Cocer Peptides ye 
ŋlɔe ɣleti 1 enye sia
NYATAKAKAWO KPLE NUSIWO WOTSƆ ƑE NYATAKAKA SIWO KAtã WOÐO LE NYATAKAKADZRAÐOƑE SIA ME LA KPLE NYATAKAKAWO kaka KPLEE NUFIAFIA ƑE TAÐOÐOWO KO.
Wotrɔ asi le atike siwo wona le nyatakakadzraɖoƒe sia ŋu na numekuku le vitro ɖeɖeko. Wowɔa numekuku le vitro (Latingbe me: *le ahuhɔ̃e me*, si gɔmee nye le ahuhɔ̃e me) le amegbetɔ ƒe ŋutilã godo. Atike siawo menye atikewo o, United States ƒe Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) meda asi ɖe wo dzi o, eye mele be woazã wo atsɔ axe mɔ ɖe atikewɔwɔ, dɔléle, alo dɔléle aɖeke nu, adae, alo adae o. Se de se vevie be woatsɔ atike siawo ade amegbetɔ alo lãwo ƒe ŋutilã me le mɔ ɖesiaɖe nu.
Le atsyɔ̃ɖoɖo kple ŋutigbalẽdzikpɔkpɔ gome la, atike siwo wozãna tsɔ tsia ʋuʋudedi nu nye nyati si me wotsɔa ɖe le vevie. Snap-8 kple botulinum aɖi nye nu eve siwo bɔ siwo tsia ʋuʋudedi nu, eye wo dometɔ ɖesiaɖe ƒe dɔwɔwɔ ƒe mɔnu tɔxɛwo kple eƒe dɔwɔwɔ ƒe nɔnɔmewo le etɔxɛ.
1. Dɔwɔwɔ ƒe Mɔnu
Snap-8 ƒe dɔwɔwɔ ƒe mɔnu: Snap-8 nye peptide tɔxɛ aɖe si ƒe dɔwɔwɔ ƒe mɔnu do ƒome kple SNARE complex ƒe wɔwɔ. Esi Snap-8 do kplamatse SNARE ƒe wɔwɔme la, eɖea ahɔhɔ̃mekawo ƒe dodo dzi kpɔtɔna, si wɔnɛ be wòxea mɔ na lãmekawo ƒe tete eye wòkpɔa ŋusẽ si ɖea ʋuʋudedi dzi kpɔtɔna. Le lãmenugbagbeviwo ƒe ɖoɖo nu la, ne wotsɔ ahɔhɔ̃mekawo ƒe dzesiwo yi lãmekawo me la, woʋãa ŋutilã ƒe dɔwɔwɔ ɖe wo nɔewo yome, eye SNARE ƒe ƒuƒoƒo si sɔ la nyea afɔɖeɖe vevi aɖe le ahɔhɔ̃mekawo ƒe dodo me. Snap-8 ƒe anyinɔnɔ xea mɔ na SNARE ƒe ƒuƒoƒoa ƒe wɔwɔme si sɔ, si wɔnɛ be ahɔhɔ̃mekawo mete ŋu ɖea asi le wo ŋu yia lãmenugbagbeviwo ƒe ʋuʋudedi me o. Esia wɔnɛ be lãmekawo mexɔa dzesi siwo fia be lãmekawo ƒe tete ɖe wo nɔewo ŋu o, si wɔnɛ be lãmekawo ƒe tete zi gbɔ zi geɖe kple woƒe sesẽ dzi ɖena kpɔtɔna. Ezazã ɣeyiɣi didi ate ŋu aɖe ɖa ƒe goglome dzi akpɔtɔ vivivi.
Alesi botulinum aɖi wɔa dɔe: Botulinum aɖi si Clostridium botulinum wɔna nye ahɔhɔ̃mekawo ƒe aɖi. Ewɔa dɔ le ahɔhɔ̃mekawo ƒe ƒoƒoƒe koŋ to protein siwo do ƒome kple ahɔhɔ̃mekawo ƒe dɔwɔwɔ, abe SNAP-25 ene, mama koŋ me, si wɔnɛ be wòxea mɔ na ahɔhɔ̃mekawo ƒe dɔwɔwɔ ƒe acetylcholine ƒe dodo. Acetylcholine ye nye ahɔhɔ̃meka vevi si tsɔa lãmekawo ƒe dzesiwo yia lãmekawo me eye wòʋãa lãmekawo ƒe tete. Ne woxe mɔ ɖe acetylcholine ƒe dodo nu la, lãmekawo mete ŋu xɔa dzesi siwo fia be lãmekawo ƒe tete ɖe wo nɔewo ŋu o, si wɔnɛ be lãmekawo ɖea dzi ɖi. Le mo ƒe dzedzeme ƒe lãmekawo me la, aɖi si nye botulinum gbɔdzɔa lãmekawo ƒe tete le mo ƒe dzedzeme me, si wɔnɛ be ʋuʋudedi siwo dona tso lãmekawo ƒe tete enuenu, abe akpɔkplɔ ƒe afɔwo kple glabellar lines ene me dzi ɖena kpɔtɔna.
