Los ntawm Cocer Peptides 
1 month ago
Tag nrho cov kab lus thiab cov ntaub ntawv ntawm cov khoom lag luam muab rau ntawm lub vev xaib no tsuas yog rau cov ntaub ntawv tshaj tawm kev tshaj tawm thiab cov hom phiaj kev kawm.
Cov khoom muab rau hauv lub vev xaib no yog npaj tshwj xeeb rau kev tshawb fawb hauv vitro. Kev tshawb fawb hauv vitro (Latin: * hauv iav *, lub ntsiab lus hauv iav) yog ua los ntawm tib neeg lub cev. Cov khoom no tsis yog tshuaj, tsis tau txais kev pom zoo los ntawm US Food and Drug Administration (FDA), thiab yuav tsum tsis txhob siv los tiv thaiv, kho, lossis kho txhua yam mob, kab mob, lossis mob. Nws raug txwv nruj raws li txoj cai los qhia cov khoom no rau hauv tib neeg lossis tsiaj lub cev hauv txhua daim ntawv.
Txheej txheem cej luam
Bam15, raws li kev xaiv mitochondrial uncoupler, tau siv rau hauv kev tshawb fawb txog metabolic nyob rau xyoo tas los no, muab kev kho tshiab rau ntau yam kab mob metabolic. Mitochondria ua lub luag haujlwm tseem ceeb hauv cellular zog metabolism, lub luag haujlwm tsim ATP los ntawm oxidative phosphorylation, yog li muab lub zog rau ntau yam ntawm tes. Hauv qee lub xeev pathological, kev ua haujlwm mitochondrial tuaj yeem ua rau tsis zoo, ua rau muaj kev cuam tshuam metabolic thiab cuam tshuam nrog kev pib thiab kev loj hlob ntawm cov kab mob xws li rog rog, ntshav qab zib, thiab kab mob tsis muaj dej cawv fatty siab.
Bam15 tshwj xeeb yog tsom rau mitochondria thiab, los ntawm kev ua haujlwm tshwj xeeb, cuam tshuam qhov sib txuas nruj ntawm kev thauj khoom hluav taws xob thiab ATP synthesis. Nws txhawb txoj kev rov qab ntawm cov protons thoob plaws hauv lub mitochondrial membrane, yog li dissipating proton gradient, cia cov mitochondrial respiratory saw txuas mus ua hauj lwm tab sis txo cov efficiency ntawm ATP synthesis. Qhov no uncoupling nyhuv muaj ib qho tseem ceeb physiological tseem ceeb, raws li nws txhawb mitochondrial respiration, tsub kom lub zog noj, thiab dissipates lub zog nyob rau hauv daim ntawv ntawm tshav kub, li no regulating lub zog ntawm lub cev metabolism.
Daim duab 1 Mechanism ntawm BAM15-induced uncoupling ntawm oxidative phosphorylation.
Cov teebmeem
Txhawb zog metabolism: Bam15 ho txhim kho lub cev lub zog metabolism theem los ntawm mitochondrial uncoupling mechanisms. Nyob rau hauv ib txwm physiological tej yam kev mob, cellular zog metabolism tseem nyob rau hauv ib tug kuj ruaj khov lub xeev los txhawb nqa ib txwm physiological functions. Thaum lub cev noj ntau lub zog uas tsis tuaj yeem noj tam sim ntawd, lub zog ntxiv yog khaws cia ua rog, ua rau hnyav nce thiab rog. Bam15 cuam tshuam qhov nyiaj tshuav no los ntawm kev ua kom mitochondrial ua pa, ua rau cov substrates hauv cov hlwb kom oxidized thiab decomposed sai dua, yog li ua kom muaj zog siv nyiaj thiab txo cov rog. Hauv kev sim tsiaj, nas kho nrog Bam15 tau nthuav tawm qhov hnyav nce txawm tias nyob rau hauv kev noj zaub mov muaj roj, ua kom pom tseeb Bam15 lub luag haujlwm hauv kev txhawb zog metabolism.
