga zivuwe na Bam15 zerekanye igabanuka rikabije ry’umwijima wa lipide hamwe n’ibimenyetso byerekana imikorere yumwijima.
Incamake
Bam15 yibasira metabolisme ya mitochondrial, igira uruhare mubikorwa byingenzi nko kutaringaniza ingufu, kurwanya insuline, indwara ya lipide, no kugenzura ubuziranenge bwa mitochondial, bityo bigatanga ingamba nshya zo kuvura indwara ziterwa na metabolike nk'umubyibuho ukabije, diyabete, n'indwara z'umwijima zibyibushye, hamwe n'ingaruka ziterwa na zo.
Inkomoko
[1] Xiong G, Zhang K, Ma Y, n'abandi. BAM15 nka mitochondrial unoupler: imiti itanga imiti itanga indwara zitandukanye [J]. Imipaka muri Endocrinology, 2023,14: 1252141.DOI: 10.3389 / fendo.2023.1252141.
[1] Paris V, Alexopoulos S, HU Y, n'abandi. Mitochondrial Uncoupler BAM15 Ameliorates Associated Metabolic PCOS Ibiranga muburyo bwimbeba ya Hyperandrogenic PCOS [J]. Uburumbuke & Imyororokere, 2022.04: 208.DOI: 10.1142 / S266 13182227411 94.
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