2. Dɔwɔwɔwo
Dɔwɔwɔ le ŋutigbalẽtikewo me - Snap-8: Wozãa Snap-8 zi geɖe le ŋutigbalẽlétike vovovowo me, abe kreme kple serum ene. Viɖe si le eŋue nye be enye atike si me mekɔ tututu o si tsia ʋuʋudedi nu si sɔ na ŋutigbalẽ ƒomevi akpa gãtɔ. To ŋutigbalẽlétike siwo me Snap-8 le zazã ɣesiaɣi to gbesiagbe zazã me la, woate ŋu ana ŋutigbalẽ ƒe ʋuʋudediwo nanyo ɖe edzi vivivi. Esi wònye be woate ŋu akpɔe le ŋutigbalẽtikewo me ta la, esɔ be woazãe eye mehiã be atikewɔla bibiwo nadoe o, si wɔnɛ be mɔxenu si xea mɔ na zazã dzi ɖena kpɔtɔna.
Dɔwɔwɔ le Atsyɔ̃ɖoɖo kple Ŋutilãmenuwo Me - Botulinum Aɖi: Wozãa botulinum aɖi le atsyɔ̃ɖoɖo ƒe akpa vevitɔ to atike dodo me. Mɔnu sia tsɔa nusi wɔa dɔa yia lãmeka aɖewo koŋ gbɔ tẽ, eye wòɖoa taɖodzinu na flitete ƒe nyawo. Zi geɖe la, wozãnɛ tsɔ daa flitete siwo goglo wu siwo meʋãna o, abe ŋgonu ƒe fliwo kple akpɔkplɔ ƒe afɔwo ene. Gake Botox-tikewo bia be atikewɔla bibiwo nado wo, eye wobia tso wo si vevie le agbɔsɔsɔme si woazã, afisi woadoe le, kple alesi woawɔe ŋu. Ne wole mo ƒe flitete dzi ɖeɖe kpɔtɔ wɔm la, ele be ɖɔktawo nabu akɔnta ahakpɔ Botox ƒe agbɔsɔsɔme dzi pɛpɛpɛ le dɔnɔa ƒe flitete ƒe nɔnɔme kple mo ƒe lãmekawo ƒe mama nu be woakpɔ ŋusẽ nyuitɔ kekeake si tsi tre ɖe ʋuʋudedi ŋu esime woaƒo asa na ŋusẽkpɔɖeamedzi gbegblẽwo abe mo ƒe lãmekawo ƒe sesẽ ene.
Dɔwɔwɔ le atikewɔwɔ me - Snap-8: Fifia la, numekuku ʋɛ aɖewo koe wowɔ tso Snap-8 zazã le atikewɔwɔ me ŋu. Gake le alesi wòwɔa dɔe nu la, le nukpɔsusu nu la, asixɔxɔ ate ŋu anɔ eŋu be wòanye atike kpeɖeŋutɔ na nɔnɔme fafɛ aɖewo alo dzesi siwo do ƒome kple lãmekawo ƒe tete fũ akpa. Le mo ƒe vevesese si nu mesẽ o alo lãmekawo ƒe ʋuʋu si lãmekawo ƒe tete hena vɛ gome la, atike siwo wozãna ɖe ŋutilã ŋu siwo me Snap-8 le ate ŋu ana gbɔdzɔe aɖe ame.
Atikewɔwɔ me Dɔwɔwɔ - Botulinum Aɖi: Botulinum aɖi ƒe dɔwɔwɔ bɔ ɖe atikewɔwɔ me. Tsɔ kpe ɖe atsyɔ̃ɖoɖo ƒe ʋuʋudedi dzi ɖeɖe kpɔtɔ ŋu la, wozãnɛ tsɔ daa lãmekawo ƒe dɔléle vovovo siwo do ƒome kple wo nɔewo. Le ahɔhɔ̃ŋutinunya me la, wozãnɛ tsɔ daa dystonia, siwo dometɔ aɖewoe nye cranial dystonia, cervical dystonia, kple abɔ kple afɔ ƒe dystonia. Ne wodo botulinum aɖi ɖe lãmeka siwo ŋu dystonia gblẽ nu le me la, enaa lãmekawo ƒe lãmetutudɔ si le teƒe ɖeka, si dzi wokpɔna, si ɖea lãmekawo ƒe tete si gbɔ eme dzi kpɔtɔna eye wònaa dzesiawo nyona ɖe edzi. Le toŋutinunya me la, woate ŋu azã aɖi si nye botulinum atsɔ ada nɔnɔmewo abe Lucia Frey ƒe dɔléle, aɖuɖɔtoe ƒe ʋuʋu, aɖuɖɔtoe si gbɔ eme ƒe dɔléle, aɖuɖɔtoe ƒe ʋuʋu, gbeɖiɖi ƒe ʋuʋu, gbeɖiɖi ƒe ʋuʋu, synkinesis le mo ƒe lãmekawo ƒe ʋuʋu megbe, nuɖuɖu ƒe dɔmawɔmawɔ nyuie, kple aɖuɖɔtoedɔ si mexɔa aɖuɖɔ o. Tsɔ kpe ɖe eŋu la, le ŋkudɔdada me la, woate ŋu azãe atsɔ ada ŋku ƒe lãmekawo ƒe dɔléle aɖewo, abe ŋkumeʋuʋu ene.
Dzɔtsoƒewo
[1] Wee SY, Park E S. Dɔlélenutsiŋutete ƒe dɔwɔwɔ le botulinum aɖi me[J]. Nudzraɖoƒe ƒe Plastic Amekoko-Aps, 2022,49 (1): 12-18.DOI: 10.5999 / aps.2021.00766.
[2] Dołomisiewicz D, Lipiec M, Mielniczek K, kple ame bubuwo. Botulinum aɖi - dɔwɔwɔ le tome kple tomeŋutinunya me ƒe wɔwɔfia[J].Polski Przegląd Otorynolaryngologiczny, 2022. https://api.semanticscholar.org/CorpusID:254297988