Txhim kho insulin tsis kam: insulin tsis kam yog ib qho ntawm cov txheej txheem tseem ceeb ntawm cov txheej txheem pathophysiological hauv qab kev loj hlob ntawm hom 2 mob ntshav qab zib. Hauv lub xeev cov tshuaj insulin-tiv taus, qhov rhiab heev ntawm cov ntaub so ntswg hauv lub cev rau insulin txo qis, tiv thaiv insulin los ntawm kev txhawb nqa cov piam thaj thiab siv, yog li ua rau cov ntshav qabzib nce siab. Bam15 tuaj yeem txhim kho cov tshuaj insulin los ntawm ntau txoj hauv kev. Nws txhawb nqa lub zog metabolism, txo cov rog ntau dhau hauv cov ntaub so ntswg, tshwj xeeb tshaj yog cov roj visceral. Cov ntaub so ntswg ntau dhau secretes ntau ntawm cov kab mob inflammatory thiab adipokines, uas cuam tshuam nrog kev sib kis ntawm cov tshuaj insulin ib txwm, ua rau cov tshuaj insulin tsis kam. Tom qab txo cov rog rog, Bam15 txo qis cov lus teb inflammatory, yog li txhim kho txoj haujlwm ntawm insulin signaling txoj kev. Bam15 tseem tuaj yeem ua ncaj qha rau ntawm cov tshuaj insulin hauv lub cev ntawm lub cev, txhim kho cov teeb liab xa mus rau insulin thiab ua kom cov cellular rhiab heev rau insulin, ua rau cov hlwb kom zoo dua thiab siv cov piam thaj, yog li txo cov ntshav qabzib.
Txhawb nqa mitochondrial autophagy: Mitochondrial autophagy yog ib qho tseem ceeb mechanism rau cov hlwb kom tswj mitochondrial zoo thiab muaj nuj nqi. Thaum mitochondria raug puas los yog ua tsis taus, cov hlwb pib cov txheej txheem mitochondrial autophagy, encapsulating puas mitochondria thiab thauj lawv mus rau lysosomes rau degradation los tswj kev noj qab haus huv ntawm mitochondrial cov pejxeem nyob rau hauv lub cell. Nyob rau hauv cov kab mob pathological xws li kev noj zaub mov muaj roj, mitochondria yog qhov ua rau muaj kev puas tsuaj, ua rau mitochondrial tsis ua haujlwm thiab ua rau muaj kev cuam tshuam ntau ntxiv hauv metabolic. Bam15 txhawb nqa mitochondrial autophagy los ntawm upregulating cov kev qhia ntawm mitochondrial autophagy marker noob Pink1 thiab Parkin, ua kom cov hlwb kom sai tshem tawm cov puas mitochondria, txhim kho mitochondrial zoo tswj, rov zoo li qub mitochondrial muaj nuj nqi, thiab tswj cellular zog metabolic homeostasis.
Kev tswj cov lipid metabolism: Bam15 ua lub luag haujlwm tseem ceeb hauv kev tswj cov lipid metabolism. Nws txhawb nqa lipolysis hauv hepatocytes, inhibits lipid synthesis, thiab txo cov lipids hauv daim siab. Hauv cov xeev pathological xws li hyperlipidemia, nce qib lipid hauv cov ntshav ua rau ntau dhau lipid tsub zuj zuj hauv cov ntaub so ntswg zoo li lub siab, ua rau muaj cov kab mob lipid xws li steatosis. Bam15 modulates cov haujlwm ntawm cov enzymes koom nrog hauv lipid metabolism, xws li txhawb kev qhia cov enzymes ntsig txog fatty acid oxidation thiab inhibiting kev ua haujlwm ntawm fatty acid synthesis enzymes, yog li ua rau fatty acid oxidation thiab decomposition thaum txo synthesis. Qhov no txo qis qib lipid hauv daim siab thiab ntshav, txhim kho cov metabolism hauv lipid.
Daim ntawv thov
Kev kho mob rog rog: Kev rog rog dhau los ua qhov teeb meem kev noj qab haus huv thoob ntiaj teb thiab cuam tshuam nrog qhov pib ntawm ntau yam kab mob. Vim nws lub peev xwm los txhawb lub zog metabolism thiab txo cov rog, Bam15 qhia tau hais tias muaj peev xwm zoo hauv kev kho mob rog. Cov txiaj ntsig ntawm kev sim tsiaj pom tau hais tias cov nas rog rog tau kho nrog Bam15 tau ntsib kev poob ceeb thawj, txhim kho lub cev muaj pes tsawg leeg, txo cov rog rog, thiab nce cov nqaij ntshiv. Yog li, Bam15 tuaj yeem ua tus neeg sawv cev kho mob rau kev rog rog los ntawm kev tswj hwm lub zog sib npaug, pab kev poob phaus hauv cov neeg mob rog, thiab txo qhov kev pheej hmoo ntawm kev rog rog.
Kev Kho Mob Ntshav Qab Zib: Muab Bam15 lub luag haujlwm tseem ceeb hauv kev txhim kho cov tshuaj insulin thiab tswj cov ntshav qabzib, nws tau txais txiaj ntsig zoo hauv kev kho mob ntshav qab zib. Cov kev tshawb fawb ua ntej tau pom tias Bam15 tuaj yeem txhim kho cov tshuaj insulin hauv cov tsiaj mob ntshav qab zib, txo cov ntshav qabzib, thiab txhim kho cov piam thaj tsis txaus siab. Qhov no muab txoj hauv kev tshiab thiab muaj peev xwm xaiv tshuaj rau kev kho mob ntshav qab zib. Piv nrog rau cov tshuaj noj ntshav qab zib ib txwm muaj, Bam15 tswj cov metabolism hauv cov txheej txheem tshwj xeeb, tswj cov ntshav qabzib kom zoo yam tsis ua rau muaj kev mob tshwm sim hnyav xws li hypoglycemia, yog li muab cov txiaj ntsig kho mob zoo dua rau cov neeg mob ntshav qab zib.
Kev kho mob ntawm cov kab mob uas tsis yog-alcoholic fatty siab: Cov kab mob uas tsis yog-alcoholic fatty siab yog ib hom kab mob metabolic siab uas tshwm sim los ntawm ntau cov lipid tsub zuj zuj hauv daim siab. Bam15 tuaj yeem txo qis hepatic steatosis thiab txhim kho daim siab ua haujlwm los ntawm kev tswj cov lipid metabolism thiab txhawb nqa mitochondrial autophagy. Hauv kev sim tsiaj, cov kab mob uas tsis yog-alcoholic fatty siab tus qauv tsiaj kho nrog Bam15 tau pom qhov txo qis hauv daim siab lipid cov ntsiab lus thiab txhim kho daim siab ua haujlwm.
Cov ntsiab lus
Bam15 lub hom phiaj mitochondrial metabolism, ua lub luag haujlwm tseem ceeb hauv cov txheej txheem tseem ceeb xws li lub zog tsis txaus, insulin tsis kam, lipid tsis txaus, thiab kev tswj hwm mitochondrial, yog li muab cov tswv yim kho tshiab rau cov kab mob metabolic xws li rog rog, ntshav qab zib, thiab rog rog, nrog rau lawv cov teeb meem cuam tshuam.
Qhov chaw
[1] Xiong G, Zhang K, Ma Y, et al. BAM15 raws li ib tug mitochondrial uncoupler: ib tug cog lus kho tus neeg sawv cev rau ntau yam kab mob [J]. Frontiers hauv Endocrinology, 2023, 14: 1252141.DOI: 10.3389/fendo.2023.1252141.
[1] Paris V, Alexopoulos S, HU Y, et al. Mitochondrial Uncoupler BAM15 Ameliorates Associated Metabolic PCOS Cov yam ntxwv hauv Hyperandrogenic PCOS Mouse Model [J]. Fertility & Reproduction, 2022,04:208.DOI:10.1142/S266 13182227411 94.
Cov khoom muaj rau kev tshawb fawb siv nkaus xwb:
